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Tumor
Section 
Satellite Symposium
Low-grade Gliomas: 
Management Strategies  Innovations
SAN DIEGO, CALIFORNIA
SEPTEMBER 23-24, 2016
SAN DIEGO CONVENTION CENTER
JOINTLY PROVIDED BY THE CONGRESS OF NEUROLOGICAL
SURGEONS AND THE AANS/CNS JOINT TUMOR SECTION
2 TUMOR SECTION SATELLITE SYMPOSIUM
Experience
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neurotechnology
innovations
Visit us during the Tumor Section and the
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TUMOR SECTION SATELLITE SYMPOSIUM 1
Dear Colleague,
Welcome to the 2016 Tumor Section Satellite Symposium in San
Diego! Over the next two days, we will explore our meeting theme,
Low-grade Gliomas: Management Strategies  Innovations,
and examine advancements in the treatment of adult and pediatric
brain tumors. With your participation, we look forward to
engaging scientific sessions covering recent clinical trials, tumor
guidelines, and next-generation techniques in surgical, medical,
and radiation therapies.
We are pleased to welcome keynote speakers Mitchel Berger,
Hugues Duffau, and James Rutka as well as many distinguished
brain tumor experts slated to present during our four General
Sessions. We are also grateful to our sponsors and exhibitors, whose
support helped make this meeting possible. Please remember
to connect with these industry partners for lunch and afternoon
breaks in the exhibit hall.
Residents, fellows, and junior attendings are invited to
participate in small-group breakfast breakout sessions on Saturday
morning. These are outstanding opportunities to meet senior brain
tumor surgeons and learn how to set up a practice, start a lab, or
seek out an academic position.
We hope to see you at the 31st Anniversary Gala Reception
Friday evening at the historic US Grant Hotel. Join us in honoring
the recipients of this year’s Wilson Award, Distinguished Service
Award, and Parsa Mentoring Award.
Finally, we are proud to host our meeting for the first time in
conjunction with the Congress of Neurological Surgeons Annual
Meeting. If you plan to stay on for more great science this week,
don’t forget to connect with us again at the Tumor Section sessions
at the CNS Annual Meeting.
Thank you for being a part of this meeting as together we move
the treatment and care of brain tumor patients forward.
Sincerely,
TABLE OF CONTENTS
Learning Objectives	 2
CME Information	 2
Program Schedule	 3-15
Floor Plans	 16-19
Exhibitors	 18
General Information	 21-22
Disclosures	 23-24
SECTION CHAIR
Steven N. Kalkanis
MEETING CHAIR
Chetan Bettegowda
MEETING CHAIR
Brian V. Nahed
2 TUMOR SECTION SATELLITE SYMPOSIUM
Symposium Description
This symposium will provide an up-to-date overview of the
management of low-grade tumors in adult and pediatric patients,
emphasizing cutting-edge and next-generation techniques
in medical, surgical, and radiation therapies. It will identify
the molecular and genetic changes and efforts to target these
mutations in state-of-the-art therapy.
Learning Objectives
Upon completion of this symposium participants should be able to:
•	 Develop treatment strategies for patients with low-grade glioma
at diagnosis and recurrence
•	 Discuss advancements in understanding of low-grade glioma
biology and relevance to outcome
•	 Discuss emerging surgical, medical, and radiation techniques to
achieve the best outcome
CME Information
ACCREDITATION
This activity has been planned and
implemented in accordance with the
accreditation requirements and policies of
the Accreditation Council of Continuing
Medical Education (ACCME) through the
joint providership of the Congress of Neurological Surgeons and
the Tumor Section. The CNS is accredited by the ACCME to
provide continuing medical education for physicians.
AMA CREDIT DESIGNATION STATEMENT
The CNS designates this live activity for a maximum of
12.75 AMA PRA Category 1 CreditsTM
. Physicians should only
claim credit commensurate with the extent of their participation
in the activity.
CLAIMING CME CREDIT
CME credits can be claimed through the online CME system at
www.cns.org. The CME tracking system allows you to create and
print a CME certificate immediately following the Tumor Section
Satellite Symposium while you are still in San Diego, or from the
convenience of your home or office. Log in using your last name
and the email address with which you registered. You will need
to enter the number of hours you are claiming for each session
you attended. Physicians should only claim credit for the learning
activities in which they actively participated. Upon completion of
this process, your CME certificate will be sent to you via email at
the email address you provided at registration.
MID-LEVEL PRACTITIONERS
Attendees will receive a certificate of completion. Please contact
your individual membership association and certification board to
determine the requirements for accepting credits.
TUMOR SECTION SATELLITE SYMPOSIUM 3
Program Schedule
Friday, September 23, 2016
8:00 am–5:00 pm
Registration	 Ballroom 6 Lobby, Upper Level
General Session 1 Room 6B, Upper Level
Biology and Management of LGG
10:00–10:10 am
Opening Remarks
Chetan Bettegowda, Steven N. Kalkanis, and
Brian Nahed
10:10–10:25 am	
Biology of Low-grade Gliomas
Robert Jenkins
10:25–10:40 am
Diagnosis: Medical Management/Chemotherapy
and Timing
Susan Chang
KEYNOTE SPEAKER 1
10:40–11:10 am
Maximizing Resection for Survival/When to
Operate	
Mitchel S. Berger, MD, chair of
neurological surgery at University of
California San Francisco, is a nationally
recognized expert in treating brain and
spinal cord tumors and tumor-related
epilepsy in adults and children. He also is a
specialist in brain mapping techniques, used
to identify areas of motor, sensory and language function during
surgery, and an expert in the use of the Gamma Knife for tumor
treatment. He is co-director of the Adult Brain Tumor Surgery
Program, director of the Brain Tumor Research Center, and
director of the Center for Neurological Injury and Repair.
11:10–11:25 am	
Radiation Therapy
Jennifer Yu
4 TUMOR SECTION SATELLITE SYMPOSIUM
11:25–11:40 am	
Recurrence and Progression to High-grade	
Houtan Noushmehr
11:40–11:55 am	
Clinical Trials, Targeted Therapies, Mechanisms
Steven Yip
11:55 am–12:10 pm
Joint Section on Tumors Guidelines
Jeffrey J. Olson
12:10–1:10 pm	
Lunch with Exhibitors in the Exhibit Hall	
Room 6A, Upper Level
12:10–1:10 pm
Sponsored Lunch Seminar Room 6B, Upper Level
Controversies in Fluorescence Guided
Surgery (FGS) of Gliomas: Fluorescein
vs. 5-ALA
General Session 2 Room 6B, Upper Level
Surgical Techniques and
Adjuvant Therapy
KEYNOTE SPEAKER 2
1:15–1:45 pm
Mapping Intraoperatively to Maximize Resection
	Hugues Duffau, MD, PhD, is professor
and head of the department of neurosurgery at
the University Hospital Centre of Montpellier,
France. A leading expert on low-grade glioma
surgery, Dr. Duffau pioneered surgery of
still-conscious patients with brain tumors,
resulting in a new model of the brain based on
plasticity and connectivity. He has authored more than 225
publications and four books, including Brain Mapping: From Neural
Basis of Cognition to Surgical Applications, published in 2011.
1:45–1:55 pm
Pre-operative Imaging/fMRI
1:55–2:05 pm	
Intraoperative Imaging
Christian Rainer Wertz
2:05–2:15 pm
Intraoperative Ultrasound
Francesco DiMeco
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 5
2:15–2:25 pm
Intraoperative 5-ALA
Walter Stummer
2:25–2:35 pm
Fluroscent Alkylphosphocholine for Intraoperative
Detection
John Kuo
2:35–2:45 pm
Intraoperative Mass Spectroscopy
Kevin Petrecca
2:45-2:55 pm
Raman Spectroscopy
Steven N. Kalkanis
2:55–3:05 pm
Intraoperative Viral Vectors
Manish Aghi
3:05–3:30 pm
Break with Exhibitors	 Room 6A, Upper Level
Sponsored by:
3:30–5:00 pm
Abstract Presentations 1: Selected Oral Abstract
Presentations and Discussion	 Room 6B, Upper Level
Moderators: Gordon Li and Pamela Jones
3:30–3:35 pm
Supratotal Resection in Low-grade Gliomas:
Feasibility and Clinical Impact	
Marco Rossi, Marco Riva, Federico Pessina,
Alessandra Casarotti, Lorenzo Bello
3:35–3:40 pm	
The Benefit of Gross Total Resection Across
Glioma Subtypes: A Comparison of Grade II/III/
IV Gliomas in the Surveillance, Epidemiology,
and End Results (SEER) Database	
Brian R. Hirshman, Ali A. Alattar, Alexander J.
Schupper, Jennifer Padwal, Michael G. Brandel,
Xuezhi Dong, Bob S. Carter, Clark C. Chen
3:40–3:45 pm	
The Value of Extent of Resection for Genetically
“Favorable” and “Unfavorable” High-grade
Gliomas: Analysis of the TCGA Data	
Shawn L. Hervey-Jumper, David Altshuler, Karam
Paul Asmaro, Lisa Scarpace, Tom Mikkelsen,
Steven N. Kalkanis
3:45–3:50 pm	
Surgical Outcomes and Complications
after Reoperation for Recurrent Skull Base
Meningiomas
Stephen T. Magill
Program Schedule
6 TUMOR SECTION SATELLITE SYMPOSIUM
3:50–3:55 pm	
Atypical and Anaplastic Meningioma (AAM):
Outcomes in a Population-based Study	
Tomas Garzon-Muvdi, Wuyang Yang, Michael Lim,
Henry Brem, Judy Huang
3:55–4:00 pm	
Thermal Injury to Corticospinal Tract Predicts
Post-operative Motor Deficits Following Laser
Interstitial Thermal Therapy	
Mayur Sharma, Ghaith Habboub, Danilo Silva,
Gene H. Barnett, Alireza M Mohammadi
4:00–4:05 pm	
Portable Intraoperative Computed Tomography
Scan in Image-guided Surgery for Brain High-
grade Gliomas: Analysis of Technical Feasibility
and Impact on Extent of Tumor Resection	
Giuseppe Barbagallo, Stefano Palmucci,
Massimiliano Visocchi, Sabrina Paratore, Giancarlo
Attinà, Giuseppe Sortino, Vincenzo Albanese,
Francesco Certo
4:05–4:10 pm	
Surgical Resection for Intracranial Malignant
Teratomas: A Population-based Study	
Wuyang Yang, Xiaoming Rong, Tomas Garzon-
Muvdi, Jose Luis Porras, Xuan Hui, Judy Huang
4:10–4:15 pm	
Sources of Variation Influencing Concordance
Between Functional MRI and Direct Cortical
Stimulation in Brain Tumor Surgery	
Melanie Morrison, Fred Tam, Marco Garavaglia,
Gregory Hare, Michael Cusimano, Tom Schweizer,
Simon Graham, Sunit Das
4:15–4:20 pm	
Sodium Fluorescein Facilitates Guided Sampling
of Diagnostic Tumor Tissue in Non-enhancing
Gliomas
Stephen G. Bowden, Brian John Andrew Gill,
Randy D’Amico, Timothy H Ung, Peter Chang,
Justin A. Neira, Jorge Samanamud, Sameer A.
Sheth, Guy M. McKhann, Michael B. Sisti, Peter D.
Canoll, Jeffrey N. Bruce
4:20–4:25 pm	
Subventricular Zone Contact, but not
Subgranular Zone, Corpus Callosal, nor Cortical
Contact, Predicts Survival in Surgically Treated
Glioblastomas	
Akshitkumar Mistry, Michael C. Dewan, Gabrielle
A. White-Dzuro, Philip Ryan Brinson, Kyle D.
Weaver, Reid C. Thompson, Rebecca Ihrie,
Lola Blackwell Chambless
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 7
4:25–4:30 pm	
Incidence of Leptomeningeal Disease
Following Ventricular Entry During Resection of
Supratentorial Grade IV Glioma	
Ben Allen Strickland, Dima Suki, Rory R. Mayer,
J. Matthew Debnam, Ian E. McCutcheon, Raymond
E. Sawaya, Jeffrey S. Weinberg
4:30–4:35 pm	
Initial Experience with an Image-guided
Robotically Positioned Optical Platform for Skull
Base Surgery
Amin B. Kassam, Srikant S. Chakravarthi, Juanita
Celix, Sammy Khalili, Martin Corsten, Sarika Walia,
Jonathan Jennings, Melanie Fukui, Richard A.
