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Target delineation in cervical cancer
3/16/2024 1
Dr Kanhu Charan Patro
MD,DNB(Radiation Oncology),MBA,FICRO,FAROI(USA),PDCR,CEPC
Clinical Director, HOD (Radiation Oncology)
ISRo- Institute of Stereotactic Radiation oncology
Mahatma Gandhi Cancer Hospital & Research Institute, Visakhapatnam
drkcpatro@gmail.com /M- +91-9160470564/ www.drkanhupatro.com
Target delineation workflow in CANCER CERVIX
DR KANHU CHARAN PATRO
STEPS GCP EXPLANATION
STEP-1 GTVp Clinicoradiological
STEP-2 CTVp Cervix
STEP-3 GTVn Clinicoradiological
STEP-4 CTVn Clinicoradiological + 0.5cm
STEP-5 CTVp ELECTIVE Uterus + Adnexa + Vagina
STEP-6 CTVn ELECTIVE Common iliac+ Internal iliac+ External Iliac + Presacral + Obturator
STEP-7 OAR As per need
STEP-8 Special editing Barriers and OAR [bone + muscle +air]
STEP-9 PTVn Institutional and technique based
STEP-10 PTVp Institutional and technique based
5th MARCH 2024/ TARGET
CTV_p EMPTY BLADDER
3/16/2024 3
CTV_p FULLBLADDER
3/16/2024 4
ITV
3/16/2024 5
GTV_n
3/16/2024 6
CTV_n HR GTV_n + 0.5cm
3/16/2024 7
CTV NODE BIFURCATION
3/16/2024 8
CTV NODE COMMON ILIAC
3/16/2024 9
CTV NODE ILIAC
3/16/2024 10
CTV NODE GUTTER – CORONAL
3/16/2024 11
CTV NODE OBTURATOR
3/16/2024 12
CTV_n PRESACRAL
3/16/2024 13
CTV PARAMETRIUM
3/16/2024 14
What is PARAMETRIUM?
1. The fat and connective tissue that
surrounds the uterus.
2. The parametrium helps connect the uterus
to other tissues in the pelvis.
PARAMETRIUM content?
1. The parametrium includes the superficial uterine pedicle (uterine artery and superficial
uterine vein) and related connective tissue and lymphatic channels.
2. The connective tissue crossing below the ureter is considered paracervix.
GUIDELINE
CTV CERVIX
PARAMETRIUM
BOUNDARY
BOUNDARY
1. Superior boundaries of the parametria are at the top of the fallopian tube, and
contours should stop once loops of bowel are seen next to the uterus as this is
clearly above the broad ligament.
2. For the very anteverted uterus, particularly where the fundus lies below the
cervix, the parametrial volume should stop once the cervix is seen.
3. Inferiorly, the parametrial tissue finish at the muscles of the pelvic floor.
4. Anteriorly, the parametrial boundary lies at the posterior wall of the bladder.
5. In patients with a very small bladder (which lies deep in the pelvis), it was
decided to set the anterior parametrial boundary in line with the posterior
border of the external iliac vessels.
6. Posteriorly, the parametrial tissue is bounded by the mesorectal fascia and
uterosacral ligaments.
7. Laterally, the parametrial volume should extend to the pelvic sidewall (excluding
bone and muscle).
THE PARAMETRIUM IN MRI
UTEROSACRAL LIGAMNET
UTEROSACRAL LIGAMNET
MRI, axial view, showing the dorsal to ventral
direction of the uterosacral ligament (USL)
( red arrow ) with its insertion to the cervix
( Cx ), Bladder ( B ), and rectum ( Rec
Uterosacral coronal view
UTEROSACRAL LIGAMNET INVOLVEMENT
ADRESSSING UTEROSACRAL LIGAMENT
1. Care must be taken to include the entire
uterosacral ligaments if they are either
clinically or radiologically involved with
disease.
2. If this is the case, an argument can be
made to include the entire mesorectum
as pararectal lymph nodes would also be
at risk.
3. In that case, parametrial volumes would
extend up to the rectal contour (Fig. 5).
4. Patients with (FIGO) stage 3B or greater
disease and those with extensive nodal
involvement should also have the entire
mesorectum included in the parametrial
volume
OVERLAPING WITH NODAL VOLUME
1. It is acknowledged that there
would be some overlap of this
volume with the nodal CTV,
particularly along the obturator
strip.
2. The pelvic sidewall was
considered a more consistent
and reproducible boundary and
any overlap between the two
volumes could be dealt with
during treatment planning.
