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Medical management of
osteoporosis
Simple 5 drugs
• Calcium
• Vit D3
• Bisphosphonates
• Teriparatide
• Denosumab
• Exercise – weight bearing , low
impact
• Exposure to sunlight
• Tobacco cessation
• Alcohol minimalization
CARBONATE CITRATE
Inexpensive Expensive
Taken with meals Fasting state also
Not with antacid drugs Can be given
40% elemental calcium
600mg per tablet
21% elemental calcium
250 mg per tablet
Small size Large size
Cause Constipation/ bloating Does not block iron
absorption
No risk of renal stones
CALCIUM
Calcium
Problems and challenges
• Bone loss – asymptomatic - Awareness
• Pts may not appreciate # prevention
• Compliance
• Affordability
Elderly person with fragility fracture – Spine , Radius , NOF
Women above 65 or post menopausal & Men
above 70
• Came for some other orthopedic ailments
• Progressive kyphosis or decrease in height
• Generalised weakness with bone pain ( osteoporosis + osteomalacia )
• Significant risk factors
Any other orthopedic fracture
• Intraoperative finding of brittle bone or thin cortex
Medical management of osteoporosis.pptx

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Medical management of osteoporosis.pptx

  • 3. • Calcium • Vit D3 • Bisphosphonates • Teriparatide • Denosumab • Exercise – weight bearing , low impact • Exposure to sunlight • Tobacco cessation • Alcohol minimalization
  • 4. CARBONATE CITRATE Inexpensive Expensive Taken with meals Fasting state also Not with antacid drugs Can be given 40% elemental calcium 600mg per tablet 21% elemental calcium 250 mg per tablet Small size Large size Cause Constipation/ bloating Does not block iron absorption No risk of renal stones CALCIUM
  • 6. Problems and challenges • Bone loss – asymptomatic - Awareness • Pts may not appreciate # prevention • Compliance • Affordability
  • 7. Elderly person with fragility fracture – Spine , Radius , NOF
  • 8. Women above 65 or post menopausal & Men above 70 • Came for some other orthopedic ailments • Progressive kyphosis or decrease in height • Generalised weakness with bone pain ( osteoporosis + osteomalacia ) • Significant risk factors
  • 9. Any other orthopedic fracture • Intraoperative finding of brittle bone or thin cortex