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Sugar Surfing with a CGM
Stephen W. Ponder MD, FAAP, CDE
Managing ā€œdā€ well requiresā€¦
ā€¢ Comprehending a system with basic
principles/concepts
ā€¢ Adjusting to changing or shifting
conditions/situations
ā€¢ Frequent assessments and re-
assessments
LIKEā€¦.
ā€¢ Driving a car
ā€¢ Flying an airplane
ā€¢ Walking a tightrope
ā€¢ Surfing
Appreciate the flux of sugar levels in non-d persons
Remember: Sugar Surfing is all about managingā€¦
Diabetes is best approached 1 day at a time
8 versus 1440 ā€œdecision pointsā€
7:03 115
9:33 129
12:15 95
3:34 131
6:12 168
9:49 107
11:53 114
3:05 132
*
*
*
*
*
*
*
*
Donā€™t pass up an opportunity to assess a trending
BG
ā€¢ Choose what you consider
ā€œactionableā€
ā€¢ Set personal action thresholds
ā€¢ Use situational thinking: consider
recent, current and impending actions
ā€¢ Check your BG results over time
ā€¢ ā€œtreat to targetā€ (repeat as needed, but donā€™t
ā€œoverstackā€ your insulin)
(Glucose production ā€“ Glucose disposal) = FLUX
Here is a picture of FLUX and DRIFT
How much sugar is in the bloodstream for a
100 mg/dl BG level?
Human circulatory system
165 pound (75 kg) man
(5.1 grams)
55 pound (25 kg) girl
(1.75 grams)
110 pound (50 kg) boy
(3.45 grams)
= 4 gram glucose tabaka ā€œglucose transit systemā€
static vs. dynamic diabetes care
static
ā€¢ Actions predetermined
ā€¢ Minimal flexibility: RIGID
ā€¢ Outcomes donā€™t immediately
affect subsequent actions
ā€¢ Easy to teach/learn
ā€¢ Less time-intensive
ā€¢ Favors concrete thinking
ā€¢ Less motivation needed
dynamic
ā€¢ Actions are dependent on
situation/circumstance
ā€¢ Flexible and adaptable
ā€¢ Outcomes constantly influence
subsequent actions
ā€¢ Training needed, plus ongoing
reinforcement
ā€¢ More time intensive
ā€¢ Favors problem-solving
ā€¢ Requires ongoing motivation
present
past future
Actions Actions
A pancreas canā€™t predict the future
ā€¢ It acts so fast it doesnā€™t need to.
ā€¢ Can shut off insulin immediately
ā€¢ Can release premade insulin
ā€¢ Insulin it releases can start
working in minutes
ā€¢ Can rapidly respond to shifts in
sugar levels
Set ā€œactionableā€ thresholds
ā€¢ Upper/Lower limits
ā€¢ 80 mg/dl and 140 mg/dl
ā€¢ 90 mg/dl and 180 mg/dl
ā€¢ Rates of change
ā€¢ Up or down arrows
ā€¢ Factor in recent/current/future
events as you are able
ā€¢ Test your skills, experiment a little
within reason
Traits of effective CGM users
ļƒ¼Wear it most of the time
ļƒ¼Check trend line often
ļƒ¼They ā€œwork the lagā€ times
ļƒ¼FOOD lag
ļƒ¼INSULIN lag
ļƒ¼SENSOR lag
ļƒ¼Not afraid to experiment
ļƒ¼Not expecting perfection
Principles of Sugar Surfing
1. A CGM is no better or
worse than the person
responding to it.
2. If you can measure it, you
can predict it.
3. Flux and drift happenā€¦
manipulate them!
4. Keep your eye on your line.
5. The trend is your friend
6. Learn lag limits; be patient
7. Zero in on your zone
8. Master micro-dosing
9. Factor in glycemic inertia
and insulin momentum
10.Donā€™t let ā€œgood enoughā€
be the enemy
11.Calibrate carefully
12.Pre-empt when you can
ā€œTHE TREND IS YOUR FRIENDā€ CHECKING INSULIN BOLUSES WITH CGM
6 pm 8 pm 10 pm
300
200
100
60
Carb bolus Correction bolus
6 pm 8 pm 10 pm
Goal: green lines
Turnaround Time : glycemic inertia
Corrections may need to be adjusted 10-20% to compensate
Goal: Try to stay between the lines
As your skills improve, lower the glucose for the upper alert
Timing 101 ā€“ 20 min. match
Insulin
Food
Timing 101 ā€“ 45 min. mismatch
Insulin
Food
Be realistic
ļƒ¼Accept that the first 6-12 months
are on a ā€œlearning curveā€
ļƒ¼Set higher and wider targets
ļƒ¼Have low expectations to start
ļƒ¼Itā€™s still a finicky technology
ļƒ¼PLEASE BE PATIENT
BG awareness vs. alarm fatigue
ā€¢ Set reasonable alarm thresholds
ā€¢ Depends on your goals
ā€¢ Avoid high spikes?
ā€¢ Avoid lows?
ā€¢ Toddler? Child? Teen? Adult?
ā€¢ Make sure you can hear/sense the
alarm
ā€¢ Anticipatory action can minimize
alarms
Cal-i-bra-tion (noun ĖŒka-lə-ĖŒbrā-
shən)
ā€¢ Comparing the sensor to an
accepted ā€œstandardā€ value
ā€¢ The accepted ā€œstandardā€ value is
a fingerstick BG level
ā€¢ So the sensor itself can be no
more accurate than the BG
meter itā€™s compared toā€¦or how
well the BG meter was used
Calibration tips
ā€¢ The first sensor day can be
erratic as it ā€œsettles inā€
ā€¢ Donā€™t over calibrate!
ā€¢ Try to calibrate on a steady trend
ā€¢ Try to calibrate when in your
target range
CGM calibration tipā€¦
steady
2 hours
Whenever possible: calibrate the CGM
system when on a ā€œsteadyā€ sugar trendline
2 hr ā€œwaitā€ time between ā€œturning onā€ sensor and
providing 2 calibration BG readings to start session
steady baseline
Daily calibrating on a steady baseline
Steady trend
2 hours
Calibrate your CGMā€¦
On a steady trend when you canā€¦
In the BG range you want to be most accurate inā€¦
Steady trend
4 hours post start up calibration (extra)
Settling in at 6 hours: wobble
Sensors are not always right
Or is it the meter thatā€™s off?
Morning madness?
After 14 hours after new
CGM sensor insertionā€¦
After calibrating with
112 mg/dl, the sensor
immediately reads this
Take home message: a new CGM sensor site might take a day or so to properly ā€œsettle inā€
or ā€œreadā€ properly. Take this under consideration and donā€™t give up on a session too soon.
But BG meter calibration
shows THISā€¦
Overnight basal testing
Overnight basal in range (glargine)
Overnight in range!
Overnight control in range
Basal testingā€¦
Overnight basal control - Lantus
Learning from the Line Graph ā€“ Insulin Timing
8a 10a
70
140
210
350
280
8a 10a
70
140
210
350
280
TodayYesterday
Insulin bolus: 7:30 AM
Breakfast: 7:30 AM
Insulin bolus: 7:10 AM
Breakfast: 7:30 AM
M
I MI
Why timing is everything
3 units @6:10 28 gm @ 6:50
Timingā€¦waiting for the bend
ā€œwindowā€
3 U lispro @ 6:22AM
28 GM CHO @ 6:52AM
Timing insulin and meals to prevent a spike
Wait for the bend!!
