Microglia are tiny cells in the brain that constantly survey the brain looking for bits of synapses to remove. They help shape the brain by pruning connections between neurons. Up next is a video about examples of evolution hidden in the human body, followed by reviews of a life science vendor and information on why graphene hasn't taken over the world yet. Recommended videos include tests of creativity and intelligence and discussions of entropy, IQ levels over generations, and characteristics of highly intelligent people.
Using neuromodulation techniques in behavioral medicine is a big step forward...Curtis Cripe
Using neuromodulation techniques in behavioral medicine is a big step forward in treating neurological and psychiatric conditions. By using precise neural stimulation, we can enhance patient outcomes and quality of life. Collaboration between clinicians, researchers, and technology developers is crucial for fully realizing the benefits of neuromodulation in behavioral medicine. #CurtisCripe
Wondering if your brain needs exercise too?Curtis Cripe
Wondering if your brain needs exercise too? Discover the incredible benefits of physical activity for your cognitive function and learn how it can help lower the risk of dementia. |Curtis Cripe
ADD/ADHD has elusive causes. No medical test can diagnose; behavioral assessments, neuro-imaging, and cognitive evaluations aid diagnosis. | Curtis Cripe
A balanced diet plays a pivotal role in mental healthCurtis Cripe
A balanced diet plays a pivotal role in mental health, delivering vital nutrients for brain wellness and mitigating the risk of mental illnesses. | Curtis Cripe
Mental health is intertwined with dietCurtis Cripe
Mental health is intertwined with diet, offering the brain essential nutrients to enhance wellness and diminish the likelihood of mental illnesses. | Curtis Cripe
Balanced nutrition is crucial for mental healthCurtis Cripe
Balanced nutrition is crucial for mental health, supplying the brain with the key nutrients to optimize wellness and lower the risk of mental illnesses. | Curtis Cripe
Optimal mental health is linked to a balanced dietCurtis Cripe
Optimal mental health is linked to a balanced diet, providing essential nutrients for brain wellness and reducing the risk of mental illnesses. | Curtis Cripe
Using neuromodulation techniques in behavioral medicine is a big step forward...Curtis Cripe
Using neuromodulation techniques in behavioral medicine is a big step forward in treating neurological and psychiatric conditions. By using precise neural stimulation, we can enhance patient outcomes and quality of life. Collaboration between clinicians, researchers, and technology developers is crucial for fully realizing the benefits of neuromodulation in behavioral medicine. #CurtisCripe
Wondering if your brain needs exercise too?Curtis Cripe
Wondering if your brain needs exercise too? Discover the incredible benefits of physical activity for your cognitive function and learn how it can help lower the risk of dementia. |Curtis Cripe
ADD/ADHD has elusive causes. No medical test can diagnose; behavioral assessments, neuro-imaging, and cognitive evaluations aid diagnosis. | Curtis Cripe
A balanced diet plays a pivotal role in mental healthCurtis Cripe
A balanced diet plays a pivotal role in mental health, delivering vital nutrients for brain wellness and mitigating the risk of mental illnesses. | Curtis Cripe
Mental health is intertwined with dietCurtis Cripe
Mental health is intertwined with diet, offering the brain essential nutrients to enhance wellness and diminish the likelihood of mental illnesses. | Curtis Cripe
Balanced nutrition is crucial for mental healthCurtis Cripe
Balanced nutrition is crucial for mental health, supplying the brain with the key nutrients to optimize wellness and lower the risk of mental illnesses. | Curtis Cripe
Optimal mental health is linked to a balanced dietCurtis Cripe
Optimal mental health is linked to a balanced diet, providing essential nutrients for brain wellness and reducing the risk of mental illnesses. | Curtis Cripe
The human brain, with over 100 billion neurons, is a marvel of memory and creativity, storing a lifetime's memories in a remarkably small space.| Curtis Cripe
Exploring the human mind, social psychology stands out as a captivating field. It investigates how human interaction shapes thoughts, emotions, and behavior| Curtis Cripe
The human brain, with 100 billion neurons, is a marvel of complexity, boasting limitless memory and creativity in a remarkably compact space.| Curtis Cripe
Healthy communication is vital throughout lifeCurtis Cripe
Healthy communication is vital throughout life, yet speech delays can occur, often due to hearing or oral issues, affecting a child's expression. | Curtis Cripe
Neurodevelopment impacts brain pathways, affecting memory, attention, reading, and social skills. Learning new skills enhances this process. | Curtis Cripe
Neurodevelopment shapes brain pathways, influencing memory, attention, reading, and social skills. Learning new skills enhances this process. | Curtis Cripe
As individuals age, a decline in memory function is expected and normal. Neve...Curtis Cripe
As individuals age, a decline in memory function is expected and normal. Nevertheless, there are strategies to help counterbalance this decline. | Curtis Cripe
Alternating high and low energy episodes are common in individuals with anxie...Curtis Cripe
Alternating high and low energy episodes are common in individuals with anxiety. Worry can hinder sleep and keep a person awake at night. | Curtis Cripe
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
The human brain, with over 100 billion neurons, is a marvel of memory and creativity, storing a lifetime's memories in a remarkably small space.| Curtis Cripe
Exploring the human mind, social psychology stands out as a captivating field. It investigates how human interaction shapes thoughts, emotions, and behavior| Curtis Cripe
The human brain, with 100 billion neurons, is a marvel of complexity, boasting limitless memory and creativity in a remarkably compact space.| Curtis Cripe
Healthy communication is vital throughout lifeCurtis Cripe
Healthy communication is vital throughout life, yet speech delays can occur, often due to hearing or oral issues, affecting a child's expression. | Curtis Cripe
Neurodevelopment impacts brain pathways, affecting memory, attention, reading, and social skills. Learning new skills enhances this process. | Curtis Cripe
Neurodevelopment shapes brain pathways, influencing memory, attention, reading, and social skills. Learning new skills enhances this process. | Curtis Cripe
As individuals age, a decline in memory function is expected and normal. Neve...Curtis Cripe
As individuals age, a decline in memory function is expected and normal. Nevertheless, there are strategies to help counterbalance this decline. | Curtis Cripe
Alternating high and low energy episodes are common in individuals with anxie...Curtis Cripe
Alternating high and low energy episodes are common in individuals with anxiety. Worry can hinder sleep and keep a person awake at night. | Curtis Cripe
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Lateral Ventricles.pdf very easy good diagrams comprehensive
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