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Presented by-
Shahnawaz Ahmad Teli
M.Pharm 2nd Semester
(clinical pharmacy)
Osteomyelitis
 Inflammation of bone and marrow
 Types
 Pyogenic osteomyelitis
 Tuberculous osteomyelitis
Case presentation
 Patient ID- 731560/17
 Name - XYZ
 Age – 18 yrs
 Sex – Man
 DOA- 26/02/17
 DOD- 15/03/17
Patient details- Subjective
Reason for admission- subjective (Cont..)
 Chief complaints at the time of admission:-
o Pain in left thigh x 3 months
o Swelling in thigh x 3 months
o Pus discharge from left thigh – since 1 month
 Provisional Diagnosis:- Chondrosarcoma
Reason for admission- subjective (cont..)
o Past Medical History:- Tuberculosis since 4 months.
o Past medication history- On Anti-tubercular treatment.
o Social history- Non-vegeterian
o Family history- Nil
Physical Examination-
General condition -- sick
CNS -- Conscious, well oriented
CVS – S1 and S2 sounds heard.
Abdomen -- Non-tender, Non-distended (Normal).
Vital signs-
B.P- 110/80 mmHg
P.R- 70/Min
Resp.- 78/min
Temp.- 98.4 F
Laboratory Test
Laboratory test 26/02/17 02/03/17 14/03/17 Discharge
time
Normal
range
Hemoglobin 7.3 (L) 8.9 (L) 9.3 (L) 11.1 (L) 12-15 g/dl
TLC 12500 (H) - 19000 (H) 10500 (H) 4000-11000
c/mm3
Neutrophils 86 (H) - 83 (H) 40 (L) 36-73 %
Lymphocytes 60 (H) - 10 (N) 25 (H) 20-24 %
ESR 112 (H) 92 (H) 70 (H) 36 (H) 0-15 mm/hr
Other Investigations
 Blood culture was positive for S.aureus and M.tuberculosis.
 MRI:- showed localized bone marrrow abnormality.
 USG:- Showed presence of fluid adjacent to bone and
Elevation and thickening of periosteum.
Final Diagnosis
 On the basis of Laboratory investigations, Blood
culture and Radio imaging, the patient was diagnosed
as Osteomyelitis.
Day to day assesment
 DAY 1ST : (26/02/17)
 Inj. Ampicillin + Cloxacillin 125gm iv –BD
 Tab. Diclofenac + paracetamol 50mg, 500mg – BD
 Tab. Omeprazole 20mg- BD
 Day 2nd: (27/02/17)
 Shifted to Ortho ward.
 Advice to perform surgery of left thigh.
Continue......
o Day 5th: (01/03/17)
 Iv fluid DNS 1 Unit
 Transfused 1 unit of blood
 Iv fluid NS 100ml/hr
o Day 6th: (02/03/17)
 Surgery removal of pus
 Inj. Cefuroxime 250mg
 Tab. Alprazolam 0.2mg HS
Continue.......
 Day 14th: (10/03/17)
 Again surgery was performed for removal of pus.
 Inj. Diclofenac- SOS
 Isoniazid+rifampicin+pyrazinamide 75mg, 150mg, 500mg
 Ethambutol 750mg- OD
 Pyridoxine 100mg –SOS
 Day 16th: (16/03/17)
 Syp. Metaclopromide 5mg/ml SOS
 Tab. Ofloxacin 200mg – BD
 Inj. Amikacin 100mg/2ml BD
 Stop Inj. Ampicillin + Cloxacillin
Treatment
Name of drug
Frequency,
Route
Strength Date Date Class
Started Stopped
Inj. Ampicillin + Cloxacillin
(BD/IV)
1.2gm 26/02/17 15/03/17 Penicillins
Tab. Diclofenac
+Paracetamol
(BD/ORAL)
50mg +
500mg
26/02/17 02/03/17 Analgesic and
Antipyretic
Tab. Omeprazole
(BD/PO)
20mg 26/02/17 till disch. PPI
Inj. Cefuroxime (BD/IV) 250mg 03/03/17 till disch. Cephalosporin
Tab. Alprazolam
(HS/PO)
0.25mg 03/03/17 09/03/17 Benzodiazepine
Tab. Pyridoxine
(OD/PO)
10mg 11/03/17 till disch. Vitamin -B6
Continue.......
