- "Some Examples explaining the Value of Open Data in HealthCare and Life Science." by Hans Constandt of ONTOFORCE at the DataOps Ghent Meetup of 24th October 2019.

1. Hans Constandt
hans.constandt@ontoforce.com
www.ontoforce.com
SKYPE: hansconstandt
TWITTER: hconstandt
LINKEDIN: hconstandt
How it All Started

2. 300 MILLION
BOOKS
2020: X2
EVERY 73 DAYS
1K READING
PER SEC
WEARABLES
44 ZB
hconstandt

3. Big Data 4 V’s
DATA VARIETY & DATA VERACITY
VOLUME VELOCIT Y VARIE T Y VERACIT Y
Data
at rest
Data
in motion
Data in
many forms
Data
In doubt
hconstandt

4. 2013: Better Data for Patients
hconstandt

5. hconstandt
From Sick Care to HealthCare

6. 2016: Better Data for Corporates
Saved
€ 120M
in 13 min
hconstandt

7. Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
Time Squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CMTarget
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CMTarget
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 hconstandt

8. $3.1M
Data Driven Value Examples
hconstandt

9. PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
Time Squeezing in Clinical Trials
Srini Dagalur. Applied Clinical Trials 2016 hconstandt
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSRProtocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSRProtocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR

10. $807M$134M
Data Driven Value Examples
hconstandt

12. Genome data are held in silos
unshared, not standardized for exchange
No one institute has enough on its own
Everyone should be able to compare
Their genomes to others
hconstandt

13. Hans Constandt
hans.constandt@ontoforce.com
www.ontoforce.com
SKYPE: hansconstandt
TWITTER: hconstandt
LINKEDIN: hconstandt
Thank you