6U @146
mg/dl Eat here @132
mg/dl
45 minutes
Wait for the ā€œbendā€!
Stopping sugar spikes
3 units
(5:32AM)
Meal
(5:48 AM)
Point ā€œAā€ Point ā€œBā€
sugar trend
Insulin ā€œcorrectionā€
Carb ā€œcorrectionā€
~ 2 hours for insulin
~ 15-30 minutes for carbs
Range of possible
BG outcomes
ā€œthe trend is your friendā€
Blood glucose level
Noticed rising trend at
1:43 PM: 165 mg/dl
Took 5 units lispro
@ 1:45 PM
4 hours
Late BG rise after the
morning: no lunch eaten
135 mg/dl @ 2 hours
ā€œDirection affects correction ā€
Although subtle, this can be ā€œfeltā€
BG = 157 mg/dl
Inj 4 U lispro @3:15
2-3 hours
20-30 minA
B
C
Correction tips
(on a steady trend)
A. Remember the lag
time before insulin
starts to effectively
lower BG
B. Remember the
length of time it
takes to accomplish
the desired task
C. Patience and
practice make
these kinds of
results possible
Micro-bolusing (dosing)
Steady baseline BG trend
BG 136 mg/dl
2 units lispro
Wait 2 hours
Target zone
ā€¢ Very advanced
ā€¢ CGM needed!
ā€¢ Note flat BG
ā€œbaselineā€ trend
ā€¢ Calibration good
ā€¢ Not ā€œcorrectionā€
per se
ā€¢ More of an
ā€œadjustmentā€
BG 137 mg/dl
and rising slowly
3 units lispro
ā€œMicro-bolusingā€
BG 124 mg/dl injected
1.5 units lispro
@3:56AM
2 hours
Microbolus experimentation
Lag time
112 mg/dl to 78 mg/dl after 1.5 units
by injection on a ā€œsteadyā€ BG
baseline
1.5 units
~ 2 hours
3U lispro
@ 3:40AM
4 unit lispro ā€œpushā€
ā€œCourse correcting for smooth sailingā€
Well balanced basal insulin
6 unit ā€œshoveā€ at 133 mg/dl ļƒ¬
Mealtime insulin @
8:30PM 7 units lispro
Duration of insulin 3hr
Insulin correction dose
@ 2:53AM 6 units lispro
lag
2 hours to correct
Teaching
pointsā€¦
a. Know your insulin
ā€œumbrellaā€
b. Slow carbs cause
unexpected highs
c. Insulin onset of
action = lag time
d. Rise in BG levels
has vector
qualities
e. It takes time to
correct a high
a
b
c
d
ea
b
6:53PM BG 108 inj 6 units
7:15-7:35
9:52PM BG 125ā†‘ inj 4 units
ā€œEffective durationā€ of insulin action: 3 hrs
ā€œActive
insulinā€
ā€¢ Example: Slow carb meal
(fried food)
ā€¢ e.g., Chicken fried steak,
cream gravy and 3 onion
rings and 8 French fries
ā€¢ Estimated 60 grams: 6
units: inject 6 units lispro
ā€¢ NO rise in BG for 3 hours,
then rapid ascent
ā€¢ Time until rise reflects
ā€œactive insulinā€ effect
ā€¢ Must do this many times
and take the average
Duration of insulin effect can be determined
here
~ 4 hours
IOB after 6 units and fried meal
6 units
3.5-4 hours
2 units
WalkFried
Meal
Rising BG trend (132
mg/dl) @ 2:06AM
5 units lispro @ 2:12
Fried Chicken
2.5 hours
8 U 6 U 5 U 5 U3 U Lispro
20 Lantus
ā€œInflectionsā€
calibration
Tex-Mex Dinner
calibration
ā€œRemember the Alamoā€
Correction and meal
6 units (161
mg/dl)
Meal
(26 gm CHO)
~ 45m
126 mg/dl
5 units @ 5:43AM; 25 gm CHO @ 6:23AM
5 units
Meal
(25 gm CHO)
40 minutes
Correction with 20 grams carbs
20 gm CHO
121 mg/dl: 3 units
@ 10:04PM
80 mg/dl: 7 units
lispro @ 6:36PM
Meter: 55 mg/dl
@ 7:56PM
My estimated duration of insulin action: 3.5 hours
Slow carbs
ā€¢ Experimented here:
ā€¢ Ate a pasta meal at the
Olive Garden
ā€¢ Took a single insulin
shot (70 gm = 7 units)
ā€¢ Sugar dropped at time
of usual peak insulin
action: ~60-90 minutes
ā€¢ BG recovered without
treatment
ā€¢ Late rise in BG required
second injection
Leveling off
Olive
Garden
2 salad
servings, 1
breadstick
and
Lasagna
lispro
121 mg/dl: 3 units
@ 10:04PM
80 mg/dl: 7 units
lispro @ 6:36PM
Meter: 55 mg/dl
@ 7:56PM
My estimated duration of insulin action: 3.5 hours
Fast insulin +
slow carbs = low
BG
ā€¢ Ate a pasta meal at the
Olive Garden
ā€¢ Took a single insulin
shot (70 gm = 7 units)
ā€¢ Sugar dropped at time
of usual peak insulin
action: ~60-90 minutes
ā€¢ BG recovered without
treatment
ā€¢ Late rise in BG required
second injection
ā€¢ Notice the insulin-food
ā€œbalanceā€ and how it
effects BG levels
Leveling off
Olive
Garden
2 salad
servings, 1
breadstick
and
Lasagna
lispro
Insulin effect
Food effect
ā€œFried-food revengeā€ and correction
Fried food earlier in evening
@ 8PM
BG = 194
6 unit correction @ 7AM
BG = 115 in 3
hours
ā€œRevenge of the Ribeyeā€ and ā€œThe Insulin Strikes
Backā€
BG 167: 4 units
LAG
2-3h
Slow BG rise from protein-fat laden meal
Slow overnight rise and early AM
correction
Correction at 2:45 AM after slow post
dinner rise with 5 units
5 units
~ 2 hours
3 units lispro
Breakfast
BG 173 mg/dl
5 units lispro
Meeting
A ā€œrandom riseā€ in BG during a routine day.
2-3 hours
Working itā€¦(i.e., glucose control exists ā€œin the momentā€)
~ 2 hours
Oops! I Ate
an EXTRA
breakfast
taco!