Rovin
4:35–4:40 pm	
Cranial Chordoma: A New Classification System
and Validation	
Harley Brito da Silva, David Straus, Manuel
Ferreira Jr., Robert C. Rostomily, Jason Barber,
Laligam N. Sekhar
4:40–4:45 pm	
Diagnostic Accuracy of PET, SPECT, and
Arterial Spin-Labeling in Differentiating Tumor
Recurrence from Necrosis in Cerebral Metastasis
after Stereotactic Radiosurgery	
Clark C. Chen, Grace Y. Lai, David Hackney,
Peter C. Warnke, Eric T. Wong, Bob S. Carter
4:45–4:50 pm	
Cochlear Radiation Dose Is Associated with
Decreased Hearing Preservation for Vestibular
Schwannoma Patients Treated with Radiosurgery
Lawrance K. Chung, Nolan Ung, Winward Choy,
Carlito Lagman, Panayiotis Emmanuel Pelargos,
Brittany Voth, Alessandra A. Gorgulho, Stephen
Tenn, Nader Pouratian, Tania B. Kaprealian,
Michael T. Selch, Antonio DeSalles, Quinton
Gopen, Isaac Yang
4:50–4:55 pm	
A Morphometric Survey of the Parasellar Region
of over 2700 Skulls with Particular Emphasis on
the Middle Clinoid Process	
Akshay Sharma, Gabrielle E. Rieth, Joseph E.
Tanenbaum, Sunil V. Manjila, Buelent Yapicilar
4:55–5:00 pm
Proposing a Validated Clinical App for Predicting
Unfavorable Outcomes in Patients Undergoing
Craniotomy for Excision of Acoustic Neuroma
Piyush Kalakoti, Jerry McLarty, Kanika Sharma,
Maura Cosetti, Anil Nanda
Program Schedule
8 TUMOR SECTION SATELLITE SYMPOSIUM
7:00–10:00 pm	
31st Anniversary Gala Reception at the historic
US Grant Hotel
Presentation of the Wilson Award, Distinguished
Service Award, and Mentoring Award
Complimentary shuttle service will depart from the
Marriott Marquis San Diego Marina Hotel’s lower front
drive at 6:45 pm. Shuttles will return to the Marriott
upon the conclusion of the event.
Saturday, September 24, 2016
7:00 am–12:00 pm
Registration	 Ballroom 6 Lobby, Upper Level
7:00 am–5:00 pm
Abstract Digital Poster Viewing in Exhibit Hall
Breakfast Breakouts for Residents,
Fellows, Medical Students, and
Young Attendings
8:00–9:00 am
Developing an Independent Research Program/
Lab as a Neurosurgeon	 Room 10, Upper Level
John Sampson and Manish Aghi
8:00–9:00 am
Neurosurgeons as Clinical Trial
Investigators	 Room 11A, Upper Level
Fred Barker, Michael Lim, and Michael Vogelbaum
8:00–9:00 am	
Finding a Neurosurgery Position as a Brain
Tumor Surgeon	 Room 11B, Upper Level
Bob Carter and Ricardo Komotar
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 9
9:10–10:20 am	
Abstract Presentations 2: Selected Oral Abstract
Presentations and Discussion	Room 6B, Upper Level
Moderators: Graeme Woodworth and Nduka
Amankulor
9:10–9:15 am	
Re-visiting Racial Disparity in Outcomes
Following Craniotomy for Resection of Adult
Intracranial Tumors	
Piyush Kalakoti, Kanika Sharma, Christina
Notarianni, Anil Nanda
9:15–9:20 am	
Racial Disparity in Short-term Outcomes and
Hospital Costs in Pediatric Patients Undergoing
Craniotomy for Resection of Brain Tumors:
Insights from Kids’ Inpatient Database (KID)	
Piyush Kalakoti, Kanika Sharma, Anil Nanda,
Christina Notarianni
9:20–9:25 am	
Early Discharge after Craniotomy Is Safe and
Associated with Decreased 30-day Readmissions
and Decreased Risk of DVT/PE
Angela Richardson, Jagteshwar Sandhu, David
McCarthy, Roxanne Mayrand, Christine Guerrero,
Ricardo Jorge Komotar, Michael E. Ivan
9:25–9:30 am	
Differences in Patterns of Care and Prognosis
in Elderly versus Non-elderly Patients with
Glioblastoma	
Patrick Michael Flanigan, Arman Jahangiri, Ruby
Kuang, Albert Truong, Sarah Choi, Alvin Chou,
Annette Molinaro, Michael William McDermott,
Mitchel S. Berger, Manish Kumar Aghi
9:30-9:35 am	
Bone Marrow Response as a Potential Biomarker
of Outcomes in Glioblastoma Patients	
Eugene John Vaios, Brian V. Nahed, Alona
Muzikansky, Amir Fathi, Jorg Dietrich
9:35–9:40 am	
Dosimetric Thresholds Predicting High Risk of
Radionecrosis in Gamma Knife Radiosurgery
for Cerebral Metastases	
Steven L. Gogela, Yair M. Gozal, John Thaman,
Bryan Matthew Krueger, Ronald E. Warnick
Program Schedule
10 TUMOR SECTION SATELLITE SYMPOSIUM
9:40–945 am	
Cochlear Function as a Novel Predictor of
Hearing Preservation in Vestibular Schwannomas
after Stereotactic Radiosurgery
Amparo M. Wolf, Svetlana Kvint, Aram Modrek,
Carolina Gesteira Benjamin, John G. Golfinos,
Joshua Silverman, Douglas Kondziolka
9:45–9:50 am	
Hypofractionated Radiosurgery for the
Treatment of Large Brain Metastases and Post-
resection Cavities	
Yair M. Gozal, Timothy Struve, Steven L. Gogela,
Eric Wolf, McGill Brian, Michael Lamba, Luke E.
Pater, John C. Breneman, Ronald E. Warnick
9:50–9:55 am	
VTE in Patients Undergoing Craniotomy for Brain
Tumors: A NSQIP Analysis	
David J. Cote, Heloise H. Dubois, Aditya Vishwas
Karhade, Timothy R. Smith
9:55–10:00 am	
Extra-pseudocapsular Dissection Technique
for Growth Hormone (GH)-Secreting Pituitary
Adenomas by Endoscopic Endonasal
Transsphenoidal Approach	
Xiao-jie Lu, Qing Wang, Bing Li, Jiang-an Li,
Jing Wang
10:00–10:05 am	
Infectious Complications after Craniotomy for
Tumor: A National Surgical Quality Improvement
Program Analysis	
Hormuzdiyar H. Dasenbrock, Sandra C. Yan,
Timothy R. Smith, Elizabeth Claus, William B.
Gormley, Ian F. Dunn
10:05–10:10 am	
Development of Persistent Mucoid Spinal Cord
Mass in a Patient Following Olfactory Mucosal
Stem Cell Transplantation to Treat Spinal Cord
Injury	
Navin Sabharwal, Elizabeth Emily Bennett,
Abdi S. Ghodsi, Glen Stevens, Andrew Torre Healy,
Edward C. Benzel
10:10–10:20 am
Questions and Answers
10:20–10:40 pm
Break with Exhibitors	 Room 6A, Upper Level
Sponsored by:
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 11
General Session 3: Room 6B, Upper Level
Pediatric Low-grade Tumors
10:40–10:50 am	
Opening Remarks
Chetan Bettegowda and Brian Nahed
10:50–11:10 am
Medical Management of Pediatric Low-grade Tumors
Nathan Robison
11:10–11:30 am	
Radiation of Pediatric Low-grade Tumors
Mary McAleer
11:30 am–12:15 pm	
Abstract Presentations 3: Selected Oral Abstract
Presentations and Discussion	 Room 6B, Upper Level
Moderators: Peter Fecci and Kaisorn Chaichana
11:30–11:35 am
Tumorigenic Alterations by Mutant IDH1 in Early
Gliomagenesis	
Aram Modrek, Themasap Khan, Danielle Golub,
Michael Kader, Guoan Zhang, Jingjing Deng, Chris
Bowman, Nermin Sumru Bayin, Joshua Frenster,
Tenzin Lhakhang, Adriana Heguy, John Dankert,
Aristotelis Tsirigos, Matija Snuderl, Thomas
Neubert, Dimitris G. Placantonakis
11:35–11:40 am	
Integrated Prognostication of Molecular
Oligodendroglioma in the Cancer Genome Atlas
Sameer H. Halani, Michael Nalisnik, Chad Holder,
Jun Kong, Jose Enrique Velazquez Vega, Jeffrey J.
Olson, Lee Cooper, Daniel J. Brat
11:40–11:45 am	
Epigenetic Regulation of Mesenchymal
Transition by CBX6 in GBMs	
Yujun Wang, Gang Li, Mike Yue Chen
11:45–11:50 am
High Dimensional Analysis of Glioblastoma
Multiforme by Mass Cytometry	
Ahmed M. Mohyeldin, Yannick Simmone,
Evan Newell, Ichiro Nakano
11:50–11:55 am	
A Cerebrospinal Fluid microRNA Signature for
Glioblastoma Detection	
Johnny Akers, Valya Ramakrishnan, Ying Mao,
Wei Hua, Bob S. Carter, Clark C. Chen
11:55 am–12:00 pm	
Three Dimensional Bioprinting of the Human
Gliovascular Unit	
Robert Thomas Wicks, Young-Joon Seol,
Goodwell Nzou, Elizabeth E. Wicks, Sang Jin Lee,
Sean V. Murphy, James J. Yoo, Anthony Atala
Program Schedule
12 TUMOR SECTION SATELLITE SYMPOSIUM
12:00–12:05 pm	
Confocal Laser Endomicroscopic (CLE)
Characterization of the Normal Brain	
Cleopatra Charalampaki, Alhadi Igressa
12:05–12:10 pm	
Putting the Brakes on Brachyury: Identifying and
Targeting a Conserved Transcriptional Network
that Drives Primary and Metastatic Brain Tumor
Initiation and Propagation	
Sagar R. Shah MS, Justin M David, Nathaniel
Tippens, Ahmed Mohyeldin, Juan Carlos Martinez-
Gutierrez, Sara Ganaha, Kristen Kozielski, Jordan
Green, Andre Levchenko, Claudia Palena, Alfredo
Quinones-Hinojosa
12:10–12:15 pm	
ZR30, an in vitro Synthesized EFEMP1-derived
Tumor Suppressor Protein Targets MMP2, EGFR,
NOTCH1, and AKT Signaling from Extracellular
Compartment of Different Glioma Cell
Subpopulations of Intracranial Xenografts
Yi-Hong Zhou, You-Xin Zhou, Yanyan Li MSc, Yuan
Hu, Chuaniin Liu, Qingyue BS Wang, Xiaoxiao Han,
Yong Han, Xue-Shun Xie, Xiong-Hui Chen,
Eric R. Siegel, Kambiz Afrasiabi, Mark E. Linskey
12:15–1:15 pm	
Lunch with Exhibitors in the Room 6A, Upper Level
Exhibit Hall	
KEYNOTE SPEAKER 3
1:15–1:45 pm	
Surgery for Pediatric Low-grade Tumors
	James Rutka, MD, PhD, is RS McLaughlin
professor and chair of the department of
surgery at the University of Toronto, and also
serves on the surgical staff at the Hospital for
Sick Children in the Division of Pediatric
Neurosurgery. Editor-in-chief of the Journal of
Neurosurgery, Dr. Rutka’s primary research and
clinical interests relate to the science and surgery of human brain
tumors. His laboratory interests lie in the molecular biology of human
brain tumors—specifically in the determination of the mechanisms by
which brain tumors grow and invade. His recent clinical interests have
centered on the surgical treatment of epilepsy in children. He has over
400 peer-reviewed publications.
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 13
General Session 4 Room 6B, Upper Level
Outcomes and the Future
1:45–2:05 pm 	
Molecular Classification and Outcomes of
Low-grade Glioma
Adam Resnick
2:05–2:25 pm
Upcoming Targets in Low-grade Glioma
Andrew Chi
2:25–2:45 pm
Emerging Technologies Monitoring for
Recurrence/Progression
Chetan Bettegowda, Clark Chen, and Brian Nahed
2:45–3:00 pm
Parsa Mentoring Award
Steven N. Kalkanis
3:00–3:35 pm 	
Break with Exhibitors	 Room 6A, Upper Level
3:35–5:00 pm	
Abstract Presentations 4: Selected Oral Abstract
Presentations and Discussion	Room 6B, Upper Level
Moderators: Sunit Das and Chris Farrell
3:35–3:40 pm	
Immune Checkpoint Blockade as a Potential
Therapeutic Target: Surveying CNS Malignancies
Sarah Tamara Garber, Yuuri Hashimoto, Shiao-
Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel
Verhaak, Shouhao Zhou, Gregory N. Fuller,
Mustafa Khasraw, John Degroot, Sandeep Reddy,
David Spetzler, Amy B. Heimberger
3:40–3:45 pm	
Peripheral Lymphocytic Immune Checkpoint
Landscape in Primary and Recurrent Glioblastoma
Leonel Ampie, Winward Choy, Jonathan
Balquiedra Lamano, Joseph D. DiDomenico, Kartik
Kesavabhotla, Orin Bloch
3:45–3:50 pm	
Treatment with Hypomethylating Agent
Decitabine Can Reverse Immune Escape by
Isocitrate Dehydrogenase Mutant Gliomas	
Xiaoran Zhang MS, Aparna Rao, Christopher P.
