A 60-year-old female presented with a 3x3cm swelling in the upper outer quadrant of her right breast, associated with pain and nipple retraction. Examination and imaging revealed an invasive grade II carcinoma in the right breast and enlarged lymph nodes in the right axilla. PET CT showed the breast mass and a metabolically active right axillary lymph node but no distant metastases. The tumor board consensus was that the working diagnosis was carcinoma of the right breast T2N1M0 and the treatment plan was modified radical mastectomy with adjuvant chemotherapy.
WOund evaluation and preparatioacfoeding to the medicinen.pptxAruneshVenkataraman
This document provides information on wound evaluation and wound bed preparation. It discusses the following key points in 3 sentences:
The universal principles of wound management include thorough evaluation of the wound, obtaining source control, eliminating confounding factors, optimizing the wound environment for healing, and closing the wound. Proper wound assessment involves determining details of the wound like location, cause, age, depth and type as well as patient factors. Chronic wounds require preparation of the wound bed through debridement to remove non-viable tissue, control of infection, maintaining proper moisture balance, and promoting epithelial growth to close the wound.
The document summarizes the key components of a comprehensive wound assessment. It states that a holistic assessment is essential to identify factors that may impact wound healing. The assessment includes general information about the patient as well as a focused wound assessment. The wound assessment examines characteristics of the wound like type, size, tissue status, exudate, surrounding skin, odor, and pain level. Identifying the presence of slough, eschar, granulation tissue or epithelialization is also important. The document emphasizes the importance of assessing the full patient and wound to determine the appropriate treatment plan.
A 60-year-old female presented with a 3x3cm swelling in the upper outer quadrant of her right breast, associated with pain and nipple retraction. Examination and imaging revealed an invasive grade II carcinoma in the right breast and enlarged lymph nodes in the right axilla. PET CT showed the breast mass and a metabolically active right axillary lymph node but no distant metastases. The tumor board consensus was that the working diagnosis was carcinoma of the right breast T2N1M0 and the treatment plan was modified radical mastectomy with adjuvant chemotherapy.
WOund evaluation and preparatioacfoeding to the medicinen.pptxAruneshVenkataraman
This document provides information on wound evaluation and wound bed preparation. It discusses the following key points in 3 sentences:
The universal principles of wound management include thorough evaluation of the wound, obtaining source control, eliminating confounding factors, optimizing the wound environment for healing, and closing the wound. Proper wound assessment involves determining details of the wound like location, cause, age, depth and type as well as patient factors. Chronic wounds require preparation of the wound bed through debridement to remove non-viable tissue, control of infection, maintaining proper moisture balance, and promoting epithelial growth to close the wound.
The document summarizes the key components of a comprehensive wound assessment. It states that a holistic assessment is essential to identify factors that may impact wound healing. The assessment includes general information about the patient as well as a focused wound assessment. The wound assessment examines characteristics of the wound like type, size, tissue status, exudate, surrounding skin, odor, and pain level. Identifying the presence of slough, eschar, granulation tissue or epithelialization is also important. The document emphasizes the importance of assessing the full patient and wound to determine the appropriate treatment plan.
AN INTRIGUING CASE SERIES ON INTESTINAL OBSTRUCTION IN TB ABDOMEN FINAL.pptxAruneshVenkataraman
This document presents two case studies of intestinal obstruction in patients with tuberculosis (TB) of the abdomen. Case 1 involved a 55-year-old female who presented with abdominal pain and constipation and was found to have adhesive intestinal obstruction due to dense adhesions, requiring emergency laparotomy. Case 2 involved a 48-year-old female with a 6-month history of abdominal pain, vomiting, and weight loss diagnosed with extrapulmonary TB, who developed paralytic ileus due to severe hypokalemia rather than a mechanical obstruction, and was managed conservatively with potassium correction. The key message is that not all cases of intestinal obstruction in TB abdomen require operative management, as paralytic ileus can cause symptoms
A 56-year-old female presented with a swelling over the dorsum of her right hand for 2 months along with an ulcer over the dorsum of her right wrist for 2 months. On examination, there was a 4x4x2 cm firm swelling over the dorsum of the right hand with restricted mobility. She had finger drop of the index and middle fingers of the right hand. The differential diagnoses included malignant peripheral nerve sheath tumor of the posterior interosseous nerve with posterior interosseous nerve palsy of the right hand and ruptured ganglion cyst over the right wrist.
