Sir William Osler was a renowned Canadian physician known as the "Father of Modern Medicine". He studied medicine in Canada and Europe, making early observations of platelets in blood. He taught at McGill University, the University of Pennsylvania, and helped establish the Johns Hopkins medical school. Osler revolutionized clinical teaching by having students study patients at the bedside. He authored influential medical textbooks and helped establish evidence-based medicine. Osler remained a prolific writer and advocate for compassionate, scientific medical practice until his death in Oxford, England in 1919.
Sir William Osler, 1st Baronet ( July 12, 1849 – December 29, 1919) was a Canadian physician and one of the four founding professors of Johns Hopkins Hospital. Osler created the first residency program for specialty training of physicians, and he was the first to bring medical students out of the lecture hall for bedside clinical training. He has frequently been described as the "Father of Modern Medicine".[Osler was a person of many interests, who in addition to being a physician, was a bibliophile, historian, author, and renowned practical joker.
Sir William Osler, 1st Baronet ( July 12, 1849 – December 29, 1919) was a Canadian physician and one of the four founding professors of Johns Hopkins Hospital. Osler created the first residency program for specialty training of physicians, and he was the first to bring medical students out of the lecture hall for bedside clinical training. He has frequently been described as the "Father of Modern Medicine".[Osler was a person of many interests, who in addition to being a physician, was a bibliophile, historian, author, and renowned practical joker.
The Real Sherlock Holmes - John RaffenspergerMX Publishing
The lost diaries of Arthur Conan Doyle relate his adventures with dr. Joe bell, the Edinburgh surgeon who was the model for Sherlock Holmes. This program explains how an education at the Edinburgh school of medicine gave them the ability to diagnose obscure medical conditions, solve crimes, save the lives of an American president and the Russian tsar as well as to avert a crisis between Britain and the united states. The program also illustrates how the literature of Conan Doyle reflect his years as a medical student and young physician.
A new way of thinking about illness . . a igi pr spetiveon .docxblondellchancy
"A new way of thinking about illness . . a igi pr spetive
on the persistence of human vulnerabilitWy.
-Peter D. Kramer, author of Listening PtoPza
The New Science of
Darwinian Medicine
Acclaim for
Randolph M. Nesse and George C. Williams's
WHY WE GET SICK
"This is the most important book written about issues in biomedi-
cine in the last fifty years. When the world's leading evolutionary
biologist (Williams) teams up with a thoughtful physician
(Nesse), the product is a gripping exploration of why our bodies
respond the way they do to injury and disease."
-Michael S. Gazzaniga, Ph.D.,
director, Center for Neuroscience,
University of California at Davis
"Darwinian medicine . . . holds that there are evolutionary expla-
nations for human disease and physical frailties, just as for
everything else in biology, and that these insights can inspire
better treatments.... In Why We Qet Sick ... two proponents
of Darwinian medicine lay out the ambitious reach of the
adventurous new discipline."
-The New York Times Magazine
"Every so often, a book comes along that has the power to
change the way we live and die. This splendid book is one, and
it could well revolutionize the way physicians are taught, the
way they practice, and even the way parents watch over their
child with a fever or a cough."
-Professor Robert Ornstein,
author of The Psychology of Consciousness
"Would you accept that eating certain kinds of red meat could
help ward off heart attacks? That taking aspirin when you are
sick could make things worse? That mothers should sleep right
next to their infants to prevent sudden infant death? You might
after hearing how your prehistoric ancestors lived, according to
a small but growing tribe of 'Darwinian medicine' thinkers.
They argue that for too long physicians have ignored the forces
that shaped us over evolutionary eons.... Such ideas are ...
controversial, but that's the point."
-Wall Street Journal
"Why We Qet Sick is certain to be recognized as one of the most
important books of the decade, and what's more, it's beautifully
written."
-Roger Lewin,
author of Human Evolution, 3rd Edition
"Why We Qet Sick offers both a provocative challenge to medi-
cine and a thoughtful discussion of how evolutionary theory
applies to people."
-Business Week
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
WHY WE GET SICK
Randolph M. Nesse, M.D., is a practicing physician and
professor and associate chair for education and academic
affairs in the Department of Psychiatry at the University
of Michigan Medical School.