Deibert, Wajin Jason Kim, Alexander Pomerantz,
Nduka M. Amankulor
3:50–3:55 pm	
CCL21 Vault Nanoparticle as an
Immunotherapeutic for Glioblastoma
Panayiotis Emmanuel Pelargos, Brittany Voth,
Nikhilesh Bhatt, Carlito Lagman, Nolan Ung,
Winward Choy, Isaac Yang
Program Schedule
14 TUMOR SECTION SATELLITE SYMPOSIUM
3:55–4:00 pm
Sulforaphane Inhibits the Formation of Glioma
Induced Myeloid Derived Suppressor Cells and
Reduces Myeloid PDL1 Expression
Ravi Kumar, Ian F. Parney
4:00-4:05 pm
Craniotomy for Intracranial Melanoma
Metastases Offers a Bridge Towards Enhancing
Efficacy of Checkpoint Inhibitor Therapy
Christopher Alvarez-Breckenridge, Corey Gill, Mia
Bertalan, Daniel P. Cahill, Ryan Sullivan, Priscilla
Brastianos
4:05–4:10 pm
Validation of the Programmed Death-Ligand 1
Antibody Clone 28-8 for Immunohistochemistry
in Brain Tumor Patients
Arnold Obungu, Saman Sizdahkhani, Graham
Lobel, Nancy A. Edwards, Edjah K. Nduom
4:10–4:15 pm
Synergistic Anti-tumor Effect with Indoleamine
2,3-dioxygenase Inhibition and Temozolomide
in a Murine Glioma Model
Hiroyuki Kinouchi, Mitsuto Hanihara, Tomoyuki
Kawataki
4:15–4:20 pm
A Potential New Adjunct to Temozolomide
Therapy in Glioblastoma
Gary R. Simonds, Cara Rogers
4:20–4:25 pm
Combined Multimodality Treatment with
Hypoxia-activated Prodrug TH-302 and XRT
Results in Enhanced Antitumor Efficacy in
Preclinical Malignant Meningioma Mouse Model
Asif Maknojia, Vaibhav Patel, Michael Garcia, Dave
Cavazos, Courtney Bosse, Aleksandra Gruslova,
Niko Papanikolaou, Andrew Brenner, John Robert
Floyd
4:25–4:30 pm
Preclinical Study and Translational Application
of Concurrent Radiotherapy and Valproic Acid
for Intracranial Hemangioblastomas in Sporadic
Hemangioblastomatosis
Gautam U. Mehta, Saman Sizdahkhani,
Charlton Smith, Christina Hayes, DeeDee Smart,
Prashant Chittiboina
Program Schedule
TUMOR SECTION SATELLITE SYMPOSIUM 15
4:30–4:35 pm	
Phosphatase 2A Inhibitor, LB100, Sensitizes
Malignant Meningioma Cells to Radiation by
Autophagy Inhibition	
Sze Chun Winson Ho, Saman Sizdahkhani,
Anita Tandle, Dragan Maric, Deric M. Park,
Zhengping Zhuang, John D. Heiss
4:35–4:40 pm	
Modulation of Radiation Induced Cell Death
in Glioma via Cadherin-mediated Tumor
Microenvironment Alteration	
Christopher Paul Cifarelli
4:40–4:45 pm	
Engineering Primary Patient-derived Adipose
Mesenchymal Stem Cells (hMSCs) with
Nanoparticles: An Autologous “Trojan Horse” for
the Intraoperative Treatment of Brain Cancer
Rawan Alkharboosh, Kristen Kozielski, Jordan
Green, Alfredo Quinones-Hinojosa
4:45–4:50 pm	
Self-assembling Camptothecin Hydrogel:
A Local Treatment for Brain Tumors
Montserrat Anilu Lara-Velazquez, Paula
Schiapparelli, Ran Lin, Pengcheng Zhang, Hao Su,
Hugo Guerrero Cazares, Honggang Cui, Alfredo
Quinones-Hinojosa
4:50–4:55 pm
Disulfiram Sensitizes Glioblastoma to Abraxane
and Temozolomide Treatment Through Inhibition
of MGMT and Aldehyde Dehydrogenase
George C. Bobustuc, Deborah L. Donohoe,
Richard A. Rovin, Amin B. Kassam, Santhi D.
Konduri
4:55–5:00 pm	
Acid Ceramidase is a Novel Drug Target Against
Multiple Pediatric Brain Tumors	
Ninh Doan, Wade M. Mueller, Shama Mirza,
Kathleen M. Schmainda, Mona Al-Gizawiy,
Andrew Montoure, Ha Nguyen
Program Schedule
16 TUMOR SECTION SATELLITE SYMPOSIUM
Convention Floor Plan
Convention Center Overview
6A
Tumor Exhi
Ballroom 6 Lobby
Tumor Registration
10, 11A, 11B
Breakfast
Breakouts
Convention Center Upper Level
San Diego Conve
GROUND LEVEL
Registration | Saturday to Wednesday
Exhibit	Hall	C | Monday to Wednesday | General Scienti
Monday  Tuesday | Operative Neurosur
Monday | Clinical Trials Update Sessions
CNS E
(Exhib
CNS HOTEL S
OVERVIEW
UPPER LEVEL MEETING ROOMS/BAL
MEZZANINE LEVEL MEETING ROOMS
GROUND LEVEL EXHIBIT HALLS
UNDERGROUND
PARKING GARAGE 2 LEVELS
SAN DIEGO BAY
FIRST
AVENUE
FRO
NT
STREET
WEST HARBOR DRIVE
GASLAMP QUARTER
98						#CNS2016
TUMOR SECTION SATELLITE SYMPOSIUM 17
6B
Tumor General
Session  Abstract
Oral Presentations
ibit Hall
5B
Speaker Ready
Room
ention Center
ific Sessions
rgery Sessions
s
EXHIBIT HALL
bit Halls A  B)
REGISTRATION ENTRANCE
from Marriott Marquis
San Diego Marina Hotel
SHUTTLES
LLROOMS/SAILS PAVILION
PARKING
STRUCTURE
FIFTH
AVENUE
SAN DIEGO BAY
CONVENTION WAY
18 TUMOR SECTION SATELLITE SYMPOSIUM
Exhibit Hall Floor Plan
EXHIBITOR			 BOOTH
Arbor Pharmaceuticals 		 307, 313
Brainlab 				 305
BioD, LLC 			 306
Carl Zeiss 			 311
Medtronic 			 309
Monteris Medical 			 304
Stryker 				 308
Exhibitors
Ballroom 6-Lobby
TUMOR SECTION SATELLITE SYMPOSIUM 19
Thank you
Corporate Supporters
Silver Supporter
Carl Zeiss
Bronze Supporters
Arbor Pharmaceuticals
Medtronic
Stryker
BioD, LLC
Monteris Medical
PP-GLD-US-0142
Vigilant ObservatIon of GlIadeL
WAfer ImplaNT (VIGILANT)
Registry: A Multicenter,
Observational Registry to
Collect Information on the
Safety and Effectiveness
of Gliadel® Wafer
(Carmustine Implant) Used in
Usual Medical Practice
Sponsored by Arbor Pharmaceuticals, LLC
For more information about
the VIGILANT Registry,
or if you are interested in
participating, please contact
the study team at:
VIGILANT@mapigroup.com
1.855.843.6778 (phone/fax)
ClinicalTrials.gov #NCT02684838
Visit Arbor Medical Affairs
Booth 313 to learn more about
TUMOR SECTION SATELLITE SYMPOSIUM 21
General Information
Americans with Disabilities Act
The Tumor Section wishes to take those steps to ensure that
no individual with a disability is excluded, denied services,
segregated, or otherwise treated differently than other
individuals because of the absence of auxiliary aids or services. If
you require any of the auxiliary aids or services identified in the
Americans with Disabilities Act in order to attend any program,
please send your requirements directly to the CNS Meetings
Department at meetings@cns.org or by calling 847-240-2500.
Attire
Professional attire is appropriate for the meeting and in the
Exhibit Hall. Professional /dressy attire is appropriate for the
Friday, September 23, Gala Reception and Dinner.
Meeting App
Conveniently manage your schedule, browse
program content, and keep up with what’s
going on. Download the free EventPilot app
from the Apple or Google Play store. Log in
with the event code:
TUMOR16
WiFi Service
For your convenience, complimentary Wi-Fi
service is provided by the CNS throughout
the San Diego Convention Center wherever
Tumor Section events are being held.
Network Name:	 cns Conference
Conference Passcode:	 cns2016
22 TUMOR SECTION SATELLITE SYMPOSIUM
Disclaimer
The material presented at the 2016 Tumor Section Satellite Symposium
has been made available by the Tumor Section for educational
purposes only. The material is not intended to represent the only, nor
necessarily the best, method or procedure appropriate for the medical
situations discussed, but rather is intended to present an approach,
view, statement, or opinion of the faculty which may be helpful to
others who face similar situations.
Neither the content (whether written or oral) of any course,
seminar, or other presentation in the program, nor the use of a specific
product in conjunction therewith, nor the exhibition of any materials
by any parties coincident with the program, should be construed
as indicating endorsement or approval of the views presented, the
products used, or the materials exhibited by the Tumor Section or by
its Committees or Affiliates.
The Tumor Section disclaims any and all liability for injury or
other damages resulting to any individual attending the meeting,
and for all claims which may arise out of the use of the techniques
demonstrated therein by such individuals, whether these claims shall
be asserted by physicians or any other person.
No reproductions of any kind, including audiotapes and
videotape, may be made of the presentations at the Tumor Section
Satellite Symposium. The Tumor Section reserves all of its rights to
such material, and commercial reproduction is specifically prohibited.
Onsite Registration Hours
Friday, September 23
8:00 am–5:00 pm
Saturday, September 24
7:00 am–12:00 pm
Exhibit Hall Hours
Friday, September 23
12:00 pm–5:00 pm
Saturday, September 24
7:00 am–5:00 pm
Admittance to the Exhibit Hall is by Tumor Section Satellite
Symposium name badge only. Children under the age of 18 are not
allowed in the Exhibit Hall.
Smoking
The San Diego Convention Center and official Tumor Section
Satellite Symposium hotels are non-smoking facilities.
Speaker Ready Room
All speakers and abstract presenters should visit the Speaker
Ready Room (Room 5B) at the San Diego Convention Center a
minimum of 1 hour prior to their presentations.
Friday, September 23
8:00 am–5:30 pm
Saturday, September 24
7:00 am–4:30 pm
TUMOR SECTION SATELLITE SYMPOSIUM 23
Disclosures
The Congress of Neurological Surgeons controls the content
and production of this CME activity and attempts to assure the
presentation of balanced, objective information. In accordance
with the Standards for Commercial Support established by the
Accreditation Council for Continuing Medical Education, speakers
are asked to disclose any relationship they have with commercial
companies which may be related to the content of their lecture.
Speakers who have disclosed a relationship with commercial
companies whose products may have a relevance to their
presentation are listed below. Faculty who are also considered
Planners are designated by P. Disclosures are current as of
August 16, 2016.
