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The document discusses the benefits of exercise for mental health. It states that regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness and well-being.
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#公園廃止 納得しない地権者「苦情が寄せられたから廃止か」「何を言われてもだめ」 公園緑地課交渉記録(抜粋)
青木島遊園地廃止について報告するための日程調整の申し入れに、反発する地権者。但し、2回目の交渉では廃止に関わる手続きの説明を受け入れている。
土地開発のための廃止等、地権者の名誉に関わるデマがネット上に見られるため、抜粋して公表。遊園地廃止推進派から存続派に対し、地権者の都合を考えろ等の批判を浴びせることがあるが、いささか的外れに感じる。
#公園廃止 荻原市長が議会を恫喝!? - 不都合な動画配信ストップが目的か
小泉による反論:
文書が指摘していると思われる動画は、全て青木島遊園地に関するもので、不都合な情報を統制しようという市長の思惑によるもの。
「回答が市の公式見解として視聴者が受け取る可能性があり、未確定の内容であったときには市民に誤解を与え、ひいては市政に混乱を招く危険性もある。」
そのような危険性があるのなら、「回答できません」「即答できないので調べます」と言えばよいハナシで、混乱を招くとすれば市の責任。電話照会に対する市の回答は、そんなにいい加減なものなのか?
「職員の氏名を視聴者が特定できる場合には、配信された内容如何によっては職員に対する誹謗中傷や攻撃につながりかねない。」
「誹謗中傷や攻撃につながりかねない」回答とはどんなものか想像もつかないが、そんな回答をする方にこそ問題がある。小泉が県職員だったときは、必ず名乗れる仕事をしろと教わった。しっかり職員を教育していただきたい。
「ライブ配信されるこうした行為により、職員は通常とは異なる状況下での対応を強いられることから、当該行為は職員に心理的圧迫を与え、職員を委縮させることにつながる。」
窓口での撮影の場合は、撮影はは止めてくださいと言えば済む話。そもそも窓口での動画は職員を映しておらず、小泉の法にカメラを向けている。
「職員の公正な職務執行を妨げ、又はその権限若しくは地位による影響力を不正に行使する働きかけを禁じた長野市議会議員の政治倫理に関する条例第３条第４号に抵触する可能性があると考えられる。」
職務がどのように妨げられたのか。小泉の照会への回答がいつになるのか、荻原健司氏の日程の照会、区長の持つ権限についての質問により、どのような不都合が生じたのか。小泉が「働きかけ」たというが、何を働きかけたのか。
「議員からの市政に関する問い合わせとはいえ、その状況をYouTubeで配信する合理的な理由はなく」
大きなお世話です。
「その行為は当該議員の宣伝行為とも受け取れ、議員の品位及び名誉を傷つけ、市民の信頼を損なう行為を禁じた同条第１号
に抵触する可能性があると考えられる。」
宣伝が目的なら、何百も視聴されません。市長の動画は公費で作っているが、自己宣伝が目的ては決して言いません。
https://www.youtube.com/watch?v=aiJfZr9Z6ew
「昨年末には、本市への情報公開請求により取得した情報をインターネットサイトに掲載したことで個人の特定につながり、市政運営に対する信頼を著しく損ねた」
情報公開決定したのは長野市であって、責任転嫁も甚だしい。なお、議会が厳重注意したのは、このような内容に対してではない。
「 これまで市議会とは、市政運営の両輪の役割を担う中で、緊張感を保ちながらも健全な関係を築いてきた。これまでの度重なる行為に加え、今回の行為は市議会との信頼関係に大きく影響を与えるおそれがあり、ひいては 市議会との関係性を見直さざるを得ない事態につながりかねないものであると憂慮している。」
市長は市議会を恫喝するのか。
Quran with Tajwid Surah 114 ﴾القرآن سورۃ الناس﴿ An-Nas 🙪 PDF
LIST OF SURAHS ► https://plus.google.com/+CallertoislamTk-site/posts/eF8NukHeGDB
Quran with Tajwid Surah 91 ﴾القرآن سورۃ الشمس﴿ Ash-Shams 🙪 PDF
LIST OF SURAHS ► https://plus.google.com/+CallertoislamTk-site/posts/eF8NukHeGDB
Recommended
#公園廃止 納得しない地権者「苦情が寄せられたから廃止か」「何を言われてもだめ」 公園緑地課交渉記録(抜粋)
青木島遊園地廃止について報告するための日程調整の申し入れに、反発する地権者。但し、2回目の交渉では廃止に関わる手続きの説明を受け入れている。
土地開発のための廃止等、地権者の名誉に関わるデマがネット上に見られるため、抜粋して公表。遊園地廃止推進派から存続派に対し、地権者の都合を考えろ等の批判を浴びせることがあるが、いささか的外れに感じる。
#公園廃止 荻原市長が議会を恫喝!? - 不都合な動画配信ストップが目的か
小泉による反論:
文書が指摘していると思われる動画は、全て青木島遊園地に関するもので、不都合な情報を統制しようという市長の思惑によるもの。
「回答が市の公式見解として視聴者が受け取る可能性があり、未確定の内容であったときには市民に誤解を与え、ひいては市政に混乱を招く危険性もある。」
そのような危険性があるのなら、「回答できません」「即答できないので調べます」と言えばよいハナシで、混乱を招くとすれば市の責任。電話照会に対する市の回答は、そんなにいい加減なものなのか?
