This document introduces the UNIQSAFE Retractable Safety Syringe produced by Axel Bio Corporation. It summarizes global trends towards using safety syringes to prevent needlestick injuries. The UNIQSAFE syringe uses a patented retractable mechanism that allows for identical operation to traditional syringes while providing enhanced safety. It aims to replace traditional syringes by offering simple use, minimal training requirements, and mechanical retraction to eliminate malfunctions. The syringe can be produced at low cost using an efficient production line with only 8 parts.

1. UNIQSAFE Retractable Safety Syringe
The NEXT Generation of The Syringe
Presented by: Axel Bio Corporation, USA

2. Outline
• Global Trend of
Using The Safety Syringe
• Global Safety Syringe Market
• Introduction of UNIQSAFE
Retractable Safety Syringe
• Product Competitive Analysis

3. Global Trend of Using The Safety Syringe

4. Why Using The Safety Syringe?

5. Why Using The Safety Syringe?
• Needlestick Injuries Are a Serious
Occupational Hazard for Healthcare
Workers.
According to the National Institute for
Occupational Safety and Health (NIOSH),
estimated 600,000 to 800,000 occupational
needlesticks occur each year in healthcare
workers. (Infection Control Resource, 2010)
According to Medical Care Data International,
accidental needlesticks account for 80% of all
occupationally acquired diseases.
• Huge Cost of Medical Compensation.
The average cost of compensation of each
case is between 850~2000USD. The total cost
of accidental needlestick compensation is
over billions of USD.

6. Governmental Legislation
United States.
The US President Clinton signed the
Needlestick Safety and Prevention Act that
required the hospitals to change over to safety
syringe starting from July 2001.
Europe.
On 10 May 2010, a directive was introduced to
prevent injuries and blood-borne infections to
hospital and healthcare workers from sharp
instruments such as needles.
Other Countries.
Followed by the US and Europe, other
countries such as Canada, Brazil, China and
Taiwan, have similar act legislated.
United Nation Organization.
WHO-UNICEF-UNFPA announced a joint
statement on the use of auto-disable syringes
in immunization services.
“Federal Needlestick Safety and Prevention Act”
Signed by President Bill Clinton on Nov 6, 2000.

7. The Development of Syringe

8. 1853 ：
C.G.Pravaz and A. Wood developed a
medical hypodermic syringe with a
needle fine enough to pierce the skin.
1962：
B.D introduced its first
plastic disposable syringe.
1970：
The plastic disposable syringe was gradually
replacing the glass syringe. Besides B.D., Kendall,
Terumo and JMS were entering the market.
1980:
The plastic disposable syringe
has entirely replaced the glass
syringe.
1897：
Becton Dickinson and Co (B.D.)
opened for business and began
selling its first syringe made of glass.
1988：
B.D has invented needle capping safety
syringe Safety-Lok. Various types of safety
syringes are invented ever since.
2001：
The US passed the Needlestick Safety and
Prevention Act. Followed by EU and other
countries have similar directive or act legislated.
The Glass syringe has been replaced
by the plastic disposable syringe after
70 years of life cycle.
The Safety syringe will entirely
replace the plastic disposable syringe
in the future and dominate the market.

9. Global Safety Syringe Market

10. Global Market Demand of The Safety Syringe
Source: Industry Data, Greystone estimated 2015
44%
45%
10%
1%
Traditional syringe
Safety syringe
Pen injector
Needleless injector

11. Global Usage of The Safety Syringe
Sources: WHO; 2007 Greystone Market Report ，2009 MediPurpose Market Research
0
10,000
20,000
30,000
40,000
50,000
60,000
70,000
80,000
2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
61,210 62,130 63,061 64,007 64,966 65,941 66,930 67,935 68,953 69,988 71,039 72,105 73,188
13,457 15,208 17,183 19,417 21,942 24,795 28,266 32,225 36,735 41,511 46,907 53,005 59,896
Total Syringe Usage
Total Safety Syringe Usage
Total Syringe Usage Total Safety Syringe Usage
Unit: Million
81.8 %

