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RHEUMATOID ARTHRITIS
- 1. Nirmal Jose Mathew Group25 RHEUMATOID ARTHRITIS
- 2. Inflammatory • Rheumatoid arthritis •Seronegative arthropathy • Crystal arthropathy Non Inflammatory • Osteoarthritis 01 02 Types of Arthritis
- 3. Definition Rheumatoid arthritis isan autoimmune disease in which the normal immune response is directed against an individual's own tissue, including the joints, tendons, and bones, resulting in inflammation and destruction of these tissues.
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- 5. Genetic Factors •HLA Factors - HLA DR B1 04, HLA DR B1 01 • Non HLA factors - PADI 4 gene, PTPN 22, CTLA 4 Environmental Factor • Smoking • Silica • Porphyromonas gingivalis FemaleGender Age >45 Risk Factors
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- 10. Blood test: anemia(in almost 50 % of patients), thrombocytosis, neutropenia, increased ESR and CRP. Immunological tests: rhematoid factor (RF) and anti-citrullinated protein (ACCP) antibodies are the main diagnostic biomarkers of RA. X-ray of hands and distal feet segments: periarticular osteoporosis, joint space narrowing, single or multiple erosions, joint luxations or subluxations, bone ankylosis Laboratory and Instrumental Diagnosis
- 11. Classification criteria forRheumatoid arthritis
- 12. Treatment Approved DMARDs : Methotrexate - DOC (7.5-20 mg) Leflunomide Sulfasalazine Hydroxychloroquine Biological Agents Infliximab Adalimumab Tocilizumab Small molecule JAK 3inhibitor Barcitinib
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