Rapid V H IC Determinarea Grupelor Sanguine la Caini si pisici baza Transfuzi...Care For Your Family SRL
Rapid V H IC, Determinarea Grupelor Sanguine la Caini si pisici, baza transfuziilor profesionale, socul transfuzional, riscurile transfuziilor la animale, achizitia de teste de determinare de grupe de sange, teste de grupe de sange la caini, donarea de sange la animale
The document summarizes research on patients with chronic obstructive pulmonary disease (COPD) and common comorbidities. It found that 87.5% of COPD patients studied had two or more comorbidities, with the most frequent being cardiovascular diseases (65%), tuberculosis (42.5%), and lung cancer (10%). Treatment costs increased substantially with more severe COPD stages and additional comorbidities. Effectively treating COPD and associated illnesses is important since comorbidities greatly influence COPD progression and outcomes.
The document discusses retained textile foreign bodies (RTFBs), also known as gossypibomas, which are surgical sponges or towels accidentally left in a patient's body after a procedure, outlining their diagnosis using imaging tests, treatment requiring removal, potential complications, and importance of prevention through accurate counting of sponges before and after surgery. RTFBs can lead to serious issues like infection, fistula formation or bowel obstruction if not addressed, and prevention is critical given incidents continue to occur despite various counting guidelines and technologies introduced over the years.
Rapid V H IC Determinarea Grupelor Sanguine la Caini si pisici baza Transfuzi...Care For Your Family SRL
Rapid V H IC, Determinarea Grupelor Sanguine la Caini si pisici, baza transfuziilor profesionale, socul transfuzional, riscurile transfuziilor la animale, achizitia de teste de determinare de grupe de sange, teste de grupe de sange la caini, donarea de sange la animale
The document summarizes research on patients with chronic obstructive pulmonary disease (COPD) and common comorbidities. It found that 87.5% of COPD patients studied had two or more comorbidities, with the most frequent being cardiovascular diseases (65%), tuberculosis (42.5%), and lung cancer (10%). Treatment costs increased substantially with more severe COPD stages and additional comorbidities. Effectively treating COPD and associated illnesses is important since comorbidities greatly influence COPD progression and outcomes.
The document discusses retained textile foreign bodies (RTFBs), also known as gossypibomas, which are surgical sponges or towels accidentally left in a patient's body after a procedure, outlining their diagnosis using imaging tests, treatment requiring removal, potential complications, and importance of prevention through accurate counting of sponges before and after surgery. RTFBs can lead to serious issues like infection, fistula formation or bowel obstruction if not addressed, and prevention is critical given incidents continue to occur despite various counting guidelines and technologies introduced over the years.
This document presents a case report of cryptorchidism in a 46-year-old male patient who underwent an orchidectomy. Cryptorchidism refers to undescended testes and affects 2-4% of male births. Undescended testes have a 3-48 times higher risk of testicular cancer. The patient had a right undescended testicle since birth and was admitted for a pseudotumoral formation in the right inguinal area. Histopathological examination found total atrophy of the germinal cells in the right testicle, confirming orchidectomy was necessary. Management of cryptorchidism in adults includes observation, orchiopexy to lower the testes, or orchiectomy
This document discusses cancer and tuberculosis, two ongoing public health challenges. It provides statistics on the global burden of smoking, lung cancer, and tuberculosis. Key risk factors for lung cancer and TB are described, including smoking, genetics, and weakened immune systems. The document then focuses on a retrospective study of 365 tuberculosis patients in Romania, of which 18 also had cancer. Results found the majority were male smokers aged 36-80. Cancers were often late-stage at diagnosis. While TB treatment outcomes were typical, 12 of the 18 cancer patients ultimately died. The association between TB and cancer highlights the need for early cancer screening in high-risk groups.
The effects of low doses codeine ibuprofen association inSandrina Dascalescu
The document summarizes a study on the effects of low doses of codeine-ibuprofen association in a cutaneous pain model in mice. The study found that while codeine (100mg/kbw) and ibuprofen (10mg/kbw) individually did not influence nociceptive reactivity, their combination resulted in increased latency response to thermal stimulation, demonstrating an analgesic effect. The experiment was conducted with mice divided into groups receiving distilled water, codeine, ibuprofen, or the combination, and tested on a hot plate for latency time responses.
