Harriet Beecher Stowe's novel 'Uncle Tom's Cabin' became famous as an anti-slavery work that influenced public perceptions of slavery in America. The story, set on a Kentucky plantation, follows Uncle Tom, a dignified enslaved man, and explores themes of slavery, morality, and human dignity. Stowe's Christian perspective and experiences with fugitive slaves informed her narrative, contrasting the notions of freedom in the North with the oppression in the South.