Salvia is a perennial herb native to Oaxaca, Mexico that contains the psychoactive compound salvinorin A. It is commonly chewed, drank, or smoked for its brief hallucinogenic effects lasting 1-30 minutes. While salvia is legal in some states and countries, 21 U.S. states have passed laws regulating or controlling its use due to lack of research on its physical and psychological effects. More research is needed to understand salvia's effects on the brain and potential risks.