JetBlue has strengths in effective aircraft operations, positioning in New York, and active marketing with low distribution costs. However, it has weaknesses such as high debt obligations, sluggish profits, and low margins. External opportunities include recovery of the US airline industry and benefits to low-cost carriers in a weak economy, but threats include intense price competition, industry consolidation, terrorism, and increased government regulations.
The document summarizes Roberto Siagri's presentation at the 2013 Trieste Forum on the impact of science and technology on society and the economy. The presentation aimed to discuss the role of human capital in assuring sustainable development and increasing human capital. It also examined how technological innovation is changing the nature of enterprises and employment. Some key points include: (1) innovation is moving from physical to more abstract domains; (2) exponential trends are accelerating progress; and (3) boundaries of enterprises are changing as virtual and entrepreneurial models become more common.
El documento habla sobre el ciberactivismo político y las iniciativas del PSOE para aprovechar las nuevas tecnologías. Explica el surgimiento de la Web 2.0 y cómo esto llevó al ciberactivismo, donde los ciudadanos usan Internet y redes sociales para participar políticamente. También describe cómo el PSOE creó la figura del "cibermilitante" para permitir la participación online, y sus esfuerzos para estar presente en plataformas como blogs, redes sociales y comentarios digitales. El objetivo final es mejorar la pre
JetBlue has strengths in effective aircraft operations, positioning in New York, and active marketing with low distribution costs. However, it has weaknesses such as high debt obligations, sluggish profits, and low margins. External opportunities include recovery of the US airline industry and benefits to low-cost carriers in a weak economy, but threats include intense price competition, industry consolidation, terrorism, and increased government regulations.
The document summarizes Roberto Siagri's presentation at the 2013 Trieste Forum on the impact of science and technology on society and the economy. The presentation aimed to discuss the role of human capital in assuring sustainable development and increasing human capital. It also examined how technological innovation is changing the nature of enterprises and employment. Some key points include: (1) innovation is moving from physical to more abstract domains; (2) exponential trends are accelerating progress; and (3) boundaries of enterprises are changing as virtual and entrepreneurial models become more common.
El documento habla sobre el ciberactivismo político y las iniciativas del PSOE para aprovechar las nuevas tecnologías. Explica el surgimiento de la Web 2.0 y cómo esto llevó al ciberactivismo, donde los ciudadanos usan Internet y redes sociales para participar políticamente. También describe cómo el PSOE creó la figura del "cibermilitante" para permitir la participación online, y sus esfuerzos para estar presente en plataformas como blogs, redes sociales y comentarios digitales. El objetivo final es mejorar la pre
My cousin helped me buy my first car after graduating and finding a job. We had an intense negotiation with the dealer that lasted all day before finally agreeing on a price the next morning. The experience taught me lessons about not rushing into big purchases, being influenced by others, and choosing negotiating partners wisely.
JetBlue has strengths in effective aircraft operations, strong positioning in the New York metropolitan area, and active marketing with low-cost distribution channels. However, JetBlue also has weaknesses such as high debt and fixed obligations, sluggish profits and margins. External threats include intense competition from low-cost airlines, industry consolidation, terrorism, and increased government regulations. The recovery of the US airline industry works in JetBlue's favor.
Peritonitis in patients undergoing peritoneal dialysis is commonly diagnosed based on symptoms of fever, abdominal pain, and nausea, along with lab findings of increased white blood cells over 100 cells/mm3 with neutrophil predominance. Infections are often gram positive or gram negative bacteria but about 20% have no growth on culture. Fungal infections are rare but Candida is the most common cause. Noninfectious complications include GERD, vomiting, electrolyte abnormalities like hypokalemia, and potentially fatal acute mesenteric ischemia.
The document discusses strategies for foreign market entry, including overcoming liability of foreignness, understanding factors that influence internationalization, and a comprehensive model for foreign market entries. It addresses questions of where, when, and how to enter foreign markets, analyzing location-specific advantages, timing of market entry, and options for entry modes. Key tradeoffs between equity and non-equity entry modes like exports, licensing, and foreign direct investment are also summarized.