PTV LR
3/16/2024 29
PTV HR
3/16/2024 30
Vaginal Marker to be placed. Vaginal CTV extends 0.5-2 cm superior to this marker
depending on thickness of vaginal cuff.
CTV for postoperative radiation
31
OAR
3/16/2024 32
Post op cervix and endometrium
3/16/2024 33
Intact cervix
3/16/2024 34
Intact cervix
3/16/2024 35
3/16/2024 36
Scan through Google lens
Go to free materials
3/16/2024 37
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU

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TARGET DELINEATION IN CERVIX CANCER BY DR KANHU

  • 1. Target delineation in cervical cancer 3/16/2024 1 Dr Kanhu Charan Patro MD,DNB(Radiation Oncology),MBA,FICRO,FAROI(USA),PDCR,CEPC Clinical Director, HOD (Radiation Oncology) ISRo- Institute of Stereotactic Radiation oncology Mahatma Gandhi Cancer Hospital & Research Institute, Visakhapatnam drkcpatro@gmail.com /M- +91-9160470564/ www.drkanhupatro.com
  • 2. Target delineation workflow in CANCER CERVIX DR KANHU CHARAN PATRO STEPS GCP EXPLANATION STEP-1 GTVp Clinicoradiological STEP-2 CTVp Cervix STEP-3 GTVn Clinicoradiological STEP-4 CTVn Clinicoradiological + 0.5cm STEP-5 CTVp ELECTIVE Uterus + Adnexa + Vagina STEP-6 CTVn ELECTIVE Common iliac+ Internal iliac+ External Iliac + Presacral + Obturator STEP-7 OAR As per need STEP-8 Special editing Barriers and OAR [bone + muscle +air] STEP-9 PTVn Institutional and technique based STEP-10 PTVp Institutional and technique based 5th MARCH 2024/ TARGET
  • 7. CTV_n HR GTV_n + 0.5cm 3/16/2024 7
  • 9. CTV NODE COMMON ILIAC 3/16/2024 9
  • 11. CTV NODE GUTTER – CORONAL 3/16/2024 11
  • 15. What is PARAMETRIUM? 1. The fat and connective tissue that surrounds the uterus. 2. The parametrium helps connect the uterus to other tissues in the pelvis.
  • 16. PARAMETRIUM content? 1. The parametrium includes the superficial uterine pedicle (uterine artery and superficial uterine vein) and related connective tissue and lymphatic channels. 2. The connective tissue crossing below the ureter is considered paracervix.
  • 21. BOUNDARY 1. Superior boundaries of the parametria are at the top of the fallopian tube, and contours should stop once loops of bowel are seen next to the uterus as this is clearly above the broad ligament. 2. For the very anteverted uterus, particularly where the fundus lies below the cervix, the parametrial volume should stop once the cervix is seen. 3. Inferiorly, the parametrial tissue finish at the muscles of the pelvic floor. 4. Anteriorly, the parametrial boundary lies at the posterior wall of the bladder. 5. In patients with a very small bladder (which lies deep in the pelvis), it was decided to set the anterior parametrial boundary in line with the posterior border of the external iliac vessels. 6. Posteriorly, the parametrial tissue is bounded by the mesorectal fascia and uterosacral ligaments. 7. Laterally, the parametrial volume should extend to the pelvic sidewall (excluding bone and muscle).
  • 24. UTEROSACRAL LIGAMNET MRI, axial view, showing the dorsal to ventral direction of the uterosacral ligament (USL) ( red arrow ) with its insertion to the cervix ( Cx ), Bladder ( B ), and rectum ( Rec
  • 27. ADRESSSING UTEROSACRAL LIGAMENT 1. Care must be taken to include the entire uterosacral ligaments if they are either clinically or radiologically involved with disease. 2. If this is the case, an argument can be made to include the entire mesorectum as pararectal lymph nodes would also be at risk. 3. In that case, parametrial volumes would extend up to the rectal contour (Fig. 5). 4. Patients with (FIGO) stage 3B or greater disease and those with extensive nodal involvement should also have the entire mesorectum included in the parametrial volume
  • 28. OVERLAPING WITH NODAL VOLUME 1. It is acknowledged that there would be some overlap of this volume with the nodal CTV, particularly along the obturator strip. 2. The pelvic sidewall was considered a more consistent and reproducible boundary and any overlap between the two volumes could be dealt with during treatment planning.
  • 31. Vaginal Marker to be placed. Vaginal CTV extends 0.5-2 cm superior to this marker depending on thickness of vaginal cuff. CTV for postoperative radiation 31
  • 33. Post op cervix and endometrium 3/16/2024 33
  • 37. Scan through Google lens Go to free materials 3/16/2024 37