The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow, releases endorphins, and promotes changes in the brain which help enhance one's emotional well-being and mental clarity.
This document summarizes a talk given by Chris Dwan at a DNA Nexus User Group Meeting. It discusses how platform requirements change as companies mature from their early startup phase focused on agility, to a growth phase where compliance and governance are important, to a mature phase where financial considerations are critical. It provides rules of thumb for choosing platforms in the different phases, noting that platforms that reduce time and work are attractive early on, but financial oversight becomes more important later.
The FY23 Somerville city budget proposes $307.77 million in expenditures, an 8.1% increase over the prior year. Revenues are projected to be $309.5 million, an 8% increase. Key investments include a historic 10% increase to the school budget, funding for mental health services and youth programs, environmental sustainability initiatives, and positions to support housing stability and equity across city departments. The budget also proposes restructuring city government with a new Chief Administrative Officer position.
Production Bioinformatics, emphasis on ProductionChris Dwan
Production bioinformatics at Sema4 can be thought of as data ops - a peer to the lab ops organization. We operate 24/7 to deliver correct and timely results on NGS and other data for thousands of samples per week. This deck introduces the Prod BI organization and systems architecture with a focus on what it takes to run bioinformatics in production rather than for R&D or pure research.
This document outlines proposals to reduce the Somerville Police Department budget and reallocate those funds. The SPD budget has grown faster than inflation while other programs like housing, arts, and sustainability have seen cuts. Specific proposals include reducing the police budget by 10-60% and allocating those funds instead to education, affordable housing, economic development, sustainability programs, and social services like crisis counseling. Cutting the police budget by 60% could double several other departmental budgets and leave millions available for alternative emergency response programs.
Training delivered in 2009 for a compute cluster customer in Calcutta, India. I honestly have no idea what I was thinking. There is no possible audience who would have been pleased with this talk.
No Free Lunch: Metadata in the life sciencesChris Dwan
This presentation covers some challenges and makes suggestions to support the work of creating flexible, interoperable data systems for the life sciences.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow, releases endorphins, and promotes changes in the brain which help enhance one's emotional well-being and mental clarity.
This document summarizes a talk given by Chris Dwan at a DNA Nexus User Group Meeting. It discusses how platform requirements change as companies mature from their early startup phase focused on agility, to a growth phase where compliance and governance are important, to a mature phase where financial considerations are critical. It provides rules of thumb for choosing platforms in the different phases, noting that platforms that reduce time and work are attractive early on, but financial oversight becomes more important later.
The FY23 Somerville city budget proposes $307.77 million in expenditures, an 8.1% increase over the prior year. Revenues are projected to be $309.5 million, an 8% increase. Key investments include a historic 10% increase to the school budget, funding for mental health services and youth programs, environmental sustainability initiatives, and positions to support housing stability and equity across city departments. The budget also proposes restructuring city government with a new Chief Administrative Officer position.
Production Bioinformatics, emphasis on ProductionChris Dwan
Production bioinformatics at Sema4 can be thought of as data ops - a peer to the lab ops organization. We operate 24/7 to deliver correct and timely results on NGS and other data for thousands of samples per week. This deck introduces the Prod BI organization and systems architecture with a focus on what it takes to run bioinformatics in production rather than for R&D or pure research.
This document outlines proposals to reduce the Somerville Police Department budget and reallocate those funds. The SPD budget has grown faster than inflation while other programs like housing, arts, and sustainability have seen cuts. Specific proposals include reducing the police budget by 10-60% and allocating those funds instead to education, affordable housing, economic development, sustainability programs, and social services like crisis counseling. Cutting the police budget by 60% could double several other departmental budgets and leave millions available for alternative emergency response programs.
Training delivered in 2009 for a compute cluster customer in Calcutta, India. I honestly have no idea what I was thinking. There is no possible audience who would have been pleased with this talk.
No Free Lunch: Metadata in the life sciencesChris Dwan
This presentation covers some challenges and makes suggestions to support the work of creating flexible, interoperable data systems for the life sciences.
