AstaZine: The World's Purest Natural Astaxanthin

1. The Athlete’s Secret Weapon

2. From the Pure Waters of the
Himalaya Mountains…

3. …to the World’s Second Largest
Astaxanthin Farm

4. Introducing:
“The Athlete’s
Secret Weapon”

5. Our Company
 Focus is on unsurpassed quality at
reasonable pricing
 Biggest market is Japan (with the
world’s toughest quality standards)
 Supplying most of the world’s largest
supplement companies
 Algae Health Sciences (AlgaeHealth)
is a subsidiary of BGG dedicated to
the research, development and
marketing of products from algae

6. Our Company
 Over 20 years in business
 Facilities in USA, Japan, China and Europe
 Supplying the dietary supplement, food & beverage
and cosmetic industries

7. Our Farm
 World’s second largest Natural Astaxanthin producer
 All glass tubing to protect from contamination
 Pristine growing region, clean air & water

8. World Class Laboratories
 State-of-the-art
 Sparkling clean
 “Most impressive labs on
the algae scene”

9. Capacity Expansion
 Nearby land
earmarked for
expansion
 Doubling size of
farm to 160 acres
(64 hectares)
 World’s largest
producer by 2020

10. Expansion Capability
 Worldwide Astaxanthin demand exceeded supply from
2011 – 2014
 Every supplier was out-of-stock with horrible lead times
 This will never happen again due to AlgaeHealth’s:
 Ability to expand capacity quickly and efficiently
 Experienced Team of engineers, scientists, constructors

11. Our Water
 Collected from the Tibetan plateau in the Himalaya
Mountains
 Run through reverse osmosis for additional safety

12. Environmental Responsibility
 One of our most
important guiding
principles
 Highly productive crop
 Closed system (no run
off into environment)
 Using the sun’s energy
 Water recycling
Located next to the Pristine Stone Forest

13. Our Product
 Purest Natural Astaxanthin
in the world: Carotenoid
fraction is 97% Pure
Astaxanthin
 Most concentrated Natural
Astaxanthin in the world
 6.0% to over 8%
concentration in the algae
biomass
 Other producers generally
range from 2.0% to 5.0%

14. Our Product
 Global Supply Chain
 Beadlets: Made in Japan
 Supercritical CO2
solvent-free oleoresins:
Made in Germany
 Softgels: Made in USA
 Powders: Made in China

15. Our Product
 World’s First Organically
Certified Astaxanthin Crop
 Certified by leading European
organic certifier:
ECOCERT

16. AlgaeHealth Firsts
 Only Organically Certified Astaxanthin Crop
 Only US FDA NDI over 12 mg per day dosage
 24 mg per day: Recommended for initial 30 days as a
“loading phase” and for the 30 days immediately
preceding a “big event” for athletes
 Only Astaxanthin producer with two European Union
Novel Foods approvals for different Astaxanthin
extraction methods
 By far the most Structure Function Claims submitted
to US FDA without objection (239)

17. Product Quality
 NAXA member
 ISO 9001-2008
 ISO 22000-2005
 HACCP
 All Natural Process
 Vegan
 GMO Free
 Allergen Free
 Non-Irradiated
 Kosher & Halal Produced under cGMP
according to 21 CFR 111

18.  NAXA Verified Seal: Setting the
Worldwide Standard for Astaxanthin
 Only producers with top quality may
join NAXA
 Three founding principals
 Distinguish between Natural Algae
Astaxanthin versus other sources
 Educate the industry and consumers
on benefits of Natural Astaxanthin
 Regulatory issues

19. NAXA Verified Seal Use—May 2017
 Nutrex BioAstin (60% market
share in USA and growing
worldwide presence issued
press release)
 Healthy Origins (US brand
with overseas presence)
 Doctors Best (US brand)
 AstaGlo (US brand selling
exclusively in Asia)

20. Products from Non-NAXA Suppliers
 Most suppliers lack expertise
 Many products are not stable
 Some labeled “Natural” are
actually Artificial Astaxanthin
 15 commercial products tested
 Only 3 had the stated level of
Astaxanthin present
 80% were cheating the
consumer
 1/3 of the products tested had
less than half of label claim
From the book “The World’s Best Kept Health Secret:
Natural Astaxanthin”

21. Major Differences from
Artificial Astaxanthin
 Source: Natural is extracted from algae while Artificial is
synthesized from petrochemicals.
 Strength: Natural is 20 – 90 times stronger as an
antioxidant.
 Animal Trials Prove Superiority: Five different pre-
clinical trials in a variety of animals prove superior efficacy
for Natural Astaxanthin for various health benefits
including survival rates, resistance to stress, protection of
internal organs, growth rates and longevity.
 Molecule Shape, Esterification and Synergy: Natural
Astaxanthin molecule is shaped differently; is 95%
esterified; and comes complexed with small amounts of
other naturally-occurring carotenoids (total opposite of the
Artificial Astaxanthin molecule).