George C. Williams, Ph.D., is a professor emeritus of
ecology and evolution at the State University at Stony
Brook and editor of The Quarterly Review of Biology.
WHY WE GET SICK
The New Science
of Darwinian Medicine
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
VINTAGE BOOKS
A Division of Random House, Inc.
New York
FIRST VINTAGE BOOKS EDITION, JANUARY 1996
Copyright ) 1994 by Randolph ...
"A new way of thinking about illness . . a igi pr spetive
on the persistence of human vulnerabilitWy.
-Peter D. Kramer, author of Listening PtoPza
The New Science of
Darwinian Medicine
Acclaim for
Randolph M. Nesse and George C. Williams's
WHY WE GET SICK
"This is the most important book written about issues in biomedi-
cine in the last fifty years. When the world's leading evolutionary
biologist (Williams) teams up with a thoughtful physician
(Nesse), the product is a gripping exploration of why our bodies
respond the way they do to injury and disease."
-Michael S. Gazzaniga, Ph.D.,
director, Center for Neuroscience,
University of California at Davis
"Darwinian medicine . . . holds that there are evolutionary expla-
nations for human disease and physical frailties, just as for
everything else in biology, and that these insights can inspire
better treatments.... In Why We Qet Sick ... two proponents
of Darwinian medicine lay out the ambitious reach of the
adventurous new discipline."
-The New York Times Magazine
"Every so often, a book comes along that has the power to
change the way we live and die. This splendid book is one, and
it could well revolutionize the way physicians are taught, the
way they practice, and even the way parents watch over their
child with a fever or a cough."
-Professor Robert Ornstein,
author of The Psychology of Consciousness
"Would you accept that eating certain kinds of red meat could
help ward off heart attacks? That taking aspirin when you are
sick could make things worse? That mothers should sleep right
next to their infants to prevent sudden infant death? You might
after hearing how your prehistoric ancestors lived, according to
a small but growing tribe of 'Darwinian medicine' thinkers.
They argue that for too long physicians have ignored the forces
that shaped us over evolutionary eons.... Such ideas are ...
controversial, but that's the point."
-Wall Street Journal
"Why We Qet Sick is certain to be recognized as one of the most
important books of the decade, and what's more, it's beautifully
written."
-Roger Lewin,
author of Human Evolution, 3rd Edition
"Why We Qet Sick offers both a provocative challenge to medi-
cine and a thoughtful discussion of how evolutionary theory
applies to people."
-Business Week
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
WHY WE GET SICK
Randolph M. Nesse, M.D., is a practicing physician and
professor and associate chair for education and academic
affairs in the Department of Psychiatry at the University
of Michigan Medical School.
George C. Williams, Ph.D., is a professor emeritus of
ecology and evolution at the State University at Stony
Brook and editor of The Quarterly Review of Biology.
WHY WE GET SICK
The New Science
of Darwinian Medicine
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
VINTAGE BOOKS
A Division of Random House, Inc.
New York
FIRST VINTAGE BOOKS EDITION, JANUARY 1996
Copyright ) 1994 by Randolph ...
History of middle ages alan moelleken lawsuit terms cottage hospital santa ba...Alan Moelleken
These documents are for inquiry into medical terms. They are basic and do not represent the expanding knowledge of medical terms, anti-trust, jury lawsuits, trial cases and legal and medical case law in courts.
Homeopaths and the Dawning of Anesthesiology IIhome
Many who helped shape anesthesiology into an independent
specialty came from the ranks of homeopathy, while others
who achieved distinction in anesthesiology later embraced
the cause of homeopathy. A short account of the history of
anesthesia will fi rst be given to provide context
The Real Sherlock Holmes - John RaffenspergerMX Publishing
The lost diaries of Arthur Conan Doyle relate his adventures with dr. Joe bell, the Edinburgh surgeon who was the model for Sherlock Holmes. This program explains how an education at the Edinburgh school of medicine gave them the ability to diagnose obscure medical conditions, solve crimes, save the lives of an American president and the Russian tsar as well as to avert a crisis between Britain and the united states. The program also illustrates how the literature of Conan Doyle reflect his years as a medical student and young physician.
