Development of Microbiome-based medicine

1. The GMO-microbiome
drug development landscape
April 2022

2. Different therapeutic approaches
employed by pharmabiotic companies
1.
FMT
2. Defined
Consortium
3. Single
Strain
8. GMO
Microorganisms
5. Diagnostics
7. Molecules for
the Microbiome
6. Phages
Adapted from Olle, 2013
4. Molecules from the
microbiome
©Copyright Sandwalk BioVentures 2022

3. Uses of GMOs in microbiome therapeutics
Expand Metabolic Activity Drug Delivery Systems Vaccines Gene Therapy
Metabolize Harmful
Substances
5-FC 5-FU
Proteins /
Peptides
Killer
Plasmids
Eg. Phe in PKU
Activate
(Pro)drugs
On-site
GMO
Off-site
GMO
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4. Infectious
diseases
23%
Oncology
21%
Immune-
mediated
diseases
16%
Metabolic
diseases
15%
Gastrointestinal
diseases
7%
Other
6%
Dermatology
5%
N/A
4%
Gut-brain axis
3%
GMOs mainly target infectious diseases,
immuno-oncology and metabolic diseases
Source: The Microbiome Drug Database™
©Copyright Sandwalk BioVentures 2022

5. 0
50
100
150
200
250
300
350
400
Infectious
diseases
Oncology Immune diseases Metabolic
diseases
Gastrointestinal
diseases
Other Dermatology Gut-brain axis
Number
of
Active
Programs
GMO approach overrepresented in
Metabolic, underrepresented in Neurology
Application – all approaches
Application – GMO
Source: The Microbiome Drug Database™
©Copyright Sandwalk BioVentures 2022

6. GMO was the top recipient of funds in
2021, followed closely by Diagnostics
-
200
400
600
800
1.000
1.200
1.400
1.600
1.800
2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021
Total
Dilutive
Funding
(€M)
GMO Microorganisms Defined consortia Single Strain
Phages and viruses FMT N/A & Other
Molecules from the microbiome Molecules for the microbiome Diagnostics
Source: The Microbiome Drug Database™
©Copyright Sandwalk BioVentures 2022
2021
Top recipient
3
1
2
3
1
2
3

7. Resources
Access the Microbiome Drug Database™
Download this presentation at
www.sandwalkbio.com
©Copyright Sandwalk BioVentures 2022

8. info@sandwalkbio.com
/sandwalkbio
www.sandwalkbio.com
Dr. Luis Gosálbez
Managing Director & Co-Founder
Sandwalk BioVentures
luis@sandwalkbio.com