12. Introduction of
UNIQSAFE Retractable Safety Syringe

13. SPEC
1 mL
3 mL
5 mL
10 mL
Patent
INVENTION Patent
of 30 countries
The US, EU, etc.
Type
Rotatable &
Retractable
Certificate
FDA 510K
CE/MDD
ISO 13485
UNIQSAFE Retractable Safety Syringe

14. Barrel front tip (section view)
Some protruded slot inside the
internal hole
Needle coupler (section view)
Rough surface at the external wall
of the adaptor
Plunger front tip (structure view)
Some leave pattern tooth in front
of plunger
Patented Technology
Safety Mechanism
UNIQSAFE Retractable Safety Syringe

16. Similar Operation
as The Traditional Syringe

17. Product Competitive Analysis

18. 操作面 結構面
設備面市場面
Operation Structure
Production
Line
Market
Product Competitive Analysis

19. Structure
Production
Line
Market
Product Competitive Analysis

20. The Limits of The Safety Syringe
Products in The Current Market

21. Step 1- Air Ejection
Other Brands
Accidental Activation of the Safety
Mechanism During Operation
General Injection Process
1. Shift of the needle coupler
2. Medication leakage
3. Non-precise dosage of medication
4. Waste of medical resources

22. Step 2 – Medication Withdrawal
Other Brands
1. Shift of the needle coupler
2. Medication leakage
3. Non-precise dosage of medication
4. Waste of medical resources
General Injection Process
Accidental Activation of the Safety
Mechanism During Operation

23. Step 3- Medication Injection
Other Brands
1. Causing pain and discomfort to
patients.
2. Higher risk due to shifting of the
needle coupler.
General Injection Process
Accidental Activation of the Safety
Mechanism During Operation

24. Step 4 – Needle Disposal After Use
Other Brands
1. Increase of Needlestick Injuries
2. Difficulty of operation
3. Other Dangers
Bad Design of
Safety Mechanism
General Injection Process

25. The Safety Syringe Reference Standards
1. Provide a shield between the operator and the needle after used.
2. The hands of operator remain behind the needle at all times.
3. The overall structure is in an integrated form and the safety mechanism is not
attached to it.
4. Before decomposing or after disposing, it should posses the safety protection
to the managing staff.
5. Easy to operate or require only simple training to make sure the objectives of
safety and effectiveness can be achieved.
TraditionalOther brands
?
?
?
?
?

26. Rotatable Retractable Safety Syringe
Has Overcome ALL the Problems

27. Step 1- Air Ejection
1. No accidental activation of safety
mechanism during ejection.
2. Same operation as the traditional
syringe.
Same Operation as The
Traditional Syringe
Eject
Injection Process of
UNIQSAFE Retractable Safety Syringe

28. Step 2 - Medication Withdrawal
1. Precise dosage of medication.
2. Same operation as the traditional
syringe.
Injection Process of
UNIQSAFE Retractable Safety Syringe
Same Operation as The
Traditional Syringe

29. Step 3 - Medication Injection
1. No accidental activation of safety
mechanism during injection.
2. No shifting of the needle coupler
Injection Process of
UNIQSAFE Retractable Safety Syringe
Same Operation as The
Traditional Syringe

30. Step 4 - Activation of Safety Mechanism
1. Simple and easy process.
2. Easy release of safety
mechanism.
Simple Training
Rotate
Retract
Injection Process of
UNIQSAFE Retractable Safety Syringe

31. Step 5 - Needle Disposal After Use
1. Needle destruction inside the
barrel.
2. Only a few parts to dispose,
environmental friendly.
Safe & Environmental Friendly
Push
Destroy
Injection Process of
UNIQSAFE Retractable Safety Syringe

32. Traditional
The Safety Syringe Reference Standards
1. Provide a shield between the operator and the needle after used.
2. The hands of operator remain behind the needle at all times.
3. The overall structure is in an integrated form and the safety mechanism is not
attached to it.
4. Before decomposing or after disposing, it should posses the safety protection
to the managing staff.
5. Easy to operate or require only simple training to make sure the objectives of
safety and effectiveness can be achieved.
Us ENTIRELY
REPLACE
The traditional
syringe!