This document summarizes various types of aneurysms and vasculitis. It discusses abdominal aortic aneurysms as the most common type of aneurysm. The main risk factors, presentations, diagnostic modalities, and surgical treatments are described. It also discusses other peripheral aneurysms such as popliteal aneurysms. Several types of vasculitis are briefly covered including Buerger's disease, temporal arteritis, and Takayasu arteritis.
This document presents a case study of a 55-year-old male patient with a 3-month history of an ulceroproliferative growth on the right side of his tongue. On examination, a 4x3 cm proliferative growth was found on the right lateral border of the tongue extending to the tip and crossing the midline. An enlarged lymph node was palpable on the right side of the neck. Based on the clinical findings and planned investigations, the diagnosis was carcinoma of the tongue with bilateral cervical nodal metastasis at clinical stage T4aN2cM0. The recommended treatment was concurrent chemoradiation.
NAME- REG NO- STATE OF REGISTRATION: MOBILE NO- TRANSACTION ID- 👆JUST COPY &...AruneshVenkataraman
1. Mr. Nagappan, a 42-year-old male, presented with abdominal pain and was found to have an infiltrating adenocarcinoma in his rectum.
2. Imaging found a large tumor involving the rectum and sigmoid colon. He underwent neoadjuvant chemoradiation.
3. Follow up imaging after treatment showed the tumor remained infiltrating the bowel wall and surrounding structures, with enlarged lymph nodes. Further PET scan was advised to evaluate for surgery.
A 55-year-old male patient presented with a growth on his tongue for 3 months following trauma. The growth began on the right side of the tongue and had rapidly progressed to involve the tip and left side. It was associated with pain, difficulty speaking and chewing, excessive salivation, and ear pain. Examination revealed a 4x3cm proliferative growth involving over half the tongue and fixing it to the floor of mouth. Bilateral enlarged cervical lymph nodes were present, with the right level 1b node being enlarged and fixed. The diagnosis was carcinoma of the tongue with intrinsic muscle involvement and bilateral lymph node metastasis at clinical stage T4aN2cM0. The proposed treatment was subtotal glossectomy
Abdominal tuberculosis can present with varied and nonspecific symptoms, making diagnosis challenging. Imaging and laboratory tests are also nonspecific. A high index of suspicion is needed, along with aggressive investigation. Treatment primarily involves medical therapy with antitubercular drugs, though surgery may be needed in some cases. Not all cases of intestinal obstruction in abdominal tuberculosis have a mechanical cause. The second case report describes a patient who developed a paralytic ileus from hypokalemia leading to a subacute obstruction, not requiring surgery. A diagnostic trial of antitubercular therapy is reasonable in endemic regions while also considering conservative management.
Safe cholecystectomy requires understanding of anatomy, mechanisms, and predictors of injury to ensure safety for both patient and surgeon. Key aspects include proper gallbladder retraction to identify structures like the hepatocystic triangle, cystic plate, and Rouviere's sulcus. Dissection must be done carefully in relation to these structures. The critical view of safety, where only two structures (cystic duct and artery) enter the gallbladder within the cleared hepatocystic triangle, must be achieved before division. Intraoperative imaging and bailout strategies can help if there is ambiguity.
