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Santanu 06-26-2020 corrected by Dr S Dey.pdf
The document discusses various retrosynthetic analysis pathways for constructing 1,3-dicarbonyl and 1,5-dicarbonyl compounds. These include retro-aldol, retro-Michael, retro-Claisen, and retro-Diels-Alder reactions. It also notes that using a Cr(VI) reagent should be avoided as it can produce cyclohexenone as a side product, and recommends a route that uses a methylvinyl ketone, methyl iodide, and an aldol reaction.
Santanu 06-26-2020 corrected by Dr S Dey.pdf
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- 5. DIS (1,5-Dicarbonyl) Avoid Cr(VI) reagentbecause it provides cyclohexenone as side pdt. Allylic C-H oxidation pdt.
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- 13. 1st introduce methylvinyl ketone,then methyl iodide and then aldol reaction to cyclize 1.Base 2. 1. Base (1 eq.) 2. Me-I
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