BG 142 ā†‘ : took 5 units
hypothetical
real
And thirdly, the correction and carb ratios is more
what youā€™d call ā€˜guidelinesā€™ than actual rules
ā€œMost of our assumptions have outlived their
usefulnessā€
Marshall McLuhan
8 U @ 9:30AM
7 U @ 10:54AM
6 U @ 12:29PM
60 grams carbs
Ultimately 21 U lispro
Insulin to carb ratios are only a start
7
5
4
5
Large bowl turkey soup and 2
small pieces cornbread @ 6:30
ā€¦flux?ā€
ā€œWhat theā€¦
Duration of insulin
9 units lispro for 90 gm
Mexican food lunch @3:30
6 units lispro @ 6:30PM for
rising BG after 3 hr IOB
Stabilization
Two gulps of juice (15-20g CHO)
5 gram CHO ā€œnudgeā€
@ 66 m/dl
Dropping < 1 mg/dl/min
ā€œThe nudgeā€ (aka microcarbing)
5 gram CHO ā€œnudgeā€
@ 66 m/dl
Glucose counter-regulation
Glucagon
Epinephrine
Cortisol
Growth hormone
Leisurely walk from 7:00 to 8:30: straight
line
Exercise ā€œbump upā€
Moderate intensity
75 minute duration
Glycogen ļƒØ Glucose
2 units
1 hr walk
ā€œWalking downā€ a trend
Blood sugar correction 160 mg/dl to 100 mg/dl in 2 hours
with 4 units insulin lispro by injection
4 units
~ 2 hours
Correction: 151 mg/dl to 103 mg/dl with 2 units
insulin lispro after walk
2 units
~ 2 hours
127 mg/dl @4:47AM
Injected 3 units lispro
1.5 hours
ā€œPushing sugarā€
BG 137 mg/dl : dose 5 U lispro
Lag time
Eat breakfast here
Timing insulin and food is like shooting clay pigeons
6 U lispro @ 1:45AM
@ 170 mg/dl
30 min lag
3 hour wait
Taking the dropā€¦
ā€œTaking the dropā€
BG 160 mg/dl @ 1:47AM
Injected 5 units lispro
Lag time
Drop time 2-3 hrs
perfect bottom turn
froth
Woke up at 3:55AM at
184 mg/dl
Took 4 units lispro
Wait (slept) about 3 hours
Bingo!
Tamale Soup at dinner
(slow carbs, slow rise)
ā€œLivinā€™ la vida Glucoā€
182 mg/dl : 7 units lispro
Insulin lag time
30-40 min
Eat breakfast here
Food lag time
124 mg/dl
Timing is everythingā€¦do you have
the patience or the time?
Slow BG rise
overnight from
fried meal
BG drop time
20-30 min
Missed 9PM basal dose (glargine)
Normal time
Lantus taken (9PM)
Detected rising sugar
level @ 2AM
Humalog dose (7U) AND
usual Lantus taken (20U)
Sensor ā€œgapā€!!
dinner
Fell asleep!
All back in range by morning!
What happens when a basal insulin dose is missed
Usual time Lantus
dose is taken: 9PM
Rising BG
discovered here
Insulin correction given
If not treated: high
BG and ketones
Treated: In range
BG and NO ketones
Stress effect
Endocrinology Board Exam taken every 10 years
Stress and
Sugar
ā€¢ Strong emotional stress
triggers release of a several
hormones
ā€¢ These hormones act on liver
and muscle to cause the
release of internal sugar from
depots inside the body
ā€¢ Stress hormones also make
the liver produce sugar from
substances like protein and
fat
ā€¢ This can overwhelm the
ability of basal insulin to
dispose of sugar faster than it
can build up in the blood
ā€¢ CGM allows for more
aggressive anti-stress
treatment of rising sugars
Crossing 140 mg/dl @ 3AM
and a 2.5 U lispro correction
~ 2 hours
Lag time
Why act?
ā€¢ Slow upward BG trend
(red arrow)
ā€¢ Crossed personal ā€œaction
considerationā€ threshold:
140 mg/dl in my case
(yellow line)
ā€¢ Knew the CGM would
alert me to a rapidly
dropping BG later if I
over treated
ā€¢ Have done this many
times before: practice,
practice, practice
Microbolus at 7:55AM when BG
was 151 mg/dl took 2 units (after
surgery)
Awakened by CGM alarm to a
BG below 60 mg/dl
Lag time
20gm
Rationale
ā€¢ Slow downward BG trend
(red arrow)
ā€¢ Crossed personal ā€œaction
considerationā€ threshold:
60 mg/dl in my case
(yellow bottom line)
ā€¢ Drank 20 gm grape juice
and went back to sleep
ā€¢ Knew the CGM would
alert me to a rapidly
rising BG later if I over
treated
ā€¢ Have done this many
times before: practice,
practice, practice
This can be ā€œsensed tooā€
CHO
A steady trend
The bodyā€™s defenses
against low blood sugar
include the brain
Downward shifts, even
small, can be sensed by
the conscious brain Once sugar levels off,
the brain senses
stability
Rationale
ā€¢ Blood sugar control is
complex, it includes the
brain and nervous system
ā€¢ Long term damage to the
autonomic nervous system
can result in loss of classic
signs/symptoms of low
blood sugar
ā€¢ But, the brain itself might
still retain the ability to
sense downward sugar
shifts before severe low BG
kicks in (e.g., < 50 mg/dl)
ā€¢ A CGM device can serve as
a ā€œbiofeedbackā€ device of
sorts in adults willing to
develop the ability over
time.
Feel the drop and level off
Subtle
correction
ā€¢ BG 125 and rising
ā€¢ Took 4 units lispro
ā€¢ 2 for the slow rise
ā€¢ 2 for the
correction
ā€¢ Waited almost 2
hours (yellow arrow)
ā€¢ Notice lag time
before BG ā€œturnsā€
(red arrow)
This feels stable> 1-2 mg/dl/min
~ 1 mg/dl/min
ā€œWorking downā€ a rising BG
4 units @
173 mg/dl
2 units @
167 mg/dl
7 units @ 2PM for
Whataburger and rings
4 units Humalog
@ 11:07PM
BG rising after insulin effect
isā€œwaningā€. BG = 146 mg/dl
Dinner (soft tacos,
refried bean and
chips/salsa); 7 units
lispro taken 20 minutes
premeal at 7PM
My ā€œDIAā€ = 3-4 hours
Notice the obligatory
ā€œlag timeā€!
Anatomy of a preemptive correction
Anatomy of a nighttime low
A) 4 hour window
B) 24 hour window
C) 6 hour window
D) Resolution
34 mg/dl
36 grams CHO
2.5 hours
6 month CGM data summary
Average BG = 103 mg/dl
Standard deviation = 34 mg/dl
Aim to keep the average BG in range and the standard deviation AT LEAST HALF the average BG value
Day vs. Night: any thoughts about why?
Interpret these two images
Hint: sensor is over two weeks old
What is it a good time for and why?
Straight line trend
Straight line trend
= 10 grams carbs
60 mg/dl
90 mg/dl
6 U
4 U
4 U 4 U
5 U
6 U
28 GM
90+ GM
1. Stacked insulin + delayed eating
2. ā€œHyper-treatedā€ severe low
3. Fought ā€œreboundā€ high BG all night
4. Took the drop and timed meal
Dislodged insulin pump siteā€¦
Picked up early by CGM
Pump site changed, insulin dose given,
carb correction takenā€¦$13,000 saved
Penny stock day trading strategyCGM is ā€œsugar surfingā€ board
Ā©
ā€œKickinā€™ Dā€™s Buttā€

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Sugar Surfing with a CGM (copyright) TLC Advanced Diabetes Retreat April 26 2014

  • 1. Sugar Surfing with a CGM Stephen W. Ponder MD, FAAP, CDE
  • 2. Managing ā€œdā€ well requiresā€¦ ā€¢ Comprehending a system with basic principles/concepts ā€¢ Adjusting to changing or shifting conditions/situations ā€¢ Frequent assessments and re- assessments LIKEā€¦. ā€¢ Driving a car ā€¢ Flying an airplane ā€¢ Walking a tightrope ā€¢ Surfing
  • 3. Appreciate the flux of sugar levels in non-d persons
  • 4. Remember: Sugar Surfing is all about managingā€¦
  • 5.
