This presentation was delivered to the WMRC in March 2017.
The first paper was published in BJS in Dec 2019. The data was collected from March 2017. The planning began in 2015.
https://bjssjournals.onlinelibrary.wiley.com/doi/full/10.1002/bjs.11440
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RIFT Study WMRC Update March 17
1. The Right Iliac Fossa pain
Treatment Audit (The RIFT audit)
RIFT Audit Group - WMRC
J Matthews, S Jain, S Bhanderi, G Morley, D Nepogodiev,
J Glasbey, R Tyler, I Mohamed, R Wilkin, A Bhangu
Acknowledgements - E Griffiths, T Pinkney, O Gee, D Morton
RIFTstudy@gmail.com
@WMRC_UK #RIFTaudit
4. “Sit Rep”
UK + ROI
Potentially 283 teams (? Less)
>3070 emails
>200 drafted documents
Adult 186 contacts
Paeds 24 contacts
REDCap 157 complete forms
>500 collaborators
? >4000 patients to be audited
?
5. “Sit Rep”
Regions Count of Involved Count of Region %
East Midlands 10 11 91
East of England 17 17 100
Jersey 1 1 100
Kent, Surrey and Sussex 12 18 67
London North Central and East 10 13 77
London North West 5 9 56
London South 10 11 91
North East 6 14 43
North West 13 28 46
Northern Ireland 7 10 70
Paediatric Surgery 24 27 89
ROI 16 16 100
Scotland 18 28 64
South West 10 14 71
Thames Valley 5 5 100
Wales 10 15 67
Wessex 7 9 78
West Midlands 15 18 83
Yorkshire and the Humber 13 18 72
Iberian peninusula 1 ?
Italy 65 ?
Grand Total 210 283 74
6. Aims and Standards
1) An initial laparoscopic approach should be used for appendicectomy unless
contraindicated
– [WSES Statement 5.1]
– [EAES Operative recommendations]
– (National Re-audit)
2) The normal appendicectomy rate should be <20%. For centres with higher or lower rates,
risk stratification data will allow interpretation of this rate in light of baseline case-mix.
1) The primary aim of this study is to determine the negative appendicectomy rate for
patients presenting with right iliac fossa pain.
2) Secondary aims of this study are:
i. to validate predictive risk scores for acute appendicitis;
ii. determine the laparoscopic appendicectomy rate in 2017;
iii. model variation in pathways for management of undifferentiated right iliac fossa pain;
iv. determine readmission rates for non-operated patients with RIF pain.
Risk stratification data using Alvarado/ AIR score will allow interpretation of individual
centres’ rates of negative and laparoscopic appendicectomy in light of their baseline case-
mix. A separate centre survey will profile local policy and service delivery for management
of RIF pain.
7. Potential Outcomes
1. New trainee collaborative networks
2. National re-audit of laparoscopy rate
3. National Re-audit of negative appendectomy rate
4. International comparison
5. Paediatric management
6. Variation between centres
7. Management differences depending on gender
8. “Incidence” of RIF pain
9. “Incidence” of Acute Appendicitis
10. “Incidence” of other pathologies and operations
11. “Incidence” of USS, CT and MRI + Findings
12. “Incidence” of risk score clinical usage
13. Calculated Risk Scores
14. Sensitivity + Specificity + PPV + NPV of the Risk Scores
15. Validated risk scores
16. Proposed pathways and guidance
8. Method - Scores
Data Point Alvarado AIR
Nausea Or vomiting 1 1
Anorexia 1
RIF Pain 2 1
Migration to RIF 1
Rebound or Gaurding 1 1 - 3
Temperature 1 1
WCC 2 1 - 2
Leukocytosis 1
Polymorphs 1 - 2
CRP 1 -2
Total Score 10 12
12. References
National Surgical Research Collaborative. Multicentre observational study of performance variation in
provision and outcome of emergency appendicectomy. Br J Surg [Internet]. 2013 Aug 1 [cited 2016 Sep
23];100(9):1240–52. Available from: http://onlinelibrary.wiley.com/doi/10.1002/bjs.9201/abstract
Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, et al. WSES Jerusalem guidelines for
diagnosis and treatment of acute appendicitis. World Journal of Emergency Surgery [Internet].
2016;11:34. Available from: http://dx.doi.org/10.1186/s13017-016-0090-5
Gorter RR, Eker HH, Gorter-Stam MAW, Abis GSA, Acharya A, Ankersmit M et al. Diagnosis and
management of acute appendicitis. EAES consensus development conference 2015. Surgical Endoscopy
[Internet]. 2016 Nov;30(11):4668-4690. Available from:
http://link.springer.com/article/10.1007/s00464-016-5245-7
Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of
pathogenesis, diagnosis, and management. The Lancet [Internet]. 2015 Sep;386(10000):1278–87.
Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673615002755
Editor's Notes
Junior member with senior advisors and expert guidance
Developing a cohort of juniors interested in collaborative research
Juniors running the centres and collecting the data, its all about developing people
A good gateway project
We would like the registrats to run the centres and advice the juniors on data collection
Validation needs methodical thought – Paul marriot
Human error – missed cases – missed operations – missed histology – missed follow up
? Theatre log book – separate data collection method – separate to protocol
HES data -? Done before
RIF pain = common symptom
Acute Appendicitis
It is unknown how much of the RIF pain is appendicitis
Proportion of RIF pain > Appendicitis
There is a large variation in the investigation and management of RIF pain and AA
Multiple Risk Stratification Scores exist
RIF pain = common symptom
Acute Appendicitis
It is unknown how much of the RIF pain is appendicitis
Proportion of RIF pain > Appendicitis
There is a large variation in the investigation and management of RIF pain and AA
Multiple Risk Stratification Scores exist
RIF pain = common symptom
Acute Appendicitis
It is unknown how much of the RIF pain is appendicitis
Proportion of RIF pain > Appendicitis
There is a large variation in the investigation and management of RIF pain and AA
Multiple Risk Stratification Scores exist
We will ask centres to collect risk stratification data to allow comparison of local population variation
Reducing unnecessary operations
We want to remove the appendix’s of the true positives and avoid taking the false positives to theatre.
Aim 1000 appendicectomies + 3-4000 RIF pain
This audit will allow us collect data on these outcomes. Ensure imaging is used appropriately for high and low risk patients
Next steps = Trial of Abx V lap, developed of new risk scores, encouraging adoption of best practice guidance, reducing unnecessary scans and operations, outcomes of leaving or removing normal appendixes
Stay in contact with John – is he going to the collaborative meeting?
WE need an admin role – keeping track of centres.
Thuva – kick to do website
Flow diagram of how to sign up – process
Potential Jobs that could be done
Admin SOP – flow diagram
Admin excel = Master + regional tabs
Admin excel = each hospital step by step in process
Start pilot process – saleem + med students … ? Other centres ? Mr griffths or Pinkney as pilot lead
WJES and BJS guidance suggests that we should risk score all RIF patients
This study is now live,
Weve got 20 sites already signed up,
Please get in contact with us via this email.
Summary for consultants = Abstract + responsibilities + authorship detail
Registration – flow diagram