The document describes a numerical model used to simulate the development of stenosis in the carotid artery. The model uses the Lattice Boltzmann Method to simulate blood flow and a stenosis growth model to simulate stenosis development. Stenosis is found to develop in regions of stagnant flow. The developed stenosis geometry is consistent with literature and shows increased velocity and loss of vortices, also consistent with observations. The results suggest the stagnation model provides a realistic approach to simulating stenosis growth.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
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International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
the most beautiful villa at Meriyanda, here one wakes to the chorus of the birds, and sweeping views of the Kote Betta Mountain. Creatively cocooned in glass and wood, each area of the villa offers an impressive view. The villa ideal for a large family features 2 king-size bedrooms with attached bathrooms designed with black stone and wood, and a spacious living room, besides a dining area, a cozy study area with a reading desk and 3 large decks,With plinth area of 2500 Square feet
En este documento encontrará la transcripción de todos los mensajes que pronunció en Ciudad de México, Ecatepec, Chiapas, Michoacán y Chihuahua, tanto los que improvisó como los que decidió dejar por escrito.
Además hemos incluido los testimonios de las familias y los jóvenes que se encontraron con él durante los eventos más grandes de su visita.
Paralegal Power Breaks are short information packed sessions that provide useful career information to paralegals at all career levels. This is the 3rd session in the Time Management series. There is a direct correlation between how well your time is spent and what you earn.
EFFECTS OF STENOSIS ON POWER LAW FLUID FLOW OF BLOOD IN BLOOD VESSELSJournal For Research
In this paper we assume that the blood is to be a Non-Newtonian and incompressible and Homogeneous fluid. An investigation has been done for the resistance to flow across mild stenosis situated symmetrically on steady blood flow through arteries with uniform or non-uniform cross section. An analytical solution for Power law fluid has been obtained. For the physiological insight of the problem various parameters systemic and pulmonary artery are taken and the study reveals that as the height of the stenosis increases in uniform or non-uniform portion of the artery, the resistance parameter and shear stress also steadily increases, whereas, flow rate decreases steadily and we analyze some cases between flux, pressure gradient and radius and give some significant results.
Casson flow of blood through an arterial tube with overlapping stenosisiosrjce
The objective of the present analysis is to study the effect of overlapping stenosis on blood flow
through an artery by taking the blood as Casson type non-Newtonian fluid. The expressions for flux and
resistance to flow have been studied here by assuming the stenosis is to be mild. The results are shown
graphically for different values of yield stress, stenosis length, stenosis height and discussed.
A One-Dimensional Model of a False AneurysmIJRESJOURNAL
ABSTRACT:A false aneurysm is a hematoma, i.e. collection of blood outside of a blood vessel, that forms due to a hole in the wall of an artery. This represents a serious medical condition that needs to be monitored and, under certain conditions, treated urgently. In this work a one-dimensional model of a false aneurysm is proposed. The new model is based on a one-dimensional model of an artery previously presented by the authors and it takes into account the interaction between the hematoma and the surrounding muscle material. The model equations are derived using rigorous asymptotic analysis for the case of a simplified geometry. Even though the model is simple it still supports a realistic behavior for the system consisting of the vessel and the hematoma. Using numerical simulations we illustrate the behavior of the model. We also investigate the effect of changing the size of the hematoma. The simulations show that our model can reproduce realistic solutions. For instance we show the typical strong pulsation of an aneurysm by blood entering the hematoma during the work phase of the cardiac cycle, and the blood returning to the vessel during the resting phase. Also we show that the aneurysm grows if the pulse rate is increased due to, e.g., a higher work load.
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
International Journal of Engineering Research and Development (IJERD)IJERD Editor
International Journal of Engineering Research and Development is an international premier peer reviewed open access engineering and technology journal promoting the discovery, innovation, advancement and dissemination of basic and transitional knowledge in engineering, technology and related disciplines.
Simulation of Physiological Non-Newtonian Blood Flow through 3-D Geometry of ...Iwate University
Abstract: A numerical simulation has been performed to investigate blood flow behavior of three dimensional idealized carotid arteries. Non-Newtonian flow has been taken for the simulation. The wall of the vessel is considered to be rigid. Physiological and parabolic velocity profile has been imposed for inlet boundary condition. Reynolds number at the inlet has been ranged approximately from 86to 966 for the investigation. Low Reynolds number k-w model has been used as governing equation. The investigations have been carried out to characterize the flow behavior of blood. The numerical results have been presented in terms of wall shear stress distributions, streamlines contours and axial velocity contours. However, highest wall shear stress has been observed in the bifurcation area. Unexpectedly, transient or unstable flow has created flow disturbance regions in the arteries. Moreover, the disturbance of flow has risen as the severity of stenosis in the artery has been increased.
