I am from Bangladesh. southeast university

1. WELCOME TO MY PRESENTATION
Presentation On: Tricyclic antidepressants
(TCAs) Drugs
MD . Abujar Gifari
ID : 2015000300018
COURSE TITLE
PHARMACOLOGY –IV
COURSE CODE
BPH- 4023
DEPARTMENT OF PHARMACY
SOUTHEAST UNIVERSITY
Date : 23/09/2018

2. OUTLINES
• Introduction
• Mechanism of action
• Pharmacokinekinetics
• Indication
• Side effects
• Contraindications
• Drug Interactions

3. Introduction
• Tricyclic antidepressants (TCAs) are a class of
anti-depressant medications that share a
similar chemical structure and biological
effects. Scientists believe that patients with
depression may have an imbalance in
neurotransmitters, chemicals that nerves
make and use to communicate with other
nerves.
• Example : Amitriptyline, Amoxapine.

4. Mechanism of action
• Inhibit the re-uptake of neurotransmitters.
• They inhibit serotonin re-uptake at nor
epinephrine or dopamine re-uptake at pre
synaptic nerve treminals thus lead to increase
concentration of these transmitters in the
synaptic cleft.
• Takes up to 4 weeks for all TCA drugs to have
an effect.

5. • Good absorption after oral administration.
• Important biotransformation in the liver –
CYP450 – 2D6 and 2C19 isoforms and active
metabolites .
• Long half - lives of elimination(s).
Pharmacokinekinetics

6. Indication
It used to treat several conditions. Include-
• Depression
• Anxiety disorder
• Agitation
• Obsessive compulsive disorders (OCD)
• Manic-depressive disorders
• Major depressive disorder
• Diabetic peripheral neuropathic pain
• Post traumatic stress disorder (PTSD) etc.

7. Side effects
Tricyclic antidepressants are more likely to cause
constipation, weight gain, and sedation than
other antidepressants.
Possible side effects of tricyclic antidepressants
include:
• Dry mouth
• Dry eyes
• Blurred vision
• Dizziness

8. • Fatigue
• Headache
• Urinary retention
• Sexual dysfunction
• Low blood pressure

9. Contraindications
• Recent myocardial infarction
• Inhibit monoamine oxidase (MAOI's)
• Seizure disorder
• Narrow angle glaucoma
• Heart block, heart failure
• Arrhythmias
• Epilepsy
• Suicidal ideation

10. Drug Interactions
Don't take TCAs if you're also taking:
• MAOIs such as Marplan (isocarboxazid)
• Zyvox (linezolid)
• Drugs for bowel preparation that contain
phosphate
• Tagamet
• Alcohol