This document provides advice on when to sell speculative stocks that have increased rapidly in value. It recommends selling when the stock price is up 10 times or more in a year, if the uptrend breaks or forms a higher uptrend, if it drops after moving sideways, or if mainstream analysts start discussing it as overvalued. The document advises not worrying about selling too early, as there will be more profitable opportunities, and to study trading strategies in depth to successfully trade volatile penny stocks.