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Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
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Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
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2. No Brasil, destaca a evolução do IGP-M e suas principais componentes, além de dados sobre vendas no varejo, capacidade instalada e horas trabalhadas na indústria de São Paulo.
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O documento agradece a amizade de alguém e explica que o encaminhamento de e-mails sem mensagens pessoais é uma forma de manter o contato quando se está ocupado, sem ter nada para dizer ou não saber o que dizer, mas querer demonstrar que a pessoa ainda é lembrada e importante.
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El resumen analiza 4 artículos de la revista Educación XX1 de diferentes años. El artículo más actualizado es el cuarto mientras que el tercero es el más anticuado. Todos los artículos muestran un abultamiento excesivo de la bibliografía en relación a las citas en texto, especialmente los artículos tercero y cuarto. Finalmente, hay poca autocitación de la revista y predominan las citas de otras revistas.
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This document summarizes research from a working group examining wireless devices and security in the workplace. It discusses new enabling wireless technologies like 5G networks, beamforming, and Project Loon. It also covers growing security challenges from the expanding use of wireless devices, bring your own device policies, and the growing Internet of Things. Specific attacks like relay attacks on keyless car entry systems and wireless mouse hijacking are also summarized.
Uma Simples Folha De Papel...
A empresa de tecnologia anunciou um novo smartphone com câmera aprimorada, maior tela e melhor processador. O novo aparelho custará US$ 100 a mais que o modelo anterior e estará disponível para pré-venda em 1 mês. Analistas esperam que o novo smartphone ajude a empresa a aumentar suas vendas e receita no próximo trimestre.
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O documento apresenta dados econômicos do Brasil e do cenário internacional, incluindo índices de preços e expectativas de inflação. Os principais indicadores de inflação no Brasil como IGP-M e IPC apresentaram desaceleração na taxa acumulada em 12 meses. As expectativas de mercado apontam para manutenção da inflação próxima da meta do Banco Central.
Project opportunity Labs
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1. O relatório apresenta dados sobre a economia internacional e brasileira, incluindo vendas e estoque de imóveis nos EUA, transações correntes e conta de capital no Brasil, balança de serviços e rendas, dívida externa e investimento estrangeiro direto.
2. Os dados mostram que as vendas de imóveis nos EUA caíram em fevereiro, enquanto o déficit em transações correntes do Brasil aumentou.
3. O relatório também analisa índices de vendas no varejo brasileiro, que t
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Um professor pediu aos alunos que trouxessem batatas representando pessoas que os magoaram e as carregassem por uma semana. Carregar as batatas tornou-se incômodo com o mau cheiro e peso, assim como carregar mágoas afeta negativamente a vida das pessoas. Os alunos aprenderam que "carregar mágoas é tão ruim quanto carregar batatas".
Presentación1
El documento explica cómo calcular y usar escalas en planos y mapas. Detalla que una escala es una relación entre las medidas reales y las representadas gráficamente, como 1:100. Explica cómo calcular la escala de un plano dado las medidas reales y representadas, y cómo usar una escala dada para calcular medidas reales a partir de las graficadas. Proporciona un ejemplo de aplicar una escala de 1/20 para crear un plano de una habitación a partir de sus medidas reales.
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Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
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Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Diagnosis and Staging
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Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
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Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
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Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
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It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
biomechanics of running. Dr.dhwani.pptx
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Patellar Instability: Diagnosis Management
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
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