Statistical analysis for measuring the effects of stenotic shapes and spiral ...Iwate University
Numerical simulations have been done for a statistical analysis to investigate the effect of stenotic shapes and spiral flows on wall shear stress in the three-dimensional idealized stenotic arteries. Non-Newtonian flow has been taken for the simulations. The wall of the vessel is considered to be rigid. Physiological, parabolic and spiral velocity profile has been imposed for inlet boundary condition. Moreover, the time-dependent pressure profile has been taken for outlet boundary condition. Reynolds number at the inlet has been ranged approximately from 86 to 966 for the investigation. Low Reynolds number k-w model has been used as governing equation. 120 simulations have been performed for getting the numerical results. However, the numerical results of wall shear stress have been taken for the statistical analysis. The simulations and the statistical analysis have been performed by using ANSYS-18.1 and SPSS respectively. The statistical analyses are significant as p-value in all cases are zero. The eccentricity is the most influencing factor for WSSmax. The WSSmin has been influenced only by the flow spirality. The stenotic length has an influence only on the WSSmax whereas the stenotic severity has an influence on the WSSmax and WSSave.
Hemodynamic assessment of partial mechanical circulatory support: data derive...Paul Schoenhagen
Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump®, where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
En este documento encontrará la transcripción de todos los mensajes que pronunció en Ciudad de México, Ecatepec, Chiapas, Michoacán y Chihuahua, tanto los que improvisó como los que decidió dejar por escrito.
Además hemos incluido los testimonios de las familias y los jóvenes que se encontraron con él durante los eventos más grandes de su visita.
Paralegal Power Breaks are short information packed sessions that provide useful career information to paralegals at all career levels. This is the 3rd session in the Time Management series. There is a direct correlation between how well your time is spent and what you earn.
EFFECTS OF STENOSIS ON POWER LAW FLUID FLOW OF BLOOD IN BLOOD VESSELSJournal For Research
In this paper we assume that the blood is to be a Non-Newtonian and incompressible and Homogeneous fluid. An investigation has been done for the resistance to flow across mild stenosis situated symmetrically on steady blood flow through arteries with uniform or non-uniform cross section. An analytical solution for Power law fluid has been obtained. For the physiological insight of the problem various parameters systemic and pulmonary artery are taken and the study reveals that as the height of the stenosis increases in uniform or non-uniform portion of the artery, the resistance parameter and shear stress also steadily increases, whereas, flow rate decreases steadily and we analyze some cases between flux, pressure gradient and radius and give some significant results.
Casson flow of blood through an arterial tube with overlapping stenosisiosrjce
The objective of the present analysis is to study the effect of overlapping stenosis on blood flow
through an artery by taking the blood as Casson type non-Newtonian fluid. The expressions for flux and
resistance to flow have been studied here by assuming the stenosis is to be mild. The results are shown
graphically for different values of yield stress, stenosis length, stenosis height and discussed.
A One-Dimensional Model of a False AneurysmIJRESJOURNAL
ABSTRACT:A false aneurysm is a hematoma, i.e. collection of blood outside of a blood vessel, that forms due to a hole in the wall of an artery. This represents a serious medical condition that needs to be monitored and, under certain conditions, treated urgently. In this work a one-dimensional model of a false aneurysm is proposed. The new model is based on a one-dimensional model of an artery previously presented by the authors and it takes into account the interaction between the hematoma and the surrounding muscle material. The model equations are derived using rigorous asymptotic analysis for the case of a simplified geometry. Even though the model is simple it still supports a realistic behavior for the system consisting of the vessel and the hematoma. Using numerical simulations we illustrate the behavior of the model. We also investigate the effect of changing the size of the hematoma. The simulations show that our model can reproduce realistic solutions. For instance we show the typical strong pulsation of an aneurysm by blood entering the hematoma during the work phase of the cardiac cycle, and the blood returning to the vessel during the resting phase. Also we show that the aneurysm grows if the pulse rate is increased due to, e.g., a higher work load.