The Urban Forestry Committee discussed upcoming public tree hearings and made recommendations. They recommended that the city work with developers to retain two mature ash trees for a hotel/residential development and use native species for replacements. For a blue spruce, they recommended asking Eversource to relocate power lines rather than removing the tree. For a Siberian elm, they suggested monitoring its health and considering treatment instead of removal.
Chris Dwan is a director of consulting and professional services at Bioteam, an independent consulting company that specializes in bridging science and information technology. He has a background in computer science and biology and has worked on projects for organizations like NASA, the CDC, and pharmaceutical companies. During the career day presentation, he discussed his work in bioinformatics, DNA sequencing, and providing consulting services to help solve problems at the intersection of biology and computer science.
Advocacy in the Enterprise (what works, what doesn't)Chris Dwan
This document summarizes strategies for advocacy and inclusion in the workplace. It discusses how leadership buy-in and removing barriers can promote inclusion, while quotas and public shaming can be counterproductive. Effective hiring practices include evaluating candidates based on job requirements rather than fit, and avoiding biases. Once hired, new employees benefit from sponsors, a supportive culture, and diversity training for managers. Overall, the document advocates for inclusive practices that promote equal opportunity and access.
The document summarizes challenges faced by early adopters of next generation DNA sequencing technology and potential solutions. It discusses issues such as high upfront costs of sequencers, data storage and management difficulties due to the large amount of data generated, networking and data transfer problems, and lack of laboratory information management systems. Potential solutions proposed include using virtualization and cloud computing through Amazon Web Services, developing a wiki-based laboratory information management system, simplifying storage architectures, and automated data capture and management.
The document discusses the history and development of high performance computing. It describes how early computers were mechanical devices, then became electronic and digital. It also summarizes the development of parallel and cluster computing technologies that allow multiple processors to work together on problems.
This document summarizes a Tree Preservation Ordinance for a city. It establishes definitions related to trees, creates roles like Tree Warden and Urban Forestry Committee, and outlines regulations for removing public shade trees, city trees, and private trees. Permits are required to remove trees, and replacements or payments to a Tree Fund are typically required for removing significant trees to maintain the city's tree canopy. The ordinance aims to enhance environmental and quality of life benefits of the urban forest.
A response from Newport Construction to the city of Somerville's demand that we be compensated for the improper destruction of our trees.
In which they respond: "No."
This document provides lighting design details for a pedestrian underpass, including:
- A luminaire schedule listing a single LED luminaire model to be used with 4,807 lumens output.
- A lighting plan showing the layout of 6 luminaires in the tunnel.
- Photometric calculations indicating the tunnel lighting will average 35.1 footcandles with a maximum of 42.9 fc and minimum of 13.4 fc.
The document discusses traffic issues and potential solutions for a neighborhood with streets named Harrison, Kent, Ivaloo, Kent Ct, Park and Beacon. It considers adding signage and speed bumps, or making some streets one-way. Several one-way configurations are proposed, each with benefits and drawbacks. In the end, it concludes that while signage and speed bumps would help reduce cut-through traffic and speeding, there is no perfect one-way solution that solves all problems without new issues. Resolving traffic issues requires balancing different neighborhood needs.
- Data challenges are growing in terms of volume, variety, velocity and quality. There is no single solution and real-world solutions will be hybrid.
- Metadata management is a huge challenge, even basic metadata is beyond most small organizations. Federated systems are needed to transform medicine.
- The document discusses challenges with data management across various domains including life sciences, healthcare, genomics, machine learning, artificial intelligence, and personal data. It emphasizes the importance of data visibility, quality, and integration across siloed systems.
Somerville experienced a catastrophic loss of trees in 2018, with over 1,800 trees removed. This is equivalent to 10 years of tree planting at current rates. The city has consistently underspent its budget for tree care, allowing dead and dying trees to remain for years. Major projects like the Green Line Extension and development at Somerville High School resulted in the removal of over 1,000 and 700 trees respectively. To replace the ecosystem services provided by these large, mature trees, it will take decades for newly planted smaller trees to grow. The document calls for improved community engagement around urban forestry, developing a tree care program, maintaining a net-neutral approach to tree removal and planting across all projects, and creating a program to
The document discusses emerging technologies including quantum computing, artificial intelligence, machine learning, blockchains, the internet of things, cloud computing, edge computing, and data analytics. While these technologies show promise, the document cautions against hype and notes that many technologies do not yet work as described or have practical applications. The author offers experience supporting genomics and building IT infrastructure and is available for consulting work.