Name of drug,
Route, frequency
strength Date Date Class
Started Stopped
Tab. INH +
Rifampicin +
Pyrazinamide +
Ethambutol
(OD/PO)
75mg,
150mg,
500mg,
750mg
11/03/17 till disch. Anti-TB drugs
Inj.
Metaclopromide
(SOS/IV)
5mg/2ml 15/03/17 Antiemetic
Tab. Ofloxacin
(Oral/BD)
200mg 15/03/17 conti.. Flouroquinolone
Inj. Amikacin
(IV/BD)
100mg/2ml 15/03/17 15/03/17 Aminoglycoside
Clinical justification
The treatment given was not satisfactory almost as the
condition of the patient was not improving, apart from this
there were some suggestions-
o The DOTS therapy should be continued otherwise relapse
may occur.
o The Alprazolam was given to the patient but there was no
complaint of insomnia.
o Aminoglycoside, cephalsporine, penicillin were not effective
still only these 3 classes of drugs are used for continuous
treatment.
Discharge summary
Tab. Ofloxacin 200mg BD Oral (7 days)
Inj. Metoclopromide 5mg/2ml SOS IV
Tab. Omeprazole 20mg BD Oral (7 days)
Tab. Diclofenac +Paracetamol 50mg+500mg BD PO (5 days)
 Ofloxacin + Diclofenac:- Minor Interaction
Displacement of GABA from receptors in brain
( risk of stimulation/Seizures)
Patient
Counseling
 Adhere to the Medications.
 To come for Review after 7 days.
Reference
 www.rxlist.com>home>drug interactions checker
 www.micromedexsolutions.com
 www.drugs.com/drug_interactions.html
Case on osteomyelitis (shahnawaz)

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Case on osteomyelitis (shahnawaz)

  • 1. Presented by- Shahnawaz Ahmad Teli M.Pharm 2nd Semester (clinical pharmacy)
  • 2. Osteomyelitis  Inflammation of bone and marrow  Types  Pyogenic osteomyelitis  Tuberculous osteomyelitis
  • 4.  Patient ID- 731560/17  Name - XYZ  Age – 18 yrs  Sex – Man  DOA- 26/02/17  DOD- 15/03/17 Patient details- Subjective
  • 5. Reason for admission- subjective (Cont..)  Chief complaints at the time of admission:- o Pain in left thigh x 3 months o Swelling in thigh x 3 months o Pus discharge from left thigh – since 1 month  Provisional Diagnosis:- Chondrosarcoma
  • 6. Reason for admission- subjective (cont..) o Past Medical History:- Tuberculosis since 4 months. o Past medication history- On Anti-tubercular treatment. o Social history- Non-vegeterian o Family history- Nil Physical Examination- General condition -- sick CNS -- Conscious, well oriented CVS – S1 and S2 sounds heard. Abdomen -- Non-tender, Non-distended (Normal). Vital signs- B.P- 110/80 mmHg P.R- 70/Min Resp.- 78/min Temp.- 98.4 F
  • 7. Laboratory Test Laboratory test 26/02/17 02/03/17 14/03/17 Discharge time Normal range Hemoglobin 7.3 (L) 8.9 (L) 9.3 (L) 11.1 (L) 12-15 g/dl TLC 12500 (H) - 19000 (H) 10500 (H) 4000-11000 c/mm3 Neutrophils 86 (H) - 83 (H) 40 (L) 36-73 % Lymphocytes 60 (H) - 10 (N) 25 (H) 20-24 % ESR 112 (H) 92 (H) 70 (H) 36 (H) 0-15 mm/hr
  • 8. Other Investigations  Blood culture was positive for S.aureus and M.tuberculosis.  MRI:- showed localized bone marrrow abnormality.  USG:- Showed presence of fluid adjacent to bone and Elevation and thickening of periosteum.