Positional Interest Codes
1	 CEO
2	 Consultant
3	 Director
4	 Editorial Board
5	 Employee
Gene H. Barnett
Consulting Agreement - Monteris
Medical Company (2)
Edward C. Benzel, MD
Consulting Agreement - Axiomed (2)
Daniel P. Cahill, MD
Consulting Agreement - Merck (2)
Susan Chang, MD
Consulting Agreement - Edge
Therapeutics (2), Neonc (2), Tocagen
(2), Other - Agios (6), Novartis (6),
Quest (6), Roche (6)
Clark C. Chen, MD, PhD
Consulting Agreement – Monteris (2),
MRI Intervention (2), Tocagen (2),
Mike Yue Chen, MD, PhD
Consulting Agreement – Globus (2):
Royalty – Globus Medical (2)
Ownership Interest – Medplate (7);
Grants – Orthofix ((N/A)
John G. Golfinos, MD
Consulting Agreement - Viewray (6)
William B. Gormley, MD
Consulting Agreement - Codman (6)
Amy B. Heimberger, MD
Consulting Agreement - Caris Life
Sciences (2)
Michael E. Ivan, MD, MBS
Consulting Agreement - Medtronic
(2)
Amin B. Kassam, MD
Consulting Agreement – Synaptive
Medical (2)
Ricardo Jorge Komotar, MD
Consulting Agreement - Medtronic
(2)
Gordon Li, MD
Consulting Agreement - Medtronic
(2)
Michael Lim, MD
Consulting Agreement - accuray (2),
bms (2), Izi (2), Stryker (2), Grants -
Accuray (6), Aegenus (6), Altor (6),
Celldex (6), Immunocellular (6)
Jeffrey J. Olson, MD
Grants - Roche (6)
Kevin Petrecca, BSc, MD, PhD
Ownership Interest - ODS Medical (8)
Dimitris G. Placantonakis, MD, PhD
Other – Tocagen, Inc. (2)
Laligam N. Sekhar, MD
Other -Spisurgical (6), Viket Medical,
Inc. (6)
Walter Stummer, MD
Consulting Agreement - Medac (2),
Nxpharmagene (2), Zeiss (2)
Michael A. Vogelbaum, MD, PhD
Honoraria - Neuralstem, Inc. (6),
Pharmicokinesis (6),
Ownership Interest - Infuseon
Therapeutics (7),
Royalty - Infuseon Therapeutics (7)
Buelent Yapicilar, MD
Grants - Stryker (6)
Yi-Hong Zhou, PhD
Ownership Interest – Patent on
protein and Nucleotide Sequences
of ETSP ((8) Nothing to
6	 N/A
7	 Officer
8	 Owner
9	 Trustee
24 TUMOR SECTION SATELLITE SYMPOSIUM
Kambiz Afrasiabi, MD
Manish Kumar Aghi, MD, PhD
Johnny Akers
Ali A. Alattar, BS
Vincenzo Albanese
Mona Al-Gizawiy, PhD
Rawan Alkharboosh, MS
David Altshuler, MD
Nduka M. Amankulor, MD
Leonel Ampie, BS
Karam Asmaro, MD
Anthony Atala, MD
Giancarlo Attinà
Giuseppe Barbagallo, MD
Jason Barber, MS
Frederick Barker, MD
Lorenzo Bello, MD
Carolina Gesteira Benjamin, MD
Elizabeth Emily Bennett, MD, MS
David BergP
Mitchel S. Berger, MD
Mia Bertalan, BS
Chetan Bettegowda, MD, PhDP
Nikhilesh Bhatt
Orin Bolch, MD
George C. Bobustuc, MD
Courtney Bosse
Stephen G. Bowden, BM
Chris Bowman
Michael G. Brandel, BA
Daniel J. Brat
Priscilla Brastianos, MD
Christopher Alvarez-Breckenridge
Henry Brem, MD
John C. Breneman, MD
Andrew Brenner, MD
Philip Ryan Brinson, BS
George G. Bowden, BM
Michael G. Brandel, BA
Harley Brito da Silva, MD
Jeffrey N. Bruce, MD
Thomas Brucke
Peter D. Canoll, MD, PhD
Bob S. Carter, MD, PhD
Alessandra Casarotti
Dave Cavazos
Juanita Celix, MD
Francesco Certo, MD
Srikant S. Chakravarthi
Lola Blackwell Chambless, MD
Peter Chang, BA
Cleopatra Charalampaki, MD, PhD
Xiong-Hui Chen, MD
Andrew Chi, MD
Prashant Chittiboina, MD, MPH
Sarah Choi
Alvin Chou
Winward Choy, BA
Lawrence K. Chung, BS
Christopher P. Cifarelli, MD, PhD
Elizabeth Claus, MD
Lee Cooper
Martin Corsten, MD
Maura Cosetti
David J. Cote, BS
Honggang Cui
Michael Cusimano, MD
Randy D’Amico, MD
David J. Daniels, MD, PhD
John Dankert
Sunit Das, MD, PhD
Hormuzdiyar H. Dasenbrock, MD
Justin M. David, PhD
Tristan de Mooij, MD
J. Matthew Debnam, MD
John Degroot
Christopher P. Deibert
Jingjing Deng
Antonio DeSalles, MD, PhD
Michael C. Dewan, MD
Joseph D. DiDomenico, BS
Jorg Dietrich, MD, PhD
Francesco DiMeco, MD
Ninh Doan, MD, PhD
Xuezhi Dong, BA
Deborah L. Donohoe, BS
Heloise H. Dubois
Hugues Duffau, MD, PhD
Ian F. Dunn, MD
Nancy A. Edwards, BA
Christopher Farrell
Amir Fathi
Peter Fecci, MD, PhD
Manuel Ferreira, Jr.
Patirick Michael Flanigan, BS
John Robert Floyd, MD
Joshua Frenster
Melanie Fukui, MD
Gregory N. Fuller, MD, PhD
Sara Ganaha, MD
Marco Garavaglia
Sarah Tamara Garber, MD
Michael Garcia
Corey Gill, BS
Tomas Garzon-Muvdi, MD, MS
Zoran Gatalica
Abdi S. Ghodsi, MD
Brian John Andrew Gill
Steven L. Gogela, MD
Danielle Golub
Quinton Gopen, MD
Alessandra A. Gorgulho, MD
Yair M. Gozal, MD, PhD
Simon Graham, PhD
Jordan Green
Aleksandra Gruslova
Christine Guerrero
Hugo Guerrero Cazares, MD, PhD
Ghaith Habboub, MD
David Hackney
Sameer H. Halani, BA, MS
Xiaoxiao Han, MD
Yong Han
Mitsuto Hanihara, MD, PhD
Gregory Hare
Yuuri Hashimoto
Christina Hayes
Andrew Torre Healy, MD
Michele HeaphyP
Adriana Heguy
John D. Heiss, MD
Shawn L. Hervey-Jumper, MD
Stacy HilsabeckP
Brian R. Hirshman, MD, MS
Sze Chun Winson Ho, MD
Chad Holder
Yuan Hu, MD
Wei Hua
Judy Huang, MD
Xuan Hui, MD, ScM
Alhadi Igressa, MD
Rebecca Ihrie
Arman Jahangiri, BS
Robert Jenkins
Jonathan Jennings, MD
Aaron Johnson, PhD
Michael Kader
Piyush Kalakoti, MD
Steven N. Kalkanis, MDP
Tania B. Kaprealian
Aditya Vishwas Karhade, BE
Tomoyuki Kawataki, MD, PhD
Kartik Kasavabhotla
Kathleen KennedyP
Sammy Khalili, MD
Themasap Khan
Mustafa Khasraw
Wajin Jason Kim
Hiroyuki Kinouchi, MD, PhD
Santhi D. Konduri
Douglas Kondziolka, MD, MSc,
FRCS(C)
Jun Kong
Kristen Kozielski
Bryan Matthew Krueger, MD
Ruby Kuang, MS
Ravi Kumar, MD
John S. Kuo, MD, PhD, FACS
Svetlana Kvint, MD
Carlito Lagman, MD
Grace Y. Lai, MD, PhD
Jonathan B. Lamano, MS
Michael Lamba
Montserrat Aniul Lara-Velazquez
Sang Jin Lee
Michele LengermanP
Andre Levchenko
Tenzin Lhakhang
Bing Li
Gang Li
Jiang-an Li
Yanyan Li, MSc
Ran Lin
Mark E. Linskey, MD
Graham Lobel
Xiao-jie Lu, MD
Stephen T. Magill, MD, PhD
Asif Maknojia, MD
Sunil V. Manjila, MBBS
Sydney ManolaP
April MartinP
Ying Mao, MD
Dragan Maric
Juan Carlos Martinez-Gutierrez
Rory R. Mayer, MD
Roxanne Mayrand
David McCarthy
Ian E. McCutcheon, MD
Michael William McDermott, MD
Brian McGill, MS
Guy M. McKhann, MD
Jerry McLarty
Gautam U. Mehta, MD
Tom Mikkelsen, MD
Shama Mirza, PhD
Akshitkumar Mistry, MD
Aram Modrek
Alireza M. Mohammadi, MD
Ahmed Mohyeldin, MD
Annette Molinaro, MA, PhD
Andrew Montoura, MD
Melanie Morrison, BS
Wade M. Mueller, MD
Sean V. Murphy, PhD
Alona Muzikansky
Brian V. Nahed, MDP
Ichiro Nakano, MD, PhD
Michael Nalisnik
Anil Nanda, MD
Edjah K. Nduom, MD
Houtan Noushmehr
Justin A. Neira, BA
Thomas Neubert, PhD
Evan Newell
Ha Nguyen, MD
Christina Notarianni, MD
Goodwell Nzou, BS
Arnold Obungu
Jennifer Padwal, BS
Claudia Palena, PhD
Stefano Palmucci
Niko Papanikolaou
Sabrina Paratore
Deric M. Park
Ian F. Parney, MD, PhD
Vaibhav M. Patel, MD, BS
Luke E. Pater, MD
Panayiotis Emmanuel Pelargos,
BA
Federico Pessina
Timothy E. Peterson, MSc
Alexander Pomerantz
Jose Luis Porras
Nader Pouratian, MD, PhD
Alfredo Quinones-Hinojosa, MD
Valya Ramakrishnan
Aparna Rao, PhD
Sandeep Reddy
Angela Richardson, MD, PhD
Gabrielle E. Rieth, BS, MS
Marco Riva, MD
Cara Rogers
Xiaoming Rong, MD
Marco Rossi, MD
Robert C. Rostomily, MD
Richard A. Rovin, MD
James T. Rutka, MD, PhD,
FRCS(C), FACS
Navin C. Sabharwal
Jorge Samanamud
John H. Sampson, MD, PhD,
MHSc, MBA
Nader Sanai, MD
Jagteshwar Sandhu
Raymond E. Sawaya, MD
Lisa Scarpace
Paula Schiapparelli
Kathleen M. Schmainda, PhD
Alexander J. Schupper
Tom Schweizer, PhD
Michael Selch
Young-Joon Seol, PhD
Sagar R. Shah, MS
Mayur Sharma, MD, MCh
Sameer A. Sheth, MD, PhD
Regina ShupakP
Eric R. Siegel MSc
Danilo Silva, MD
Joshua Silverman, MD
Yannick Simmone
Gary R. Simonds, MD
Michael B. Sisti, MD
Saman Sizdahkhani
DeeDee Smart
Charlton Smith
Timothy R. Smith, MD, PhD, MPH
Matija Snuderl
Giuseppe Sortino
David Spetzler
Deanne StarrP
Glen Stevens, DO, PhD
David Straus, BA
Ryan Sullivan, MD
Ben Allen Strickland, MD
Timothy Struve, MD
Hao Su, PhD
Dima Suki, PhD
Nermin Sumru Bayin, MS
Fred Tam
Anita Tandle
Joseph E. Tanenbaum, BA
Stephen Tenn
John Thaman
Reid C. Thompson, MD
Nathaniel Tippens
Albert Truong
Aristotelis Tsirigos, PhD
Nolan Ung, BS
Timothy H. Ung, MD
Eugene John Vaios, MA
Jose Enrique Velazquez Vega
Roel Verhaak
Massimiliano Visocchi
Brittany Voth, BS
Sarika Walia, MD
Jing Wang
Qing Wang
Qingyue Wang, BS
Yujun Wang, PhD
Ronald E. Warnick, MD
Peter C. Warnke, MD
Shiao-Pei Weathers
Kyle D. Weaver, MD
Jeffrey S. Weinberg, MD
Christian Rainer-Wertz
Gabrielle A. White-Dzuro, MD
Elizabeth E. Wicks
Robert Thomas Wicks, MD
Amparo M. Wolf, MD, PhD
Eric Wolf, MS
Eric T. Wong, MD
Graeme Woodworth, MD
Xue-Shun Xie, BSc
Joanne Xiu
Sandra C. Yan, BS, BA
Isaac Yang, MD
Wuyang Yang, MD, MS
Stephen Yip, MD
James J. Yoo, MD, PhD
Jennifer Yu
Guoan Zhang
Pengcheng Zhang, PhD
Xiaoran Zhang, MD, MS
Shouhao Zhou, MD, PhD
You-Xin Zhou
Zhengping Zhuang
Disclosures
Nothing to Disclose
FLOSEAL Hemostatic Matrix Indication
FLOSEAL Matrix is indicated in surgical procedures (other than ophthalmic) as
an adjunct to hemostasis when control of bleeding by ligature or conventional
procedures is ineffective or impractical.
Important Risk Information for FLOSEAL Matrix
Do not inject or compress FLOSEAL Matrix into blood vessels. Do not apply FLOSEAL
Matrix in the absence of active blood flow, e.g., while the vessel is clamped or
bypassed, as extensive intravascular clotting and even death may result.
Do not use FLOSEAL Matrix in patients with known allergies to materials of bovine
origin. Do not use FLOSEAL Matrix in the closure of skin incisions because it may
interfere with the healing of the skin edges.
FLOSEAL Matrix contains Thrombin made from human plasma. It may carry a risk
of transmitting infectious agents, e.g., viruses, and theoretically, the Creutzfeldt-
Jakob disease (CJD) agent.
FLOSEAL Matrix is not intended as a substitute for meticulous surgical technique and
the proper application of ligatures or other conventional procedures for hemostasis.
Excess FLOSEAL Matrix (material not incorporated in the hemostatic clot) should
always be removed by gentle irrigation from the site of application.
FLOSEAL Matrix swells by approximately 10% to 20% after product is applied.
Maximum swell volume is achieved within about 10 minutes.
The safety and effectiveness of FLOSEAL Matrix has not been established in
children under 2 years of age and pregnant women.
Do not use air to remove residual FLOSEAL Matrix from Applicator tip. The
Applicator tips should not be cut. Do not use FLOSEAL Matrix on bone surfaces
where adhesives, such as methylmethacrylate or other acrylic adhesives, will be
required to attach a prosthetic device.
Rx Only. For safe and proper use of this device, refer to the full Instructions for Use.
