Persuasive Message—Business Communication TrainingScenario .docxmattjtoni51554
Persuasive Message—Business Communication Training
Scenario:
You are a manager at a regional office of a mid-large sized technology company, called NanoSmart Technologies. You have noted that several of your colleagues in your regional office struggle with professional business communication and you believe that their lack of professionalism is costing the company valuable business.
To collect data, you decide to personally mentor two of your fellow team members in professional business communication, measuring sales results before and after your intervention. To your delight, each team member increased sales by 10% in one month. You cannot allocate enough time to personally mentor everyone in the office, but you believe that you might be able to convince the National Manager of NanoSmart to provide funding to formally train 15 additional employees at your regional office.
To get training course cost estimates, you visit the website of a credible training organization, the American Management Association (AMA). You select an appropriate course and research the training costs (http://www.amanet.org/training/seminars/communication-skills-training.aspx). Once you determine the approximate amount you must request, you write a logical, yet persuasive message to convince the National Manager, Dana Buckminster, to approve and fund the training course.
You know that the budget is tight and she will not be excited about the additional upfront expense, but you firmly believe that if your colleagues were better trained in business communication, measurable benefits would be obtained. You also know that Dana will expect a price estimate and reasonable assurance that the money spent on training will produce tangible benefits.
For more information on the American Management Association visit: http://www.amanet.org/
Your assignment: Use the AIDA model, and provide a persuasive argument to convince the National Manager to allocate the necessary funding to train 15 employees in business communication at your regional office.
Write an email or a block style letter with your request. You should address your correspondence to Dana Buckminster, the National Manager at NanoSmart Technologies. You may develop additional contact information and scenario details as needed.
98% Alike --- Jonathan Marks
" Human and chimps are said to differ b a mere 2 percent of our DNA." ( Park 81) the introduction of the article "98% Alike" cited that. When we examine their own DNA, discovery and chimpanzee is not much different. But it is precisely because these small but subtle differences, completely changed the world, let us become a "human".You don't have to be a biologist or anthropologists, can see the great apes - gorillas, chimpanzees, bonobos and orangutans -- similar to how much we humans.
In addition to them in some parts of the body is too large and long have more hair, even if the child can see that they are the same with.
Design of a consciousness detector; the phylogeny of consciousness; a quantum-mechanics inspired model of consciousness as an non-material entailment of brain
Slides that go with the first in a series of four talks by Mahasraddha on Buddhism, science, philosphy, and consciousness. Given at the Manchester Buddhist Centre on 26th March 2007.
Persuasive Message—Business Communication TrainingScenario .docxmattjtoni51554
Persuasive Message—Business Communication Training
Scenario:
You are a manager at a regional office of a mid-large sized technology company, called NanoSmart Technologies. You have noted that several of your colleagues in your regional office struggle with professional business communication and you believe that their lack of professionalism is costing the company valuable business.
To collect data, you decide to personally mentor two of your fellow team members in professional business communication, measuring sales results before and after your intervention. To your delight, each team member increased sales by 10% in one month. You cannot allocate enough time to personally mentor everyone in the office, but you believe that you might be able to convince the National Manager of NanoSmart to provide funding to formally train 15 additional employees at your regional office.
To get training course cost estimates, you visit the website of a credible training organization, the American Management Association (AMA). You select an appropriate course and research the training costs (http://www.amanet.org/training/seminars/communication-skills-training.aspx). Once you determine the approximate amount you must request, you write a logical, yet persuasive message to convince the National Manager, Dana Buckminster, to approve and fund the training course.
You know that the budget is tight and she will not be excited about the additional upfront expense, but you firmly believe that if your colleagues were better trained in business communication, measurable benefits would be obtained. You also know that Dana will expect a price estimate and reasonable assurance that the money spent on training will produce tangible benefits.
For more information on the American Management Association visit: http://www.amanet.org/
Your assignment: Use the AIDA model, and provide a persuasive argument to convince the National Manager to allocate the necessary funding to train 15 employees in business communication at your regional office.
Write an email or a block style letter with your request. You should address your correspondence to Dana Buckminster, the National Manager at NanoSmart Technologies. You may develop additional contact information and scenario details as needed.
98% Alike --- Jonathan Marks
" Human and chimps are said to differ b a mere 2 percent of our DNA." ( Park 81) the introduction of the article "98% Alike" cited that. When we examine their own DNA, discovery and chimpanzee is not much different. But it is precisely because these small but subtle differences, completely changed the world, let us become a "human".You don't have to be a biologist or anthropologists, can see the great apes - gorillas, chimpanzees, bonobos and orangutans -- similar to how much we humans.
