Electron microscopy is a technique used to study the ultrastructure of macromolecules, cells, and tissues at high resolution. An aqueous biological sample is rapidly frozen and bombarded with electrons, and a detector senses how the electrons scatter to allow a computer to reconstruct a 3D image of the molecule. Cryo-electron microscopy services are useful when samples are small, difficult to crystallize, require atomic-level details, involve large biomolecular complexes, or analyzing native state structures is important.

1. Electron microscope
Electron microscopy (EM) has become an extremely popular method for the
ultrastructural study of macromolecules, cells and tissues. An aqueous biological
sample is frozen rapidly and irradiated with a beam of electrons. A detector
senses how the electrons are scattered and a computer reconstructs the 3D-
shape of the molecule.
Why you need this service?
• You have small amount of materials;
• The material is hard to crystallize;
• You are looking into the molecules in atomic details;
• It is a large biomolecular complex (>150 kDa, up to 2000 Å);
• You want to observe the real "native state" structure.
https://www.creative-biostructure.com/cryo-em-services_4.htm