This document discusses syncope, which is a transient loss of consciousness due to temporary reduced blood flow to the brain. It notes that syncope accounts for around 1% of emergency department visits and is a common cause of hospitalization for those over 65. Establishing the exact cause is difficult as the patient has usually recovered by the time they are examined. The document then discusses various causes of syncope and nonsyncopal attacks that can be mistaken for syncope. It provides breakdowns of common causes by age group and discusses the natural history and risk stratification of syncope of unknown cause in the emergency department.
Myocardial Viability - the STICH Trial NEJM May 2011callroom
This study examined whether testing for myocardial viability can identify patients with coronary artery disease and left ventricular dysfunction who benefit most from coronary artery bypass grafting (CABG) compared to medical therapy alone. Of over 1200 patients enrolled in the main trial, 601 who underwent viability testing by single-photon emission computed tomography (SPECT) or dobutamine echocardiography were included in this substudy. Patients who had viability testing were more likely to have certain risk factors and worse heart function. The study aimed to determine if viability testing could identify which patients would have improved survival rates with CABG versus medical therapy.
This document discusses flail mitral leaflet, which is a cause of mitral regurgitation requiring surgical correction. It occurs when the chordae tendineae connecting the mitral leaflet to the papillary muscles rupture. This causes the mitral leaflet to flail or balloon into the left atrium during systole. If left untreated, it can lead to complications like congestive heart failure, atrial fibrillation, thromboembolism and death. Surgical repair or replacement of the mitral valve is usually required to treat significant flail mitral leaflet.
This study examined the association between cardiorespiratory fitness, adiposity, and mortality in older adults. It found that higher fitness levels were associated with lower mortality rates regardless of body composition. Specifically, even obese individuals had lower mortality if they were fit compared to unfit normal-weight or lean individuals. The study also found a J-shaped relationship between BMI and mortality both before and after adjusting for fitness levels.
An 80 year old female with a history of hypertension, hyperlipidemia, diabetes, and prior stroke presented with 2 weeks of continuous chest pain and was found to have a left bundle branch block. Cardiac enzymes were negative. She was transferred to the hospital for further management and evaluation.
This document describes a case of an 80 year old female patient with a history of hypertension, hyperlipidemia, diabetes, and prior stroke who presented with 2 weeks of continuous chest pain. She was found to have left bundle branch block of unknown duration on EKG. Cardiac enzymes were negative. The patient was transferred for further cardiac management.
The document discusses several cases presenting with abnormal liver function tests (LFTs). Case 1 shows a mild isolated transaminitis. Case 2 involves severe hepatocellular injury and mild cholestasis in an alcoholic patient. Case 3 examines LFT patterns in an alcoholic cirrhotic with possible alcoholic hepatitis.
This document summarizes methods for predicting the functional effects of amino acid substitutions, including SIFT (Sorts Intolerant From Tolerant), which uses sequence conservation to predict whether an amino acid substitution will affect protein function. SIFT has similar prediction accuracy to tools using protein structure. Case studies on disease genes like MSHR, PPARα, and MTHFR show SIFT can distinguish pathogenic from benign variants and detect variants under balancing selection. Focusing genetic association studies on predicted functional variants in genes and conserved non-coding regions improves the direct approach to finding disease loci.
This document summarizes a 56-year-old African American man who presented to the hospital after an abnormal stress test. He has a history of hypertension and was previously diagnosed with left ventricular hypertrophy. A recent stress test found ventricular tachycardia and imaging showed an apical aneurysm and small inferior wall ischemia. He is currently taking medications for hypertension and has a family history of coronary artery disease.
Clostridium difficile infection rates in the US increased from 30-40 per 100,000 in the mid-1990s to 84 per 100,000 in 2005, and in Britain C. diff became the primary cause of an increasing number of deaths from 499 in 1999 to 3393 in 2006. While metronidazole and vancomycin have been the standard treatments since the 1970s, failure rates for metronidazole increased significantly to 18.2% since 2000. Metronidazole is recommended as the first line treatment for mild cases, but vancomycin should be used for more severe infections. The ultimate goal in treating recurrent C. diff infections is to discontinue all antibiotics
The document provides an overview and introduction to the key features and functionality of the Android 2.3 mobile operating system. It describes how to perform basic tasks like starting up Android for the first time, getting familiar with the home screen and user interface, managing notifications, using applications and more. The guide is organized by topic, with each section providing details on a different aspect of the Android system like calls, contacts, browsing the web, and changing system settings.