A new way of thinking about illness . . a igi pr spetiveon .docxblondellchancy
"A new way of thinking about illness . . a igi pr spetive
on the persistence of human vulnerabilitWy.
-Peter D. Kramer, author of Listening PtoPza
The New Science of
Darwinian Medicine
Acclaim for
Randolph M. Nesse and George C. Williams's
WHY WE GET SICK
"This is the most important book written about issues in biomedi-
cine in the last fifty years. When the world's leading evolutionary
biologist (Williams) teams up with a thoughtful physician
(Nesse), the product is a gripping exploration of why our bodies
respond the way they do to injury and disease."
-Michael S. Gazzaniga, Ph.D.,
director, Center for Neuroscience,
University of California at Davis
"Darwinian medicine . . . holds that there are evolutionary expla-
nations for human disease and physical frailties, just as for
everything else in biology, and that these insights can inspire
better treatments.... In Why We Qet Sick ... two proponents
of Darwinian medicine lay out the ambitious reach of the
adventurous new discipline."
-The New York Times Magazine
"Every so often, a book comes along that has the power to
change the way we live and die. This splendid book is one, and
it could well revolutionize the way physicians are taught, the
way they practice, and even the way parents watch over their
child with a fever or a cough."
-Professor Robert Ornstein,
author of The Psychology of Consciousness
"Would you accept that eating certain kinds of red meat could
help ward off heart attacks? That taking aspirin when you are
sick could make things worse? That mothers should sleep right
next to their infants to prevent sudden infant death? You might
after hearing how your prehistoric ancestors lived, according to
a small but growing tribe of 'Darwinian medicine' thinkers.
They argue that for too long physicians have ignored the forces
that shaped us over evolutionary eons.... Such ideas are ...
controversial, but that's the point."
-Wall Street Journal
"Why We Qet Sick is certain to be recognized as one of the most
important books of the decade, and what's more, it's beautifully
written."
-Roger Lewin,
author of Human Evolution, 3rd Edition
"Why We Qet Sick offers both a provocative challenge to medi-
cine and a thoughtful discussion of how evolutionary theory
applies to people."
-Business Week
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
WHY WE GET SICK
Randolph M. Nesse, M.D., is a practicing physician and
professor and associate chair for education and academic
affairs in the Department of Psychiatry at the University
of Michigan Medical School.
George C. Williams, Ph.D., is a professor emeritus of
ecology and evolution at the State University at Stony
Brook and editor of The Quarterly Review of Biology.
WHY WE GET SICK
The New Science
of Darwinian Medicine
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
VINTAGE BOOKS
A Division of Random House, Inc.
New York
FIRST VINTAGE BOOKS EDITION, JANUARY 1996
Copyright ) 1994 by Randolph ...
"A new way of thinking about illness . . a igi pr spetive
on the persistence of human vulnerabilitWy.
-Peter D. Kramer, author of Listening PtoPza
The New Science of
Darwinian Medicine
Acclaim for
Randolph M. Nesse and George C. Williams's
WHY WE GET SICK
"This is the most important book written about issues in biomedi-
cine in the last fifty years. When the world's leading evolutionary
biologist (Williams) teams up with a thoughtful physician
(Nesse), the product is a gripping exploration of why our bodies
respond the way they do to injury and disease."
-Michael S. Gazzaniga, Ph.D.,
director, Center for Neuroscience,
University of California at Davis
"Darwinian medicine . . . holds that there are evolutionary expla-
nations for human disease and physical frailties, just as for
everything else in biology, and that these insights can inspire
better treatments.... In Why We Qet Sick ... two proponents
of Darwinian medicine lay out the ambitious reach of the
adventurous new discipline."
-The New York Times Magazine
"Every so often, a book comes along that has the power to
change the way we live and die. This splendid book is one, and
it could well revolutionize the way physicians are taught, the
way they practice, and even the way parents watch over their
child with a fever or a cough."
-Professor Robert Ornstein,
author of The Psychology of Consciousness
"Would you accept that eating certain kinds of red meat could
help ward off heart attacks? That taking aspirin when you are
sick could make things worse? That mothers should sleep right
next to their infants to prevent sudden infant death? You might
after hearing how your prehistoric ancestors lived, according to
a small but growing tribe of 'Darwinian medicine' thinkers.