  • 9. Final Diagnosis  On the basis of Laboratory investigations, Blood culture and Radio imaging, the patient was diagnosed as Osteomyelitis.
  • 10. Day to day assesment  DAY 1ST : (26/02/17)  Inj. Ampicillin + Cloxacillin 125gm iv –BD  Tab. Diclofenac + paracetamol 50mg, 500mg – BD  Tab. Omeprazole 20mg- BD  Day 2nd: (27/02/17)  Shifted to Ortho ward.  Advice to perform surgery of left thigh.
  • 11. Continue...... o Day 5th: (01/03/17)  Iv fluid DNS 1 Unit  Transfused 1 unit of blood  Iv fluid NS 100ml/hr o Day 6th: (02/03/17)  Surgery removal of pus  Inj. Cefuroxime 250mg  Tab. Alprazolam 0.2mg HS
  • 12. Continue.......  Day 14th: (10/03/17)  Again surgery was performed for removal of pus.  Inj. Diclofenac- SOS  Isoniazid+rifampicin+pyrazinamide 75mg, 150mg, 500mg  Ethambutol 750mg- OD  Pyridoxine 100mg –SOS  Day 16th: (16/03/17)  Syp. Metaclopromide 5mg/ml SOS  Tab. Ofloxacin 200mg – BD  Inj. Amikacin 100mg/2ml BD  Stop Inj. Ampicillin + Cloxacillin
  • 13. Treatment Name of drug Frequency, Route Strength Date Date Class Started Stopped Inj. Ampicillin + Cloxacillin (BD/IV) 1.2gm 26/02/17 15/03/17 Penicillins Tab. Diclofenac +Paracetamol (BD/ORAL) 50mg + 500mg 26/02/17 02/03/17 Analgesic and Antipyretic Tab. Omeprazole (BD/PO) 20mg 26/02/17 till disch. PPI Inj. Cefuroxime (BD/IV) 250mg 03/03/17 till disch. Cephalosporin Tab. Alprazolam (HS/PO) 0.25mg 03/03/17 09/03/17 Benzodiazepine Tab. Pyridoxine (OD/PO) 10mg 11/03/17 till disch. Vitamin -B6
  • 14. Continue....... Name of drug, Route, frequency strength Date Date Class Started Stopped Tab. INH + Rifampicin + Pyrazinamide + Ethambutol (OD/PO) 75mg, 150mg, 500mg, 750mg 11/03/17 till disch. Anti-TB drugs Inj. Metaclopromide (SOS/IV) 5mg/2ml 15/03/17 Antiemetic Tab. Ofloxacin (Oral/BD) 200mg 15/03/17 conti.. Flouroquinolone Inj. Amikacin (IV/BD) 100mg/2ml 15/03/17 15/03/17 Aminoglycoside
  • 15. Clinical justification The treatment given was not satisfactory almost as the condition of the patient was not improving, apart from this there were some suggestions- o The DOTS therapy should be continued otherwise relapse may occur. o The Alprazolam was given to the patient but there was no complaint of insomnia. o Aminoglycoside, cephalsporine, penicillin were not effective still only these 3 classes of drugs are used for continuous treatment.
  • 16. Discharge summary Tab. Ofloxacin 200mg BD Oral (7 days) Inj. Metoclopromide 5mg/2ml SOS IV Tab. Omeprazole 20mg BD Oral (7 days) Tab. Diclofenac +Paracetamol 50mg+500mg BD PO (5 days)
  • 17.  Ofloxacin + Diclofenac:- Minor Interaction Displacement of GABA from receptors in brain ( risk of stimulation/Seizures)
  • 18. Patient Counseling  Adhere to the Medications.  To come for Review after 7 days.
  • 19. Reference  www.rxlist.com>home>drug interactions checker  www.micromedexsolutions.com  www.drugs.com/drug_interactions.html