PARTENERIAT TRANSFRONTALIER REPUBLICA MOLDOVA-ROMÂNIAFlorinaTrofin
olaborarea la nivel transfrontalier prin împărtășirea opiniilor, practicilor, metodelor și strategiilor de lucru cu cadrele didactice din Republica Moldova și România pentru îmbunătățirea procesului educațional cu finalități comune.
PROIECT DE PARTENERIAT TRANSFRONTALIER „Educație online fără hotare”DusikaLevinta1
Colaborarea la nivel transfrontalier prin împărtășirea opiniilor, practicilor, metodelor și strategiilor de lucru cu cadrele didactice Republica Moldova și România pentru îmbunătățirea procesului educațional cu finalități comune.
OBIECTIVE Contribuirea la dezvoltarea unei educații de calitate;
Încurajarea formării continue a cadrelor didactice și manageriale;
Facilitarea accesului transfrontalier la resurse educative;
Promovarea dimensiunii interculturale a educației;
Încurajarea inovărilor în elaborarea materialelor didactice;
Utilizarea noilor tehnologii în educație.
Poveștile pentru copii au un rol complex și benefic în dezvoltarea lor, le vor oferi nu doar divertisment, ci și oportunități de învățare și creștere personală.
This document presents a case report of cryptorchidism in a 46-year-old male patient who underwent an orchidectomy. Cryptorchidism refers to undescended testes and affects 2-4% of male births. Undescended testes have a 3-48 times higher risk of testicular cancer. The patient had a right undescended testicle since birth and was admitted for a pseudotumoral formation in the right inguinal area. Histopathological examination found total atrophy of the germinal cells in the right testicle, confirming orchidectomy was necessary. Management of cryptorchidism in adults includes observation, orchiopexy to lower the testes, or orchiectomy
This document discusses cancer and tuberculosis, two ongoing public health challenges. It provides statistics on the global burden of smoking, lung cancer, and tuberculosis. Key risk factors for lung cancer and TB are described, including smoking, genetics, and weakened immune systems. The document then focuses on a retrospective study of 365 tuberculosis patients in Romania, of which 18 also had cancer. Results found the majority were male smokers aged 36-80. Cancers were often late-stage at diagnosis. While TB treatment outcomes were typical, 12 of the 18 cancer patients ultimately died. The association between TB and cancer highlights the need for early cancer screening in high-risk groups.
The effects of low doses codeine ibuprofen association inSandrina Dascalescu
The document summarizes a study on the effects of low doses of codeine-ibuprofen association in a cutaneous pain model in mice. The study found that while codeine (100mg/kbw) and ibuprofen (10mg/kbw) individually did not influence nociceptive reactivity, their combination resulted in increased latency response to thermal stimulation, demonstrating an analgesic effect. The experiment was conducted with mice divided into groups receiving distilled water, codeine, ibuprofen, or the combination, and tested on a hot plate for latency time responses.
PARTENERIAT TRANSFRONTALIER REPUBLICA MOLDOVA-ROMÂNIAFlorinaTrofin
olaborarea la nivel transfrontalier prin împărtășirea opiniilor, practicilor, metodelor și strategiilor de lucru cu cadrele didactice din Republica Moldova și România pentru îmbunătățirea procesului educațional cu finalități comune.
PROIECT DE PARTENERIAT TRANSFRONTALIER „Educație online fără hotare”DusikaLevinta1
Colaborarea la nivel transfrontalier prin împărtășirea opiniilor, practicilor, metodelor și strategiilor de lucru cu cadrele didactice Republica Moldova și România pentru îmbunătățirea procesului educațional cu finalități comune.
OBIECTIVE Contribuirea la dezvoltarea unei educații de calitate;
Încurajarea formării continue a cadrelor didactice și manageriale;
Facilitarea accesului transfrontalier la resurse educative;
Promovarea dimensiunii interculturale a educației;
Încurajarea inovărilor în elaborarea materialelor didactice;
Utilizarea noilor tehnologii în educație.
Poveștile pentru copii au un rol complex și benefic în dezvoltarea lor, le vor oferi nu doar divertisment, ci și oportunități de învățare și creștere personală.
