New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Victory Over Neck And Back Pain Dr Shriniwas Kashalikar
1. VICTORY
OVER
NECK AND BACK
PAIN
BY
DR. SHRINIWAS
JANARDAN
KASHALIKAR
2. INTRODUCTION
I had following and many questions in
my mind, about ailments and healing.
Would I like to keep ailing like many
others are?
Would I like to go from doctor to
doctor belonging to different systems
of medicine as others are?
Would I like to go through a vicious
chain or cycle of expensive
investigations and subsequent
admonition [without any guarantee of
health and happiness] as many of us
are forced to go through?
3. Would I like to spend exorbitant
money on treatment, as many have to
spend?
Would I like to be eternally dependent
on medical professionals belonging to
some or other particular system of
medicine or a healer of some kind or
other as many of us depending?
Would I like to live in the threatening
shadow of disease and death forever as
many others are living?
The answer was a big NO.
This was probably why; I, as a medical
student and later as a
medical professional; kept on working
on this issue and realized;
that all medical systems of are part of
one single PATH OF HEALING. In
4. fact in the course of time I realized
that all the fields
of knowledge and art, could contribute
to the health or disease of an
individual and society. This is the
concept of HOLISTIC
MEDICINE.
But what was the HOLISTIC
MEDICINE expected to do?
Was it to impart only physical health?
No. So-called health, which
is determined by and endorsed by
laboratory and other
investigations, considers only physical
well being. But physical
well-being is not at all a true indicator
of health. A person cannot be judged
in the same way as we judge a statue.
A person is judged by his or her
5. actions. The actions in turn spring
from one’s
instincts, emotions, thoughts and
perspective.
HOLISTIC HEALTH therefore is
nothing else but a process of acquiring
the perspective of global welfare,
policies and plans and commitment to
these and
coordinated and concerted efforts of
experts in that direction from different
walks of life! Holistic Medicine is
understanding and practicing the
wisdom in their respective fields, for
the well being of one and all is the key
to HOLISTIC HEALTH which I call
TOTAL STRESS MANAGEMENT
also.
This small book is a humble effort in
that direction.
6. Precautions:
1. In this book you will find a variety
of remedies. It is important to be
aware of the legislations involved in
the use of the different
remedies.
2. It is quite possible that concurrent
use some of these remedies may not be
acceptable to some medical
practitioners.
3. It is also true that I do not have
clinical trials to quote;
for some of these remedies.
4. The quality of a particular
product is something I cannot vouch
on at all.
5. Some of the remedies may require
doctor’s prescription.
7. 6. Some of the YOGASANAs or other
procedures/endeavors may require
expert guidance.
7. It is also important to note that we
are different individuals with
different constitutions. We are of
different age groups and genders.
We may vary in terms of different
physiological conditions such as
pregnancy, menstruation and
lactation. These variable factors alter
the efficacy and safety of medications
and practice of yogasanas or exercises.
8. The ailment may have
different causes and the stage of the
ailment may also vary.
9. We may have different histories of
past and family illnesses.
10. These different considerations may
limit the utility of this book.
8. However this book would surely
provide you, with new options for
substantial improvement in your
HOLISTIC HEALTH irrespective
of whether you belong to a non-
medical or a medical profession.
DR. SHRINIWAS KASHALIKAR
AYURVEDA
• Mix Manjishtha and Guggul in cold
water and release drop
9. by drop in the nostrils
• Dashamularishta 1-3 tea spoon ful
1-3 three times a day
• Rumalaya ointment and tablets.
Ointment to be rubbed in a
gentle manner without bringing it in
contact with eyes or
mucous membranes and tablet should
be taken 1-2 tablets 1-3
times a day depending upon your
tolerance.
• Sameer yograj Guggul 250 mg three
times a day
• Urad oil [Extract of Urad in Sesame
i.e. Til oil] to be released
in nostrils, taken orally 1-2 tea
spoonful 1-2 times a day
according to your tolerance
• Drink Urad quath i.e. boiled urad
extract
• Put drops urad extract in nose
10. • Atasyadi gutika. The pills of Alsi,
devadar and sunth. 1 to 3
pills 1to 3 times a day according to
your comfort.