In addition to them in some parts of the body is too large and long have more hair, even if the child can see that they are the same with.
Design of a consciousness detector; the phylogeny of consciousness; a quantum-mechanics inspired model of consciousness as an non-material entailment of brain
Slides that go with the first in a series of four talks by Mahasraddha on Buddhism, science, philosphy, and consciousness. Given at the Manchester Buddhist Centre on 26th March 2007.
This inspiring novel is grounded in the concept of education driven by the curiosity of learners. This science-fiction narrative incorporates hyperlinks that guide readers towards a variety of credible scientific and educational resources. This feature affords a level of freedom and choice that traditional print novels simply cannot offer.
The first story The 4th Birth is (just seemingly) about the Lemurians, an ancient race which appears to have existed prior to and during the time of the equally mysterious empire of Atlantis. Some authors believe that Lemurians developed their civilisation (also called Lapita and Mu - Motherland) some 70,000 to 80,000 years ago, mainly in the South-West Pacific, between China and Australia.
Lemurians were living through alternating periods of peace and prosperity, conflicts and crises over the millennia. During this time, they made considerable advances in culture, politics, sciences and technology causing only minor ecological catastrophes. At the peak of their civilisation, the Lemurian people were both technically advanced and very spiritual. However, they were unaware that the indifferent Nature was leading their world towards an ultimate cataclysm. Fortunately, alongside the Lemurians and several neighbouring nations that worked hard to enslave one another, another civilisation (if one is to believe the fragments that appear in certain legends), much older and hence somewhat more mature, was witnessing this course of events.
How Brain-Friendly Learning Can Release Your Child’s Infinite Proposal! Enchanted Learning Experiences – Why They Should Be The Norm For Our Children?
Brain Based Research And Your Child – Learn some very interesting information on the development of your child and how you can interact with your child to help in this development. Discover the latest research of the brain and ways in which you can help your baby develop and learn.
Discover:
What you must cultivate in your child to ensure he/she is ready to learn?
That certain approaches to teaching can systematically damage your child’s brain.
What is the brain’s most powerful ability and how you can help stimulate it’s development in your child?
What you must do for your child if his brain is to develop and grow?
Why some children have superior language skills
Who is your child’s most important preschool teacher?
What is the definition of genius? You’ll be surprised
How high you should set your aspirations for your child?
And so much more!
81018, 1018 AMWhat Defines a Meme Arts & Culture Smith.docxsleeperharwell
8/10/18, 10'18 AMWhat Defines a Meme? | Arts & Culture | Smithsonian
Page 1 of 4https://www.smithsonianmag.com/arts-culture/what-defines-a-meme-1904778/
Smithsonian.com
What Defines a Meme?
Our world is a place where information can behave like human genes and ideas can replicate, mutate
and evolve
With the rise of information theory, ideas were seen as behaving like organisms, replicating by
leaping from brain to brain, interacting to form new ideas and evolving in what the scientist Roger
Sperry called “a burstwise advance.” (Illustration by Stuart Bradford)
By James Gleick
Smithsonian Magazine | Subscribe
May 2011
What lies at the heart of every living thing is not a fire, not warm breath, not a ‘spark of life.’ It is information, words, instructions,” Richard Dawkins declared in
1986. Already one of the world’s foremost evolutionary biologists, he had caught the spirit of a new age. The cells of an organism are nodes in a richly interwoven
communications network, transmitting and receiving, coding and decoding. Evolution itself embodies an ongoing exchange of information between organism and
environment. “If you want to understand life,” Dawkins wrote, “don’t think about vibrant, throbbing gels and oozes, think about information technology.”
We have become surrounded by information technology; our furniture includes iPods and plasma displays, and our skills include texting and Googling. But our
capacity to understand the role of information has been sorely taxed. “TMI,” we say. Stand back, however, and the past does come back into focus.
The rise of information theory aided and abetted a new view of life. The genetic code—no longer a mere metaphor—was being deciphered. Scientists spoke grandly
of the biosphere: an entity composed of all the earth’s life-forms, teeming with information, replicating and evolving. And biologists, having absorbed the methods
and vocabulary of communications science, went further to make their own contributions to the understanding of information itself.
Jacques Monod, the Parisian biologist who shared a Nobel Prize in 1965 for working out the role of messenger RNA in the transfer of genetic information, proposed
an analogy: just as the biosphere stands above the world of nonliving matter, so an “abstract kingdom” rises above the biosphere. The denizens of this kingdom?
Ideas.
“Ideas have retained some of the properties of organisms,” he wrote. “Like them, they tend to perpetuate their structure and to breed; they too can fuse, recombine,
segregate their content; indeed they too can evolve, and in this evolution selection must surely play an important role.”