They argue that for too long physicians have ignored the forces
that shaped us over evolutionary eons.... Such ideas are ...
controversial, but that's the point."
-Wall Street Journal
"Why We Qet Sick is certain to be recognized as one of the most
important books of the decade, and what's more, it's beautifully
written."
-Roger Lewin,
author of Human Evolution, 3rd Edition
"Why We Qet Sick offers both a provocative challenge to medi-
cine and a thoughtful discussion of how evolutionary theory
applies to people."
-Business Week
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
WHY WE GET SICK
Randolph M. Nesse, M.D., is a practicing physician and
professor and associate chair for education and academic
affairs in the Department of Psychiatry at the University
of Michigan Medical School.
George C. Williams, Ph.D., is a professor emeritus of
ecology and evolution at the State University at Stony
Brook and editor of The Quarterly Review of Biology.
WHY WE GET SICK
The New Science
of Darwinian Medicine
Randolph M. Nesse, M.D.
George C. Williams, Ph.D.
VINTAGE BOOKS
A Division of Random House, Inc.
New York
FIRST VINTAGE BOOKS EDITION, JANUARY 1996
Copyright ) 1994 by Randolph ...
History of middle ages alan moelleken lawsuit terms cottage hospital santa ba...Alan Moelleken
These documents are for inquiry into medical terms. They are basic and do not represent the expanding knowledge of medical terms, anti-trust, jury lawsuits, trial cases and legal and medical case law in courts.
Homeopaths and the Dawning of Anesthesiology IIhome
Many who helped shape anesthesiology into an independent
specialty came from the ranks of homeopathy, while others
who achieved distinction in anesthesiology later embraced
the cause of homeopathy. A short account of the history of
anesthesia will fi rst be given to provide context
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
1. 23 de junio del 2010.
Sir William Osler.
Ha sido llamado uno de los grandes iconos de la
medicina, "El Padre de la Medicina Moderna“.
Creador: gamottar@yahoo.com.mx
2. Soy egresado de la Escuela Médico Militar (EMM).
Soy médico militar, radiólogo, con postgrado en Imagen
Seccional y ejerzo tanto institucional como en forma privada.
3. Cuando decidí ser médico, opte por la Escuela Médico Militar:
Porque representa un crisol del saber, con una seriedad y
profesionalismo basada en los valores que todo instituto
armado posee y que enriquece la formación médica en alguno
de sus aspectos.
4. 1984, Cursaba el 4to año y era cabo de cadetes
Más esta aventura de ser médico, de ser médico militar, no
termina cuándo finalice mis estudios …..
ahí fue donde empezó.
5. 1994, en el Consultorio del Pelotón de Sanidad en Tenosique, Tabasco.
.
En esos años – 28 años - he tenido vivencias, vicisitudes,
sinsabores, satisfacciones y he intentado acorde a mi profesión
el de siempre aprender y de servir al ser humano.
6. Dr. Píndaro Martínez Elizondo
Dr. Rafael de la Huerta
Dr. Antonio Ruiz Moreno
Dr. Mario Cardona Pérez
Dr. Antonio Moreno Guzmán
Dr. Rodolfo Lerma Shiumoto
y mas.
Me congratulo de haber convivido con médicos brillantes cuyas
personalidades me impactaron en todo sentido y no quisiera
dejar de mencionar a ninguno.
A TODOS ellos mi sincero agradecimiento.
La presente revisión de la biografía del Dr. William Osler viene
al caso dado que mencionare a 2 de los tantos médicos que me
enseñaron este arte y ciencia del ejercicio de la Medicina.
7. El 1ero fue quien por primera vez, ya siendo residente de
especialidad, me facilito un libro en el que la figura del Dr.
William Osler estaba presente.
Tte. Cor MC Ret. Melchor Sánchez Mendiola,
promotor de la EMB –Medicina basada en Evidencias -.
El 2do, quien fuese director de la EMM cuando ingrese, que a
la fecha logramos mantener comunicación, misma que es
enriquecedora y fructífera al ser mi General un medico con una
experiencia invaluable para mi, y con un deseo constante por
aprender.
