The Spanish flu, a 1918 pandemic caused by the H1N1 influenza A virus, originated in the United States and led to over 50 million deaths worldwide, including 675,000 in the U.S. The pandemic was exacerbated by World War I troop movements and had a particularly high mortality rate among healthy adults aged 15 to 34. Initial symptoms evolved rapidly into severe respiratory failure, with the virus impacting a significant portion of the global population.