Ideas have “spreading power,” he noted—“infectivity, as it were”—and some more than others. An example of an infectious idea might be a religious ideology that
gains sway over a large group of people. The American neurophysiologist Roger Sperry had put forward a similar notion several years earlier, arguing that ideas are
“just as real” as the .
Lifesciences Ted Talks are video presentations of ideas worth spreading, often given in 18 minutes or less. TED is an organization with a mission to “discover, curate, and disseminate the world’s most compelling ideas and insights in the form
Supervenience Update on Commonalities, Coding, AdministrationTony Smith
Presentation to Melbourne Emergence Meetup 12 February 2019 with run of mostly shortish video clips and interspersed stills consolidated into a single external 18:44 video.
Using neuromodulation techniques in behavioral medicine is a big step forward...Curtis Cripe
Using neuromodulation techniques in behavioral medicine is a big step forward in treating neurological and psychiatric conditions. By using precise neural stimulation, we can enhance patient outcomes and quality of life. Collaboration between clinicians, researchers, and technology developers is crucial for fully realizing the benefits of neuromodulation in behavioral medicine. #CurtisCripe
Wondering if your brain needs exercise too?Curtis Cripe
Wondering if your brain needs exercise too? Discover the incredible benefits of physical activity for your cognitive function and learn how it can help lower the risk of dementia. |Curtis Cripe
This inspiring novel is grounded in the concept of education driven by the curiosity of learners. This science-fiction narrative incorporates hyperlinks that guide readers towards a variety of credible scientific and educational resources. This feature affords a level of freedom and choice that traditional print novels simply cannot offer.
The first story The 4th Birth is (just seemingly) about the Lemurians, an ancient race which appears to have existed prior to and during the time of the equally mysterious empire of Atlantis. Some authors believe that Lemurians developed their civilisation (also called Lapita and Mu - Motherland) some 70,000 to 80,000 years ago, mainly in the South-West Pacific, between China and Australia.
Lemurians were living through alternating periods of peace and prosperity, conflicts and crises over the millennia. During this time, they made considerable advances in culture, politics, sciences and technology causing only minor ecological catastrophes. At the peak of their civilisation, the Lemurian people were both technically advanced and very spiritual. However, they were unaware that the indifferent Nature was leading their world towards an ultimate cataclysm. Fortunately, alongside the Lemurians and several neighbouring nations that worked hard to enslave one another, another civilisation (if one is to believe the fragments that appear in certain legends), much older and hence somewhat more mature, was witnessing this course of events.
How Brain-Friendly Learning Can Release Your Child’s Infinite Proposal! Enchanted Learning Experiences – Why They Should Be The Norm For Our Children?
Brain Based Research And Your Child – Learn some very interesting information on the development of your child and how you can interact with your child to help in this development. Discover the latest research of the brain and ways in which you can help your baby develop and learn.
Discover:
What you must cultivate in your child to ensure he/she is ready to learn?
That certain approaches to teaching can systematically damage your child’s brain.
What is the brain’s most powerful ability and how you can help stimulate it’s development in your child?
What you must do for your child if his brain is to develop and grow?
Why some children have superior language skills
Who is your child’s most important preschool teacher?
What is the definition of genius? You’ll be surprised
How high you should set your aspirations for your child?
And so much more!
81018, 1018 AMWhat Defines a Meme Arts & Culture Smith.docxsleeperharwell
8/10/18, 10'18 AMWhat Defines a Meme? | Arts & Culture | Smithsonian
Page 1 of 4https://www.smithsonianmag.com/arts-culture/what-defines-a-meme-1904778/
Smithsonian.com
What Defines a Meme?
Our world is a place where information can behave like human genes and ideas can replicate, mutate
and evolve
With the rise of information theory, ideas were seen as behaving like organisms, replicating by
leaping from brain to brain, interacting to form new ideas and evolving in what the scientist Roger
Sperry called “a burstwise advance.” (Illustration by Stuart Bradford)
By James Gleick
Smithsonian Magazine | Subscribe
May 2011
What lies at the heart of every living thing is not a fire, not warm breath, not a ‘spark of life.’ It is information, words, instructions,” Richard Dawkins declared in
1986. Already one of the world’s foremost evolutionary biologists, he had caught the spirit of a new age. The cells of an organism are nodes in a richly interwoven
communications network, transmitting and receiving, coding and decoding. Evolution itself embodies an ongoing exchange of information between organism and
environment. “If you want to understand life,” Dawkins wrote, “don’t think about vibrant, throbbing gels and oozes, think about information technology.”