22. Major Differences from
Artificial Astaxanthin
 Safety: Natural has an extensive portfolio of human safety
studies and over 15 years of commercial use; Artificial has
never been tested in humans.
 Efficacy: Natural has been clinically validated to have
many diverse health benefits in approximately 100 human
clinical trials; Artificial has never been shown to have any
health benefits.
 Dosage: Should Artificial Astaxanthin ultimately be
proven safe for long-range human consumption, dosage
would have to be at least 20 times greater than Natural due
to its inferior antioxidant profile.

23. What is Astaxanthin?
 Haematococcus pluvialis algae cells become red as they
accumulate the antioxidant carotenoid Astaxanthin
 Astaxanthin is so protective the cells can live for over 40
years without food or water and in extreme heat or cold

24. Green to Red in Seven Days
Haematococcus hyperaccumulates Astaxanthin in just
one week when subjected to environmental stress

25. Chemical Structure
 Astaxanthin molecule is different from other
carotenoids
 Hydroxyl groups on the end of the molecule provide
unique benefits

26. The World’s Purest Astaxanthin:
AstaZine®
 AstaZine’s
carotenoid faction is
97% Pure
Astaxanthin
 3% supporting
carotenoids
 Other producers’
product is 85% - 95%
Pure Astaxanthin

27. Astaxanthin as a Feed Ingredient
 Used to pigment salmon and
trout
 Improves health, survival
rates, immunity of animals
 Used for strength and health
in sled dogs
 Nestle Purina’s top researcher
says Astaxanthin caused the
most noticeable change he
ever saw in over 20 years of
testing nutrients in sled dogs

28. Safety of Natural Astaxanthin
 In the food chain—salmon, lobster, shrimp, crab, trout
 Over 15 years as a supplement
 Chronic and acute safety studies in humans
 Artificial Astaxanthin has no human safety study

29. Nature’s Aquatic Marathon: Salmon show
how Astaxanthin can Benefit Athletes
 The highest concentration
of Astaxanthin in animals is
in salmon where it
concentrates in their
muscles
 Astaxanthin enables
salmon to perform nature’s
greatest endurance test—
swimming up raging rivers
for weeks

30. Medical Research Depth for Athletes:
12 Human Clinical Studies

31. What Makes Astaxanthin the
Athlete’s Secret Weapon?
 Clinical Research Says Astaxanthin:
 Increases power output by 15% (Earnest,
2011)
 Decreases racing time by 5% in
competitive cyclists (Earnest, 2011)
 Increases strength in healthy young
men 3X faster than placebo (Malmsten,
2008)
 Decreases heart rate by 10% during
endurance training (Talbott, 2017)
 Helps prevent muscle damage and
inflammation (Baralic, 2015)
 Decreases lactic acid levels after training
(Sawaki, 2002)
 Prevents joint soreness after exercise
(Fry, 2001)

32. AstaZine® Proprietary
Research in Athletes
 Study to be published in
Summer 2017
 12mg per day over 60 days
 10% decrease in heart rate
at submaximal endurance
intensities (Talbott, 2017)
 In long distance trail
runners (not sprinting),
AstaZine® enabled the heart
to function well at 10%
slower heart beat
 “Cardiotonic Effect”
 Patent pending

33. AstaZine® Future Research
in Athletes
 Additional study to be published in late 2017 (cannot
discuss yet—patent to be submitted)
 Plan is at least one clinical study each year

34. Study Sponsored by Gatorade®
in Competitive Cyclists
 4mg per day over four weeks
 2o km time trial
 Made the cyclists 5% faster
 Increased power output by 15%
(Earnest, 2011)

