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What do we know about heme iron II


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Some more published studies and conclusions from them

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What do we know about heme iron II

  1. 1. HEMOGLOBIN IRON II What do we know? Some more published studies of heme iron supplementation
  2. 2. Heme iron is absorbed by human duodenal mucosal cells in a specific uptake process which is not influenced by extrinsic factors like phytates, calcium or oxalates. The two different absorption pathways are complimentary and additive. Heme iron will not desensitize mucosa cells like non-heme iron. It will be absorbed for instance during proton pump inhibitor/antacid treatment as opposed to non-heme. EFFECT OF TEA AND OTHER DIETARY FACTORS ON IRON ABSORPTION. Zijp IM, Korver O, Tijburg LB. Crit Rev Food Sci Nutr. 2000 Sep;40(5):371-98.
  3. 3. Low iron counts and even anaemia is often found in patiens using proton pumb inhibitors such as Losec (omeprazole). These drugs make stomach content less acidic. A lowered gastric acid pH effectively stops non-heme iron uptake. PROTON PUMP INHIBITORS SUPPRESS ABSORPTION OF DIETARY NON-HAEM IRON IN HEREDITARY HAEMOCHROMATOSIS. Hutchinson C, Geissler CA, Powell JJ, Bomford A. Gut. 2007 Sep;56(9):1291-5
  4. 4. Heme iron tablets often contain both hemoglobin and non-heme iron such as Ferrous fumarate or Ferrous sulphate, since the hemoglobin raw material is voluminous in comparison. Heme- and non-heme iron will however not interact or compete for uptake or efficacy. In fact they complement each other. NON-HEME IRON AS FERROUS SULFATE DOES NOT INTERACT WITH HEME IRON ABSORPTION IN HUMANS. Gaitán D, Olivares M, Lönnerdal B, Brito A, Pizarro F. Biol Trace Elem Res. 2012 Dec;150(1-3):68-73
  5. 5. In the literature mechanisms for both organic (heme) and inorganic (non-heme) iron uptake are well documented. The special pathway through which heme iron is absorbed has great benefits, mainly because the uptake is substantially higher. Since the hemoglobin molecule is absorbed as a whole no free iron ions are released in the intestine to trigger disturbancies. PATHWAYS OF IRON ABSORPTION Marcel E. Conrad and Jay N. Umbreit Blood Cells, Molecules, and Diseases (2002) 29(3) Nov/Dec: 336–355
  6. 6. Heme iron tablets typically have a tolerance close to placebo level, whereas non-heme oral iron has a therapy failure rate due to side- effects of around 30 % Heme iron products have the potential to complement anaemia therapy. This would mean substantial savings for the community and a much improved quality of life for the patients. HEME IRON-BASED DIETARY INTERVENTION FOR IMPROVEMENT OF IRON STATUS IN YOUNG WOMEN. Hoppe M, Brun B, Larsson MP, Moraeus L, Hulthen L. Nutrition. 2013 Jan;29(1):89-95.
  7. 7. Heme iron works well with children and is absorbed to a greater degree than non- heme iron. It will also not inhibit zinc absorption. PRODUCTION OF STABLE-ISOTOPE-LABELED BOVINE HEME AND ITS USE TO MEASURE HEME-IRON ABSORPTION IN CHILDREN. Paz Etcheverry, Gordon E Carstens, Erin Brown, Keli M Hawthorne, Zhensheng Chen, and Ian J Griffin The American Journal of Clinical Nutrition Am J Clin Nutr 2007;85:452–9.