Gral. Div MC Ret. Jaime Cohen Yánez
8. Sir William Osler
12 de julio, 1849
Nacimiento
Bond Head, Ontario
29 de diciembre,
Fallecimiento
1919, Oxford.
Referencia núm. 1
9. As Sir William Osler wrote,
“Errors in judgment must occur in the
practice of
an art which consists largely of balancing
probabilities.
Medicine is a science of uncertainty and an
art of probability.”
(The Quotable Osler, American College
of Physicians, Philadelphia, PA, 2003.)
Referencia núm. 1,10
10. Gracias a un interés común, que nos une tanto a mi Gral. Jaime
Cohen Yáñez como a mi, en lo referente a la traducción al español
del Dr. Osler:
“Errors in judgment must occur in the practice of an art
which consists largely of balancing probabilities.
Medicine is a science of uncertainty and an art of probability.”
Quedando así:
Los errores de juicio son inevitables en un
arte que consiste principalmente en balancear (o evaluar)
probabilidades. La medicina es una ciencia de la
incertidumbre y un arte de la probabilidad.
11. The practice of medicine is an
art, not a trade; a calling, not a
business; a calling in which your
heart will be exercised equally
with your head.
Aequanimitas:With other addresses to
medical students... 2nd ed.(Philadelphia:
Blakiston's Son,1920) p.386
Referencia núm. 9
12. “The practice of medicine is an art,
not a trade; a calling, not a business;
a calling in which your heart will be
exercised equally with your head.
Often the best part of your work will
have nothing to do with potions and
powders, but with the exercise of an
influence of the strong upon the weak,
of the righteous upon the wicked, of
the wise upon the foolish.”
Referencia núm. 15
13. Nació en Bond Head Canadá oeste
(ahora Ontario) y estudió en la
Universidad McGill en Montreal,
Quebec donde obtuvo la
licenciatura en Medicina.
Posteriormente fue profesor en la
Universidad de Pennsylvania y Jefe
de Medicina Clínica en dicha
universidad.
Referencia núm. 1,10
14. Universidad McGillen en Montreal, Quebec
Edificio de la Facultad de Artes. Es el edificio más
antiguo del campus, fue construido en 1843. Referencia núm. 1
15. Teaching At the Bedside:
Sir William Osler M.D.,
1849-1919 - 16"X20"
Limited Edition Print - Signed
En 1889 fue el primer profesor de Medicina de la
Universidad Johns Hopkins. En 1905 se traslada a
Inglaterra, permaneciendo en Oxford hasta su
muerte. Fue nombrado Sir en 1911 por sus grandes
contribuciones en el campo de la medicina.
Osler fue un gran coleccionista de libros de Historia
de la medicina. Referencia núm. 23
16. Estudió Medicina en Canadá y en Europa, donde
fue el primero en observar las plaquetas de la
Sangre en 1873.
Regresó a Canadá para dar clases en la
Universidad McGill de Montreal (1875-1884). Se
marchó a los EEUU para enseñar en la Universidad
de Pennsylvania (1884-1888) y allí fundó la
Association of American Physicians (Asociación de
médicos americanos). Referencia núm. 2
17. A picture of Johns Hopkins hospital, taken in 2006.
Desde 1888 a 1905 impartió clases en la recién
creada facultad de medicina de la Universidad
Johns Hopkins. Referencia núm. 2,12
18. William Osler, at the bedside of
a patient, while professor of
medicine at Johns Hopkins,
He helped transform clinical teaching; students
studied patients in the wards and took their
problems to the lab, and experts pooled their
knowledge to benefit both patient and student in
public teaching sessions. Referencia núm. 11
19. Revolucionó el concepto de la enseñanza de la medicina insistiendo en que los
alumnos de Medicina tuvieran responsabilidades ante los pacientes y reclamando
niveles de enseñanza y práctica de la medicina más profesionales y científicos.
21. 1900 1909
1892
Su obra Principles and Practice of Medicine (1892) se
consideró durante mucho tiempo el libro de texto oficial de
las facultades de medicina de todo el mundo.