Study design
Prospective, randomized, multi-center trial comparing FLOSEAL Matrix
with GELFOAM®
Hemostat+thrombin in stopping intraoperative
bleeding during spinal surgery. Four centers randomized 127 patients,
21 years of age or older. Randomization occurred after a bleeding
lesion requiring a topical hemostatic agent was identified. The primary
endpoint was hemostasis success for the first treated bleeding site. There
was no difference in the adverse event profile between the two groups.2
References: 1. FLOSEAL Hemostatic Matrix Instructions for Use. Hayward, CA: Baxter Healthcare
Corporation. 2. Renkens KL Jr, Payner TD, Leipzig TJ, et al. A multicenter, prospective, randomized
trial evaluating a new hemostatic agent for spinal surgery. Spine. 2001;26:1645-1650.
Baxter and Floseal are registered trademarks of Baxter International Inc.
Gelfoam is a registered trademark of Pharmacia  Upjohn Company LLC,
and is used under license.
USMP/9/16-0019 07/2016
THE POWER OF FAST
ACHIEVES HEMOSTASIS TWICE AS FAST
AS GELFOAM®
HEMOSTAT + THROMBIN IN SPINE SURGERY1
(Median time to hemostasis: 1.5 minutes compared to 3.0 minutes)1,2
For more information or to place an order call 1-888-229-0001
DO YOU OWN THE MOMENT?
Visit us at booth 307
Gliadel® is manufactured by Eisai Inc. for Arbor Pharmaceuticals, LLC.
Gliadel® is a registered trademark of Eisai Inc ©2015 Arbor Pharmaceuticals, LLC.
PP-GLD-US-0049 All rights reserved.

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Tumor Symposium

  • 1. Tumor Section Satellite Symposium Low-grade Gliomas: Management Strategies Innovations SAN DIEGO, CALIFORNIA SEPTEMBER 23-24, 2016 SAN DIEGO CONVENTION CENTER JOINTLY PROVIDED BY THE CONGRESS OF NEUROLOGICAL SURGEONS AND THE AANS/CNS JOINT TUMOR SECTION
  • 2. 2 TUMOR SECTION SATELLITE SYMPOSIUM Experience our latest neurotechnology innovations Visit us during the Tumor Section and the Congress of Neurosurgeons Annual Meeting strykerneurotechnology.com/cns
  • 3. TUMOR SECTION SATELLITE SYMPOSIUM 1 Dear Colleague, Welcome to the 2016 Tumor Section Satellite Symposium in San Diego! Over the next two days, we will explore our meeting theme, Low-grade Gliomas: Management Strategies Innovations, and examine advancements in the treatment of adult and pediatric brain tumors. With your participation, we look forward to engaging scientific sessions covering recent clinical trials, tumor guidelines, and next-generation techniques in surgical, medical, and radiation therapies. We are pleased to welcome keynote speakers Mitchel Berger, Hugues Duffau, and James Rutka as well as many distinguished brain tumor experts slated to present during our four General Sessions. We are also grateful to our sponsors and exhibitors, whose support helped make this meeting possible. Please remember to connect with these industry partners for lunch and afternoon breaks in the exhibit hall. Residents, fellows, and junior attendings are invited to participate in small-group breakfast breakout sessions on Saturday morning. These are outstanding opportunities to meet senior brain tumor surgeons and learn how to set up a practice, start a lab, or seek out an academic position. We hope to see you at the 31st Anniversary Gala Reception Friday evening at the historic US Grant Hotel. Join us in honoring the recipients of this year’s Wilson Award, Distinguished Service Award, and Parsa Mentoring Award. Finally, we are proud to host our meeting for the first time in conjunction with the Congress of Neurological Surgeons Annual Meeting. If you plan to stay on for more great science this week, don’t forget to connect with us again at the Tumor Section sessions at the CNS Annual Meeting. Thank you for being a part of this meeting as together we move the treatment and care of brain tumor patients forward. Sincerely, TABLE OF CONTENTS Learning Objectives 2 CME Information 2 Program Schedule 3-15 Floor Plans 16-19 Exhibitors 18 General Information 21-22 Disclosures 23-24 SECTION CHAIR Steven N. Kalkanis MEETING CHAIR Chetan Bettegowda MEETING CHAIR Brian V. Nahed
  • 4. 2 TUMOR SECTION SATELLITE SYMPOSIUM Symposium Description This symposium will provide an up-to-date overview of the management of low-grade tumors in adult and pediatric patients, emphasizing cutting-edge and next-generation techniques in medical, surgical, and radiation therapies. It will identify the molecular and genetic changes and efforts to target these mutations in state-of-the-art therapy. Learning Objectives Upon completion of this symposium participants should be able to: • Develop treatment strategies for patients with low-grade glioma at diagnosis and recurrence • Discuss advancements in understanding of low-grade glioma biology and relevance to outcome • Discuss emerging surgical, medical, and radiation techniques to achieve the best outcome CME Information ACCREDITATION This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council of Continuing Medical Education (ACCME) through the joint providership of the Congress of Neurological Surgeons and the Tumor Section. The CNS is accredited by the ACCME to provide continuing medical education for physicians. AMA CREDIT DESIGNATION STATEMENT The CNS designates this live activity for a maximum of 12.75 AMA PRA Category 1 CreditsTM . Physicians should only claim credit commensurate with the extent of their participation in the activity. CLAIMING CME CREDIT CME credits can be claimed through the online CME system at www.cns.org. The CME tracking system allows you to create and print a CME certificate immediately following the Tumor Section Satellite Symposium while you are still in San Diego, or from the convenience of your home or office. Log in using your last name and the email address with which you registered. You will need to enter the number of hours you are claiming for each session you attended. Physicians should only claim credit for the learning activities in which they actively participated. Upon completion of this process, your CME certificate will be sent to you via email at the email address you provided at registration. MID-LEVEL PRACTITIONERS Attendees will receive a certificate of completion. Please contact your individual membership association and certification board to determine the requirements for accepting credits.
  • 5. TUMOR SECTION SATELLITE SYMPOSIUM 3 Program Schedule Friday, September 23, 2016 8:00 am–5:00 pm Registration Ballroom 6 Lobby, Upper Level General Session 1 Room 6B, Upper Level Biology and Management of LGG 10:00–10:10 am Opening Remarks Chetan Bettegowda, Steven N. Kalkanis, and Brian Nahed 10:10–10:25 am Biology of Low-grade Gliomas Robert Jenkins 10:25–10:40 am Diagnosis: Medical Management/Chemotherapy and Timing Susan Chang KEYNOTE SPEAKER 1 10:40–11:10 am Maximizing Resection for Survival/When to Operate Mitchel S. Berger, MD, chair of neurological surgery at University of California San Francisco, is a nationally recognized expert in treating brain and spinal cord tumors and tumor-related epilepsy in adults and children. He also is a specialist in brain mapping techniques, used to identify areas of motor, sensory and language function during surgery, and an expert in the use of the Gamma Knife for tumor treatment. He is co-director of the Adult Brain Tumor Surgery Program, director of the Brain Tumor Research Center, and director of the Center for Neurological Injury and Repair. 11:10–11:25 am Radiation Therapy Jennifer Yu
  • 6. 4 TUMOR SECTION SATELLITE SYMPOSIUM 11:25–11:40 am Recurrence and Progression to High-grade Houtan Noushmehr 11:40–11:55 am Clinical Trials, Targeted Therapies, Mechanisms Steven Yip 11:55 am–12:10 pm Joint Section on Tumors Guidelines Jeffrey J. Olson 12:10–1:10 pm Lunch with Exhibitors in the Exhibit Hall Room 6A, Upper Level 12:10–1:10 pm Sponsored Lunch Seminar Room 6B, Upper Level Controversies in Fluorescence Guided Surgery (FGS) of Gliomas: Fluorescein vs. 5-ALA General Session 2 Room 6B, Upper Level Surgical Techniques and Adjuvant Therapy KEYNOTE SPEAKER 2 1:15–1:45 pm Mapping Intraoperatively to Maximize Resection Hugues Duffau, MD, PhD, is professor and head of the department of neurosurgery at the University Hospital Centre of Montpellier, France. A leading expert on low-grade glioma surgery, Dr. Duffau pioneered surgery of still-conscious patients with brain tumors, resulting in a new model of the brain based on plasticity and connectivity. He has authored more than 225 publications and four books, including Brain Mapping: From Neural Basis of Cognition to Surgical Applications, published in 2011. 1:45–1:55 pm Pre-operative Imaging/fMRI 1:55–2:05 pm Intraoperative Imaging Christian Rainer Wertz 2:05–2:15 pm Intraoperative Ultrasound Francesco DiMeco Program Schedule
  • 7. TUMOR SECTION SATELLITE SYMPOSIUM 5 2:15–2:25 pm Intraoperative 5-ALA Walter Stummer 2:25–2:35 pm Fluroscent Alkylphosphocholine for Intraoperative Detection John Kuo 2:35–2:45 pm Intraoperative Mass Spectroscopy Kevin Petrecca 2:45-2:55 pm Raman Spectroscopy Steven N. Kalkanis 2:55–3:05 pm Intraoperative Viral Vectors Manish Aghi 3:05–3:30 pm Break with Exhibitors Room 6A, Upper Level Sponsored by: 3:30–5:00 pm Abstract Presentations 1: Selected Oral Abstract Presentations and Discussion Room 6B, Upper Level Moderators: Gordon Li and Pamela Jones 3:30–3:35 pm Supratotal Resection in Low-grade Gliomas: Feasibility and Clinical Impact Marco Rossi, Marco Riva, Federico Pessina, Alessandra Casarotti, Lorenzo Bello 3:35–3:40 pm The Benefit of Gross Total Resection Across Glioma Subtypes: A Comparison of Grade II/III/ IV Gliomas in the Surveillance, Epidemiology, and End Results (SEER) Database Brian R. Hirshman, Ali A. Alattar, Alexander J. Schupper, Jennifer Padwal, Michael G. Brandel, Xuezhi Dong, Bob S. Carter, Clark C. Chen 3:40–3:45 pm The Value of Extent of Resection for Genetically “Favorable” and “Unfavorable” High-grade Gliomas: Analysis of the TCGA Data Shawn L. Hervey-Jumper, David Altshuler, Karam Paul Asmaro, Lisa Scarpace, Tom Mikkelsen, Steven N. Kalkanis 3:45–3:50 pm Surgical Outcomes and Complications after Reoperation for Recurrent Skull Base Meningiomas Stephen T. Magill Program Schedule