09 Dr.Kannan Fistula in ano chennai (21-07-2023) Final.pptxAruneshVenkataraman
The document discusses locating the internal opening of a fistula in ano. It provides information on the clinical presentation and classifications of fistulas. Methods for locating the internal opening are described, including digital examination, probing, and injecting saline or dye into the external opening. Imaging modalities like MRI and endorectal ultrasound can help identify complex anatomies. The key takeaway is that failure to find the internal opening significantly increases the risk of recurrence after surgery to treat the fistula.
This document provides information on gastric carcinoma, including:
1. It describes the classification, epidemiology, risk factors, pathogenesis, histology, staging, clinical features, investigations, and management of gastric adenocarcinoma.
2. The main risk factors include H. pylori infection, dietary nitrites, genetic mutations, and polyps. Gastric adenocarcinoma is classified based on cell type, location, depth of invasion, and metastasis.
3. Management involves endoscopic resection for early cancers, while advanced cancers are treated with surgery such as gastrectomy, with or without chemotherapy and radiotherapy. Complications and palliative care are also discussed.
The document discusses the workup and diagnosis of liver masses. It describes various benign and malignant liver lesions including hemangioma, focal nodular hyperplasia, hepatic adenoma, liver cysts, hepatocellular carcinoma, cholangiocarcinoma, and metastases. Multiphasic CT is useful for characterizing lesions based on enhancement patterns in the arterial, portal venous, and delayed phases. Biopsy may be needed to confirm diagnosis of suspicious lesions.
This document discusses various liver conditions including liver abscesses, hydatid disease, and liver tumors. It provides details on:
1) The surgical anatomy of the liver including segments and fissures.
2) Causes, symptoms, diagnostic tests, and treatments for pyogenic and amoebic liver abscesses.
3) Causes, life cycle, clinical features, diagnosis with ultrasonography, and treatments including albendazole and surgery for hydatid liver disease.
4) Types of benign and malignant liver tumors including hemangiomas, focal nodular hyperplasia, hepatic adenomas, hepatocellular carcinoma, and hepatoblastoma. Risk factors, symptoms, diagnostic tests
This document outlines various protocols and procedures for operating theatres, including:
- Preparing meticulous operating theatre lists with patient details in advance for surgeons and staff.
- Maintaining various records and registers related to surgeries, sterilization, temperature control, microbiology testing, and more for documentation purposes.
- Following principles of sterile technique which include proper patient and surgical site preparation, aseptic handling of instruments, maintenance of different zones in the operating theatre, and other infection control measures.
A 58-year-old female presented with a lump in her right breast for 2 months, along with pain over the lump for 1 month. Examination found two lumps in the right breast measuring 3x2 cm and 4x3 cm. Ultrasound showed lesions in the right breast and multiple subcentimetric lymph nodes in the right axilla. Core needle biopsy revealed invasive ductal carcinoma (IDC), grade 3, estrogen receptor negative, HER2 neu negative, with a Ki67 of 40%. The working diagnosis was carcinoma of the right breast cT2N0M0, clinical stage IIA. The plan was for modified radical mastectomy followed by chemotherapy with or without radiotherapy and/or hormonal
This document summarizes a case of carcinoma in a 30-year-old female patient. She presented with a 1-year history of a left breast lump. Various tests were performed, including ultrasounds and biopsies. Initial tests showed proliferative breast disease without atypia. A recent trucut biopsy revealed invasive ductal carcinoma, grade II in the left breast. The working diagnosis is carcinoma of the right breast, stage IIA. The treatment plan is a wide local excision of the breast lump along with axillary staging and adjuvant chemotherapy and radiation therapy.
1. A 33-year-old woman presented with a 1-month history of a lump in her right breast. She underwent surgery at a private hospital where a biopsy revealed breast carcinoma.
2. Examination found sutured wound and induration in the right breast, with no palpable lump or skin changes. Axilla examination was normal.
3. Imaging found a 3.1x2.1cm irregular hypoechoic lesion in the right breast and enlarged lymph nodes in the right axilla. Further scans found no evidence of metastasis.