「職員の氏名を視聴者が特定できる場合には、配信された内容如何によっては職員に対する誹謗中傷や攻撃につながりかねない。」
「誹謗中傷や攻撃につながりかねない」回答とはどんなものか想像もつかないが、そんな回答をする方にこそ問題がある。小泉が県職員だったときは、必ず名乗れる仕事をしろと教わった。しっかり職員を教育していただきたい。
「ライブ配信されるこうした行為により、職員は通常とは異なる状況下での対応を強いられることから、当該行為は職員に心理的圧迫を与え、職員を委縮させることにつながる。」
窓口での撮影の場合は、撮影はは止めてくださいと言えば済む話。そもそも窓口での動画は職員を映しておらず、小泉の法にカメラを向けている。
「職員の公正な職務執行を妨げ、又はその権限若しくは地位による影響力を不正に行使する働きかけを禁じた長野市議会議員の政治倫理に関する条例第３条第４号に抵触する可能性があると考えられる。」
職務がどのように妨げられたのか。小泉の照会への回答がいつになるのか、荻原健司氏の日程の照会、区長の持つ権限についての質問により、どのような不都合が生じたのか。小泉が「働きかけ」たというが、何を働きかけたのか。
「議員からの市政に関する問い合わせとはいえ、その状況をYouTubeで配信する合理的な理由はなく」
大きなお世話です。
「その行為は当該議員の宣伝行為とも受け取れ、議員の品位及び名誉を傷つけ、市民の信頼を損なう行為を禁じた同条第１号
に抵触する可能性があると考えられる。」
宣伝が目的なら、何百も視聴されません。市長の動画は公費で作っているが、自己宣伝が目的ては決して言いません。
https://www.youtube.com/watch?v=aiJfZr9Z6ew
「昨年末には、本市への情報公開請求により取得した情報をインターネットサイトに掲載したことで個人の特定につながり、市政運営に対する信頼を著しく損ねた」
情報公開決定したのは長野市であって、責任転嫁も甚だしい。なお、議会が厳重注意したのは、このような内容に対してではない。
「 これまで市議会とは、市政運営の両輪の役割を担う中で、緊張感を保ちながらも健全な関係を築いてきた。これまでの度重なる行為に加え、今回の行為は市議会との信頼関係に大きく影響を与えるおそれがあり、ひいては 市議会との関係性を見直さざるを得ない事態につながりかねないものであると憂慮している。」
市長は市議会を恫喝するのか。
Quran with Tajwid Surah 114 ﴾القرآن سورۃ الناس﴿ An-Nas 🙪 PDF
LIST OF SURAHS ► https://plus.google.com/+CallertoislamTk-site/posts/eF8NukHeGDB
Quran with Tajwid Surah 91 ﴾القرآن سورۃ الشمس﴿ Ash-Shams 🙪 PDF
LIST OF SURAHS ► https://plus.google.com/+CallertoislamTk-site/posts/eF8NukHeGDB
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RNA INTERFERENCE: UNRAVELING GENETIC SILENCING
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
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The ASGCT Annual Meeting was packed with exciting progress in the field advancing efforts to deliver highly promising therapies to more patients.
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Leaf initiation, growth and differentiation, genetic control of leaf development.
Richard's aventures in two entangled wonderlands
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate Pathway
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
SCHIZOPHRENIA Disorder/ Brain Disorder.pdf
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Structural Classification Of Protein (SCOP)
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
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