2. Tetraciclinele
• Familie de antibiotice cu efect bacteriostatic, care actioneaza
prin stoparea sintezei proteice, inhiband formarea
complexului aminoacil-ARNt – ARNm-ribozom, prin legarea la
subunitatile 30S ale ribozomilor
• Clortetraciclina si oxitetraciclina – primele tetracicline
descoperite, in 1940
• Gliciclina – cea mai recenta tetraciclina descoperita
5. Naturale Semi sintetice
Tetraciclina Doxiciclina
Clortetraciclina Limeciclina
Oxitetraciclina Meclociclina
Minociclina
Demeclociclina
Rolitetraciclina
* Obtinute ca produsi de
metabolism a diverse specii de
Streptomyce
6. Spectru de activitate
• Bacterii Gram, pozitive si negative
• Chlamydii
• Ricketsii
• Coxiella
• Spirochete
• Mycobacterii
• Plasmodii
• Protozoare parazite
7. Farmacocinetica
Generatia I
• timp de injumatatire scurt
• absorbtie de circa 80% la nivelul stomacului
• inactivate de unele alimente (lapte) si prezenta
cationilor plurivalenti (Ca++, Mg++, Fe ++, Al+++)
Generatia II
• timp de injumatatire crescut
• liposolubilitate crescuta – realizeaza concentratii mari
in bila, plamani, saliva, organe genitale
8.
9. Farmacodinamie
• absorbite in general la nivel gastrointestinal »»»
- iritarea mucoasei
- distrugerea florei comesale – devine posibila
colonizarea cu bacterii patogene, precum Candida fungi
- tulburari gastrointestinale: diaree, greata, voma, colici
abdominale, pancreatita, hepatotoxicitate
• abilitatea de a chela calciul le ofera posibilitatea de a se
acumula la nivelul dintilor si oaselor, in special a celor in
crestere »»»
- colorarea ireversibila a dintilor intr-o culoare galben-
maronie
- inhibitie reversibila a cresterii oaselor
10. • nefrotoxicitate
• cresc fotosensibilitatea pielii
• tulburari pe mucoase: stomatite, glosite, vaginite, rectite
• suprainfectii locale
• la nivelul SNC produc sindromul Pseudotumor cerebri
(sindrom fals de hipertensiune intracraniana)
12. • Holera
• Boala Lyme
• Ulcer peptic, gastrita cauzata de infectia cu Helicobacter pylori
• Infectii determinate de Staphylococcus aureus, cand antibiograma
indica o sensibilitate adecvata
• Medicatie de rezerva in gonoree, lues, actinomicoza
• Adjuvant in amoebioza intestinala acuta, conjunctivita, acnee
severa
• Tratament topic in acnee si infectii ale pielii cu streptococi,
stafilococi si alti germeni sensibili
• In profilaxia leptospirozelor, holerei, malariei, diareei calatorilor si
tifosului tropical (boala Tsutsugamushi)
13. Contraindicatii
• Asocierea cu peniciline sau cefalosporine, sau administrarea
concomitenta a antiacidelor, suplimente cu multivitamine,
calciu sau fier, sau laxative
• Contraindicate la copii, in sarcina sau alaptare
14. Rezistenta la tetracicline
I. Mecanism enzimatic
- modificarea enzimatica a nucleului tetraciclinelor,
printr-o reactie de acetilare
II. Mecanism de eflux
III. Protectie ribozomala
- blocarea legarii tetraciclinei de ribozomi
- legarea de ribozomi, concomitent cu deformarea
sterica
- legarea de ribozomi, concomitent cu deslocuirea
tetraciclinei
16. Alte utilizari
• Acvacultura – controlul infectiilor la pisica-de-mare, raci si
somon
• Agricultura - pentru tratamentul infectiilor cu Bacillus larvae
sau Streptococcus pluton la albine
- pentru controlul infectiei cu Erwinia amylovara,
mycoplasme si Xanthomonas campestis la pomii
fructiferi, seminte si alte plante
• Medicina veterinara
• In hranirea animalelor, in doze subterapeutice, ca factor
adjuvant de crestere – imbunatatirea productiei de vitamine de catre
microorganisme gastrointestinale, eliminarea populatiilor patogene subclinice, cresterea
absorbtiei intestinale a nutrientilor