A 55-year-old man presented with 7 months of upper abdominal pain, vomiting, loose stools, and weight loss. Imaging showed a large irregular mass in the stomach wall communicating with the transverse colon, indicative of a gastrocolic fistula. Biopsy confirmed a diagnosis of moderately differentiated adenocarcinoma of the stomach with metastases to the liver and lymph nodes. The tumor board consensus was that the patient was suitable for palliative resection and diversion procedure or feeding jejunostomy, followed by chemotherapy.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
AN INTRIGUING CASE SERIES ON INTESTINAL OBSTRUCTION IN TB ABDOMEN FINAL.pptxAruneshVenkataraman
This document presents two case studies of intestinal obstruction in patients with tuberculosis (TB) of the abdomen. Case 1 involved a 55-year-old female who presented with abdominal pain and constipation and was found to have adhesive intestinal obstruction due to dense adhesions, requiring emergency laparotomy. Case 2 involved a 48-year-old female with a 6-month history of abdominal pain, vomiting, and weight loss diagnosed with extrapulmonary TB, who developed paralytic ileus due to severe hypokalemia rather than a mechanical obstruction, and was managed conservatively with potassium correction. The key message is that not all cases of intestinal obstruction in TB abdomen require operative management, as paralytic ileus can cause symptoms
A 56-year-old female presented with a swelling over the dorsum of her right hand for 2 months along with an ulcer over the dorsum of her right wrist for 2 months. On examination, there was a 4x4x2 cm firm swelling over the dorsum of the right hand with restricted mobility. She had finger drop of the index and middle fingers of the right hand. The differential diagnoses included malignant peripheral nerve sheath tumor of the posterior interosseous nerve with posterior interosseous nerve palsy of the right hand and ruptured ganglion cyst over the right wrist.
This document summarizes various types of aneurysms and vasculitis. It discusses abdominal aortic aneurysms as the most common type of aneurysm. The main risk factors, presentations, diagnostic modalities, and surgical treatments are described. It also discusses other peripheral aneurysms such as popliteal aneurysms. Several types of vasculitis are briefly covered including Buerger's disease, temporal arteritis, and Takayasu arteritis.
This document presents a case study of a 55-year-old male patient with a 3-month history of an ulceroproliferative growth on the right side of his tongue. On examination, a 4x3 cm proliferative growth was found on the right lateral border of the tongue extending to the tip and crossing the midline. An enlarged lymph node was palpable on the right side of the neck. Based on the clinical findings and planned investigations, the diagnosis was carcinoma of the tongue with bilateral cervical nodal metastasis at clinical stage T4aN2cM0. The recommended treatment was concurrent chemoradiation.
NAME- REG NO- STATE OF REGISTRATION: MOBILE NO- TRANSACTION ID- 👆JUST COPY &...AruneshVenkataraman
1. Mr. Nagappan, a 42-year-old male, presented with abdominal pain and was found to have an infiltrating adenocarcinoma in his rectum.
2. Imaging found a large tumor involving the rectum and sigmoid colon. He underwent neoadjuvant chemoradiation.
3. Follow up imaging after treatment showed the tumor remained infiltrating the bowel wall and surrounding structures, with enlarged lymph nodes. Further PET scan was advised to evaluate for surgery.