Se trasladó a Oxford (Inglaterra) para presidir la cátedra de
medicina (1905-1919). Referencia núm. 2, 7
22. Hombre de gran energía, escribió muchos libros,
ofreció numerosas conferencias, fundó varias
organizaciones y también se distinguió como
historiador de la medicina y coleccionista de libros
médicos. Referencia núm. 2
25. Wm Osler, Last Studio Portrait, 1919, 6.25" x 10"
Inscription by Wilburt C. Davison, M.D.
" To Jack McGovern from Dave WCDavison "
On back of item in pencil
" This is a copy of Sir William's
last studio picture, which Lady
Osler sent me after his death.
Harold Pierce "
Referencia núm. 9
26. Osler, que fue un profesor brillante e innovador y un erudito en la evolución natural
de la enfermedad, revolucionó el arte de ejercer la medicina a la cabecera del
enfermo.
Es idolatrado por generaciones de estudiantes de medicina y de médicos
generales para quienes encarnó al médico ideal.
Pero fue más que un médico, fue un humanista muy inteligente. Plasmó el arte de
vivir en sus escritos, en su propia vida y a través del prisma de la Gran Guerra.
Quizá su legendaria compasión fue lo que elevó sus talentos curativos a una
especie de arte y lo que atrajo a su consulta privada estudiantes, colegas, poetas
(Walt Whitman, por ejemplo), políticos, miembros de la realeza, y gente anónima y
ordinaria con dolencias insólitas. modificado de Referencia núm. 4
27. Después de su muerte su colección formó la parte
principal de la Biblioteca de Historia de la Medicina
de la Universidad McGill, que fue fundada en 1929.
Referencia núm. 6
28. Es muy seguro que si Osler estuviese vivo hoy,
principios del siglo XXI, estaría de acuerdo con D.L.
Sackett, uno de los pontífices de la medicina
basada en la evidencia, quien en 1996 anotaba que
esta nueva estrategia es la integración del saber y
la experiencia médica, con lo mejor de la evidencia
disponible en la literatura científica, y que tal
evidencia jamás reemplazará a la habilidad y la
experiencia clínicas.
Referencia núm. 3
29. Sir William Osler & D.L. Sackett, EBM
Sackett DL, Haynes RB, Tugwell P. Clinical
epidemiology : a basic science for clinical medicine.
Boston: Little, Brown; 1985. This book on „clinical
epidemiology,‟ written by four physicians from
McMaster University in Canada, represents one of the
founding texts of evidence-based medicine.
Referencia núm. 13,14
30. Sir William Osler & EBM
The term “evidence–based medicine” (EBM) is usually attributed to a
commentary written in 1991 by Gordon Guyatt, an internist and clinical
epidemiologist at McMaster University in Canada, though the term
“evidence-based” had been introduced in 1990 by David Eddy, an
American surgeon and healthcare economist.
Referencia núm. 13,14
31. Canada's Osler stamp. Date of issue, June 23, 1969
Thirty-five million Osler stamps were printed by the
British American Bank Note Co., of Ottawa, the originators
of the design.
The six-cent stamp celebrated the 50th anniversary of the
year in which Osler died.
32. Look wise, say nothing, and grunt. Speech was given to conceal thought.
Sir William Osler
Shut out all of your past except that which will help you weather your tomorrows.
Sir William Osler
The greater the ignorance the greater the dogmatism.
Sir William Osler
To study the phenomenon of disease without books is to sail an uncharted sea,
while to study books without patients is not to go to sea at all.
Sir William Osler
One of the first duties of the physician is to educate the masses not to take
medicine. Sir William Osler, Aphorisms from his Bedside Teachings (1961) p. 105
The desire to take medicine is perhaps the greatest feature which distinguishes
man from animals.
Sir William Osler, In H. Cushing, Life of Sir William Osler (1925)
Live neither in the past nor in the future, but let each day's work absorb your entire
energies, and satisfy your widest ambition.
Sir William Osler, to his students Referencia núm. 5
33. The Four Doctors by John Singer Sargent,
1905, depicts the four physicians who founded
Johns Hopkins Hospital. The original hangs in
the William H. Welch Medical Library of Johns
Hopkin University. From left to right: William
Henry Welch, William Stewart Halsted, Osler,
Howard Kelly.