33. 1. Identical to The Traditional
Syringe
2. Simplicity of Use
3. Minimal Additional Training
4. Mechanical Retraction
Eliminates Malfunction
5. Compliance with FDA
Standards

34. 操作面 結構面
設備面市場面
Operation Structure
Production
Line
Market
Product Competitive Analysis

35. Operation
Production
Line
Market
Product Competitive Analysis

36. There Are Only a Total of 8 Parts to Our Product
1. Needle
protecting cap
2. Needle
3. Needle hub
4. Needle coupler
5. O-ring
6. Barrel
7. Piston
8. Plunger

37. Two Features of the Design
Simple Design
1. Easy access to raw materials
2. Low cost
Flexibility of the O-ring Seal
1. High resistance of temperature variation.
2. Indicator of activation of safety mechanism.

38. 操作面 結構面
設備面市場面
Operation Structure
Production
Line
Market
Product Competitive Analysis

39. Operation Structure
Market
Product Competitive Analysis

40. Manual
Semi-automatic
Fully automatic
The Development of The Production Line of The Traditional Syringe
10~70 PCS / Min
70~140 PCS / Min
140~ PCS / Min

41. Auto Needle-gluing equipment Needle-Body Printer General Assembly Equipment
Packing Supplies Feeder Packing Equipment Sterilization Equipment
The Production Line of The Traditional Syringe
200 PCS per min.

42. O-ring Assembly machine
Packing Equipment Sterilization Equipment
Auto Needle-gluing equipment Needle-Body Printer General Assembly Equipment
The Production Line of Our Safety Syringe 280 PCS per min.
Packing Supplies Feeder

43. 操作面 結構面
設備面市場面
Operation Structure
Production
Line
Market
Product Competitive Analysis

44. Operation Structure
Production
Line
Product Competitive Analysis

45. SAME
COST
The Traditional Syringe UNIQSAFE
Retractable Safety Syringe

46. BD Integra™ Syringe BD Safety-Lok™ Syringe BD SafetyGlide™ Syringe BD SafetyGlide™ Needle BD Eclipse™ Needle
USD 0.79 USD 0.63 USD 1.05 USD 1.21 USD 0.31
Terumo SurGuard®
Syringes
Kendall Monoject Safety
Syringes
Monoject Insulin Safety
Syringes
Magellan™ Safety
Needles
Sol-Millennium
USD 0.36 USD 0.62 USD 0.62 USD 0.37 USD 0.16

47. BD Integra™ Syringe BD Safety-Lok™ Syringe BD SafetyGlide™ Syringe BD SafetyGlide™ Needle BD Eclipse™ Needle
USD 0.79 USD 0.63 USD 1.05 USD 1.21 USD 0.31
Terumo SurGuard®
Syringes
Kendall Monoject Safety
Syringes
Monoject Insulin Safety
Syringes
Magellan™ Safety
Needles
Sol-Millennium
USD 0.36 USD 0.62 USD 0.62 USD 0.37 USD 0.16
We Are The MOST Competitive Product in The Market!

48. ISO 13485
FDA510K
CE/MDD
Invention Patents Granted by 30 countries,
including The US and EU.
FDA 510K, CE/MDD and ISO 13485 Certified

49. Compliance with the
capacity of the traditional
production line
Simple Design O-ring Assembly machine
1. High speed fully automatic
production line
2. Direct adaptability to the
traditional production line
1. Availability of 1 mL, 3 mL, 5 mL and
10 mL (0.5 mL in progress)
2. Simplicity of use
3. Lowest medication residue
4. Little Medical waste
1. Invention Patent
2. Mechanical fully automatic
equipment, fully increase
the capacity
LOW cost！ Meet
Market demand
Higher Capacity than
traditional syringes
Comprehensive Advantages of
UNIQSAFE Retractable Safety Syringe

50. The NEXT Generation of Safety Syringe

51. THANK YOU!