  • 8. 6 TUMOR SECTION SATELLITE SYMPOSIUM 3:50–3:55 pm Atypical and Anaplastic Meningioma (AAM): Outcomes in a Population-based Study Tomas Garzon-Muvdi, Wuyang Yang, Michael Lim, Henry Brem, Judy Huang 3:55–4:00 pm Thermal Injury to Corticospinal Tract Predicts Post-operative Motor Deficits Following Laser Interstitial Thermal Therapy Mayur Sharma, Ghaith Habboub, Danilo Silva, Gene H. Barnett, Alireza M Mohammadi 4:00–4:05 pm Portable Intraoperative Computed Tomography Scan in Image-guided Surgery for Brain High- grade Gliomas: Analysis of Technical Feasibility and Impact on Extent of Tumor Resection Giuseppe Barbagallo, Stefano Palmucci, Massimiliano Visocchi, Sabrina Paratore, Giancarlo Attinà, Giuseppe Sortino, Vincenzo Albanese, Francesco Certo 4:05–4:10 pm Surgical Resection for Intracranial Malignant Teratomas: A Population-based Study Wuyang Yang, Xiaoming Rong, Tomas Garzon- Muvdi, Jose Luis Porras, Xuan Hui, Judy Huang 4:10–4:15 pm Sources of Variation Influencing Concordance Between Functional MRI and Direct Cortical Stimulation in Brain Tumor Surgery Melanie Morrison, Fred Tam, Marco Garavaglia, Gregory Hare, Michael Cusimano, Tom Schweizer, Simon Graham, Sunit Das 4:15–4:20 pm Sodium Fluorescein Facilitates Guided Sampling of Diagnostic Tumor Tissue in Non-enhancing Gliomas Stephen G. Bowden, Brian John Andrew Gill, Randy D’Amico, Timothy H Ung, Peter Chang, Justin A. Neira, Jorge Samanamud, Sameer A. Sheth, Guy M. McKhann, Michael B. Sisti, Peter D. Canoll, Jeffrey N. Bruce 4:20–4:25 pm Subventricular Zone Contact, but not Subgranular Zone, Corpus Callosal, nor Cortical Contact, Predicts Survival in Surgically Treated Glioblastomas Akshitkumar Mistry, Michael C. Dewan, Gabrielle A. White-Dzuro, Philip Ryan Brinson, Kyle D. Weaver, Reid C. Thompson, Rebecca Ihrie, Lola Blackwell Chambless Program Schedule
  • 9. TUMOR SECTION SATELLITE SYMPOSIUM 7 4:25–4:30 pm Incidence of Leptomeningeal Disease Following Ventricular Entry During Resection of Supratentorial Grade IV Glioma Ben Allen Strickland, Dima Suki, Rory R. Mayer, J. Matthew Debnam, Ian E. McCutcheon, Raymond E. Sawaya, Jeffrey S. Weinberg 4:30–4:35 pm Initial Experience with an Image-guided Robotically Positioned Optical Platform for Skull Base Surgery Amin B. Kassam, Srikant S. Chakravarthi, Juanita Celix, Sammy Khalili, Martin Corsten, Sarika Walia, Jonathan Jennings, Melanie Fukui, Richard A. Rovin 4:35–4:40 pm Cranial Chordoma: A New Classification System and Validation Harley Brito da Silva, David Straus, Manuel Ferreira Jr., Robert C. Rostomily, Jason Barber, Laligam N. Sekhar 4:40–4:45 pm Diagnostic Accuracy of PET, SPECT, and Arterial Spin-Labeling in Differentiating Tumor Recurrence from Necrosis in Cerebral Metastasis after Stereotactic Radiosurgery Clark C. Chen, Grace Y. Lai, David Hackney, Peter C. Warnke, Eric T. Wong, Bob S. Carter 4:45–4:50 pm Cochlear Radiation Dose Is Associated with Decreased Hearing Preservation for Vestibular Schwannoma Patients Treated with Radiosurgery Lawrance K. Chung, Nolan Ung, Winward Choy, Carlito Lagman, Panayiotis Emmanuel Pelargos, Brittany Voth, Alessandra A. Gorgulho, Stephen Tenn, Nader Pouratian, Tania B. Kaprealian, Michael T. Selch, Antonio DeSalles, Quinton Gopen, Isaac Yang 4:50–4:55 pm A Morphometric Survey of the Parasellar Region of over 2700 Skulls with Particular Emphasis on the Middle Clinoid Process Akshay Sharma, Gabrielle E. Rieth, Joseph E. Tanenbaum, Sunil V. Manjila, Buelent Yapicilar 4:55–5:00 pm Proposing a Validated Clinical App for Predicting Unfavorable Outcomes in Patients Undergoing Craniotomy for Excision of Acoustic Neuroma Piyush Kalakoti, Jerry McLarty, Kanika Sharma, Maura Cosetti, Anil Nanda Program Schedule
  • 10. 8 TUMOR SECTION SATELLITE SYMPOSIUM 7:00–10:00 pm 31st Anniversary Gala Reception at the historic US Grant Hotel Presentation of the Wilson Award, Distinguished Service Award, and Mentoring Award Complimentary shuttle service will depart from the Marriott Marquis San Diego Marina Hotel’s lower front drive at 6:45 pm. Shuttles will return to the Marriott upon the conclusion of the event. Saturday, September 24, 2016 7:00 am–12:00 pm Registration Ballroom 6 Lobby, Upper Level 7:00 am–5:00 pm Abstract Digital Poster Viewing in Exhibit Hall Breakfast Breakouts for Residents, Fellows, Medical Students, and Young Attendings 8:00–9:00 am Developing an Independent Research Program/ Lab as a Neurosurgeon Room 10, Upper Level John Sampson and Manish Aghi 8:00–9:00 am Neurosurgeons as Clinical Trial Investigators Room 11A, Upper Level Fred Barker, Michael Lim, and Michael Vogelbaum 8:00–9:00 am Finding a Neurosurgery Position as a Brain Tumor Surgeon Room 11B, Upper Level Bob Carter and Ricardo Komotar Program Schedule
  • 11. TUMOR SECTION SATELLITE SYMPOSIUM 9 9:10–10:20 am Abstract Presentations 2: Selected Oral Abstract Presentations and Discussion Room 6B, Upper Level Moderators: Graeme Woodworth and Nduka Amankulor 9:10–9:15 am Re-visiting Racial Disparity in Outcomes Following Craniotomy for Resection of Adult Intracranial Tumors Piyush Kalakoti, Kanika Sharma, Christina Notarianni, Anil Nanda 9:15–9:20 am Racial Disparity in Short-term Outcomes and Hospital Costs in Pediatric Patients Undergoing Craniotomy for Resection of Brain Tumors: Insights from Kids’ Inpatient Database (KID) Piyush Kalakoti, Kanika Sharma, Anil Nanda, Christina Notarianni 9:20–9:25 am Early Discharge after Craniotomy Is Safe and Associated with Decreased 30-day Readmissions and Decreased Risk of DVT/PE Angela Richardson, Jagteshwar Sandhu, David McCarthy, Roxanne Mayrand, Christine Guerrero, Ricardo Jorge Komotar, Michael E. Ivan 9:25–9:30 am Differences in Patterns of Care and Prognosis in Elderly versus Non-elderly Patients with Glioblastoma Patrick Michael Flanigan, Arman Jahangiri, Ruby Kuang, Albert Truong, Sarah Choi, Alvin Chou, Annette Molinaro, Michael William McDermott, Mitchel S. Berger, Manish Kumar Aghi 9:30-9:35 am Bone Marrow Response as a Potential Biomarker of Outcomes in Glioblastoma Patients Eugene John Vaios, Brian V. Nahed, Alona Muzikansky, Amir Fathi, Jorg Dietrich 9:35–9:40 am Dosimetric Thresholds Predicting High Risk of Radionecrosis in Gamma Knife Radiosurgery for Cerebral Metastases Steven L. Gogela, Yair M. Gozal, John Thaman, Bryan Matthew Krueger, Ronald E. Warnick Program Schedule
  • 12. 10 TUMOR SECTION SATELLITE SYMPOSIUM 9:40–945 am Cochlear Function as a Novel Predictor of Hearing Preservation in Vestibular Schwannomas after Stereotactic Radiosurgery Amparo M. Wolf, Svetlana Kvint, Aram Modrek, Carolina Gesteira Benjamin, John G. Golfinos, Joshua Silverman, Douglas Kondziolka 9:45–9:50 am Hypofractionated Radiosurgery for the Treatment of Large Brain Metastases and Post- resection Cavities Yair M. Gozal, Timothy Struve, Steven L. Gogela, Eric Wolf, McGill Brian, Michael Lamba, Luke E. Pater, John C. Breneman, Ronald E. Warnick 9:50–9:55 am VTE in Patients Undergoing Craniotomy for Brain Tumors: A NSQIP Analysis David J. Cote, Heloise H. Dubois, Aditya Vishwas Karhade, Timothy R. Smith 9:55–10:00 am Extra-pseudocapsular Dissection Technique for Growth Hormone (GH)-Secreting Pituitary Adenomas by Endoscopic Endonasal Transsphenoidal Approach Xiao-jie Lu, Qing Wang, Bing Li, Jiang-an Li, Jing Wang 10:00–10:05 am Infectious Complications after Craniotomy for Tumor: A National Surgical Quality Improvement Program Analysis Hormuzdiyar H. Dasenbrock, Sandra C. Yan, Timothy R. Smith, Elizabeth Claus, William B. Gormley, Ian F. Dunn 10:05–10:10 am Development of Persistent Mucoid Spinal Cord Mass in a Patient Following Olfactory Mucosal Stem Cell Transplantation to Treat Spinal Cord Injury Navin Sabharwal, Elizabeth Emily Bennett, Abdi S. Ghodsi, Glen Stevens, Andrew Torre Healy, Edward C. Benzel 10:10–10:20 am Questions and Answers 10:20–10:40 pm Break with Exhibitors Room 6A, Upper Level Sponsored by: Program Schedule
  • 13. TUMOR SECTION SATELLITE SYMPOSIUM 11 General Session 3: Room 6B, Upper Level Pediatric Low-grade Tumors 10:40–10:50 am Opening Remarks Chetan Bettegowda and Brian Nahed 10:50–11:10 am Medical Management of Pediatric Low-grade Tumors Nathan Robison 11:10–11:30 am Radiation of Pediatric Low-grade Tumors Mary McAleer 11:30 am–12:15 pm Abstract Presentations 3: Selected Oral Abstract Presentations and Discussion Room 6B, Upper Level Moderators: Peter Fecci and Kaisorn Chaichana 11:30–11:35 am Tumorigenic Alterations by Mutant IDH1 in Early Gliomagenesis Aram Modrek, Themasap Khan, Danielle Golub, Michael Kader, Guoan Zhang, Jingjing Deng, Chris Bowman, Nermin Sumru Bayin, Joshua Frenster, Tenzin Lhakhang, Adriana Heguy, John Dankert, Aristotelis Tsirigos, Matija Snuderl, Thomas Neubert, Dimitris G. Placantonakis 11:35–11:40 am Integrated Prognostication of Molecular Oligodendroglioma in the Cancer Genome Atlas Sameer H. Halani, Michael Nalisnik, Chad Holder, Jun Kong, Jose Enrique Velazquez Vega, Jeffrey J. Olson, Lee Cooper, Daniel J. Brat 11:40–11:45 am Epigenetic Regulation of Mesenchymal Transition by CBX6 in GBMs Yujun Wang, Gang Li, Mike Yue Chen 11:45–11:50 am High Dimensional Analysis of Glioblastoma Multiforme by Mass Cytometry Ahmed M. Mohyeldin, Yannick Simmone, Evan Newell, Ichiro Nakano 11:50–11:55 am A Cerebrospinal Fluid microRNA Signature for Glioblastoma Detection Johnny Akers, Valya Ramakrishnan, Ying Mao, Wei Hua, Bob S. Carter, Clark C. Chen 11:55 am–12:00 pm Three Dimensional Bioprinting of the Human Gliovascular Unit Robert Thomas Wicks, Young-Joon Seol, Goodwell Nzou, Elizabeth E. Wicks, Sang Jin Lee, Sean V. Murphy, James J. Yoo, Anthony Atala Program Schedule
  • 14. 12 TUMOR SECTION SATELLITE SYMPOSIUM 12:00–12:05 pm Confocal Laser Endomicroscopic (CLE) Characterization of the Normal Brain Cleopatra Charalampaki, Alhadi Igressa 12:05–12:10 pm Putting the Brakes on Brachyury: Identifying and Targeting a Conserved Transcriptional Network that Drives Primary and Metastatic Brain Tumor Initiation and Propagation Sagar R. Shah MS, Justin M David, Nathaniel Tippens, Ahmed Mohyeldin, Juan Carlos Martinez- Gutierrez, Sara Ganaha, Kristen Kozielski, Jordan Green, Andre Levchenko, Claudia Palena, Alfredo Quinones-Hinojosa 12:10–12:15 pm ZR30, an in vitro Synthesized EFEMP1-derived Tumor Suppressor Protein Targets MMP2, EGFR, NOTCH1, and AKT Signaling from Extracellular Compartment of Different Glioma Cell Subpopulations of Intracranial Xenografts Yi-Hong Zhou, You-Xin Zhou, Yanyan Li MSc, Yuan Hu, Chuaniin Liu, Qingyue BS Wang, Xiaoxiao Han, Yong Han, Xue-Shun Xie, Xiong-Hui Chen, Eric R. Siegel, Kambiz Afrasiabi, Mark E. Linskey 12:15–1:15 pm Lunch with Exhibitors in the Room 6A, Upper Level Exhibit Hall KEYNOTE SPEAKER 3 1:15–1:45 pm Surgery for Pediatric Low-grade Tumors James Rutka, MD, PhD, is RS McLaughlin professor and chair of the department of surgery at the University of Toronto, and also serves on the surgical staff at the Hospital for Sick Children in the Division of Pediatric Neurosurgery. Editor-in-chief of the Journal of Neurosurgery, Dr. Rutka’s primary research and clinical interests relate to the science and surgery of human brain tumors. His laboratory interests lie in the molecular biology of human brain tumors—specifically in the determination of the mechanisms by which brain tumors grow and invade. His recent clinical interests have centered on the surgical treatment of epilepsy in children. He has over 400 peer-reviewed publications. Program Schedule
