The document discusses the factors that make a mutant allele dominant, focusing on loss-of-function and gain-of-function mutations. It explains that dominant mutations can arise from increased activity or changed regulatory function of a gene product. Additionally, it touches on concepts like haploinsufficiency and dominant negative mutations.

1. WHAT MAKES A MUTANT
ALLELE DOMINANT?
BY ARIJIT PANI

2. Mutation
Dominant
Loss of
Function
Gain of
Function
Recessive
Loss of
Function

3. Dominant Mutations

4. GAIN OF FUNCTION
Increased activity of given gene product
Change in regulatory function of the gene product
New activity conferred on the gene product
0
2
4
6
Wild type Mutant
ActivityofProtein

5. LOSS OF FUNCTION
Haploinsufficiency
Dominant negative mutations

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