A 55-year-old male patient presented with a growth on his tongue for 3 months following trauma. The growth began on the right side of the tongue and had rapidly progressed to involve the tip and left side. It was associated with pain, difficulty speaking and chewing, excessive salivation, and ear pain. Examination revealed a 4x3cm proliferative growth involving over half the tongue and fixing it to the floor of mouth. Bilateral enlarged cervical lymph nodes were present, with the right level 1b node being enlarged and fixed. The diagnosis was carcinoma of the tongue with intrinsic muscle involvement and bilateral lymph node metastasis at clinical stage T4aN2cM0. The proposed treatment was subtotal glossectomy
Abdominal tuberculosis can present with varied and nonspecific symptoms, making diagnosis challenging. Imaging and laboratory tests are also nonspecific. A high index of suspicion is needed, along with aggressive investigation. Treatment primarily involves medical therapy with antitubercular drugs, though surgery may be needed in some cases. Not all cases of intestinal obstruction in abdominal tuberculosis have a mechanical cause. The second case report describes a patient who developed a paralytic ileus from hypokalemia leading to a subacute obstruction, not requiring surgery. A diagnostic trial of antitubercular therapy is reasonable in endemic regions while also considering conservative management.
Safe cholecystectomy requires understanding of anatomy, mechanisms, and predictors of injury to ensure safety for both patient and surgeon. Key aspects include proper gallbladder retraction to identify structures like the hepatocystic triangle, cystic plate, and Rouviere's sulcus. Dissection must be done carefully in relation to these structures. The critical view of safety, where only two structures (cystic duct and artery) enter the gallbladder within the cleared hepatocystic triangle, must be achieved before division. Intraoperative imaging and bailout strategies can help if there is ambiguity.
09 Dr.Kannan Fistula in ano chennai (21-07-2023) Final.pptxAruneshVenkataraman
The document discusses locating the internal opening of a fistula in ano. It provides information on the clinical presentation and classifications of fistulas. Methods for locating the internal opening are described, including digital examination, probing, and injecting saline or dye into the external opening. Imaging modalities like MRI and endorectal ultrasound can help identify complex anatomies. The key takeaway is that failure to find the internal opening significantly increases the risk of recurrence after surgery to treat the fistula.
This document provides information on gastric carcinoma, including:
1. It describes the classification, epidemiology, risk factors, pathogenesis, histology, staging, clinical features, investigations, and management of gastric adenocarcinoma.
2. The main risk factors include H. pylori infection, dietary nitrites, genetic mutations, and polyps. Gastric adenocarcinoma is classified based on cell type, location, depth of invasion, and metastasis.
3. Management involves endoscopic resection for early cancers, while advanced cancers are treated with surgery such as gastrectomy, with or without chemotherapy and radiotherapy. Complications and palliative care are also discussed.
The document discusses the workup and diagnosis of liver masses. It describes various benign and malignant liver lesions including hemangioma, focal nodular hyperplasia, hepatic adenoma, liver cysts, hepatocellular carcinoma, cholangiocarcinoma, and metastases. Multiphasic CT is useful for characterizing lesions based on enhancement patterns in the arterial, portal venous, and delayed phases. Biopsy may be needed to confirm diagnosis of suspicious lesions.
This document discusses various liver conditions including liver abscesses, hydatid disease, and liver tumors. It provides details on:
1) The surgical anatomy of the liver including segments and fissures.
2) Causes, symptoms, diagnostic tests, and treatments for pyogenic and amoebic liver abscesses.
3) Causes, life cycle, clinical features, diagnosis with ultrasonography, and treatments including albendazole and surgery for hydatid liver disease.
4) Types of benign and malignant liver tumors including hemangiomas, focal nodular hyperplasia, hepatic adenomas, hepatocellular carcinoma, and hepatoblastoma. Risk factors, symptoms, diagnostic tests
This document outlines various protocols and procedures for operating theatres, including:
- Preparing meticulous operating theatre lists with patient details in advance for surgeons and staff.
- Maintaining various records and registers related to surgeries, sterilization, temperature control, microbiology testing, and more for documentation purposes.
- Following principles of sterile technique which include proper patient and surgical site preparation, aseptic handling of instruments, maintenance of different zones in the operating theatre, and other infection control measures.
