Comprehensive energy efficiency retrofit projects can achieve reductions in energy use of 50% or greater by making fundamental systemic changes rather than just upgrading discrete components. Such deep retrofits may have 7-10 year paybacks but can attain significant carbon emissions savings of 50% or more. Example retrofit projects discussed include redesigning lighting in offices, classrooms and laboratories using occupancy sensors and updated fixtures, converting parking lots to LED lights, and installing demand controlled ventilation and low flow fume hoods in laboratories to reduce air changes and exhaust flows.