We have become surrounded by information technology; our furniture includes iPods and plasma displays, and our skills include texting and Googling. But our
capacity to understand the role of information has been sorely taxed. “TMI,” we say. Stand back, however, and the past does come back into focus.
The rise of information theory aided and abetted a new view of life. The genetic code—no longer a mere metaphor—was being deciphered. Scientists spoke grandly
of the biosphere: an entity composed of all the earth’s life-forms, teeming with information, replicating and evolving. And biologists, having absorbed the methods
and vocabulary of communications science, went further to make their own contributions to the understanding of information itself.
Jacques Monod, the Parisian biologist who shared a Nobel Prize in 1965 for working out the role of messenger RNA in the transfer of genetic information, proposed
an analogy: just as the biosphere stands above the world of nonliving matter, so an “abstract kingdom” rises above the biosphere. The denizens of this kingdom?
Ideas.
“Ideas have retained some of the properties of organisms,” he wrote. “Like them, they tend to perpetuate their structure and to breed; they too can fuse, recombine,
segregate their content; indeed they too can evolve, and in this evolution selection must surely play an important role.”
Ideas have “spreading power,” he noted—“infectivity, as it were”—and some more than others. An example of an infectious idea might be a religious ideology that
gains sway over a large group of people. The American neurophysiologist Roger Sperry had put forward a similar notion several years earlier, arguing that ideas are
“just as real” as the .
Lifesciences Ted Talks are video presentations of ideas worth spreading, often given in 18 minutes or less. TED is an organization with a mission to “discover, curate, and disseminate the world’s most compelling ideas and insights in the form
Supervenience Update on Commonalities, Coding, AdministrationTony Smith
Presentation to Melbourne Emergence Meetup 12 February 2019 with run of mostly shortish video clips and interspersed stills consolidated into a single external 18:44 video.
Similar to Revenge of the lizard brain scientific american blog network (19)
Using neuromodulation techniques in behavioral medicine is a big step forward...Curtis Cripe
Using neuromodulation techniques in behavioral medicine is a big step forward in treating neurological and psychiatric conditions. By using precise neural stimulation, we can enhance patient outcomes and quality of life. Collaboration between clinicians, researchers, and technology developers is crucial for fully realizing the benefits of neuromodulation in behavioral medicine. #CurtisCripe
Wondering if your brain needs exercise too?Curtis Cripe
Wondering if your brain needs exercise too? Discover the incredible benefits of physical activity for your cognitive function and learn how it can help lower the risk of dementia. |Curtis Cripe
ADD/ADHD has elusive causes. No medical test can diagnose; behavioral assessments, neuro-imaging, and cognitive evaluations aid diagnosis. | Curtis Cripe
A balanced diet plays a pivotal role in mental healthCurtis Cripe
A balanced diet plays a pivotal role in mental health, delivering vital nutrients for brain wellness and mitigating the risk of mental illnesses. | Curtis Cripe
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Mental health is intertwined with diet, offering the brain essential nutrients to enhance wellness and diminish the likelihood of mental illnesses. | Curtis Cripe
Balanced nutrition is crucial for mental healthCurtis Cripe
Balanced nutrition is crucial for mental health, supplying the brain with the key nutrients to optimize wellness and lower the risk of mental illnesses. | Curtis Cripe
Optimal mental health is linked to a balanced dietCurtis Cripe
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The human brain, with over 100 billion neurons, is a marvel of memory and creativity, storing a lifetime's memories in a remarkably small space.| Curtis Cripe
Exploring the human mind, social psychology stands out as a captivating field. It investigates how human interaction shapes thoughts, emotions, and behavior| Curtis Cripe
The human brain, with 100 billion neurons, is a marvel of complexity, boasting limitless memory and creativity in a remarkably compact space.| Curtis Cripe
Healthy communication is vital throughout lifeCurtis Cripe
Healthy communication is vital throughout life, yet speech delays can occur, often due to hearing or oral issues, affecting a child's expression. | Curtis Cripe
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
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Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Nutraceutical market, scope and growth: Herbal drug technology
Revenge of the lizard brain scientific american blog network
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Guest Blog
S U B S C R I B E
Revenge of the Lizard Brain
By Ben Thomas on September 7, 2012
There’s a scene in Fear & Loathing in Las Vegas in which the writer,
high out of his mind on hallucinogens, watches a roomful of casino
patrons transform into giant lizards and lunge at each other in bloody
ADVER TISE MENT
2. combat. Under the veneer of civilization, the scene suggests, we’re all
still reptiles, just waiting for the moment to strike.