  • 15. TUMOR SECTION SATELLITE SYMPOSIUM 13 General Session 4 Room 6B, Upper Level Outcomes and the Future 1:45–2:05 pm Molecular Classification and Outcomes of Low-grade Glioma Adam Resnick 2:05–2:25 pm Upcoming Targets in Low-grade Glioma Andrew Chi 2:25–2:45 pm Emerging Technologies Monitoring for Recurrence/Progression Chetan Bettegowda, Clark Chen, and Brian Nahed 2:45–3:00 pm Parsa Mentoring Award Steven N. Kalkanis 3:00–3:35 pm Break with Exhibitors Room 6A, Upper Level 3:35–5:00 pm Abstract Presentations 4: Selected Oral Abstract Presentations and Discussion Room 6B, Upper Level Moderators: Sunit Das and Chris Farrell 3:35–3:40 pm Immune Checkpoint Blockade as a Potential Therapeutic Target: Surveying CNS Malignancies Sarah Tamara Garber, Yuuri Hashimoto, Shiao- Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel Verhaak, Shouhao Zhou, Gregory N. Fuller, Mustafa Khasraw, John Degroot, Sandeep Reddy, David Spetzler, Amy B. Heimberger 3:40–3:45 pm Peripheral Lymphocytic Immune Checkpoint Landscape in Primary and Recurrent Glioblastoma Leonel Ampie, Winward Choy, Jonathan Balquiedra Lamano, Joseph D. DiDomenico, Kartik Kesavabhotla, Orin Bloch 3:45–3:50 pm Treatment with Hypomethylating Agent Decitabine Can Reverse Immune Escape by Isocitrate Dehydrogenase Mutant Gliomas Xiaoran Zhang MS, Aparna Rao, Christopher P. Deibert, Wajin Jason Kim, Alexander Pomerantz, Nduka M. Amankulor 3:50–3:55 pm CCL21 Vault Nanoparticle as an Immunotherapeutic for Glioblastoma Panayiotis Emmanuel Pelargos, Brittany Voth, Nikhilesh Bhatt, Carlito Lagman, Nolan Ung, Winward Choy, Isaac Yang Program Schedule
  • 16. 14 TUMOR SECTION SATELLITE SYMPOSIUM 3:55–4:00 pm Sulforaphane Inhibits the Formation of Glioma Induced Myeloid Derived Suppressor Cells and Reduces Myeloid PDL1 Expression Ravi Kumar, Ian F. Parney 4:00-4:05 pm Craniotomy for Intracranial Melanoma Metastases Offers a Bridge Towards Enhancing Efficacy of Checkpoint Inhibitor Therapy Christopher Alvarez-Breckenridge, Corey Gill, Mia Bertalan, Daniel P. Cahill, Ryan Sullivan, Priscilla Brastianos 4:05–4:10 pm Validation of the Programmed Death-Ligand 1 Antibody Clone 28-8 for Immunohistochemistry in Brain Tumor Patients Arnold Obungu, Saman Sizdahkhani, Graham Lobel, Nancy A. Edwards, Edjah K. Nduom 4:10–4:15 pm Synergistic Anti-tumor Effect with Indoleamine 2,3-dioxygenase Inhibition and Temozolomide in a Murine Glioma Model Hiroyuki Kinouchi, Mitsuto Hanihara, Tomoyuki Kawataki 4:15–4:20 pm A Potential New Adjunct to Temozolomide Therapy in Glioblastoma Gary R. Simonds, Cara Rogers 4:20–4:25 pm Combined Multimodality Treatment with Hypoxia-activated Prodrug TH-302 and XRT Results in Enhanced Antitumor Efficacy in Preclinical Malignant Meningioma Mouse Model Asif Maknojia, Vaibhav Patel, Michael Garcia, Dave Cavazos, Courtney Bosse, Aleksandra Gruslova, Niko Papanikolaou, Andrew Brenner, John Robert Floyd 4:25–4:30 pm Preclinical Study and Translational Application of Concurrent Radiotherapy and Valproic Acid for Intracranial Hemangioblastomas in Sporadic Hemangioblastomatosis Gautam U. Mehta, Saman Sizdahkhani, Charlton Smith, Christina Hayes, DeeDee Smart, Prashant Chittiboina Program Schedule
  • 17. TUMOR SECTION SATELLITE SYMPOSIUM 15 4:30–4:35 pm Phosphatase 2A Inhibitor, LB100, Sensitizes Malignant Meningioma Cells to Radiation by Autophagy Inhibition Sze Chun Winson Ho, Saman Sizdahkhani, Anita Tandle, Dragan Maric, Deric M. Park, Zhengping Zhuang, John D. Heiss 4:35–4:40 pm Modulation of Radiation Induced Cell Death in Glioma via Cadherin-mediated Tumor Microenvironment Alteration Christopher Paul Cifarelli 4:40–4:45 pm Engineering Primary Patient-derived Adipose Mesenchymal Stem Cells (hMSCs) with Nanoparticles: An Autologous “Trojan Horse” for the Intraoperative Treatment of Brain Cancer Rawan Alkharboosh, Kristen Kozielski, Jordan Green, Alfredo Quinones-Hinojosa 4:45–4:50 pm Self-assembling Camptothecin Hydrogel: A Local Treatment for Brain Tumors Montserrat Anilu Lara-Velazquez, Paula Schiapparelli, Ran Lin, Pengcheng Zhang, Hao Su, Hugo Guerrero Cazares, Honggang Cui, Alfredo Quinones-Hinojosa 4:50–4:55 pm Disulfiram Sensitizes Glioblastoma to Abraxane and Temozolomide Treatment Through Inhibition of MGMT and Aldehyde Dehydrogenase George C. Bobustuc, Deborah L. Donohoe, Richard A. Rovin, Amin B. Kassam, Santhi D. Konduri 4:55–5:00 pm Acid Ceramidase is a Novel Drug Target Against Multiple Pediatric Brain Tumors Ninh Doan, Wade M. Mueller, Shama Mirza, Kathleen M. Schmainda, Mona Al-Gizawiy, Andrew Montoure, Ha Nguyen Program Schedule
  • 18. 16 TUMOR SECTION SATELLITE SYMPOSIUM Convention Floor Plan Convention Center Overview 6A Tumor Exhi Ballroom 6 Lobby Tumor Registration 10, 11A, 11B Breakfast Breakouts Convention Center Upper Level San Diego Conve GROUND LEVEL Registration | Saturday to Wednesday Exhibit Hall C | Monday to Wednesday | General Scienti Monday Tuesday | Operative Neurosur Monday | Clinical Trials Update Sessions CNS E (Exhib CNS HOTEL S OVERVIEW UPPER LEVEL MEETING ROOMS/BAL MEZZANINE LEVEL MEETING ROOMS GROUND LEVEL EXHIBIT HALLS UNDERGROUND PARKING GARAGE 2 LEVELS SAN DIEGO BAY FIRST AVENUE FRO NT STREET WEST HARBOR DRIVE GASLAMP QUARTER 98 #CNS2016
  • 19. TUMOR SECTION SATELLITE SYMPOSIUM 17 6B Tumor General Session Abstract Oral Presentations ibit Hall 5B Speaker Ready Room ention Center ific Sessions rgery Sessions s EXHIBIT HALL bit Halls A B) REGISTRATION ENTRANCE from Marriott Marquis San Diego Marina Hotel SHUTTLES LLROOMS/SAILS PAVILION PARKING STRUCTURE FIFTH AVENUE SAN DIEGO BAY CONVENTION WAY
  • 20. 18 TUMOR SECTION SATELLITE SYMPOSIUM Exhibit Hall Floor Plan EXHIBITOR BOOTH Arbor Pharmaceuticals 307, 313 Brainlab 305 BioD, LLC 306 Carl Zeiss 311 Medtronic 309 Monteris Medical 304 Stryker 308 Exhibitors Ballroom 6-Lobby
  • 21. TUMOR SECTION SATELLITE SYMPOSIUM 19 Thank you Corporate Supporters Silver Supporter Carl Zeiss Bronze Supporters Arbor Pharmaceuticals Medtronic Stryker BioD, LLC Monteris Medical
  • 22. PP-GLD-US-0142 Vigilant ObservatIon of GlIadeL WAfer ImplaNT (VIGILANT) Registry: A Multicenter, Observational Registry to Collect Information on the Safety and Effectiveness of Gliadel® Wafer (Carmustine Implant) Used in Usual Medical Practice Sponsored by Arbor Pharmaceuticals, LLC For more information about the VIGILANT Registry, or if you are interested in participating, please contact the study team at: VIGILANT@mapigroup.com 1.855.843.6778 (phone/fax) ClinicalTrials.gov #NCT02684838 Visit Arbor Medical Affairs Booth 313 to learn more about
  • 23. TUMOR SECTION SATELLITE SYMPOSIUM 21 General Information Americans with Disabilities Act The Tumor Section wishes to take those steps to ensure that no individual with a disability is excluded, denied services, segregated, or otherwise treated differently than other individuals because of the absence of auxiliary aids or services. If you require any of the auxiliary aids or services identified in the Americans with Disabilities Act in order to attend any program, please send your requirements directly to the CNS Meetings Department at meetings@cns.org or by calling 847-240-2500. Attire Professional attire is appropriate for the meeting and in the Exhibit Hall. Professional /dressy attire is appropriate for the Friday, September 23, Gala Reception and Dinner. Meeting App Conveniently manage your schedule, browse program content, and keep up with what’s going on. Download the free EventPilot app from the Apple or Google Play store. Log in with the event code: TUMOR16 WiFi Service For your convenience, complimentary Wi-Fi service is provided by the CNS throughout the San Diego Convention Center wherever Tumor Section events are being held. Network Name: cns Conference Conference Passcode: cns2016
  • 24. 22 TUMOR SECTION SATELLITE SYMPOSIUM Disclaimer The material presented at the 2016 Tumor Section Satellite Symposium has been made available by the Tumor Section for educational purposes only. The material is not intended to represent the only, nor necessarily the best, method or procedure appropriate for the medical situations discussed, but rather is intended to present an approach, view, statement, or opinion of the faculty which may be helpful to others who face similar situations. Neither the content (whether written or oral) of any course, seminar, or other presentation in the program, nor the use of a specific product in conjunction therewith, nor the exhibition of any materials by any parties coincident with the program, should be construed as indicating endorsement or approval of the views presented, the products used, or the materials exhibited by the Tumor Section or by its Committees or Affiliates. The Tumor Section disclaims any and all liability for injury or other damages resulting to any individual attending the meeting, and for all claims which may arise out of the use of the techniques demonstrated therein by such individuals, whether these claims shall be asserted by physicians or any other person. No reproductions of any kind, including audiotapes and videotape, may be made of the presentations at the Tumor Section Satellite Symposium. The Tumor Section reserves all of its rights to such material, and commercial reproduction is specifically prohibited. Onsite Registration Hours Friday, September 23 8:00 am–5:00 pm Saturday, September 24 7:00 am–12:00 pm Exhibit Hall Hours Friday, September 23 12:00 pm–5:00 pm Saturday, September 24 7:00 am–5:00 pm Admittance to the Exhibit Hall is by Tumor Section Satellite Symposium name badge only. Children under the age of 18 are not allowed in the Exhibit Hall. Smoking The San Diego Convention Center and official Tumor Section Satellite Symposium hotels are non-smoking facilities. Speaker Ready Room All speakers and abstract presenters should visit the Speaker Ready Room (Room 5B) at the San Diego Convention Center a minimum of 1 hour prior to their presentations. Friday, September 23 8:00 am–5:30 pm Saturday, September 24 7:00 am–4:30 pm
  • 25. TUMOR SECTION SATELLITE SYMPOSIUM 23 Disclosures The Congress of Neurological Surgeons controls the content and production of this CME activity and attempts to assure the presentation of balanced, objective information. In accordance with the Standards for Commercial Support established by the Accreditation Council for Continuing Medical Education, speakers are asked to disclose any relationship they have with commercial companies which may be related to the content of their lecture. Speakers who have disclosed a relationship with commercial companies whose products may have a relevance to their presentation are listed below. Faculty who are also considered Planners are designated by P. Disclosures are current as of August 16, 2016. Positional Interest Codes 1 CEO 2 Consultant 3 Director 4 Editorial Board 5 Employee Gene H. Barnett Consulting Agreement - Monteris Medical Company (2) Edward C. Benzel, MD Consulting Agreement - Axiomed (2) Daniel P. Cahill, MD Consulting Agreement - Merck (2) Susan Chang, MD Consulting Agreement - Edge Therapeutics (2), Neonc (2), Tocagen (2), Other - Agios (6), Novartis (6), Quest (6), Roche (6) Clark C. Chen, MD, PhD Consulting Agreement – Monteris (2), MRI Intervention (2), Tocagen (2), Mike Yue Chen, MD, PhD Consulting Agreement – Globus (2): Royalty – Globus Medical (2) Ownership Interest – Medplate (7); Grants – Orthofix ((N/A) John G. Golfinos, MD Consulting Agreement - Viewray (6) William B. Gormley, MD Consulting Agreement - Codman (6) Amy B. Heimberger, MD Consulting Agreement - Caris Life Sciences (2) Michael E. Ivan, MD, MBS Consulting Agreement - Medtronic (2) Amin B. Kassam, MD Consulting Agreement – Synaptive Medical (2) Ricardo Jorge Komotar, MD Consulting Agreement - Medtronic (2) Gordon Li, MD Consulting Agreement - Medtronic (2) Michael Lim, MD Consulting Agreement - accuray (2), bms (2), Izi (2), Stryker (2), Grants - Accuray (6), Aegenus (6), Altor (6), Celldex (6), Immunocellular (6) Jeffrey J. Olson, MD Grants - Roche (6) Kevin Petrecca, BSc, MD, PhD Ownership Interest - ODS Medical (8) Dimitris G. Placantonakis, MD, PhD Other – Tocagen, Inc. (2) Laligam N. Sekhar, MD Other -Spisurgical (6), Viket Medical, Inc. (6) Walter Stummer, MD Consulting Agreement - Medac (2), Nxpharmagene (2), Zeiss (2) Michael A. Vogelbaum, MD, PhD Honoraria - Neuralstem, Inc. (6), Pharmicokinesis (6), Ownership Interest - Infuseon Therapeutics (7), Royalty - Infuseon Therapeutics (7) Buelent Yapicilar, MD Grants - Stryker (6) Yi-Hong Zhou, PhD Ownership Interest – Patent on protein and Nucleotide Sequences of ETSP ((8) Nothing to 6 N/A 7 Officer 8 Owner 9 Trustee
