This document provides guidelines for Siddha practitioners for treating COVID-19. It discusses the current status of COVID-19 in India, how the Siddha system views epidemics/pandemics, and provides recommendations for preventive care, anti-virals, immunity boosters, and symptom-specific treatments. The guidelines include formulations, herbs, and procedures to enhance immunity and treat mild, moderate, and comorbid cases of fever and respiratory illness associated with COVID-19. External therapies like fomentation and varmam are also described.