A 58-year-old female presented with a lump in her right breast for 2 months, along with pain over the lump for 1 month. Examination found two lumps in the right breast measuring 3x2 cm and 4x3 cm. Ultrasound showed lesions in the right breast and multiple subcentimetric lymph nodes in the right axilla. Core needle biopsy revealed invasive ductal carcinoma (IDC), grade 3, estrogen receptor negative, HER2 neu negative, with a Ki67 of 40%. The working diagnosis was carcinoma of the right breast cT2N0M0, clinical stage IIA. The plan was for modified radical mastectomy followed by chemotherapy with or without radiotherapy and/or hormonal
This document summarizes a case of carcinoma in a 30-year-old female patient. She presented with a 1-year history of a left breast lump. Various tests were performed, including ultrasounds and biopsies. Initial tests showed proliferative breast disease without atypia. A recent trucut biopsy revealed invasive ductal carcinoma, grade II in the left breast. The working diagnosis is carcinoma of the right breast, stage IIA. The treatment plan is a wide local excision of the breast lump along with axillary staging and adjuvant chemotherapy and radiation therapy.
1. A 33-year-old woman presented with a 1-month history of a lump in her right breast. She underwent surgery at a private hospital where a biopsy revealed breast carcinoma.
2. Examination found sutured wound and induration in the right breast, with no palpable lump or skin changes. Axilla examination was normal.
3. Imaging found a 3.1x2.1cm irregular hypoechoic lesion in the right breast and enlarged lymph nodes in the right axilla. Further scans found no evidence of metastasis.
A 55-year-old man presented with 7 months of upper abdominal pain, vomiting, loose stools, and weight loss. Imaging showed a large irregular mass in the stomach wall communicating with the transverse colon, indicative of a gastrocolic fistula. Biopsy confirmed a diagnosis of moderately differentiated adenocarcinoma of the stomach with metastases to the liver and lymph nodes. The tumor board consensus was that the patient was suitable for palliative resection and diversion procedure or feeding jejunostomy, followed by chemotherapy.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
1. DEPARTMENT OF GENERAL SURGERY
PROF DR T SIVAKUMAR SIR’S UNIT S1
LIST OF CASES POSTED IN NSB 1 ST FLOOR OT ON 07.09.22 S1 TABLE NO 5,6
TABLE – 5
TABLE - 6
S.
N
O
NAME AGE/SE
X
IP NO DIAGNOSIS PROCEDURE PLANNED ANAESTHES
IA
REQUIREMENTS CMCHIS COMORB
IDITY
1 MRS.TAMILSELVI 37/F 2271970 SYMPTOMATIC
CHOLELITHIASIS
LAPAROSCOPIC
CHOLECYSTECTOMY
GA LAP INSTRUMENTS
CHOLE CLIPS
APPROVED T2DM
2 MRS.DEEPA DEVI 45/F 2272191 NEUROFIBROMA
LEFT FOOT
LEFT BELOW KNEE
AMPUTATION
RA AMPUTATION TRAY APPROVED NEURO
FIBROMA
TOSIS
3 MR.VENKATESAN 35/M 2276077 PHIMOSIS CIRCUMCISION RA - - NIL
S.N
O
NAME AGE/SE
X
IP NO DIAGNOSIS PROCEDURE PLANNED ANAESTHES
IA
REQUIREMENTS CMCHIS COMORB
IDITY
1 MR.PORKATHER 40/F 2275448 PHYLLODES
TUMOR LEFT
BREAST
EXCISION BIOPSY GA BIOPSY TRAY APPROVED OLD PTB
2 MR.THIRUNAVUKKARASU 60/M 2276621 RECURRENT
EPIGASTRIC
HERNIA
ANATOMICAL REPAIR
WITH ONLAY MESH
PLASTY
GA/RA ABDOMEN TRAY
PROLENE MESH
APPROVED HYPO
THYROID
ISM
3 MRS.HEMVATHY 34/F 2276194 RIGHT GLUTEAL
LIPOMA
EXCISION BIOPSY RA BIOPSY TRAY -