UPSTREAM PROCESS
• Upstream processing in industrial
microbiology encompasses the initial steps of
biomanufacturing, focusing on microorganism
selection, genetic improvement, media formulation,
and cultivation in bioreactors to maximize product
yield.
• It involves developing an active inoculum, sterilizing,
and optimizing growth conditions (pH, temperature,
oxygen) to produce high-quality biomass or
metabolites.
Steps:
• Microorganism Selection and Modification: Isolating, screening, and
improving strains (e.g., bacteria, fungi) for enhanced product
formation.
• Media Formulation and Sterilization: Preparing nutrients (carbon,
nitrogen sources, salts) and ensuring sterility of the medium and
equipment to prevent contamination.
• Inoculum Development: Scaling up the culture from lab scale to
industrial scale (seed train) to ensure a healthy, active population for
the main fermenter.
• Bioreactor Cultivation: Managing fermentation parameters like pH,
temperature, agitation, and aeration within fermenters to optimize
growth.
• Cell Harvesting: Collecting the cells or culture broth, often using
centrifugation or filtration, before transferring the product to
downstream processing.
Upstream and Downstream Processing-1.pptx
Upstream and Downstream Processing-1.pptx
Upstream and Downstream Processing-1.pptx
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Upstream and Downstream Processing-1.pptx
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Upstream and Downstream Processing-1.pptx
Upstream and Downstream Processing-1.pptx
Upstream and Downstream Processing-1.pptx

Upstream and Downstream Processing-1.pptx

  • 9.
    UPSTREAM PROCESS • Upstreamprocessing in industrial microbiology encompasses the initial steps of biomanufacturing, focusing on microorganism selection, genetic improvement, media formulation, and cultivation in bioreactors to maximize product yield. • It involves developing an active inoculum, sterilizing, and optimizing growth conditions (pH, temperature, oxygen) to produce high-quality biomass or metabolites.
  • 10.
    Steps: • Microorganism Selectionand Modification: Isolating, screening, and improving strains (e.g., bacteria, fungi) for enhanced product formation. • Media Formulation and Sterilization: Preparing nutrients (carbon, nitrogen sources, salts) and ensuring sterility of the medium and equipment to prevent contamination. • Inoculum Development: Scaling up the culture from lab scale to industrial scale (seed train) to ensure a healthy, active population for the main fermenter. • Bioreactor Cultivation: Managing fermentation parameters like pH, temperature, agitation, and aeration within fermenters to optimize growth. • Cell Harvesting: Collecting the cells or culture broth, often using centrifugation or filtration, before transferring the product to downstream processing.