IP & Life Sciences Division of Thomson Reuters is a global pro- vider of scientific information related to patents, clinical trials, regulatory affairs, drug competitive intelligence, systems biology, and other information. Sweeney discusses how taxonomy management software enables day-to-day processes and operations of professional services of the division as well as innovative approaches in taxonomy applications. He also shows how a taxonomy cross-mapping tool enables quick evaluation of taxonomy overlap and creates an environment for subject matter experts to establish equivalence or ontological relations for terms from different taxonomies.

1. THOMSON REUTERS
Life Sciences Taxonomy Software Solutions
November 2015

2. AGENDA
• Thomson Reuters Life Sciences annotation services
and use cases
• Taxonomy Management System – Synaptica KMS
2

3. THOMSON REUTERS
The world's leading source of intelligent information for
businesses and professionals
Tax & Accounting
Financial & Risk
Thomson Reuters Tax & Accounting
is the leading global provider of
integrated tax compliance and
accounting information, software
and services for professionals in
accounting firms, corporations,
law firms and government.
Intellectual Property & Science
Legal
Thomson Reuters Intellectual Property &
Science is the leading provider of
comprehensive intellectual property (IP) and
scientific information, decision support tools,
and services that enable pharmaceutical
companies, governments, academia,
publishers, corporations and law firms to
discover, develop and deliver innovations.
Thomson Reuters Legal is the leading
provider of critical information, decision
support tools, software and services
to legal, investigation, business and
government professionals around
the world. We offer a broad range
of online services that utilize our
databases of legal, regulatory,
news and business information.
Thomson Reuters Financial & Risk
is the leading provider of regulatory and
operational risk management solutions.
These solutions deliver critical news,
information and analytics, enable
transactions, and bring together
communities that allow trading, investing,
financial and corporate professionals to
connect.
Reuters News
2,800 journalists reporting in 20 languages from bureaus around the world
Reuters is the world’s largest international news organization

4. INTELLECTUAL PROPERTY & SCIENCE
Supporting the R&D community
SCIENTIFIC &
SCHOLARLY
RESEARCH
LIFE
SCIENCES
IP
SOLUTIONS
Our Mission:
Helping Our Customers Bring Ideas and Innovations to the World
Reliable content, analytics
and services that improve
Pharma R&D productivity
World-class solutions to
manage, protect and
capitalize on IP assets
Research data and tools to
identify, evaluate and
promote the best research
15,000 Customers representing over 20 Million users

5. LIFE SCIENCES-
Supporting the R&D community
CONTENT
TECHNOLOGY
EXPERTISE
We are trusted for the decisions that matter most, empowering decision-
makers to act with confidence in a complex world

6. THOMSON REUTERS LIFE SCIENCES
SERVICES- Annotation services
• Thomson Reuters provides manual and automated
searches for our customers:
– Biomedical literature
– Customer documents
– Databases
– Websites
6
Sources of relevant information. Search and annotation manually or with
automated technologies
or

7. THOMSON REUTERS LIFE SCIENCES
SERVICES- Automated annotation
• Thomson Reuters automated annotation services
are powered by taxonomies, custom algorithms
and domain experts.
7
Taxonomies Rules and Algorithms Domain
experts

8. ©2012ThomsonReuters.
Thomson Reuters annotation services-
Use cases
8

9. THOMSON REUTERS ANNOTATION
SERVICE- Use cases
• Product use monitoring
• Competitive intelligence
• Adverse Event monitoring
• Portfolio management
9
Customer
terminology
Public
terminology Custom
terminology
Final
terminology
Secure storage
of taxonomies
Edit
taxonomies
Map
taxonomies
Automated access to
taxonomies
Domain
specific
terminology

10. PRODUCT USE AND ADVERSE EVENT
MONITORING USE CASE
10
Data Approach Results
•Monitoring of 50 products using
automated approaches
•Indexing includes: indication, dose,
adverse effects, demographics, hot
topics
• Output in client’s terminology to
match their in-house library
database
• Thomson Reuters
literature collection
• Customer drug list
• Customer taxonomy
Goal: Due to growth in number of articles and products marketed, an innovative solution
to literature monitoring for in-house database maintenance is needed.
• Automated search and indexing of
the biomedical literature.
• Map customer thesaurus to public
and Thomson Reuters’ taxonomies
for a more robust final text-mining
ontology source.
• Identify unique terms not found in
the client’s taxonomy and
recommend to the client.
Manual
Mixed
Text Mining
$$ Time and volume
Client
taxonomy
Public
taxonomy
Thomson
Reuters’
taxonomy
Unique
terms

11. PORTFOLIO MANAGEMENT USE CASE
11
Data Approach Results
Automated search of the biomedical
literature. Link genes/protein terms to
immunoassay terms.
Article counts per month for
gene/protein used in a specific
immunoassay.
Monthly report with month-to-
month analytics
Raw data
>2 million gene/protein
and synonym terms +
immunoassay and
synonym terms
Goal: Monitor >70,000 human, mouse and rat genes/proteins in the biomedical literature
linked to immunoassays to confirm a current portfolio content, as well as identify the new
up-and-coming needs for a life sciences reagent company.
Confidence score based on natural
language, complexity, case, context
clues (‘anti-’), proximity of terms
Tumor protein p53
p53
TP53
BCC7
LFS1
Cellular tumor antigen
p53
Phosphoprotein p53
Antigen NY-CO-13

12. ©2012ThomsonReuters.
How Synaptica KMS Enables THOMSON
REUTERS Annotation Services
12

13. How Synaptica KMS Enables THOMSON
REUTERS Annotation Services
13
Customer
terminology
Public
terminology Custom
terminology
Final
terminology
Secure storage
of taxonomies
Edit
taxonomies
Map
taxonomies
Automated access to
taxonomies
Domain
specific
terminology
Review of Thomson Reuters Use Cases

14. Collaboration, Import, Linked Data, and Term
Creation
14
Customer
terminology
Public
terminology
Custom
terminology
Domain
specific
terminology
• Collaborative Work Spaces
allow for team effort
development
• Public and Enterprise term sets
may be imported via various
source formats (CSV, TXT,
XLSX, XML)
• Linked Data technologies provide access to public and
private resources across organizations throughout the world
(Coming Soon)
• Enable the customer to create new controlled vocabularies,
metadata fields, and new terms on the fly and on demand

15. Taxonomy Management, Mapping and
Distribution
15
Final
terminology
Secure storage
of taxonomies
Edit
taxonomies
Map
taxonomies
Automated access to
taxonomies
• Provide interface for
editing new and existing
terms along with their
governance and lifecycle
characteristics.
• Both automated and
manual mapping features
to provide alignment
between public, internal,
and external controlled
vocabularies.

16. APIs and Web Services for direct integration
with external applications
16
APIs / Web
Services
Synaptica GUI
Cloud Based or
Locally Hosted
Editors
Administrators / Modelers
Reviewers / Stakeholders
End Users
Database – Data and Model
Database API
Stored Procedures
3rd Party Applications
Vocabulary Distribution
via Scheduled Export
Import / Export Files
Full and Incremental
via Web
Service
via Scheduled
DB Job

17. For More Information Please Contact Us!
17
Elizabeth Sweeney, PhD
Senior Research Scientist
Thomson Reuters
elizabeth.sweeney@thomsonreuters.com
www.thomsonreuters.com
Jim Sweeney
Product Manager
Synaptica, LLC
jim.sweeney@synaptica.com
www.synaptica.com