Referencias núms. 11,12
34. Cover of JAMA The Journal of the
American Medical Association, Vol.
193, No.6, August 9, 1965
Inscription by Wilburt C. Davison,
M.D.
"To Jack McGovern from Davis - W.C.
Davison"
Referencia núm. 9
35. William Osler
conducting
Grand Rounds
"The natural man has only two primal passions, to get and to beget."
"There is a form of laughter that springs from the heart, heard every day in the merry voice of
childhood, the expression of a laughter -- loving spirit that defies analysis by the philosopher,
which has nothing rigid or mechanical in it, and totally without social significance. Bubbling
spontaneously from the heart of child or man. Without egotism and full of feeling, laughter is
the music of life."
"Variability is the law of life, and as no two faces are the same, so no two bodies are alike,
and no two individuals react alike and behave alike under the abnormal conditions which we
know as disease.” quotes by Sir William Osler
Referencia núm. 11, 17
37. One of the first duties of the physician is to educate the masses not to take
medicine.
Sir William Osler, Aphorisms from his Bedside Teachings (1961) p. 105
38. En un bajorrelieve, el sereno perfil de Sir William Osler cubre el sueño eterno de las cenizas de
quien, en la invocación de la ecuanimidad, había dicho: “Los grandes bienes de una universidad están
constituidos por sus grandes hombres. No son el “orgullo, pompa y circunstancia” de una institución los
que la honran, ni su riqueza, ni el número de sus facultades, ni los estudiantes que atestan sus aulas,
sino los hombres que han hallado la espinosa senda que a través del esfuerzo, y hasta a través del odio,
conduce a la serena morada de la Fama, ascendiendo como astros hasta su cima designada”.
Referencia núm. 8,9
39. The course of William Osler's life took him from a
parsonage in the Canadian wilderness, the youngest of a
clergyman's children, to a prestigious post at Oxford
University, a baronetcy, and the reputation of being the
world's greatest living physician.
Referencia núm. 10
40. A scientist, doctor and teacher, Osler never made any
major medical discoveries. But he wrote a landmark
medical textbook, reformed medical education, and
changed the lives of multitudes.
Referencia núm. 10
41. “The good physician treats the disease; the great physician treats the patient who has the disease”
“We are here to add what we can to life, not to get what we can from life.”
“He who studies medicine without books sails an uncharted sea, but he who studies medicine without
patients does not go to sea at all.”
“There is no more difficult art to acquire than the art of observation, and for some men it is quite as difficult
to record an observation in brief and plain language.”
“The young physician starts life with 20 drugs for each disease, and the old physician ends life with one
drug for 20 diseases.”
“Courage and cheerfulness will not only carry you over the rough places in life, but will enable you to bring
comfort and help to the weak-hearted and will console you in the sad hours”
“It is much more important to know what sort of a patient has a disease than what sort of a disease a
patient has.”
“Observe, record, tabulate, communicate. Use your five senses. . . . Learn to see, learn to hear, learn to
feel, learn to smell, and know that by practice alone you can become expert.”
quotes by Sir William Osler
Referencia núm. 15
42. “The best preparation for tomorrow is
to do today's work superbly well.”
“The value of experience is not in
seeing much, but in seeing wisely.”
“The future is today.”
“Medicine is learned by the bedside and not in the classroom. Let not your conceptions of disease come
from words heard in the lecture room or read from the book. See, and then reason and compare and
control. But see first.”
“No bubble is so iridescent or floats longer than that blown by the successful teacher.”
“There is no disease more conducive to clinical humility than aneurysm of the aorta.”
“The very first step towards success in any occupation is to become interested in it.”
“What is the student but a lover courting a fickle mistress who ever eludes his grasp?”
quotes by Sir William Osler
Referencia núm. 15,21
43. Johns Hopkins Hospital:
Harvey Cushing,
Howard Kelly,
William Osler, and
William S. Thayer
(seated in front) ca. 1900
“By far the most dangerous foe we have to fight is apathy - indifference from whatever cause, not from a
lack of knowledge, but from carelessness, from absorption in other pursuits, from a contempt bred of self
satisfaction”
“It is much simpler to buy books than to read them and easier to read them than to absorb their contents.”
