TRANSDERMAL DRUG DELIVERY SYSYTEM (TDDS) pptx BY AKANKSHA PURI

1. Targeted drug delivery
System
Presented by: Akanksha Balasaheb Puri
Roll No: 74

2. Content:
Introduction
Definition
Objective
Approaches for TDDS
Advantages and Disadvantages
Carriers or markers

3. Introduction
Recent developments in drug delivery systems are primarily focused on smart
DD, which focuses on drug administration
at the appropriate time, dosage, and location with maximum safety and
efficacy.
Targeted drug delivery means delivering of drugs to a specific site like infected
organ, tissue or cell.
The drug may be delivered to :
1.Capillary bed of active sites
2.Specific type of cell or intracellular region
e.g. Tumour cell
3.Specific organ or tissue

4. Objective
To achieve the desired pharmacological response at selected site without
undesireable interactions at other site. the medication is transported or
concentrated selectively at the site of action to localize the interaction of drug
with diseased site and to avoid the harmful effects to healthy tissue due to drug
interactions.
concentrate the medication in the tissues of interest while reducing the relative
concentration of the medication in the remaining tissues.

5. Approaches for drug targeting

6. • Passive targeting
It targets systemic circulation
In this technique, drug targeting occurs because of the body’s natural response
to physicochemical characteristics of the drug or drug-carrier system Bind to
particular receptor . Lock and key model
• Active targeting
In this approach carrier system bearing drug reaches to specific site on the basis
of modification made on its surface rather than natural uptake by RES
Drug + Carrier = Specific receptor.
Surface modification Techniqes 1.Coating 2.Tissue antibodies 3. Albumin Protein
Types:
1st order targeting
2nd order tagetting
3rd order targetting

7. • Inverse Targeting
In this type of targeting attempts are made to avoid passive uptake of colloidal carrier by RES
and hence the process is referred as inverse targeting.
RES normal function is suppressed by pre injecting large amount of blank colloidal
carriers or macromolecules like dextran sulphate leads to saturation of RES and suppression of
defense mechanism
• Ligand-mediated Targeting
Ligands confer recognition and specificity upon drug carrier and provides them with an ability
to approach the respective target selectivity and deliver the drug
approach ligands are used as carrier surface group(s), which can selectively direct the carrier to
the pre-specified site(s) housing the appropriate receptor units to serve as ‘homing device’ to
the carrier/drug
Carrier
Drug Molecule Ligand
Carrier
Target Tissue

8. • Physical Targeting
Delivery system that releases the drug only when exposed to a specific microenvironment such
as change in pH or temp., ionic strength. Physical reaction between drug and receptor
• Chemical targeting
the localization of agents to targeted areas through the use of site- specific prodrugs Enzymatic
or chemical reactions
• Biological targeting – Biomolecules having affinity with receptor
• Dual Targetting - carrier molecule itself have their own therapeutic activity and thus increase
the therapeutic effect of drug. E.g. Antiviral drug + Antiviral Carrier = Synergistic effect
+
Both have therapeutic activity Synergistic effect
Drug Targeting Molecule Increased Therapeutic effect

9. • Local targeting - Locally targeted systems are noninvasive targeting strategies
with the principal goal of delivering the drug to the local site for the management
of local pathologies.
• Systemic Targeting
Delivery of such therapeutic systems occurs through an invasive route, such as
intravenous administration of nanotechnological systems
Major limitations - adverse effects of the drugs in a specific tissue
• Location-Based - It is a targeted delivery to specific cells, organs, and
organelles.
Brain targeting, Respiratory targeting, GI targeting.
• Disease-Based Targeting - Disease-based targeted delivery is a site-specific
therapy targeting tumors and other targetable infectious diseases

10. Advantages
Patient Compliance
Modulated Pharmacokinetics

11. Carriers or Markers
o Liposomes
Defined as an artificial microscopic vesicle consisting of a central aqueous
compartment surrounded by one or more concentric phospholipid layers
o Neosomes
Drug carriers that have a bilayer structure and are formed by self-association of
nonionic surfactants and cholesterol in an aqueous phase niosomes are more
stable and also more cost-effective than liposomes
o Nanoparticles
particles ranging from 10 to 1000 nm , having the surface layer, shell layer, core.
o Monoclonal antibody
Monoclonal antibodies are antibodies produced by clones of a single cell which
recognize and bind to a specific antigen.

12. THANK YOU !!