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
International Journal of Engineering Research and Development (IJERD)IJERD Editor
International Journal of Engineering Research and Development is an international premier peer reviewed open access engineering and technology journal promoting the discovery, innovation, advancement and dissemination of basic and transitional knowledge in engineering, technology and related disciplines.
Simulation of Physiological Non-Newtonian Blood Flow through 3-D Geometry of ...Iwate University
Abstract: A numerical simulation has been performed to investigate blood flow behavior of three dimensional idealized carotid arteries. Non-Newtonian flow has been taken for the simulation. The wall of the vessel is considered to be rigid. Physiological and parabolic velocity profile has been imposed for inlet boundary condition. Reynolds number at the inlet has been ranged approximately from 86to 966 for the investigation. Low Reynolds number k-w model has been used as governing equation. The investigations have been carried out to characterize the flow behavior of blood. The numerical results have been presented in terms of wall shear stress distributions, streamlines contours and axial velocity contours. However, highest wall shear stress has been observed in the bifurcation area. Unexpectedly, transient or unstable flow has created flow disturbance regions in the arteries. Moreover, the disturbance of flow has risen as the severity of stenosis in the artery has been increased.
Statistical analysis for measuring the effects of stenotic shapes and spiral ...Iwate University
Numerical simulations have been done for a statistical analysis to investigate the effect of stenotic shapes and spiral flows on wall shear stress in the three-dimensional idealized stenotic arteries. Non-Newtonian flow has been taken for the simulations. The wall of the vessel is considered to be rigid. Physiological, parabolic and spiral velocity profile has been imposed for inlet boundary condition. Moreover, the time-dependent pressure profile has been taken for outlet boundary condition. Reynolds number at the inlet has been ranged approximately from 86 to 966 for the investigation. Low Reynolds number k-w model has been used as governing equation. 120 simulations have been performed for getting the numerical results. However, the numerical results of wall shear stress have been taken for the statistical analysis. The simulations and the statistical analysis have been performed by using ANSYS-18.1 and SPSS respectively. The statistical analyses are significant as p-value in all cases are zero. The eccentricity is the most influencing factor for WSSmax. The WSSmin has been influenced only by the flow spirality. The stenotic length has an influence only on the WSSmax whereas the stenotic severity has an influence on the WSSmax and WSSave.
Hemodynamic assessment of partial mechanical circulatory support: data derive...Paul Schoenhagen
Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump®, where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
EFFECT OF NEGATIVE ANGLE CANNULATION DURING CARDIOPULMONARY BYPASS – A COMPUT...ijbesjournal
Creation of emboli in the aortic root and changes in flow distribution between supra-aortic arteries and descending aorta can lead to stroke and perfusion related tissue damage during cardiopulmonary bypass. A thorough understanding of how the angle of cannulation affects the overall success of cardiopulmonary bypass during cannulation of the ascending aorta is needed. Previous simulation research has observed the effect of outflow cannula position by changing the location of the cannulation site to the subclavian artery and other vessels, as well as positions for innovative cannula designs. The purpose of this study is to evaluate the success of the procedure while using a straight cannula, modulating the angle of cannulation below horizontal in the frontal plane. A simplified geometry of the aorta was used. The success of the procedure was quantified by observing wall shear stress, normal stress, intra-fluid shear stress, and flow distribution. A numerical study was performed to solve the Reynolds Averaged Naiver Stokes governing equations, which were used in conjunction with a constant density fluid to simulate blood, and a realizable two-layer k-ε turbulence model
Peristaltic flow of blood through coaxial vertical channel with effect of mag...ijmech
The present paper investigates the effects of peristaltic flow of blood through coaxial vertical channel with
effect of magnetic field: blood flow study.The effects of various physical parameters on axial velocity and
pressure gradient have been computed numerically. It is observed that the maximum velocity increases
with increase in Magnetic field (M) even though for phase shiptııııı/ 4 for all the two cases
= - 0.5,
= -1. However, opposite effects are noticed for
= 0.5,
= 1.
Similar to SIMBIO_Conference_paper (Aikaterini_Stamou) (20)
Peristaltic flow of blood through coaxial vertical channel with effect of mag...
