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İnflamatuvar Barsak Hastalıklarında
Eklem Tutulumu
Dr. H. Seval Pehlevan
Fatih Üniversitesi Tıp Fakültesi
Romatoloji BD.
Spondiloartropatiler
Çocukluk çağı
SPA
İnflamatuvar
barsak
hastalıkları
Ankilozan Spondilit
Reaktif artrit
Sınıflandırılmayan
SPA
• Spondilit ve sakroiliit
• Tip I eklem tutulumu
• Tip II eklem tutulumu
Spondilit ve sakroiliit
• Bel, kalça ve sırt ağrısı
• Uzun süreli dinlenme sonrası tutukluk
• Sabah tutukluğu
• Erkek hastalar daha sık tutulur
• Barsak semptomları ile ilişkisizdir
• Muayene bulgusu omurganın öne eğilmesinde kısıtlılık ve göğüs
genişlemesinde azalma vardır.
Tip I eklem tutulumu
• Ani başlangıçlıdır
• Altı veya daha az eklem tutulur
• Hastalığın alevlenmesi ile ilişkilidir
• Genellikle kendi kendine iyileşebilir
• Eklemde sakatlık bırakmaz
• Diz en sık etkilenen eklemdir
• Barsak hastalığı tanısından önce de olabilir
Tip II eklem tutulumu
• Çok sayıda eklem tutulur
• En sık el eklemleri tutulur
• Eklemdeki iltihap aylarca sürebilir ve tekrarlayabilir
• Bu olaylar yıllarca devam edebilir
• Eklem tutulumu barsak hastalığından önce çok nadirdir
• Eklem şikayetleri barsak şikayetleri ile paralel değildir.
Muayene bulguları
• Muayene bulgusu omurganın öne eğilmesinde kısıtlılık ve göğüs
genişlemesinde azalma vardır.
• Tüm eklemlerde hassasiyet ve şişlik muayene edilir
• Entesopati muayenesi
Laboratuvar bulguları
• Tam kan sayımı
• Sedimentasyon
• CRP
• HLA B27 (Omurga tutulumlu hastaların%50-75)
• Eklem sıvısı incelemesi (septik artrit dışlanmalıdır, özellikle
immunsupressif ilaç kullanan hastalarda risk fazladır)
• Eklem zarının biyopsisi
Radyoloji
Tedavi
• Ağrı kesiciler
• Salozopyrin
• İmuran
• Kortizon
• Biyolojik tedavi
• İlaç dışı Egzersiz
1-Spondilit-Sakroiliit
2-Tip I eklem tutulumu
3-Tip 2 eklem tutulumu

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Dr. H. Seval Pehlevan İBH'de Romatoloji Hastalıklar ve Tedavisi

  • 1. İnflamatuvar Barsak Hastalıklarında Eklem Tutulumu Dr. H. Seval Pehlevan Fatih Üniversitesi Tıp Fakültesi Romatoloji BD.
  • 3.
  • 4. • Spondilit ve sakroiliit • Tip I eklem tutulumu • Tip II eklem tutulumu
  • 5. Spondilit ve sakroiliit • Bel, kalça ve sırt ağrısı • Uzun süreli dinlenme sonrası tutukluk • Sabah tutukluğu • Erkek hastalar daha sık tutulur • Barsak semptomları ile ilişkisizdir • Muayene bulgusu omurganın öne eğilmesinde kısıtlılık ve göğüs genişlemesinde azalma vardır.
  • 6. Tip I eklem tutulumu • Ani başlangıçlıdır • Altı veya daha az eklem tutulur • Hastalığın alevlenmesi ile ilişkilidir • Genellikle kendi kendine iyileşebilir • Eklemde sakatlık bırakmaz • Diz en sık etkilenen eklemdir • Barsak hastalığı tanısından önce de olabilir
  • 7. Tip II eklem tutulumu • Çok sayıda eklem tutulur • En sık el eklemleri tutulur • Eklemdeki iltihap aylarca sürebilir ve tekrarlayabilir • Bu olaylar yıllarca devam edebilir • Eklem tutulumu barsak hastalığından önce çok nadirdir • Eklem şikayetleri barsak şikayetleri ile paralel değildir.
  • 8. Muayene bulguları • Muayene bulgusu omurganın öne eğilmesinde kısıtlılık ve göğüs genişlemesinde azalma vardır. • Tüm eklemlerde hassasiyet ve şişlik muayene edilir • Entesopati muayenesi
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16. Laboratuvar bulguları • Tam kan sayımı • Sedimentasyon • CRP • HLA B27 (Omurga tutulumlu hastaların%50-75) • Eklem sıvısı incelemesi (septik artrit dışlanmalıdır, özellikle immunsupressif ilaç kullanan hastalarda risk fazladır) • Eklem zarının biyopsisi
  • 18.
  • 19. Tedavi • Ağrı kesiciler • Salozopyrin • İmuran • Kortizon • Biyolojik tedavi • İlaç dışı Egzersiz 1-Spondilit-Sakroiliit 2-Tip I eklem tutulumu 3-Tip 2 eklem tutulumu

Editor's Notes

  1. Type I arthropathy — In type I arthropathy, the peripheral arthritis tends to be acute, is pauciarticular (affecting six or fewer joints), is often associated with flares of the bowel disease, occurs early in the course of the bowel disease, is self-limiting (90 percent under 6 months), and does not result in joint deformities [9,15]. The knee is most commonly affected. Five percent of IBD patients develop type I arthropathy. Joint symptoms may occur prior to the onset of symptoms suggestive of bowel disease.
  2. Type I arthropathy — In type I arthropathy, the peripheral arthritis tends to be acute, is pauciarticular (affecting six or fewer joints), is often associated with flares of the bowel disease, occurs early in the course of the bowel disease, is self-limiting (90 percent under 6 months), and does not result in joint deformities [9,15]. The knee is most commonly affected. Five percent of IBD patients develop type I arthropathy. Joint symptoms may occur prior to the onset of symptoms suggestive of bowel disease.
  3. Type II arthropathy — In Type II arthropathy, patients have polyarticular disease, with metacarpophalangeal (MCP) joints being particularly involved [9]. Other joints (knees, ankles, elbows, shoulders, wrists, proximal interphalangeal [PIP], and metatarsophalangeal [MTP] joints) are less often affected. Approximately one-half of the patients with IBD have migratory arthritis. Active synovitis may persist for months, and may recur repeatedly. Episodes of exacerbations and remissions may continue for years. Type II arthropathy affects 3 to 4 percent of patients with IBD. Articular involvement rarely precedes the diagnosis of IBD, and joint symptoms typically do not parallel the activity of bowel disease
  4. The peripheral white blood cell count, hematocrit, erythrocyte sedimentation rate, and serum C-reactive protein concentration usually reflect the activity of the intestinal disease and are therefore of little help in assessing arthritis or spondylitis. Serum levels of rheumatoid factor are not elevated. HLA-B27 is found in 50 to 75 percent of the patients with axial arthritis [11]. An increase in frequency in HLA-B27, B35, and DRB1*0103 has been described in those with a type I peripheral arthritis; type II arthropathy has been associated with HLA-B44 (and not B27) [9]. While the reported HLA associations are of interest, HLA typing has no role in management of individual patients. Synovial fluids have yielded from 5000 to 12,000 white blood cells per microliter, predominantly polymorphonuclear leukocytes [11,12]. Synovial membrane biopsies reveal nonspecific abnormalities, including: proliferation of synovial lining cells, increased vascularity, and infiltration of mononuclear cells [11,12].