  • 26. 24 TUMOR SECTION SATELLITE SYMPOSIUM Kambiz Afrasiabi, MD Manish Kumar Aghi, MD, PhD Johnny Akers Ali A. Alattar, BS Vincenzo Albanese Mona Al-Gizawiy, PhD Rawan Alkharboosh, MS David Altshuler, MD Nduka M. Amankulor, MD Leonel Ampie, BS Karam Asmaro, MD Anthony Atala, MD Giancarlo Attinà Giuseppe Barbagallo, MD Jason Barber, MS Frederick Barker, MD Lorenzo Bello, MD Carolina Gesteira Benjamin, MD Elizabeth Emily Bennett, MD, MS David BergP Mitchel S. Berger, MD Mia Bertalan, BS Chetan Bettegowda, MD, PhDP Nikhilesh Bhatt Orin Bolch, MD George C. Bobustuc, MD Courtney Bosse Stephen G. Bowden, BM Chris Bowman Michael G. Brandel, BA Daniel J. Brat Priscilla Brastianos, MD Christopher Alvarez-Breckenridge Henry Brem, MD John C. Breneman, MD Andrew Brenner, MD Philip Ryan Brinson, BS George G. Bowden, BM Michael G. Brandel, BA Harley Brito da Silva, MD Jeffrey N. Bruce, MD Thomas Brucke Peter D. Canoll, MD, PhD Bob S. Carter, MD, PhD Alessandra Casarotti Dave Cavazos Juanita Celix, MD Francesco Certo, MD Srikant S. Chakravarthi Lola Blackwell Chambless, MD Peter Chang, BA Cleopatra Charalampaki, MD, PhD Xiong-Hui Chen, MD Andrew Chi, MD Prashant Chittiboina, MD, MPH Sarah Choi Alvin Chou Winward Choy, BA Lawrence K. Chung, BS Christopher P. Cifarelli, MD, PhD Elizabeth Claus, MD Lee Cooper Martin Corsten, MD Maura Cosetti David J. Cote, BS Honggang Cui Michael Cusimano, MD Randy D’Amico, MD David J. Daniels, MD, PhD John Dankert Sunit Das, MD, PhD Hormuzdiyar H. Dasenbrock, MD Justin M. David, PhD Tristan de Mooij, MD J. Matthew Debnam, MD John Degroot Christopher P. Deibert Jingjing Deng Antonio DeSalles, MD, PhD Michael C. Dewan, MD Joseph D. DiDomenico, BS Jorg Dietrich, MD, PhD Francesco DiMeco, MD Ninh Doan, MD, PhD Xuezhi Dong, BA Deborah L. Donohoe, BS Heloise H. Dubois Hugues Duffau, MD, PhD Ian F. Dunn, MD Nancy A. Edwards, BA Christopher Farrell Amir Fathi Peter Fecci, MD, PhD Manuel Ferreira, Jr. Patirick Michael Flanigan, BS John Robert Floyd, MD Joshua Frenster Melanie Fukui, MD Gregory N. Fuller, MD, PhD Sara Ganaha, MD Marco Garavaglia Sarah Tamara Garber, MD Michael Garcia Corey Gill, BS Tomas Garzon-Muvdi, MD, MS Zoran Gatalica Abdi S. Ghodsi, MD Brian John Andrew Gill Steven L. Gogela, MD Danielle Golub Quinton Gopen, MD Alessandra A. Gorgulho, MD Yair M. Gozal, MD, PhD Simon Graham, PhD Jordan Green Aleksandra Gruslova Christine Guerrero Hugo Guerrero Cazares, MD, PhD Ghaith Habboub, MD David Hackney Sameer H. Halani, BA, MS Xiaoxiao Han, MD Yong Han Mitsuto Hanihara, MD, PhD Gregory Hare Yuuri Hashimoto Christina Hayes Andrew Torre Healy, MD Michele HeaphyP Adriana Heguy John D. Heiss, MD Shawn L. Hervey-Jumper, MD Stacy HilsabeckP Brian R. Hirshman, MD, MS Sze Chun Winson Ho, MD Chad Holder Yuan Hu, MD Wei Hua Judy Huang, MD Xuan Hui, MD, ScM Alhadi Igressa, MD Rebecca Ihrie Arman Jahangiri, BS Robert Jenkins Jonathan Jennings, MD Aaron Johnson, PhD Michael Kader Piyush Kalakoti, MD Steven N. Kalkanis, MDP Tania B. Kaprealian Aditya Vishwas Karhade, BE Tomoyuki Kawataki, MD, PhD Kartik Kasavabhotla Kathleen KennedyP Sammy Khalili, MD Themasap Khan Mustafa Khasraw Wajin Jason Kim Hiroyuki Kinouchi, MD, PhD Santhi D. Konduri Douglas Kondziolka, MD, MSc, FRCS(C) Jun Kong Kristen Kozielski Bryan Matthew Krueger, MD Ruby Kuang, MS Ravi Kumar, MD John S. Kuo, MD, PhD, FACS Svetlana Kvint, MD Carlito Lagman, MD Grace Y. Lai, MD, PhD Jonathan B. Lamano, MS Michael Lamba Montserrat Aniul Lara-Velazquez Sang Jin Lee Michele LengermanP Andre Levchenko Tenzin Lhakhang Bing Li Gang Li Jiang-an Li Yanyan Li, MSc Ran Lin Mark E. Linskey, MD Graham Lobel Xiao-jie Lu, MD Stephen T. Magill, MD, PhD Asif Maknojia, MD Sunil V. Manjila, MBBS Sydney ManolaP April MartinP Ying Mao, MD Dragan Maric Juan Carlos Martinez-Gutierrez Rory R. Mayer, MD Roxanne Mayrand David McCarthy Ian E. McCutcheon, MD Michael William McDermott, MD Brian McGill, MS Guy M. McKhann, MD Jerry McLarty Gautam U. Mehta, MD Tom Mikkelsen, MD Shama Mirza, PhD Akshitkumar Mistry, MD Aram Modrek Alireza M. Mohammadi, MD Ahmed Mohyeldin, MD Annette Molinaro, MA, PhD Andrew Montoura, MD Melanie Morrison, BS Wade M. Mueller, MD Sean V. Murphy, PhD Alona Muzikansky Brian V. Nahed, MDP Ichiro Nakano, MD, PhD Michael Nalisnik Anil Nanda, MD Edjah K. Nduom, MD Houtan Noushmehr Justin A. Neira, BA Thomas Neubert, PhD Evan Newell Ha Nguyen, MD Christina Notarianni, MD Goodwell Nzou, BS Arnold Obungu Jennifer Padwal, BS Claudia Palena, PhD Stefano Palmucci Niko Papanikolaou Sabrina Paratore Deric M. Park Ian F. Parney, MD, PhD Vaibhav M. Patel, MD, BS Luke E. Pater, MD Panayiotis Emmanuel Pelargos, BA Federico Pessina Timothy E. Peterson, MSc Alexander Pomerantz Jose Luis Porras Nader Pouratian, MD, PhD Alfredo Quinones-Hinojosa, MD Valya Ramakrishnan Aparna Rao, PhD Sandeep Reddy Angela Richardson, MD, PhD Gabrielle E. Rieth, BS, MS Marco Riva, MD Cara Rogers Xiaoming Rong, MD Marco Rossi, MD Robert C. Rostomily, MD Richard A. Rovin, MD James T. Rutka, MD, PhD, FRCS(C), FACS Navin C. Sabharwal Jorge Samanamud John H. Sampson, MD, PhD, MHSc, MBA Nader Sanai, MD Jagteshwar Sandhu Raymond E. Sawaya, MD Lisa Scarpace Paula Schiapparelli Kathleen M. Schmainda, PhD Alexander J. Schupper Tom Schweizer, PhD Michael Selch Young-Joon Seol, PhD Sagar R. Shah, MS Mayur Sharma, MD, MCh Sameer A. Sheth, MD, PhD Regina ShupakP Eric R. Siegel MSc Danilo Silva, MD Joshua Silverman, MD Yannick Simmone Gary R. Simonds, MD Michael B. Sisti, MD Saman Sizdahkhani DeeDee Smart Charlton Smith Timothy R. Smith, MD, PhD, MPH Matija Snuderl Giuseppe Sortino David Spetzler Deanne StarrP Glen Stevens, DO, PhD David Straus, BA Ryan Sullivan, MD Ben Allen Strickland, MD Timothy Struve, MD Hao Su, PhD Dima Suki, PhD Nermin Sumru Bayin, MS Fred Tam Anita Tandle Joseph E. Tanenbaum, BA Stephen Tenn John Thaman Reid C. Thompson, MD Nathaniel Tippens Albert Truong Aristotelis Tsirigos, PhD Nolan Ung, BS Timothy H. Ung, MD Eugene John Vaios, MA Jose Enrique Velazquez Vega Roel Verhaak Massimiliano Visocchi Brittany Voth, BS Sarika Walia, MD Jing Wang Qing Wang Qingyue Wang, BS Yujun Wang, PhD Ronald E. Warnick, MD Peter C. Warnke, MD Shiao-Pei Weathers Kyle D. Weaver, MD Jeffrey S. Weinberg, MD Christian Rainer-Wertz Gabrielle A. White-Dzuro, MD Elizabeth E. Wicks Robert Thomas Wicks, MD Amparo M. Wolf, MD, PhD Eric Wolf, MS Eric T. Wong, MD Graeme Woodworth, MD Xue-Shun Xie, BSc Joanne Xiu Sandra C. Yan, BS, BA Isaac Yang, MD Wuyang Yang, MD, MS Stephen Yip, MD James J. Yoo, MD, PhD Jennifer Yu Guoan Zhang Pengcheng Zhang, PhD Xiaoran Zhang, MD, MS Shouhao Zhou, MD, PhD You-Xin Zhou Zhengping Zhuang Disclosures Nothing to Disclose
  • 27. FLOSEAL Hemostatic Matrix Indication FLOSEAL Matrix is indicated in surgical procedures (other than ophthalmic) as an adjunct to hemostasis when control of bleeding by ligature or conventional procedures is ineffective or impractical. Important Risk Information for FLOSEAL Matrix Do not inject or compress FLOSEAL Matrix into blood vessels. Do not apply FLOSEAL Matrix in the absence of active blood flow, e.g., while the vessel is clamped or bypassed, as extensive intravascular clotting and even death may result. Do not use FLOSEAL Matrix in patients with known allergies to materials of bovine origin. Do not use FLOSEAL Matrix in the closure of skin incisions because it may interfere with the healing of the skin edges. FLOSEAL Matrix contains Thrombin made from human plasma. It may carry a risk of transmitting infectious agents, e.g., viruses, and theoretically, the Creutzfeldt- Jakob disease (CJD) agent. FLOSEAL Matrix is not intended as a substitute for meticulous surgical technique and the proper application of ligatures or other conventional procedures for hemostasis. Excess FLOSEAL Matrix (material not incorporated in the hemostatic clot) should always be removed by gentle irrigation from the site of application. FLOSEAL Matrix swells by approximately 10% to 20% after product is applied. Maximum swell volume is achieved within about 10 minutes. The safety and effectiveness of FLOSEAL Matrix has not been established in children under 2 years of age and pregnant women. Do not use air to remove residual FLOSEAL Matrix from Applicator tip. The Applicator tips should not be cut. Do not use FLOSEAL Matrix on bone surfaces where adhesives, such as methylmethacrylate or other acrylic adhesives, will be required to attach a prosthetic device. Rx Only. For safe and proper use of this device, refer to the full Instructions for Use. Study design Prospective, randomized, multi-center trial comparing FLOSEAL Matrix with GELFOAM® Hemostat+thrombin in stopping intraoperative bleeding during spinal surgery. Four centers randomized 127 patients, 21 years of age or older. Randomization occurred after a bleeding lesion requiring a topical hemostatic agent was identified. The primary endpoint was hemostasis success for the first treated bleeding site. There was no difference in the adverse event profile between the two groups.2 References: 1. FLOSEAL Hemostatic Matrix Instructions for Use. Hayward, CA: Baxter Healthcare Corporation. 2. Renkens KL Jr, Payner TD, Leipzig TJ, et al. A multicenter, prospective, randomized trial evaluating a new hemostatic agent for spinal surgery. Spine. 2001;26:1645-1650. Baxter and Floseal are registered trademarks of Baxter International Inc. Gelfoam is a registered trademark of Pharmacia Upjohn Company LLC, and is used under license. USMP/9/16-0019 07/2016 THE POWER OF FAST ACHIEVES HEMOSTASIS TWICE AS FAST AS GELFOAM® HEMOSTAT + THROMBIN IN SPINE SURGERY1 (Median time to hemostasis: 1.5 minutes compared to 3.0 minutes)1,2 For more information or to place an order call 1-888-229-0001
  • 28. DO YOU OWN THE MOMENT? Visit us at booth 307 Gliadel® is manufactured by Eisai Inc. for Arbor Pharmaceuticals, LLC. Gliadel® is a registered trademark of Eisai Inc ©2015 Arbor Pharmaceuticals, LLC. PP-GLD-US-0049 All rights reserved.