  • 6. Diabetes is best approached 1 day at a time
  • 7. 8 versus 1440 ā€œdecision pointsā€ 7:03 115 9:33 129 12:15 95 3:34 131 6:12 168 9:49 107 11:53 114 3:05 132 * * * * * * * *
  • 8. Donā€™t pass up an opportunity to assess a trending BG ā€¢ Choose what you consider ā€œactionableā€ ā€¢ Set personal action thresholds ā€¢ Use situational thinking: consider recent, current and impending actions ā€¢ Check your BG results over time ā€¢ ā€œtreat to targetā€ (repeat as needed, but donā€™t ā€œoverstackā€ your insulin)
  • 9. (Glucose production ā€“ Glucose disposal) = FLUX Here is a picture of FLUX and DRIFT
  • 10. How much sugar is in the bloodstream for a 100 mg/dl BG level? Human circulatory system 165 pound (75 kg) man (5.1 grams) 55 pound (25 kg) girl (1.75 grams) 110 pound (50 kg) boy (3.45 grams) = 4 gram glucose tabaka ā€œglucose transit systemā€
  • 11. static vs. dynamic diabetes care static ā€¢ Actions predetermined ā€¢ Minimal flexibility: RIGID ā€¢ Outcomes donā€™t immediately affect subsequent actions ā€¢ Easy to teach/learn ā€¢ Less time-intensive ā€¢ Favors concrete thinking ā€¢ Less motivation needed dynamic ā€¢ Actions are dependent on situation/circumstance ā€¢ Flexible and adaptable ā€¢ Outcomes constantly influence subsequent actions ā€¢ Training needed, plus ongoing reinforcement ā€¢ More time intensive ā€¢ Favors problem-solving ā€¢ Requires ongoing motivation
  • 13. A pancreas canā€™t predict the future ā€¢ It acts so fast it doesnā€™t need to. ā€¢ Can shut off insulin immediately ā€¢ Can release premade insulin ā€¢ Insulin it releases can start working in minutes ā€¢ Can rapidly respond to shifts in sugar levels
  • 14. Set ā€œactionableā€ thresholds ā€¢ Upper/Lower limits ā€¢ 80 mg/dl and 140 mg/dl ā€¢ 90 mg/dl and 180 mg/dl ā€¢ Rates of change ā€¢ Up or down arrows ā€¢ Factor in recent/current/future events as you are able ā€¢ Test your skills, experiment a little within reason
  • 15. Traits of effective CGM users ļƒ¼Wear it most of the time ļƒ¼Check trend line often ļƒ¼They ā€œwork the lagā€ times ļƒ¼FOOD lag ļƒ¼INSULIN lag ļƒ¼SENSOR lag ļƒ¼Not afraid to experiment ļƒ¼Not expecting perfection
  • 16. Principles of Sugar Surfing 1. A CGM is no better or worse than the person responding to it. 2. If you can measure it, you can predict it. 3. Flux and drift happenā€¦ manipulate them! 4. Keep your eye on your line. 5. The trend is your friend 6. Learn lag limits; be patient 7. Zero in on your zone 8. Master micro-dosing 9. Factor in glycemic inertia and insulin momentum 10.Donā€™t let ā€œgood enoughā€ be the enemy 11.Calibrate carefully 12.Pre-empt when you can
  • 17. ā€œTHE TREND IS YOUR FRIENDā€ CHECKING INSULIN BOLUSES WITH CGM 6 pm 8 pm 10 pm 300 200 100 60 Carb bolus Correction bolus 6 pm 8 pm 10 pm Goal: green lines
  • 18. Turnaround Time : glycemic inertia Corrections may need to be adjusted 10-20% to compensate
  • 19. Goal: Try to stay between the lines As your skills improve, lower the glucose for the upper alert
  • 20. Timing 101 ā€“ 20 min. match Insulin Food
  • 21. Timing 101 ā€“ 45 min. mismatch Insulin Food
  • 22. Be realistic ļƒ¼Accept that the first 6-12 months are on a ā€œlearning curveā€ ļƒ¼Set higher and wider targets ļƒ¼Have low expectations to start ļƒ¼Itā€™s still a finicky technology ļƒ¼PLEASE BE PATIENT
  • 23. BG awareness vs. alarm fatigue ā€¢ Set reasonable alarm thresholds ā€¢ Depends on your goals ā€¢ Avoid high spikes? ā€¢ Avoid lows? ā€¢ Toddler? Child? Teen? Adult? ā€¢ Make sure you can hear/sense the alarm ā€¢ Anticipatory action can minimize alarms
  • 24. Cal-i-bra-tion (noun ĖŒka-lə-ĖŒbrā- shən) ā€¢ Comparing the sensor to an accepted ā€œstandardā€ value ā€¢ The accepted ā€œstandardā€ value is a fingerstick BG level ā€¢ So the sensor itself can be no more accurate than the BG meter itā€™s compared toā€¦or how well the BG meter was used
  • 25. Calibration tips ā€¢ The first sensor day can be erratic as it ā€œsettles inā€ ā€¢ Donā€™t over calibrate! ā€¢ Try to calibrate on a steady trend ā€¢ Try to calibrate when in your target range
  • 26. CGM calibration tipā€¦ steady 2 hours Whenever possible: calibrate the CGM system when on a ā€œsteadyā€ sugar trendline 2 hr ā€œwaitā€ time between ā€œturning onā€ sensor and providing 2 calibration BG readings to start session steady baseline
  • 27. Daily calibrating on a steady baseline
  • 28. Steady trend 2 hours Calibrate your CGMā€¦ On a steady trend when you canā€¦ In the BG range you want to be most accurate inā€¦ Steady trend
  • 29. 4 hours post start up calibration (extra)
  • 30. Settling in at 6 hours: wobble
  • 31. Sensors are not always right Or is it the meter thatā€™s off?
  • 32. Morning madness? After 14 hours after new CGM sensor insertionā€¦ After calibrating with 112 mg/dl, the sensor immediately reads this Take home message: a new CGM sensor site might take a day or so to properly ā€œsettle inā€ or ā€œreadā€ properly. Take this under consideration and donā€™t give up on a session too soon. But BG meter calibration shows THISā€¦
  • 34. Overnight basal in range (glargine)
  • 39.
  • 40. Learning from the Line Graph ā€“ Insulin Timing 8a 10a 70 140 210 350 280 8a 10a 70 140 210 350 280 TodayYesterday Insulin bolus: 7:30 AM Breakfast: 7:30 AM Insulin bolus: 7:10 AM Breakfast: 7:30 AM M I MI
  • 41. Why timing is everything
  • 42. 3 units @6:10 28 gm @ 6:50 Timingā€¦waiting for the bend ā€œwindowā€
  • 43. 3 U lispro @ 6:22AM 28 GM CHO @ 6:52AM Timing insulin and meals to prevent a spike
  • 44. Wait for the bend!! 6U @146 mg/dl Eat here @132 mg/dl 45 minutes Wait for the ā€œbendā€!