“Care more for the individual patient than for the special features of the disease. . . . Put yourself in his
place . . . The kindly word, the cheerful greeting, the sympathetic look -- these the patient understands.”
“Here's the advice Sir William Osler gave the students at Yale: "Live neither in the past nor in the future,
but let each day absorb all your interest, energy and enthusiasm. The best preparation for tomorrow is to
live today superbly well."”
“To study the phenomena of disease without books is to sail an uncharted sea, while to study books
without patients is not to go to sea at all.” quotes by Sir William Osler
Referencia núm. 15,18
44. “The librarian of today, and it will be true still more of the librarians of tomorrow, are not fiery dragons
interposed between the people and the books. They are useful public servants, who manage libraries in
the interest of the public . . . Many still think that a great reader, or a writer of books, will make an
excellent librarian. This is pure fallacy.”
“Throw away all ambition beyond that of doing the day's work well. The travelers on the road to success
live in the present, heedless of taking thought for the morrow. Live neither in the past nor in the future, but
let each day's work absorb your entire energies, and satisfy your wildest ambition.”
“The search for static security - in the law and elsewhere - is misguided. The fact is security can only be
achieved through constant change, adapting old ideas that have outlived their usefulness to current
facts.”
“Work is the open sesame of every portal, the great equalizer in the world, the true philosopher's stone
Which transmutes all the base metal of humanity into gold.”
“For the general practitioner a well-used library is one of the few correctives of the premature senility
Which is so apt to take him.”
quotes by Sir William Osler
Referencia núm. 15
45. Mi hijo Luis Alberto,
lector ávido desde sus 6 años
“Study until 25, investigate until 40, profession until 60, at which age I would
have him retired on a double allowance.”
William Osler
46. “Soap and water and common sense are the best disinfectants.”
“No dreams, no visions, no delicious fantasies, no castles in the air, with which, as the old song so truly
says, "hearts are broken, heads are turned".”
“In seeking absolute truth we aim at the unattainable and must be content with broken portions.”
“Things cannot always go your way. Learn to accept in silence the minor aggravations, cultivate the gift of
taciturnity and consume your own smoke with an extra draught of hard work, so that those about you may
not be annoyed with the dust and soot of your complaint.”
“No human being is constituted to know the truth, the whole truth and nothing but the truth; and even the
best of men must be content with fragments, with partial glimpses, never the full fruition”
“There are, in truth, no specialties in medicine, since to know fully many of the most important diseases a
man must be familiar with their manifestations in many organs.”
“The philosophies of one age have become the absurdities of the next, and the foolishness of yesterday
has become the wisdom of tomorrow.”
quotes by Sir William Osler
Referencia núm. 15
47. 23 de junio del 2010.
Cushing’s Biography of Osler, 1925
Grace Revere Osler, now Lady Osler, asked Cushing to write
the official biography of his mentor William Osler, who had died
in 1919. Cushing put himself into this huge labor of love and
wrote two large volumes. The book won a Pulitzer Prize.
Harvey Cushing, The Life of Sir William Osler. 2 vols. Oxford:
Clarendon press, 1925.
De ambos médicos militares he aprendido y esta es mi forma
de agradecérselos.
De ambos, reconocí a este gran ser humano, Sir William Osler
de quien me he ocupado el día de hoy de conocer más
ampliamente su quehacer y…..
Referencia núm. 17
48. ….. porque la intención es lograr que otros, como yo, no
olvidemos el legado de enseñanza y de humildad de nuestros
antecesores.
49. Dr. Osler in the Almshouse.
One of my first assignments for
Reader's Digest was a series of
paintings illustrating the life of Sir
William Osler. Dr. Osler was a
prominent nineteenth-century
physician, and a founder of the
Johns Hopkins School of
Medicine in Baltimore.
Referencia núm. 19
50. Nowhere in medicine is the use of observation, instinct, and innate
experience more important than in attempting to make a clinical
diagnosis.
I like to refer to this as the actual clinical medicine, because
modern doctors their language and communication skills are
limited; they depend on others to sort out their problems; and
when ill they prefer to be left alone.
Sir William Osler said
“There is no more difficult art to acquire than the art of observation”.
Modificado de referencia núm. 21