SIMBIO_Conference_paper (Aikaterini_Stamou)
1. Modelling stenosis development in the carotid artery at the early stages of
stenosis development
A.C.Stamou*, J.M.Buick**
*Faculty of Engineering and Computing, Coventry University, Priory Street, Coventry CV1 5FB, UK
**School of Engineering, Anglesea Building, Anglesea Road University of Portsmouth,
Portsmouth, PO1 3DJ, UK
Abstract: A numerical model is used to simulate the development of a stenosis in the carotid artery where the stenosis
forms in regions of stagnant flow. The blood flow properties are computed here using the Lattice Boltzmann Method. The
stenosed geometry is presented and found to be consistent with stenosed artery profiles from the literature. Flow fields are
also presented which indicate that the flow in the stenosed artery is also consistent with observations form the literature.
Keywords: Stenosis development; Blood flow modelling; Atheroscerosis; lattice Boltzmann Method; arterial wall
movement; stagnation
NOTATION
ei Grid link
fi (x,t) Distribution function
fi
(eq)
(x,t) Equilibrium distribution function
h Stenosis development step
i Lattice label
N Number of stagnant sites
SI Stagnation index
Ts Number of sites, originally in the blood flow, encroached by the developing stenosis
T Period
t Time
u Velocity
wi Weight function
x Position
Density
i Collision function
ω Vorticity
INTRODUCTION
Atherosclerosis is one of the major causes of ischemic stroke as it can drive the narrowing of the
blood vessels due to a built-up of plaque [1]. There is a mass of evidence suggesting that
atherosclerosis develops in regions where the velocity and wall shear stress are low [2-4]. Here we
consider how the development of the stenosis affects the haemodynamic characteristics of the carotid
artery. The blood flow is simulated using the Lattice Boltzmann Model (LBM). The LBM is relatively
novel technique to simulate fluid flow and is based on a mesoscopic kinematic approach. LBM
simulations have been considered where the blood flow affects a change in the boundary geometry. It
has been applied [5, 6] for blood clotting, either on a backward facing step or a pre-existing idealized
stenosis [7]. We simulate the development of the stenosis using a model based on [8], where here the
stenosis develops in regions of stagnant flow. The sites of maximum stagnation are assumed as the
most susceptible regions to the development of the stenosis
METHOD
The simulations are performed using the LBM to simulate the blood flow and using a stenosis growth
model to simulate the development of the stenosis.
2. LBM
In the LBM [9] the particle distributions, fi( 𝐱,t) at point 𝐱, at time t, are confined to move
synchronously on a regular lattice. The distribution functions interact on the lattice in such a way that
they conserve mass and momentum, and they preserve isotropy and Galilean invariance. The D2Q9
LBM, used in this study, evolves according to the kinetic equation [9, 10]:
fi( 𝐱+ 𝐞i,t + 1) = fi( 𝐱,t) + Ωi( 𝐱,t) [1]
where i = 0,1, …, 8 labels the link directions of the underlying grid, given by:
𝐞0 = (0,0)
𝐞i = (cos(
π
2
(i − 1)) sin (
π
2
(i − 1))) for i = 1,2,3,4 [2]
𝐞i = √2(cos (
π
2
(i − 1) +
π
4
) sin (
π
2
(i − 1)) +
π
4
) for i = 5,6,7,8,
fi is the distribution function for each of the discrete link directions and Ω𝑖 is the collision operator.
The fluid density, ρ, and velocity, u, can be calculated from the distribution functions at each node by:
ρ= ∑ fii and ρu=∑ fii 𝐞i . [3]
The collision operator, Ω𝑖 , is given by the Bhatnaghar-Gross-Krook approximation [10], as:
Ω𝑖 = −
1
τ
[fi( 𝐱,t) − fi
eq
( 𝐱,t)] [4]
where τ is the relaxation time and fi
eq
( 𝐱,t) is the equilibrium value of the distribution function:
fi
eq
( 𝐱,t) = wiρ(1 + 3𝐞i ∙ 𝐮 +
9
2
( 𝐞i ⋅ 𝐮)2 −
3
2
𝐮 𝟐), [5]
where w0 =
4
9
, w1 = w2 = w3 = w4 =
1
9
and w5 = w6 = w7 = w8 =
1
36
.
A sub-grid extrapolation boundary scheme [11] is applied at the solid boundaries and the cardiac
pulse is introduced at the inflow boundary. The form of the pulse is presented in the results section.