  • 45. Stopping sugar spikes 3 units (5:32AM) Meal (5:48 AM)
  • 46. Point ā€œAā€ Point ā€œBā€ sugar trend Insulin ā€œcorrectionā€ Carb ā€œcorrectionā€ ~ 2 hours for insulin ~ 15-30 minutes for carbs Range of possible BG outcomes ā€œthe trend is your friendā€ Blood glucose level
  • 47. Noticed rising trend at 1:43 PM: 165 mg/dl Took 5 units lispro @ 1:45 PM 4 hours Late BG rise after the morning: no lunch eaten 135 mg/dl @ 2 hours ā€œDirection affects correction ā€
  • 48. Although subtle, this can be ā€œfeltā€
  • 49. BG = 157 mg/dl Inj 4 U lispro @3:15 2-3 hours 20-30 minA B C Correction tips (on a steady trend) A. Remember the lag time before insulin starts to effectively lower BG B. Remember the length of time it takes to accomplish the desired task C. Patience and practice make these kinds of results possible
  • 50. Micro-bolusing (dosing) Steady baseline BG trend BG 136 mg/dl 2 units lispro Wait 2 hours Target zone ā€¢ Very advanced ā€¢ CGM needed! ā€¢ Note flat BG ā€œbaselineā€ trend ā€¢ Calibration good ā€¢ Not ā€œcorrectionā€ per se ā€¢ More of an ā€œadjustmentā€
  • 51. BG 137 mg/dl and rising slowly 3 units lispro ā€œMicro-bolusingā€
  • 52. BG 124 mg/dl injected 1.5 units lispro @3:56AM 2 hours Microbolus experimentation Lag time
  • 53. 112 mg/dl to 78 mg/dl after 1.5 units by injection on a ā€œsteadyā€ BG baseline 1.5 units ~ 2 hours
  • 55. 4 unit lispro ā€œpushā€ ā€œCourse correcting for smooth sailingā€ Well balanced basal insulin
  • 56. 6 unit ā€œshoveā€ at 133 mg/dl ļƒ¬
  • 57. Mealtime insulin @ 8:30PM 7 units lispro Duration of insulin 3hr Insulin correction dose @ 2:53AM 6 units lispro lag 2 hours to correct Teaching pointsā€¦ a. Know your insulin ā€œumbrellaā€ b. Slow carbs cause unexpected highs c. Insulin onset of action = lag time d. Rise in BG levels has vector qualities e. It takes time to correct a high a b c d ea b
  • 58. 6:53PM BG 108 inj 6 units 7:15-7:35 9:52PM BG 125ā†‘ inj 4 units ā€œEffective durationā€ of insulin action: 3 hrs ā€œActive insulinā€ ā€¢ Example: Slow carb meal (fried food) ā€¢ e.g., Chicken fried steak, cream gravy and 3 onion rings and 8 French fries ā€¢ Estimated 60 grams: 6 units: inject 6 units lispro ā€¢ NO rise in BG for 3 hours, then rapid ascent ā€¢ Time until rise reflects ā€œactive insulinā€ effect ā€¢ Must do this many times and take the average
  • 59. Duration of insulin effect can be determined here ~ 4 hours
  • 60. IOB after 6 units and fried meal 6 units 3.5-4 hours 2 units WalkFried Meal
  • 61. Rising BG trend (132 mg/dl) @ 2:06AM 5 units lispro @ 2:12 Fried Chicken 2.5 hours
  • 62. 8 U 6 U 5 U 5 U3 U Lispro 20 Lantus ā€œInflectionsā€ calibration Tex-Mex Dinner calibration ā€œRemember the Alamoā€
  • 63. Correction and meal 6 units (161 mg/dl) Meal (26 gm CHO) ~ 45m 126 mg/dl
  • 64. 5 units @ 5:43AM; 25 gm CHO @ 6:23AM 5 units Meal (25 gm CHO) 40 minutes
  • 65. Correction with 20 grams carbs 20 gm CHO
  • 66. 121 mg/dl: 3 units @ 10:04PM 80 mg/dl: 7 units lispro @ 6:36PM Meter: 55 mg/dl @ 7:56PM My estimated duration of insulin action: 3.5 hours Slow carbs ā€¢ Experimented here: ā€¢ Ate a pasta meal at the Olive Garden ā€¢ Took a single insulin shot (70 gm = 7 units) ā€¢ Sugar dropped at time of usual peak insulin action: ~60-90 minutes ā€¢ BG recovered without treatment ā€¢ Late rise in BG required second injection Leveling off Olive Garden 2 salad servings, 1 breadstick and Lasagna lispro
  • 67. 121 mg/dl: 3 units @ 10:04PM 80 mg/dl: 7 units lispro @ 6:36PM Meter: 55 mg/dl @ 7:56PM My estimated duration of insulin action: 3.5 hours Fast insulin + slow carbs = low BG ā€¢ Ate a pasta meal at the Olive Garden ā€¢ Took a single insulin shot (70 gm = 7 units) ā€¢ Sugar dropped at time of usual peak insulin action: ~60-90 minutes ā€¢ BG recovered without treatment ā€¢ Late rise in BG required second injection ā€¢ Notice the insulin-food ā€œbalanceā€ and how it effects BG levels Leveling off Olive Garden 2 salad servings, 1 breadstick and Lasagna lispro Insulin effect Food effect
  • 68. ā€œFried-food revengeā€ and correction Fried food earlier in evening @ 8PM BG = 194 6 unit correction @ 7AM BG = 115 in 3 hours
  • 69. ā€œRevenge of the Ribeyeā€ and ā€œThe Insulin Strikes Backā€ BG 167: 4 units LAG 2-3h
  • 70. Slow BG rise from protein-fat laden meal
  • 71. Slow overnight rise and early AM correction
  • 72. Correction at 2:45 AM after slow post dinner rise with 5 units 5 units ~ 2 hours
  • 73. 3 units lispro Breakfast BG 173 mg/dl 5 units lispro Meeting A ā€œrandom riseā€ in BG during a routine day. 2-3 hours
  • 74. Working itā€¦(i.e., glucose control exists ā€œin the momentā€) ~ 2 hours Oops! I Ate an EXTRA breakfast taco! BG 142 ā†‘ : took 5 units hypothetical real
  • 75. And thirdly, the correction and carb ratios is more what youā€™d call ā€˜guidelinesā€™ than actual rules ā€œMost of our assumptions have outlived their usefulnessā€ Marshall McLuhan
  • 76. 8 U @ 9:30AM 7 U @ 10:54AM 6 U @ 12:29PM 60 grams carbs Ultimately 21 U lispro Insulin to carb ratios are only a start
  • 77. 7 5 4 5 Large bowl turkey soup and 2 small pieces cornbread @ 6:30 ā€¦flux?ā€ ā€œWhat theā€¦
  • 79. 9 units lispro for 90 gm Mexican food lunch @3:30 6 units lispro @ 6:30PM for rising BG after 3 hr IOB Stabilization
  • 80. Two gulps of juice (15-20g CHO)
  • 81. 5 gram CHO ā€œnudgeā€ @ 66 m/dl Dropping < 1 mg/dl/min ā€œThe nudgeā€ (aka microcarbing)
  • 82. 5 gram CHO ā€œnudgeā€ @ 66 m/dl Glucose counter-regulation Glucagon Epinephrine Cortisol Growth hormone
  • 83. Leisurely walk from 7:00 to 8:30: straight line
  • 84. Exercise ā€œbump upā€ Moderate intensity 75 minute duration Glycogen ļƒØ Glucose
  • 85. 2 units 1 hr walk ā€œWalking downā€ a trend
  • 86. Blood sugar correction 160 mg/dl to 100 mg/dl in 2 hours with 4 units insulin lispro by injection 4 units ~ 2 hours
  • 87. Correction: 151 mg/dl to 103 mg/dl with 2 units insulin lispro after walk 2 units ~ 2 hours
  • 88. 127 mg/dl @4:47AM Injected 3 units lispro 1.5 hours ā€œPushing sugarā€
  • 89. BG 137 mg/dl : dose 5 U lispro Lag time Eat breakfast here Timing insulin and food is like shooting clay pigeons
  • 90. 6 U lispro @ 1:45AM @ 170 mg/dl 30 min lag 3 hour wait Taking the dropā€¦
  • 91. ā€œTaking the dropā€ BG 160 mg/dl @ 1:47AM Injected 5 units lispro Lag time Drop time 2-3 hrs perfect bottom turn froth
  • 92. Woke up at 3:55AM at 184 mg/dl Took 4 units lispro Wait (slept) about 3 hours Bingo! Tamale Soup at dinner (slow carbs, slow rise) ā€œLivinā€™ la vida Glucoā€
  • 93. 182 mg/dl : 7 units lispro Insulin lag time 30-40 min Eat breakfast here Food lag time 124 mg/dl Timing is everythingā€¦do you have the patience or the time? Slow BG rise overnight from fried meal BG drop time 20-30 min
  • 94. Missed 9PM basal dose (glargine) Normal time Lantus taken (9PM) Detected rising sugar level @ 2AM Humalog dose (7U) AND usual Lantus taken (20U) Sensor ā€œgapā€!! dinner Fell asleep! All back in range by morning!