• You can tie a leaf of rui or errand
and foament the area.
• Drink 1 to 3 teaspoon ful of neem
and bala root extracts
• Combination of Trifala Guggul and
4 parts and Vatavidhvans
2 parts to be taken in the dose 250 mg
three times a day.
ALLOPATHY
1] Anti-inflammatory drugs such as
Ibuprofen, Diclofenac sodium,
Diclofenac potassium, Aspirin, 1 to 2
tablets 1 to3 times a day
according to the severity and always
after food.
11. These drugs should not be taken on
empty stomach, in case of
acidity problems and in association
with alcohol.
There are pain killers such as
dextropropxyphene and paracetamol.
Sometimes muscle relaxants such as
Chlorzoxazone in the dose of
250 mg 1 to 3 times a day or diazepam
in the dose 2 mg three
times a day are advised
Sometimes combinations of above
drugs are used.
Artiflex [plus]
• Chlorzoxazone 250 mg
• Ibuprofen 400 mg
• Paracetamol 300 mg
Chlorizok
• Chlorzoxazone 250 mg
• Diclofenac potassium 50 mg
• Paracetamol 325 mg
12. Agile MR
• Chlorzoxazone 300 mg
• Diclofenac potassium 50 mg
• Paracetamol 300 mg
are some of the combinations.
2] Hot and cold fomentation
3] Short wave diathermy provided by
physiotherapist [physical
therapists]
4] Treatment by ultra sound
vibrations given through ultra sound
machine by physiotherapist [physical
therapists]
5] Traction is vertical stretching given
with traction machine by
physiotherapist [physical therapists]
6] Cervical collar usually advised by
doctors and provided by the
agencies manufacturing or retailing it
7] Belladonna plaster usually available
with chemists and can be
13. applied on the painful region
8] In severe cases some times
decompression of the nerve roots in
the particular region of the vertebral
column is done is done by
surgery
EXERCISE
1] Suryanamaskar
2] Shoulder exercises
3] The physical training exercises
4] Neck exercises
5] Exercises of toes, feet, knee, fingers,
wrists, elbows while on
sedentary job
WALKING
1] The care to be taken
2] Namasmaran while walking
Synchronizing the namsmaran with
foot steps and with abdominal
breathing
14. 3] Climbing the staircases
4] Trekking
DIET
Nachani, bajara, jwar, patni,
shingada, soyabean,
Different oils
Green leafy vegetables
Seasonal fruits
Use of sprouted beans
POSTURE
Alexander technique of integrated
posture
Erect seating, standing, walking
UTILITIES
Avoid foam cushion, foam pillow and
foam bed
Avoid gust of ceiling fan
15. Avoid high heals use platform shoes if
you want to look taller
Use of towel roll under neck
Sleeping in lateral position
Covering of the neck to avoid severe
cold breeze or wind.
MORNING ABLUTIONS
Gum and palate massage
Washing of face
BODY MOVEMENTS
Avoid jerks
Avoid lifting heavy articles bringing
strain on back or neck
YOGA
(Physical Hathayoga Techniques)
Makarasan, Bhujangasan,
Dhanurasan, Shalabhasan, Vakrasan,
Simhamudra, Brahmamudra,
16. Nasikagra Drishti, Bhrumadhya,
dristhi, Kapalbhati
Avoid sheershasan, halasan,
sarvangasan, viparitkarani in acute,
conditions.
MASSAGE
Gentle massage along the length of the
muscles with Mahanarayan
or other suitable oil. Til oil is also
good.
HOMEOPATHY
Rhododendron >< 30, 2 to 4 pills 3 to 4
times a day. This is
especially useful if there is tingling and
numbness in upper
extremities i.e. arms and hands
reaching up to fingertips.
OSTEOPATHY
17. Manual Traction
Mobilization
Exercises
One could find many more techniques
and remedies from books, but,
The most important healing
principle
is to get out of the trap of forces of
pettiness which trap you and suffocate
you without your being aware of them!
To succeed in this, practice
NAMSMARAN daily irrespective of
illusory threatening times and
difficulties and the agonies produced
by them.
Dr. Shriniwas Kashalikar