- A 53-year-old female with a history of breast cancer was admitted for an elective ureteral stent placement due to tumor compression of her left ureter.
- Shortly after the uncomplicated procedure, the patient became hypotensive, hypoxic, and unresponsive. Imaging showed bowel ischemia with pneumatosis and hemoperitoneum.
- Despite pressor support and broad-spectrum antibiotics, the patient's condition deteriorated and she eventually passed away.
The document discusses the use of an intra-aortic balloon pump (IABP), including appropriate timing of inflation in the cardiac cycle, risks of premature or late deflation, and guidelines for weaning a patient from the device. It notes that the IABP has applications in cardiac failure, refractory angina, cardiogenic shock, and as a bridge to transplantation. Risks include limb ischemia, thrombosis, emboli, bleeding, and aortic complications. Weaning should occur over 24-48 hours with decreasing inotropic support and pump ratios monitored closely.
My cousin helped me buy my first car after graduating and finding a job. We had an intense negotiation with the dealer that lasted all day before finally agreeing on a price the next morning. The experience taught me lessons about not rushing into big purchases, being influenced by others, and choosing negotiating partners wisely.
JetBlue has strengths in effective aircraft operations, strong positioning in the New York metropolitan area, and active marketing with low-cost distribution channels. However, JetBlue also has weaknesses such as high debt and fixed obligations, sluggish profits and margins. External threats include intense competition from low-cost airlines, industry consolidation, terrorism, and increased government regulations. The recovery of the US airline industry works in JetBlue's favor.
Peritonitis in patients undergoing peritoneal dialysis is commonly diagnosed based on symptoms of fever, abdominal pain, and nausea, along with lab findings of increased white blood cells over 100 cells/mm3 with neutrophil predominance. Infections are often gram positive or gram negative bacteria but about 20% have no growth on culture. Fungal infections are rare but Candida is the most common cause. Noninfectious complications include GERD, vomiting, electrolyte abnormalities like hypokalemia, and potentially fatal acute mesenteric ischemia.
The document discusses strategies for foreign market entry, including overcoming liability of foreignness, understanding factors that influence internationalization, and a comprehensive model for foreign market entries. It addresses questions of where, when, and how to enter foreign markets, analyzing location-specific advantages, timing of market entry, and options for entry modes. Key tradeoffs between equity and non-equity entry modes like exports, licensing, and foreign direct investment are also summarized.
This document discusses syncope, which is a transient loss of consciousness due to temporary reduced blood flow to the brain. It notes that syncope accounts for around 1% of emergency department visits and is a common cause of hospitalization for those over 65. Establishing the exact cause is difficult as the patient has usually recovered by the time they are examined. The document then discusses various causes of syncope and nonsyncopal attacks that can be mistaken for syncope. It provides breakdowns of common causes by age group and discusses the natural history and risk stratification of syncope of unknown cause in the emergency department.
Myocardial Viability - the STICH Trial NEJM May 2011callroom
This study examined whether testing for myocardial viability can identify patients with coronary artery disease and left ventricular dysfunction who benefit most from coronary artery bypass grafting (CABG) compared to medical therapy alone. Of over 1200 patients enrolled in the main trial, 601 who underwent viability testing by single-photon emission computed tomography (SPECT) or dobutamine echocardiography were included in this substudy. Patients who had viability testing were more likely to have certain risk factors and worse heart function. The study aimed to determine if viability testing could identify which patients would have improved survival rates with CABG versus medical therapy.