35. Recovery from Exercise
Prevention of Muscle Fatigue
 5mg per day
 Improved metabolism during
exercise load
 Increase in creatine phosphokinase
 Decrease in LDL cholesterol
 Anti-fatigue and antioxidative
 Conclusion: May promote recovery
and help prevent muscle fatigue
(Nagata, 2003)

36. Lactic Acid Levels Decreased
by 28.6% in Runners
 6mg per day for four weeks
 Lactic acid levels measured two
minutes after 1200 meter run
 Decrease of 28.6% in lactic acid
levels in Astaxanthin group as
compared to control group
 Conclusion: “Astaxanthin is
effective for improvement of
muscle fatigue that may lead to
sports performance benefits”
(Sawaki, 2002)

37. Increases Strength in Healthy Young Men
 6 month trial
 Healthy young men were
given placebo or 4mg
Natural Astaxanthin per day
 Strength measured as
number of deep knee bends
until exhaustion
 Astaxanthin group’s
strength increased three
times faster than placebo
(Malmsten, 2008)

38. Also Increases Strength in Patients
Suffering from Tendonitis
 Tennis elbow sufferers
(a form of tendonitis)
 12mg per day for 8 weeks
 Grip strength increased by
93% in Astaxanthin group
 Self-assessment of pain
levels decreased
 Trend toward increased
mobility (Spiller, 2006)

39. Prevents Joint Soreness After Exercise in
Healthy Young Men
 University of Memphis placebo-controlled, double-blind
study on young men who were weight-training
 4mg per day for three weeks
 Placebo group showed significant joint pain after intense
knee-extension exercise was performed
 Astaxanthin group showed no knee soreness (Fry, 2001)

40. Three Clinical Trials in
Elite European Soccer Players
 All three studies at 4mg per day for
90 days
 All three studies were double-blind
and placebo-controlled
 Study #1: Reduction in exercise-
induced free radical production
(Djordjevic, 2012)
 Study #2: Improvement of oxidative
status (Baralic, 2013)
 Study #3: Prevention of muscle
damage and inflammation (Baralic,
2015)

41. Medical Research Depth for Athletes:
Hundreds of Pre-Clinical Trials

42. Some of the Best Rodent Trials
 Increases time to exhaustion in
mice (swimming endurance,
Polotow, 2014; Ikeuchi, 2006)
 Promotes lipid metabolism
rather than glucose utilization
during exercise which led to
improvement of endurance in
mice (treadmill endurance, Aoi,
2008)
 Prevents exercise-induced
skeletal and cardiac muscle
damage in mice (treadmill
endurance, Aoi, 2003)
 Prevents muscular atrophy in
rats (Sugiura, 2005)

43. Benefits for Cells’
Energy-Producing Mitochondria
 Many studies showing positive effects in mammals’
mitochondria. Among the more important studies:
 University of Pittsburg School of Medicine study showed
protection against mitochondrial dysfunction (Lee, 2011)
 Kochi Medical School study in Japan showed superior protection
of mitochondria compared to a-tocopherol (Kurashige, 1990)
 Washington State University study showed prevention of age-
related mitochondrial dysfunction in dogs (Park, 2013)
 University study from Taiwan showed protection of
mitochondrial membrane and prevention of DNA damage and
cell death (Chan, 2009)
 Mitochondrial protection in various studies against oxidative
stress, heat stress, in organs such as the heart, brain, central
nervous system, kidneys and liver (Ma, 2011; Song, 2011; Manabe,
2008; Nakao, 2010; Liu, 2009; Liu and Osawa, 2009; Lu, 2010)

44. Safe & Natural Anti-Inflammatory
 Over 50 pre-clinical trials
 Broad-spectrum anti-
inflammatory reduces 8
different inflammatory
markers (Lee, 2003; Ohgami,
2003; Choi, 2008)
 No side effects or
contraindications
 But takes 2 – 6 weeks to work
 OTC and prescription anti-
inflammatories all have
dangerous side effects
Inflammatory Markers
• Tumor Necrosis Factor-A
• Prostaglandin E-2
• Interleukin 1-b
• Interleukin 6
• Nitric Oxide
• Nuclear Factor Kappa-B
• Cox 1 enzyme
• Cox 2 enzyme

45. World’s Strongest Natural Antioxidant
to Combat Oxidation in Muscle Tissue
(over 80 pre-clinical trials)
12.34
0.59
0.19
0.86
0.23
0.69
0
2
4
6
8
10
12
14
%inhibitionpermg
20X – 60X
stronger
than
other
antioxidants
in free radical
scavenging
Natural Synthetic Vit. C Vit. E Beta Pycnogenol
AX AX Carotene
Capelli, 2013

