This document compares accessibility standards Section 508 and EN 301 549. It provides side-by-side comparisons of various accessibility criteria between the two standards. Some key differences noted are that Section 508 specifies the non-visual mode of operation must use speech output, while EN 301 549 allows for other non-visual modes. EN 301 549 also refers to specific standards for magnetic coupling of hearing technologies. The standards also take different approaches to calculating minimum text size, with Section 508 assuming a fixed screen distance and EN 301 549 accounting for variable distances.