Strange as it seems, this drug-
fueled vision reflects a
biological theory that, back in
the ‘60s, looked like it might be
gaining some traction: Paul
MacLean’s infamous “Triune
Brain” theory, whose basic idea
is that every human brain
contains three independent
competing minds - the reptile, the early mammal, and the modern
primate.
Like the Fear & Loathing scene, the Triune Brain idea holds a certain
allegorical appeal: The primal lizard - a sort of ancestral trickster god -
lurking within each of us. But today, writers and speakers are dredging
up the corpse of this old theory, dressing it with some smart-sounding
jargon, and parading it around as if it’s scientific fact. This isn’t just
late-night-radio fringe stuff, either: it’s showing up at TED and in
Forbes.
3. To understand what it is, exactly, that these people are claiming, it
helps to know a few key points about MacLean’s - shall we say - unique
personal views on neuroanatomy. Take, for instance, the basal ganglia -
that bundle of neural structures near the base of the forebrain. They’re
crucial for learning and reinforcing habits, like nail-biting and
toothbrushing. Back in the 1960s, biologists thought the forebrains of
reptiles and birds were mainly composed of basal ganglia (they aren’t),
so MacLean decided to group these structures, along with the
brainstem, under the label “reptilian complex.” This “R-complex,”
MacLean claimed, was responsible for the “aggression, dominance,
territoriality, and ritual displays” of our distant reptilian ancestors.
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4. MacLean also noticed that some of the more complex neural structures
folded around the basal ganglia - such as the amygdala, the
hypothalamus and the cingulate cortex - play central roles in emotions
like disgust, nervousness, doubt and so on. So he figured these brain
areas must’ve arisen in the earliest mammals to cope with tasks like
family bonding and child-rearing. He gathered them under a heading
and slapped the label “paleomammalian complex” on it.
Finally, MacLean noted that the neocortex - the uppermost, outermost
layer of the brain - is found only in mammals, and is linked with “high-
level cognitive abilities” like abstract planning, tool-making, language,
and self-awareness. Thus, he termed it the “neomammalian complex.”
But MacLean wasn’t done. He went on to hypothesize that these three
“complexes” not only represented three distinct stages of brain
evolution, but remained three separate, semi-independent brains,
“[each] with its own special intelligence, its own subjectivity, its own
sense of time and space and its own memory." MacLean was saying, in
other words, that every human brain contains three independent
subjective consciousnesses.
All in all, a truly mind-blowing trip to lay on your friends. Problem is,
MacLean’s pet hypothesis doesn’t hold up under scrutiny. For example:
5. 1. Basal ganglia are found in the brains of the earliest jawed fish, which
means MacLean’s “reptile complex” originated long before the first
tetrapods wriggled onto land.
2. The earliest mammals already had well-formed neocortices, which
means at least some “high-level cognitive abilities” predate
mammals altogether.
3. Many reptiles exhibit “paleomammalian” behaviors such as familial
bonding and child-rearing, and many birds exhibit “neomammalian”
skills like tool-making, verbal comprehension and dialect
development.
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6. 4. In functional terms, a human brain doesn’t behave like a series of
separate “complexes,” but as a unified whole. Some neural networks
do inhibit others - but the shapes of those networks have nothing to
do with “reptilian” or “mammalian” layers.
How is it, then, that modern authors as educated as Seth Godin and
Rick Hanson (among others) are writing entire essays that present “the
lizard brain” as well-documented scientific fact? How does Godin keep
a straight face onstage as he tells us that “the lizard is a physical part of
your brain” and that “the reason we call wild animals ‘wild’ is because
they have lizard brains”?
It’s because the idea makes a weird kind of intuitive sense. We’re
bundles of instincts and inhibitions and desires that don’t fit neatly
together. It’d be comforting, in a way, if we could pin those conflicts on
little lizard brains - just name those ancient demons and drive ‘em out,
like we did in simpler times.
Whether we like it or not, though, the lizard is simply us. Every habit
and hangup, every dread and desire in our minds is dependent on
neural pathways that were once laid down by our personal experiences.
Like every other organism on earth, we carry the history of a long,
successful lineage in our genetic and biological makeup. The question
of what to do with those resources, though, isn’t predetermined by the
past. It’s up to you.
7. Image: Genesis12, modified by Ben Thomas
The views expressed are those of the author(s) and are not necessarily those of Scientific American.
A B O UT THE AU T H O R ( S )
Ben Thomas
Ben Thomas is an author, journalist, inventor and independent researcher who studies
consciousness and the brain. A lifelong lover of all things mysterious and unexplained, he
weaves tales from the frontiers of science into videos, podcasts and unique multimedia
events. Lots more of his work is available at http://the-connectome.com.
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