This document provides a charter and roadmap for a Computing, Data, and Informatics Working Group. It discusses their vision of enabling data, computing, and identity services at unlimited scale. It highlights how information technology has been critical but also a source of tension in large projects like the Human Genome Project. The document outlines current enabling technologies like machine learning, blockchain, and DevOps practices. It identifies key challenge areas the working group will focus on, including identity and authorization, information security and privacy, and issues around data storage in multi-cloud environments. The working group members are then listed.
This document summarizes a presentation on leveraging the cloud to transform laboratory informatics processes. Some key points from the presentation include:
1) The presenter has experience transitioning genomic workflows to public clouds like AWS and Google Cloud over the past 15 years and has seen data volumes grow exponentially from petabytes to exabytes.
2) Senior leadership is often supportive of moving to the cloud because it removes support burdens, simplifies licensing and budgeting, enables automatic technology updates, and provides unlimited scalability.
3) "Cloud" is simply a means to an end - people ultimately care about business, scientific, and clinical outcomes. The cloud provides infrastructure that can help deliver those outcomes.
4
The Urban Forestry Committee discussed upcoming public tree hearings and made recommendations. They recommended that the city work with developers to retain two mature ash trees for a hotel/residential development and use native species for replacements. For a blue spruce, they recommended asking Eversource to relocate power lines rather than removing the tree. For a Siberian elm, they suggested monitoring its health and considering treatment instead of removal.
Chris Dwan is a director of consulting and professional services at Bioteam, an independent consulting company that specializes in bridging science and information technology. He has a background in computer science and biology and has worked on projects for organizations like NASA, the CDC, and pharmaceutical companies. During the career day presentation, he discussed his work in bioinformatics, DNA sequencing, and providing consulting services to help solve problems at the intersection of biology and computer science.
Advocacy in the Enterprise (what works, what doesn't)Chris Dwan
This document summarizes strategies for advocacy and inclusion in the workplace. It discusses how leadership buy-in and removing barriers can promote inclusion, while quotas and public shaming can be counterproductive. Effective hiring practices include evaluating candidates based on job requirements rather than fit, and avoiding biases. Once hired, new employees benefit from sponsors, a supportive culture, and diversity training for managers. Overall, the document advocates for inclusive practices that promote equal opportunity and access.
The document summarizes challenges faced by early adopters of next generation DNA sequencing technology and potential solutions. It discusses issues such as high upfront costs of sequencers, data storage and management difficulties due to the large amount of data generated, networking and data transfer problems, and lack of laboratory information management systems. Potential solutions proposed include using virtualization and cloud computing through Amazon Web Services, developing a wiki-based laboratory information management system, simplifying storage architectures, and automated data capture and management.
The document discusses the history and development of high performance computing. It describes how early computers were mechanical devices, then became electronic and digital. It also summarizes the development of parallel and cluster computing technologies that allow multiple processors to work together on problems.
This document summarizes a Tree Preservation Ordinance for a city. It establishes definitions related to trees, creates roles like Tree Warden and Urban Forestry Committee, and outlines regulations for removing public shade trees, city trees, and private trees. Permits are required to remove trees, and replacements or payments to a Tree Fund are typically required for removing significant trees to maintain the city's tree canopy. The ordinance aims to enhance environmental and quality of life benefits of the urban forest.
A response from Newport Construction to the city of Somerville's demand that we be compensated for the improper destruction of our trees.
In which they respond: "No."
This document provides lighting design details for a pedestrian underpass, including:
- A luminaire schedule listing a single LED luminaire model to be used with 4,807 lumens output.
- A lighting plan showing the layout of 6 luminaires in the tunnel.
- Photometric calculations indicating the tunnel lighting will average 35.1 footcandles with a maximum of 42.9 fc and minimum of 13.4 fc.