Stenosis Growth Model
The development of the stenosis is modelled following [8], where the artery wall is adjusted by a
small step, set here to be 0.5 of a lattice spacing, each period of motion; at a position determined by
the local haemodynamic properties. Here the position for the development of the stenosis is selected
based on the Stagnation Index:
SI = N/T [6]
where T is the period of the cardiac pulse and N is the number of time-steps in a period when the
near-wall velocity (defined to be the velocity one lattice spacing from the wall) at a given site is less
than 1% of the average near-wall velocity, over the whole of the wall, a period earlier. The position
selected, after each period, for the stenosis to develop, is the wall point where SI is maximum.
3. RESULTS
As observed in [8], the stenosis is formed in layers which are built up on the outer walls of the
External Carotid Artery (ECA) and the Internal Carotid Artery (ICA). After each layer is completed a
new layer starts, either on the same artery wall or on the opposite wall. This is shown in Figure 1 at
times when a switch occurs between the ICA, on the right of the image, and the ECA, shown on the
left.
The layers are depicted in terms of Ts which represents the number of grid sites, originally in the
blood flow region, which have been encroached by the growing stenosis. Ts gives a measure of the
level of stenosis development. The development occurs on the ECA below the bifurcation, while in
the ICA the stenosis occurs from slightly below the bifurcation and extends significantly in to the
ICA. Although the geometry of a stenosis can vary significantly from patient to patient, the profile
shown in Figure 1 has geometrical similarities to some imaged stenosed arteries [12, 13].
Figure 1. The development of the stenosis in layers
Flow profiles
The effect of the stenosis growth on the blood flow for a stenosed artery (corresponding to Ts = 754 in
Figure 1) is shown in Figure 2 for the velocity and Figure 3 for the vorticity, where the stenosed artery
is shown on the left and the corresponding healthy artery is shown on the right. The profiles are
shown at t = 4T/66 (parts a and b) corresponding to the acceleration phase; t = 7T/66 (parts c and d)
corresponding to approximately the peak velocity; and t = 12T/66 (parts e and f) corresponding to the
deceleration phase.
In Figures 2 and 3, the driving pulse and healthy geometry are shown as an insert in each figure, while
the pulse phase and the stenosed geometry are depicted in the inserts by the red dot and the red
geometry respectively.
A higher velocity is observed in both the ICA and the ECA for the stenosed case, relative to the
healthy artery. This is in agreement with other studies [14, 15] which predicted a high velocity jet at
the base of the ICA and ECA. Significant vorticity develops in the healthy artery towards the bottom
of both the ICA and ECA. This can be seen to develop at the peak flow in Figure 3d and fully develop
during the deceleration phase, Figure 3f. In contrast, the simulation results for the stenosed artery
4. (Figure 3 c and e) show that the vortex motion is no longer present in the artery. Figure 1, shows that
the region where the vortex motion develops in the healthy artery corresponds to the region where the
stenosis forms. The change in the artery geometry in this region explains this change in the blood
flow. This is in accordance with earlier observations [15] reported in the literature.
Figure 2a. Stenosed artery velocity field at t=4T/66 Figure 2b. Healthy artery velocity field at t=4T/66
Figure 2c. Stenosed artery velocity field at t=7T/66 Figure 2d. Healthy artery velocity field at t=7T/66
Figure 2e. Stenosed artery velocity field at t=12T/66 Figure 2f. Healthy artery velocity field at t=12T/66
5. Figure 3a. Stenosed artery vorticity field at t=4T/66 Figure 3b. Healthy artery vorticity field at t=4T/66
Figure 3c. Stenosed artery vorticity field at t=7T/66 Figure 3d. Healthy artery vorticity field at t=7T/66
Figure 3e. Stenosis artery vorticity field at t=12T/66 Figure 3f. Healthy artery vorticity field at t=12T/66
6. CONCLUSION
A numerical model for stenosis growth has been considered. The position of the stenosis has been
simulated here based on regions of flow stagnation. This is based on the observation that regions of
low velocity have been considered as the prone sites to the atherosclerosis. The stenosis formed on the
outer wall of both the ICA and the ECA in the region where vortex motion develops in the healthy
artery. This is consistent with regions where stenosis formation has been observed in the literature.
The changing flow patterns in the artery with the formed stenosis were shown to be consistent with
the literature. In particular an increased velocity was observed in both the ICA and the ECA.
Additionally the vortices which were observed in the healthy artery were no longer present once the
stenosis had formed. The results suggest that the stagnation model provides a realistic approach to
simulating stenosis growth.
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