  • 95. What happens when a basal insulin dose is missed Usual time Lantus dose is taken: 9PM Rising BG discovered here Insulin correction given If not treated: high BG and ketones Treated: In range BG and NO ketones
  • 97. Endocrinology Board Exam taken every 10 years Stress and Sugar ā€¢ Strong emotional stress triggers release of a several hormones ā€¢ These hormones act on liver and muscle to cause the release of internal sugar from depots inside the body ā€¢ Stress hormones also make the liver produce sugar from substances like protein and fat ā€¢ This can overwhelm the ability of basal insulin to dispose of sugar faster than it can build up in the blood ā€¢ CGM allows for more aggressive anti-stress treatment of rising sugars
  • 98. Crossing 140 mg/dl @ 3AM and a 2.5 U lispro correction ~ 2 hours Lag time Why act? ā€¢ Slow upward BG trend (red arrow) ā€¢ Crossed personal ā€œaction considerationā€ threshold: 140 mg/dl in my case (yellow line) ā€¢ Knew the CGM would alert me to a rapidly dropping BG later if I over treated ā€¢ Have done this many times before: practice, practice, practice
  • 99. Microbolus at 7:55AM when BG was 151 mg/dl took 2 units (after surgery)
  • 100. Awakened by CGM alarm to a BG below 60 mg/dl Lag time 20gm Rationale ā€¢ Slow downward BG trend (red arrow) ā€¢ Crossed personal ā€œaction considerationā€ threshold: 60 mg/dl in my case (yellow bottom line) ā€¢ Drank 20 gm grape juice and went back to sleep ā€¢ Knew the CGM would alert me to a rapidly rising BG later if I over treated ā€¢ Have done this many times before: practice, practice, practice
  • 101. This can be ā€œsensed tooā€ CHO A steady trend The bodyā€™s defenses against low blood sugar include the brain Downward shifts, even small, can be sensed by the conscious brain Once sugar levels off, the brain senses stability Rationale ā€¢ Blood sugar control is complex, it includes the brain and nervous system ā€¢ Long term damage to the autonomic nervous system can result in loss of classic signs/symptoms of low blood sugar ā€¢ But, the brain itself might still retain the ability to sense downward sugar shifts before severe low BG kicks in (e.g., < 50 mg/dl) ā€¢ A CGM device can serve as a ā€œbiofeedbackā€ device of sorts in adults willing to develop the ability over time.
  • 102.
  • 103. Feel the drop and level off
  • 104. Subtle correction ā€¢ BG 125 and rising ā€¢ Took 4 units lispro ā€¢ 2 for the slow rise ā€¢ 2 for the correction ā€¢ Waited almost 2 hours (yellow arrow) ā€¢ Notice lag time before BG ā€œturnsā€ (red arrow)
  • 105. This feels stable> 1-2 mg/dl/min ~ 1 mg/dl/min
  • 106. ā€œWorking downā€ a rising BG 4 units @ 173 mg/dl 2 units @ 167 mg/dl 7 units @ 2PM for Whataburger and rings
  • 107. 4 units Humalog @ 11:07PM BG rising after insulin effect isā€œwaningā€. BG = 146 mg/dl Dinner (soft tacos, refried bean and chips/salsa); 7 units lispro taken 20 minutes premeal at 7PM My ā€œDIAā€ = 3-4 hours Notice the obligatory ā€œlag timeā€! Anatomy of a preemptive correction
  • 108. Anatomy of a nighttime low A) 4 hour window B) 24 hour window C) 6 hour window D) Resolution 34 mg/dl 36 grams CHO 2.5 hours
  • 109. 6 month CGM data summary Average BG = 103 mg/dl Standard deviation = 34 mg/dl Aim to keep the average BG in range and the standard deviation AT LEAST HALF the average BG value
  • 110. Day vs. Night: any thoughts about why?
  • 111. Interpret these two images Hint: sensor is over two weeks old
  • 112. What is it a good time for and why?
  • 113. Straight line trend Straight line trend = 10 grams carbs 60 mg/dl 90 mg/dl
  • 114.