The document discusses traffic issues and potential solutions for a neighborhood with streets named Harrison, Kent, Ivaloo, Kent Ct, Park and Beacon. It considers adding signage and speed bumps, or making some streets one-way. Several one-way configurations are proposed, each with benefits and drawbacks. In the end, it concludes that while signage and speed bumps would help reduce cut-through traffic and speeding, there is no perfect one-way solution that solves all problems without new issues. Resolving traffic issues requires balancing different neighborhood needs.
- Data challenges are growing in terms of volume, variety, velocity and quality. There is no single solution and real-world solutions will be hybrid.
- Metadata management is a huge challenge, even basic metadata is beyond most small organizations. Federated systems are needed to transform medicine.
- The document discusses challenges with data management across various domains including life sciences, healthcare, genomics, machine learning, artificial intelligence, and personal data. It emphasizes the importance of data visibility, quality, and integration across siloed systems.
Somerville experienced a catastrophic loss of trees in 2018, with over 1,800 trees removed. This is equivalent to 10 years of tree planting at current rates. The city has consistently underspent its budget for tree care, allowing dead and dying trees to remain for years. Major projects like the Green Line Extension and development at Somerville High School resulted in the removal of over 1,000 and 700 trees respectively. To replace the ecosystem services provided by these large, mature trees, it will take decades for newly planted smaller trees to grow. The document calls for improved community engagement around urban forestry, developing a tree care program, maintaining a net-neutral approach to tree removal and planting across all projects, and creating a program to
The document discusses emerging technologies including quantum computing, artificial intelligence, machine learning, blockchains, the internet of things, cloud computing, edge computing, and data analytics. While these technologies show promise, the document cautions against hype and notes that many technologies do not yet work as described or have practical applications. The author offers experience supporting genomics and building IT infrastructure and is available for consulting work.
This document provides a charter and roadmap for a Computing, Data, and Informatics Working Group. It discusses their vision of enabling data, computing, and identity services at unlimited scale. It highlights how information technology has been critical but also a source of tension in large projects like the Human Genome Project. The document outlines current enabling technologies like machine learning, blockchain, and DevOps practices. It identifies key challenge areas the working group will focus on, including identity and authorization, information security and privacy, and issues around data storage in multi-cloud environments. The working group members are then listed.
This document summarizes a presentation on leveraging the cloud to transform laboratory informatics processes. Some key points from the presentation include:
1) The presenter has experience transitioning genomic workflows to public clouds like AWS and Google Cloud over the past 15 years and has seen data volumes grow exponentially from petabytes to exabytes.
2) Senior leadership is often supportive of moving to the cloud because it removes support burdens, simplifies licensing and budgeting, enables automatic technology updates, and provides unlimited scalability.
3) "Cloud" is simply a means to an end - people ultimately care about business, scientific, and clinical outcomes. The cloud provides infrastructure that can help deliver those outcomes.
4
Kinetic studies on malachite green dye adsorption from aqueous solutions by A...Open Access Research Paper
Water polluted by dyestuffs compounds is a global threat to health and the environment; accordingly, we prepared a green novel sorbent chemical and Physical system from an algae, chitosan and chitosan nanoparticle and impregnated with algae with chitosan nanocomposite for the sorption of Malachite green dye from water. The algae with chitosan nanocomposite by a simple method and used as a recyclable and effective adsorbent for the removal of malachite green dye from aqueous solutions. Algae, chitosan, chitosan nanoparticle and algae with chitosan nanocomposite were characterized using different physicochemical methods. The functional groups and chemical compounds found in algae, chitosan, chitosan algae, chitosan nanoparticle, and chitosan nanoparticle with algae were identified using FTIR, SEM, and TGADTA/DTG techniques. The optimal adsorption conditions, different dosages, pH and Temperature the amount of algae with chitosan nanocomposite were determined. At optimized conditions and the batch equilibrium studies more than 99% of the dye was removed. The adsorption process data matched well kinetics showed that the reaction order for dye varied with pseudo-first order and pseudo-second order. Furthermore, the maximum adsorption capacity of the algae with chitosan nanocomposite toward malachite green dye reached as high as 15.5mg/g, respectively. Finally, multiple times reusing of algae with chitosan nanocomposite and removing dye from a real wastewater has made it a promising and attractive option for further practical applications.
