some recent news in the field of hepatology اخبار سريعه عن بعض التطورات في مجال امراض الكبد

2. BYBY
Omer Mohammed SalehOmer Mohammed Saleh
Assistant lecturer of Tropical Medicine and GastroenterologyAssistant lecturer of Tropical Medicine and Gastroenterology
Hadramout University College of Medicine,Hadramout University College of Medicine,
YemenYemen
LIVER TRANSPLANT
NEWS

3. Hepatocyte-derived MicroRNAs as Serum
Biomarkers of Hepatic Injury and Rejection
after Liver Transplantation
liver injury is associated with the release of HDmiRs into
the circulation which now considered as a promising,
early, stable, and sensitive biomarkers of rejection
after liver transplantation.
Farid W, et al, Liver Transpl, 2012.

4. Diagnosing Cirrhosis from Recurrent Hepatitis C
Accurately With Ultrasound Technology
Ultrasound-based transient elastography provides
excellent diagnostic accuracy (98 % sensitivity and 83
% specificity) in recurrent HCV related cirrhosis in
post-LTx.
Adebbajo C, et al, Liver Transpl , 2012.

5. A 7-Gene Signature of the Recipient Predicts the
Progression of Fibrosis After Liver
Transplantation
for Hepatitis C Virus Infection
The genetic signature of the recipient predicts the
likelihood of severe liver fibrosis in the graft after
HCV recurrence.
Nicole T, et al, Liver Transpl, 2012.

6. A Novel Model for Evaluating the Risk ofA Novel Model for Evaluating the Risk of
Hepatitis B Recurrence After LiverHepatitis B Recurrence After Liver
TransplantationTransplantation
Pre-transplant HBV DNA, presence of HCC, AVT
status and post-transplant viral mutation are the
major risk factors associated with HBV recurrence
after LTx.
Xiao Xu, et al, Liver International, 2012.

8. Effect of Maintenance Therapy With Low –doseEffect of Maintenance Therapy With Low –dose
Peginterferon for Recurrent Hepatitis C AfterPeginterferon for Recurrent Hepatitis C After
Living Donor Liver TransplantationLiving Donor Liver Transplantation
Continuing long-term maintenance therapy with
peg-interferon prevented histological
progression of hepatitis C in patients who had
undergone LDLT.
Ueda Y, et al, J viral Hepat. 2012.

9. Prevention of Hepatitis B Recurrence in LiverPrevention of Hepatitis B Recurrence in Liver
Transplant Patients Using oral antivrial therapyTransplant Patients Using oral antivrial therapy
without long term hepatitis B immunoglobulinwithout long term hepatitis B immunoglobulin
Nucleos(t)ide analogue therapy with short term or no
HBIG was efficacious and safe in preventing post-LT
HBV.
Ahn J and Martin S, Hepat Mon. 2011.

10. Hepatitis B Virus Infection Has no Significant role
on
Lymphoproliferative Disorders Post Liver
Transplantation
HBV infection has no significant impact on inducing
PTLD and represents no survival effect in PTLD
setting.
Izadi M and Taheri S, Annals of Hepatology, 2011.

12. Sorafenib for Hepatocellular Carcinoma Patients
Beyond Milan Criteria after
Orthotopic Liver Transplantation: A Case
Control Study
Adjuvant sorafenib could possibly extend both
disease-free and overall survival for HCC patients
beyond Milan criteria after OLT.
Chieh-Lin Teng, et al, World J Surg oncol 2012.

13. Living Donor Liver Transplantation Versus
Deceased Donor Liver Transplantation for
Hepatocellular Carcinoma: Comparable
Survival and Recurrence
in well-matched cohorts of LDLT and DDLT
recipients, LDLT and DDLT provide similarly low
recurrence rates and high survival rates for the
treatment of HCC.
Sandhu L, et al, Liver Transpl, 2012.

14. Prognostic Factors for Late Mortality after Liver
Transplantation for Benign End-stage Liver
Disease
The major causes of late mortality were infection,
biliary complications and Hepatitis B virus
recurrence/reinfection.
Five variables (Age, ABO blood group, cold
ischemia time, infection, and biliary complications)
had significant impacts on patient survival.
ZHANG Ying-cai, Chinese Medical Journal 2011.

16. Safety and Efficacy of ERCP
in Patients with Post-Liver Transplant Biliary
Complications: Results of a
Cohort Study with Long-Term Follow-Up
ERCP is safe and effective for the treatment of
post-OLT biliary complications, has a low
rate of pancreatitis and results in a durable
effect.
Sanna C, et al, Gut and Liver, 2011.

17. Liver Transplantation for Autoimmune HepatitisLiver Transplantation for Autoimmune Hepatitis
in Peru: Outcomes and Recurrencein Peru: Outcomes and Recurrence
Rejection and recurrence were commonly
associated with AIH, but did not affect patient
survival .
Rapid progression to cirrhosis should be
considered in severe recurrences.
Padilla M, et al, Annals of hepatology, 2012.

19. Pregnancy Outcomes in Liver TransplantPregnancy Outcomes in Liver Transplant
Recipients: A Systematic Review and Meta-Recipients: A Systematic Review and Meta-
analysisanalysis
Post-LTx miscarriage rate (15.6%) , Pre-
eclampsia (21.9%), Cesarean section
(44.6%), and preterm delivery (39.4%).
Deshpande NA, et al, Liver Transpl, 2012.

20. Quality of Life and Psychological Outcome of
Donors after Living Donor Liver Transplantation
No major impact on HRQOL and psychological
outcomes in living liver transplant donors after
donation.
Guang S, et al, World j Gastroenterol, 2012.

22. Yemen Egypt
Hope For all ArabHope For all Arab
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