46. World’s Strongest Natural Antioxidant
 Singlet Oxygen Quenching
 800 times stronger than
CoQ10
 550 times stronger than
Green Tea Catechins
 6000 times stronger than
Vitamin C
 550 times stronger than
Vitamin E
 11 times stronger than Beta
Carotene
Shimidzu, et al 1996; Nishida, et al, 2007 Nishida, Yamashita, Miki, 2007. Carotenoid Science Vol. 11, 2007

47. Plus, Astaxanthin is the
World’s Highest Quality Antioxidant
 Astaxanthin is unique in many ways
 Astaxanthin has four distinct properties that other
antioxidants do not possess
 Some may share one or two, but no other antioxidant
has all four (Capelli, 2014)

48. 1) World’s Highest Quality Antioxidant
Astaxanthin Spans the Cell Membrane to
Protect the Entire Cell Capelli, 2014

49. 2) World’s Highest Quality Antioxidant
 Many good antioxidants can become Pro-Oxidants
under certain condition and cause damage to cells
 Astaxanthin can never become a “Pro-Oxidant”
Capelli, 2014

50. 3) World’s Highest Quality Antioxidant
 Astaxanthin can cross the blood-
brain barrier and bring its
profound antioxidant activity
and broad-spectrum anti-
inflammatory properties to help
protect the brain
 Once in the brain, Astaxanthin
crosses the blood-retinal barrier
to help protect the eyes
Capelli, 2014

51. 4) World’s Highest Quality Antioxidant
 Astaxanthin can bond with muscle tissue to control
oxidation and inflammation (key benefit for Athletes!)
Capelli, 2014

52. Related Clinical Research:
A Healthy Heart for a Hard-Working Body
 Improves blood lipid levels
(Yoshida, 2010)
 Prevents blood lipid
peroxidation (Karpii, 2007;
Iwamoto, 2000; Hiroshige, 2004)
 Improves blood flow (Miyawaki,
2008)
 May prevent atherosclerosis
(Hiroshige, 2004)

53. Related Clinical Research:
A Healthy Brain for a Healthy Body
 Three human clinical studies
showing potential brain health
benefits (Satoh, 2009; Nakagawa,
2011; Katagiri, 2012)
 Latest brain health research:
Famous researcher Paula
Bickford, PhD from University of
South Florida has started animal
trials which show neurotoxicity
benefits in a rat model (Grimmig,
2017)

54. Related Clinical Research: A Healthy
Immune System for Consistent Training
 Washington State University study
 0 mg, 2 mg and 8 mg per day
 8 week trial
 Best results were at 2 mg per day
 Improvement in several immune
markers
 “Astaxanthin is a strong immune
system stimulator”
 Decrease in DNA damage by 40%
 Reduction in CRP levels and
oxidative stress (Park, 2010)

55. Related Clinical Research:
UV Protection for Athletes Training Outdoors
 Prevention of photo-aging (Suganuma, 2010; Camera, 2009;
Mizutani, 2005; Arakane, 2003)
 Prevention of UV damage (Nakajima, 2016; Savoure, 1995)
 Prevention of skin cancer (Rao, 2013; Black 1998)
 Pre-clinical trials

56. Summary:
The Athlete’s Secret Weapon
 Human clinical research on
Strength; Endurance; Power Output;
Racing Time; Heart Rate during
Training; Muscle Damage;
Inflammation; Lactic Acid Levels;
Joint Soreness after Exercise.
 Pre-Clinical trials on Mitochondrial
Support; Antioxidant Strength &
Quality; Anti-Inflammatory Activity.
 Related Clinical Research on Heart
Health; Brain Health; Immune
Support; UV Protection.

57. Product Formats
 Multiple Product Formats
 5%, 10% and 20% oleoresin
 Supercritical CO2 solvent-free
extraction and ethanol extraction
 2.0 and 2.5% beadlets
 2% water dispersible powder
 Organic 5% spray-dried powder
 4mg, 6mg, 8mg and 12mg gelcaps
(available in select markets)
 Private label bottles “Made in
USA” (available in select markets)

58. Thank You for Your Attention
 For questions or more information please contact us at
www.bggworld.com or www.algaehealthsciences.com