  • 115. 6 U 4 U 4 U 4 U 5 U 6 U 28 GM 90+ GM 1. Stacked insulin + delayed eating 2. ā€œHyper-treatedā€ severe low 3. Fought ā€œreboundā€ high BG all night 4. Took the drop and timed meal
  • 116. Dislodged insulin pump siteā€¦ Picked up early by CGM Pump site changed, insulin dose given, carb correction takenā€¦$13,000 saved
  • 117. Penny stock day trading strategyCGM is ā€œsugar surfingā€ board

Editor's Notes

  1. Music: Beach Boys
  2. Change ā€œManaging ā€œdā€ well with the words: Sugar Surfing requires the following skills and equipment
  3. Normal tides and swells in non-d humans
  4. Itā€™s all about riding the waves, crests and troughs
  5. Based on the principle of FPM (frequent pattern management)
  6. BG (mg/dl) x 75 ml/kg blood volumes x weight in kg x 1dL/100 ml = mg of BG in TBV
  7. Timing 3 at 6:32 28 GM at 6:52 started at 127 and are at 108
  8. ā€œThe Umbrella Effectā€Iā€™ve packed a lot of useful teaching points into one image here.While long-acting or basal insulin delivery(insulin glargine, insulin detemir, or the basal delivery rate on a pump) is like having a long roof over your glycemic ā€˜headā€™. Injections or boluses of rapid acting insulin have umbrella-likeproperties. Properties of any insulin include 1) time to onset of sugar lowering effect, 2) duration of peak sugar lowering activity, and 3) an effective duration of action. I always include a fourth dimension: day to day inconsistency, which can wobble or vary a bit. Itā€™s not only helpful, but crucial that a person using insulin have a good working understanding of these properties of the insulin being taken. Without this understanding, manipulation of sugar levels as Iā€™m about to describe are not possible. When properly applied, rapid-acting insulin protects the user (like an umbrella) from the ā€˜showerā€™ of after meal hyperglycemia that rains down for a certain period of time (a). It does so by disposing of glucose into cells. Extending the metaphor fully, basal insulin acts as a roof with gutters that continually and gradually shunts sugar into cells, but without a great capacity. So, in a sense insulin has umbrella-like qualities as I show here on my CGM sensor plot (a 12 hour display in this case). I ate late on this evening and chose one of my more challenging foods to manage: fried chicken (b). Itā€™s a favorite and I donā€™t eat it regularly for this reason. Nevertheless it was my choice. Fried meals often take more time to digest into blood sugar. That time can extend well beyond the action of the meal time insulin used to cover the meal (i.e., the umbrella), as it did in this case. As you can see, my CGM device allows me to validate my duration of active insulin time, which for me is 3 hours (a). This is the actual span of my insulin umbrella in this case. After that time, the waning insulin effect is no longer able to contain the steady input of sugar coming into my blood stream from my fried meal and the basal insulin in my body canā€™t properly ā€œcoverā€ this slow influx of sugar. The end result is a slow accumulation of sugar in my blood stream, registered as the rise on my CGM plot shown here (b).Well, I awoke and looked at my sensor and noted I was at 171 mg/dl (d) but the arrow was straight, meaning a gradual upward trend of under 1 mg/dl/minute. Looking at the trend line, recalling what I ate and knowing my prior responses to fried meals, I decided to correct this trend so I would not wake up in the morning with a BG well over 200 mg/dl. Therefore, I took 6 units of insulin to accomplish this. Normally this would take about 3 units since my correction factor is between 1:25 and 1:33 most of the time. But here is another teaching point: my BG was slowly rising and had a form of ā€œmomentumā€ behind it. Had it been trending straight, or even downward, I would have taken very different actions. But since it was trending up, I knew from experience that I needed a greater insulin ā€œforceā€ to neutralize the rise, turn the BG trend downward, and back to my desired target BG of 100 mg/dl. Soā€¦I doubled it (6 units). As illustrated here, there was the customary 20 minute or longer ā€œlagā€ time before any measureable effect of my correction insulin was seen (c). After the insulin lowering effect was underway, it took a full two hours to arrive and stabilize at my target (e). And by the way, I went back to sleep after I took those 6 units of lispro in the middle of the night. Crazy? I would agree with you 100% if I were not using a CGM device. I would be hesitant to take rapid-acting insulin so aggressively although I would have taken the standard 3 units. The result would have most likely been less than optimal, but it would have blunted the rise. My practice here is the end result of lots of practice and careful observation of my own unique responses. Anyone who attempts these maneuvers must find what best works for them. Itā€™s also wise to discuss with your diabetes doctor. Although I must say that many docs might discourage such self-care independence. This is a look into how I manage the daily ebb and flow of my blood sugars. This is not childā€™s play and requires the input of an experienced and motivated adult. Parents of children with diabetes can master these skills and many have, but it takes patience, consistency and resilience to achieve the confidence illustrated here. I hope this teaching slide is helpful to many of you. This further demonstrates how tight glycemic control truly exists ā€œin the momentā€, as I try to illustrate all the time.
  9. ā€œPlaying Chickenā€ with a CGM, blood sugar and insulinI have a weakness for fried chicken. I try not to indulge myself with it often since it requires some extra work to manage the after effects on my blood sugar. The other night I had two pieces of chicken, a roll, cole slaw and green beans (not shown) around 7PM. By midnight, the slowly digesting meal (lots of fat and carbs) combined with the waning effect of my suppertime insulin, could no longer contain the rising tide of glucose entering my bloodstream and hence the levels began to rise after midnight. I woke up and noticed this rise at 2:06 AM. I of course knew what I had eaten the night before, my typical BG pattern with foods like this (a slow steady rise after my meal insulin wears off), plus I realized that some chicken remained in my stomach and was waiting to get into the gut (fatty foods linger in the stomach longer, not a lot of glucose absorption happens there). Knowing this, plus my response to prior doses of insulin to offset these sorts of rises, I took 5 units of rapid-acting mealtime insulin (lispro), then went back to sleep. If I was still on my insulin pump, I would have taken a combination (dual-wave) bolus, but that is another discussion.Let me say that I would NEVER have taken 5 units of insulin at 132 mg/dl and then gone back to sleep. At least not before I had my Dexcom G4. My graphic shows what would most likely have happened if I had just slept through the night and done nothing. Waking up the next morning my BG would be over 200 mg/dl even though at bedtime I was in range. In fact, it is possible I would have taken a snack at bedtime on top of all this, further driving the reading up overnight. The training and understanding of health care providers has some catching up to do in regards to using dynamic versus static data sets created by CGM technologies. The preference is to have a machine make the call (the artificial pancreas or AP). That makes the most sense for the most people I agree. But cruise control is rarely used in rough terrain. I find that a well practiced working knowledge of oneā€™s own body and responses, combined with experience and judgment, can allow some of us now to benefit from a ā€œmanualā€ version of the AP of our own creation. But I agree this isnā€™t anything kids are able to do quite yet. But IMO the principles used to do this can help everyone in their daily problem-solving and trouble-shooting situations. Anyway, notice that over the next 2-3 hours, I was able to ā€œbendā€ the glucose curve back the way I wanted it to go. The waviness in the line might have been the sensor on itā€™s final day since I changed it the next day, but when I calibrated at 5:30, the sensor said 97 mg/dl and my meter said 102 mg/dl. Thank you, Dexcom G4!The power to safely experiment with otherwise forbidden or dangerous practices like taking a dose of 5 units rapid-acting insulin and then going back to sleep is something that is not discussed enough about CGMā€™s. This is like practicing a high wire trapeze act with a big safety net underneath me: itā€™s hard to get hurt too badly. Of course I have ample sources of fast sugar (juice) by my bedside (or car or at work) when I do this. My CGM gives me the ability to see highs or lows coming from a distance, not when they are right upon me. This is a tremendous benefit of these devices. When patients ask me, I tell them that a CGM can serve two functions. One the one hand it can serve as a ā€œburglar alarmā€ that will buzz or beep at alert me when hypo or hyperglycemia is entering my body. On the other hand, it can also be a surveillance system that scans the horizon for possible intruders, allowing you to pick them off before they get too close. As you can see, I use it very proactively, but I am also still reacting to what is happening to me (the fried chicken on this occasion). But a CGM is also a biodfeedback device. I teaches me what different BG levels FEEL LIKE. I can now reliably predict when my BG is shiftingā€¦up or down. What an added benefit indeed. I hope this post teaches a few things about knowing yourself, safely experimenting new approaches, and always looking at diabetes self care as a practicable skill, which in my opinion is exactly what it is. As always, feel free to share this post with others who might benefit. I hope you all turned your clocks BACK last night before going to bed. That includes all your diabetes devices too: pumps, sensors and meters.