RoHS stands for Restriction of Hazardous Substances, which is also known as t...vijaykumar292010
RoHS stands for Restriction of Hazardous Substances, which is also known as the Directive 2002/95/EC. It includes the restrictions for the use of certain hazardous substances in electrical and electronic equipment. RoHS is a WEEE (Waste of Electrical and Electronic Equipment).
Evolving Lifecycles with High Resolution Site Characterization (HRSC) and 3-D...Joshua Orris
The incorporation of a 3DCSM and completion of HRSC provided a tool for enhanced, data-driven, decisions to support a change in remediation closure strategies. Currently, an approved pilot study has been obtained to shut-down the remediation systems (ISCO, P&T) and conduct a hydraulic study under non-pumping conditions. A separate micro-biological bench scale treatability study was competed that yielded positive results for an emerging innovative technology. As a result, a field pilot study has commenced with results expected in nine-twelve months. With the results of the hydraulic study, field pilot studies and an updated risk assessment leading site monitoring optimization cost lifecycle savings upwards of $15MM towards an alternatively evolved best available technology remediation closure strategy.
Improving the viability of probiotics by encapsulation methods for developmen...Open Access Research Paper
The popularity of functional foods among scientists and common people has been increasing day by day. Awareness and modernization make the consumer think better regarding food and nutrition. Now a day’s individual knows very well about the relation between food consumption and disease prevalence. Humans have a diversity of microbes in the gut that together form the gut microflora. Probiotics are the health-promoting live microbial cells improve host health through gut and brain connection and fighting against harmful bacteria. Bifidobacterium and Lactobacillus are the two bacterial genera which are considered to be probiotic. These good bacteria are facing challenges of viability. There are so many factors such as sensitivity to heat, pH, acidity, osmotic effect, mechanical shear, chemical components, freezing and storage time as well which affects the viability of probiotics in the dairy food matrix as well as in the gut. Multiple efforts have been done in the past and ongoing in present for these beneficial microbial population stability until their destination in the gut. One of a useful technique known as microencapsulation makes the probiotic effective in the diversified conditions and maintain these microbe’s community to the optimum level for achieving targeted benefits. Dairy products are found to be an ideal vehicle for probiotic incorporation. It has been seen that the encapsulated microbial cells show higher viability than the free cells in different processing and storage conditions as well as against bile salts in the gut. They make the food functional when incorporated, without affecting the product sensory characteristics.
Optimizing Post Remediation Groundwater Performance with Enhanced Microbiolog...Joshua Orris
Results of geophysics and pneumatic injection pilot tests during 2003 – 2007 yielded significant positive results for injection delivery design and contaminant mass treatment, resulting in permanent shut-down of an existing groundwater Pump & Treat system.
Accessible source areas were subsequently removed (2011) by soil excavation and treated with the placement of Emulsified Vegetable Oil EVO and zero-valent iron ZVI to accelerate treatment of impacted groundwater in overburden and weathered fractured bedrock. Post pilot test and post remediation groundwater monitoring has included analyses of CVOCs, organic fatty acids, dissolved gases and QuantArray® -Chlor to quantify key microorganisms (e.g., Dehalococcoides, Dehalobacter, etc.) and functional genes (e.g., vinyl chloride reductase, methane monooxygenase, etc.) to assess potential for reductive dechlorination and aerobic cometabolism of CVOCs.
In 2022, the first commercial application of MetaArray™ was performed at the site. MetaArray™ utilizes statistical analysis, such as principal component analysis and multivariate analysis to provide evidence that reductive dechlorination is active or even that it is slowing. This creates actionable data allowing users to save money by making important site management decisions earlier.
The results of the MetaArray™ analysis’ support vector machine (SVM) identified groundwater monitoring wells with a 80% confidence that were characterized as either Limited for Reductive Decholorination or had a High Reductive Reduction Dechlorination potential. The results of MetaArray™ will be used to further optimize the site’s post remediation monitoring program for monitored natural attenuation.