This document discusses flail mitral leaflet, which is a cause of mitral regurgitation requiring surgical correction. It occurs when the chordae tendineae connecting the mitral leaflet to the papillary muscles rupture. This causes the mitral leaflet to flail or balloon into the left atrium during systole. If left untreated, it can lead to complications like congestive heart failure, atrial fibrillation, thromboembolism and death. Surgical repair or replacement of the mitral valve is usually required to treat significant flail mitral leaflet.
This study examined the association between cardiorespiratory fitness, adiposity, and mortality in older adults. It found that higher fitness levels were associated with lower mortality rates regardless of body composition. Specifically, even obese individuals had lower mortality if they were fit compared to unfit normal-weight or lean individuals. The study also found a J-shaped relationship between BMI and mortality both before and after adjusting for fitness levels.
An 80 year old female with a history of hypertension, hyperlipidemia, diabetes, and prior stroke presented with 2 weeks of continuous chest pain and was found to have a left bundle branch block. Cardiac enzymes were negative. She was transferred to the hospital for further management and evaluation.
This document describes a case of an 80 year old female patient with a history of hypertension, hyperlipidemia, diabetes, and prior stroke who presented with 2 weeks of continuous chest pain. She was found to have left bundle branch block of unknown duration on EKG. Cardiac enzymes were negative. The patient was transferred for further cardiac management.
The document discusses several cases presenting with abnormal liver function tests (LFTs). Case 1 shows a mild isolated transaminitis. Case 2 involves severe hepatocellular injury and mild cholestasis in an alcoholic patient. Case 3 examines LFT patterns in an alcoholic cirrhotic with possible alcoholic hepatitis.
This document summarizes methods for predicting the functional effects of amino acid substitutions, including SIFT (Sorts Intolerant From Tolerant), which uses sequence conservation to predict whether an amino acid substitution will affect protein function. SIFT has similar prediction accuracy to tools using protein structure. Case studies on disease genes like MSHR, PPARα, and MTHFR show SIFT can distinguish pathogenic from benign variants and detect variants under balancing selection. Focusing genetic association studies on predicted functional variants in genes and conserved non-coding regions improves the direct approach to finding disease loci.
This document summarizes a 56-year-old African American man who presented to the hospital after an abnormal stress test. He has a history of hypertension and was previously diagnosed with left ventricular hypertrophy. A recent stress test found ventricular tachycardia and imaging showed an apical aneurysm and small inferior wall ischemia. He is currently taking medications for hypertension and has a family history of coronary artery disease.
Clostridium difficile infection rates in the US increased from 30-40 per 100,000 in the mid-1990s to 84 per 100,000 in 2005, and in Britain C. diff became the primary cause of an increasing number of deaths from 499 in 1999 to 3393 in 2006. While metronidazole and vancomycin have been the standard treatments since the 1970s, failure rates for metronidazole increased significantly to 18.2% since 2000. Metronidazole is recommended as the first line treatment for mild cases, but vancomycin should be used for more severe infections. The ultimate goal in treating recurrent C. diff infections is to discontinue all antibiotics
The document provides an overview and introduction to the key features and functionality of the Android 2.3 mobile operating system. It describes how to perform basic tasks like starting up Android for the first time, getting familiar with the home screen and user interface, managing notifications, using applications and more. The guide is organized by topic, with each section providing details on a different aspect of the Android system like calls, contacts, browsing the web, and changing system settings.
- A 53-year-old female with a history of breast cancer was admitted for an elective ureteral stent placement due to tumor compression of her left ureter.
- Shortly after the uncomplicated procedure, the patient became hypotensive, hypoxic, and unresponsive. Imaging showed bowel ischemia with pneumatosis and hemoperitoneum.
- Despite pressor support and broad-spectrum antibiotics, the patient's condition deteriorated and she eventually passed away.
The document discusses the use of an intra-aortic balloon pump (IABP), including appropriate timing of inflation in the cardiac cycle, risks of premature or late deflation, and guidelines for weaning a patient from the device. It notes that the IABP has applications in cardiac failure, refractory angina, cardiogenic shock, and as a bridge to transplantation. Risks include limb ischemia, thrombosis, emboli, bleeding, and aortic complications. Weaning should occur over 24-48 hours with decreasing inotropic support and pump ratios monitored closely.