  10. FFA Field trip home at 10PM. BG shot up at 2PM. Ate pizza for dinner at 8PM. Unknown insulin dose taken relative to meal Meter says 420 at 379 on sensor. Went to 56 by 10:45AM next AM
  11. At sensor calibration time, sensor read 103 mg/dl and meter read 101 mg/dl. After calibration it reset to 99 mg/dl
  12. Straight line trends need more subtle corrections
  13. Bad pump siteā€¦
  14. Requirements of Penny Stock InvestorsYou should not get involved with day trading unless you are able to effectively monitor your holdings and can commit with the proper mind set and outlook. This strategy takes time, research, and a good deal of money (I suggest at least $4,000). Otherwise, you may not be able to benefit from such a trading methodology.You need to be able to check the prices of stocks on a moment&apos;s notice, and get an accurate and up-to-the-minute quote. Having internet access or a computer connection to your broker from work or home is generally best. When day trading, you may need to check stock prices frequently, possibly watching their prices all day. Using a computer it takes only a few minutes each time, you can get current prices, and can alter or submit new orders on-line after checking the penny stock&apos;s activity.Most of all, you need patience. Although day trading in penny stocks is probably the quickest profit and loss method in the financial world, patience still comes into play. The best day trading strategies involve often going a week or so without a trade, because you must wait to get the best prices. Impatience immediately negates the effectiveness of the day trading strategy.Finally, you need a strong stomach. You should understand that day trading in penny stocks can result in one week gains that are monumental, or can set you up for a loss. Whether making a big profit or taking an ugly loss, you should be able to handle both the good and bad stress that will come with this method of trading. Otherwise, you may make moves for the wrong reasons and compromise your objectives.What Day Trading IsDay trading is simply an attempt to capitalize on short term fluctuations in stocks. For example, with penny stocks it is possible to buy an issue at $0.12 and sell it the next week, day, or even a few hours later at $0.15, giving you a 25% short-term profit on your investment.If a profit of more than 20% to 25% presents itself, you often take it. Do this a few times and you are looking at a highly successful investment strategy.The downside of day trading comes into play when you buy an issue and it drops in value. At that point you either take a quick loss to keep your money available, or you sit and wait for a profit opportunity that may arise later, in which case your money is tied up until that time. This becomes less of a concern for traders who have more assets at their disposal, because while only a portion of their money is temporarily tied up in a stock that has fallen in value, the rest of their portfolio could be actively used.Now, let me tell you how to take advantage of day trading without significant risk, and with maximum profit potential. If you are going to begin day trading, read this section a few times through and adjust your own investment style accordingly.Goals of Day TradingThis is very important if you intend to be successful at day trading. Your overall goal is to make several hundred of percent on your investments on a year by year basis. However, this is to be done 40% and 30%, even sometimes 10% at a time. That is where most day trading strategies fall apart - investors donā€™t understand that taking the smaller gains more frequently will actually be more effective than the larger gains less frequently!Your goals for an effective day trading strategy should be as follows:ā€¢Keep on top of your open buy and sell orders, and the trading activity of the underlying stocks so that you are rarely surprised by a penny stockā€™s action.ā€¢To take small profits when they present themselves. You will find that you have the opportunity for small 15-25% profits very frequently.You wonā€™t often be in a position to be taking the larger 30%-50% profits, because you already would have sold when your shares first began to rise. Therefore, as backwards as it sounds, if you find that you are taking 50% profits more often than 25% gains, you are probably doing something wrong. In the long run, you would likely make more money by grabbing the 25% gains again and again, instead of holding out for the larger returns.Effective Strategies and ConsiderationsThe first consideration of this trading method compared to others is that you will be taking commissions more frequently. If you are not already with a discount broker, or are paying more than $20 per trade, you probably should switch to a cheaper broker. You can read all about penny stock brokers, and get my list of the top ones earlier in this site.With penny stocks, you may often find that a buy or sell order goes partially filled. For example, you may only get $200 worth of shares and be stuck with a $20 commission. To avoid this, keep track of your orders during the trading day - you may pick up a portion of your order at the price you want, then have to adjust the purchase or sell price to make sure you get the rest of the order filled. Changing an existing order to get all the shares you want on one day, instead of over two or three days, means that you will only be subject to one commission.The beauty of day trading is that company fundamentals and overall market action become less significant. You are playing the day by day fluctuations instead of hoping the market will rise or the company will increase its earnings. Buying at the low end of volatility and selling at the high end equals success, despite monthly trends, company fundamentals, or the market outlook.Therefore, it doesnā€™t matter if the companies you invest in have a positive future or are bad long-term purchases. Whatā€™s important is that you keep an eye on the trading activity of the issue in question, try to pick its higher and lower trading ranges, then execute buy and sell orders accordingly.With day trading you need to realize that most of your buy orders should go unfilled, because your bid price needs to be lower than the going trading price of the stock. Buy on the dips and you will have success - put in orders to acquire shares at or below the current bid price. If you put in ten buy orders over the course of a month, you may wind up only getting one of the buys you had wanted, but those shares will be yours at a great price, making it easier to unload them for a quick profit.When tigers hunt, they only catch a meal one out of ten attempts.Deciding on appropriate buy and sell prices at which to submit your orders is relatively simple. Look at a stock that has both high volume of bid lots, and high volume of ask lots. Many people are trying to buy at one price and many people are attempting to sell at another. Look at the spread between the bid and ask prices. If it is about 15% or more, you may want to put in a buy order at the bid price, and if it gets filled immediately put in a sell order at the ask price.Of great importance is the number of bid lots compared to the number of ask lots. There is a very different stock price outlook if the number of bid shares vastly outnumber the ask shares, or vice-versa. The more bid lots, the greater the buying pressure and price strength at that level. In other words, if there is a large level of demand, the price will likely solidify at that level and begin to climb, unless there are enough shares for sale to meet the demand.When getting a stock price quote, look at the number of bid lots and ask lots to get an idea of the demand and supply. This will give you a relatively accurate indicator of the direction the penny stock price will travel in the day, and perhaps throughout the following few days. Use the bid lot and ask lot volumes to help you come up with a price range that the penny stock will trade within.Day trading will prove most effective when you trade in penny stocks that you have been watching for a long time. You will be able to produce better results since you have developed a feel for the upper and lower price ranges. This is not a requirement for success, but rather an advantage.Hedging and Averaging DownAs a more advanced strategy, you may want to incorporate hedging into your day trading practices. When buying, this involves putting in buy orders for the same stock at different prices.Let&apos;s use an example: You put in an order to buy 4000 shares of OCN @ $0.23 and a separate order to buy 4000 shares of OCN @ $0.17. Now consult the chart below to see the possible outcomes of your strategy.Possible Hedging Outcomesā€¢Outcome #1: If the price falls to or below $0.23, your first order gets filled. Now if the price drops further, you may get your second order filled at a lower price, averaging the price of your 8000 shares to $0.20. Profits could be realized now by selling at $0.22 or greater. If the price climbs, you will make a profit. If it continues to fall you will take a paper loss. This becomes an actual loss if you sell the shares, or if the shares never return to their $0.22 levels. However, in all likelihood the price will bounce around and will present an opportunity to profit or at least break even at some point in the future.ā€¢Outcome #2: The price falls to or below $0.23 and your first order gets filled. The price then rises, leaving your second order unfilled, but providing you with the ability to profit on the 4000 shares you did buy.ā€¢Outcome #3: The price does not fall low enough to fill your buy order. You donā€™t get the shares, but you are no worse off. You can extend your order, adjust your prices, or move on to a different penny stock. Again we must stress that an unfilled buy order means that you probably have the right idea. It is better to have an unfilled buy order than to get shares at too high of a price.These hedging strategies can also apply in the same manner when selling penny stocks.Of course, you are also getting exposed to extra commissions with this strategy.Day Trading SummaryDay trading penny stocks is as straight forward as it sounds. However, you will need a little luck, a lot of patience, and the ability to take the profits that present themselves. By keeping a close eye on the markets and following a simple strategy such as the one outlined above, day trading becomes a straight-forward technical process that requires little thought, yet can provide impressive penny stock returns.