W H A T I S A N U S A N D H A N Dr
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Anusandhan is a state of being connected to one's true self, which traditions identify as God as inspired by the Guru. This state has surpassed subjective prejudices and is associated solely with global welfare. It has no petty pursuits or mean considerations, and is an objective state that has a benevolent effect of facilitating freedom for the entire universe. Anusandhan can also be considered the state of ultimate freedom in the truest sense.
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The document discusses three main points about spiritualism and the practice of namasmaran.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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W H A T I S A N U S A N D H A N Dr
- 2. Anusandhan is said to be a state of one’s being connected with true self. This true self is identified in the traditions with the name of God as inspired by the Guru. This is supposed to be state that has surpassed and transcended all the subjective prejudices. This is supposed to be a sate that is associated with the aim of and aspiration of global welfare only. This is said to be a state which has no
- 3. petty pursuits and no mean considerations. This state is supposed to be an objective state that has benevolent effect on the entire universe. Benevolent effect means the effect that facilitates the ANUSANDHAN! ANUSANDHAN can also be said to be THE state of ultimate FREEDOM in true sense. DR. SHRINIWAS KASHALIKAR