Enkele quotes van onze oud-renner "IJzeren Briek" Schotte, laatste der Flandriens. Hij geeft aan hoe het er in zijn tijd aan toeging. Heel wat blijft eeuwig toepasbaar, wijze lessen voor iedereen die zelfbewust in het leven staat!
In most chemical engineering curriculums, distillation and liquid-liquid extraction (LLE) do not receive equal billing. Yet, this powerful separations technology is in place across the CPI, pharmaceutical and oil/gas industries. Discover how to design an LLE column with industry experts Don Glatz and Brendan Cross as they discuss specific examples and separations challenges.
Basic understanding of HAZOP it covers:
-Basic understanding of HAZOP
-HAZOP requirements
-How it works
-Case study
-HAZOP team
-Advantage & disadvantage
Impurities in Drug Substance & in Drug ProductKamal Ambalia
The document provides guidance on impurities in drug substances and products. It discusses the classification of impurities into organic, inorganic, and residual solvents. It describes the rationale for reporting and controlling impurities and outlines identification thresholds, reporting thresholds, and qualification thresholds based on maximum daily dose. Analytical procedures for impurity detection and identification must be validated. Impurities above thresholds require identification and qualification. The new drug specification must include impurities above reporting thresholds. Residual solvent limits are based on ICH Q3C guidelines.
This document provides copyright information and technical support contact details for Aspen Technology's HYSYS 2004.2 Dynamic Modeling software. It lists over 200 Aspen product names that are copyrighted and/or trademarked by Aspen Technology. Contact information is provided for Aspen's Online Technical Support Center, phone support, and email support.
This document provides lecture notes on mass and energy balances. It covers key topics such as dimensions, units, unit conversion, material balances, and energy balances. Chapter 1 defines dimensions, units, and common unit systems used in engineering. It explains how to perform unit conversions and check the dimensional homogeneity of equations. Later chapters discuss using material and energy balances to analyze processes involving multiple units and unit operations.
Continuous Flow Chemistry And The Manufacture Of Active Pharmaceutical Ingr...Stuart Silverman
A Series Of Informative Disquisitions About Continuous Flow Chemistry
Part Three:
Translation of flow protocols from the bench to the plant
Reaction Classes
Workup and isolation
Data Collection on the ProteinSimple Maurice: Driving Compliance with the Emp...KBI Biopharma
This document discusses using the ProteinSimple Maurice system with Empower control software for analyzing proteins. It provides an overview of KBI Biopharma's analytical services and locations. It then describes the Maurice system and Empower software, highlighting how the software can be used to analyze charge heterogeneity, pI, purity and size of proteins from Maurice runs. It also notes some calculations that may need to be done in Excel if the Empower software does not automatically provide certain analysis values.
This document appears to be a piping and instrumentation diagram (P&I diagram) for material storage and transfer. It shows a storage tank (T-201), two transfer pumps (P-201A/B), associated piping, and instrumentation. Liquid is transferred from the storage tank to another location (T-301) via the pumps and piping. The diagram labels piping sizes and materials, and instrumentation includes flow transmitters, control valves and indicators.
In most chemical engineering curriculums, distillation and liquid-liquid extraction (LLE) do not receive equal billing. Yet, this powerful separations technology is in place across the CPI, pharmaceutical and oil/gas industries. Discover how to design an LLE column with industry experts Don Glatz and Brendan Cross as they discuss specific examples and separations challenges.
Basic understanding of HAZOP it covers:
-Basic understanding of HAZOP
-HAZOP requirements
-How it works
-Case study
-HAZOP team
-Advantage & disadvantage
Impurities in Drug Substance & in Drug ProductKamal Ambalia
The document provides guidance on impurities in drug substances and products. It discusses the classification of impurities into organic, inorganic, and residual solvents. It describes the rationale for reporting and controlling impurities and outlines identification thresholds, reporting thresholds, and qualification thresholds based on maximum daily dose. Analytical procedures for impurity detection and identification must be validated. Impurities above thresholds require identification and qualification. The new drug specification must include impurities above reporting thresholds. Residual solvent limits are based on ICH Q3C guidelines.
This document provides copyright information and technical support contact details for Aspen Technology's HYSYS 2004.2 Dynamic Modeling software. It lists over 200 Aspen product names that are copyrighted and/or trademarked by Aspen Technology. Contact information is provided for Aspen's Online Technical Support Center, phone support, and email support.
This document provides lecture notes on mass and energy balances. It covers key topics such as dimensions, units, unit conversion, material balances, and energy balances. Chapter 1 defines dimensions, units, and common unit systems used in engineering. It explains how to perform unit conversions and check the dimensional homogeneity of equations. Later chapters discuss using material and energy balances to analyze processes involving multiple units and unit operations.
Continuous Flow Chemistry And The Manufacture Of Active Pharmaceutical Ingr...Stuart Silverman
A Series Of Informative Disquisitions About Continuous Flow Chemistry
Part Three:
Translation of flow protocols from the bench to the plant
Reaction Classes
Workup and isolation
Data Collection on the ProteinSimple Maurice: Driving Compliance with the Emp...KBI Biopharma
This document discusses using the ProteinSimple Maurice system with Empower control software for analyzing proteins. It provides an overview of KBI Biopharma's analytical services and locations. It then describes the Maurice system and Empower software, highlighting how the software can be used to analyze charge heterogeneity, pI, purity and size of proteins from Maurice runs. It also notes some calculations that may need to be done in Excel if the Empower software does not automatically provide certain analysis values.
This document appears to be a piping and instrumentation diagram (P&I diagram) for material storage and transfer. It shows a storage tank (T-201), two transfer pumps (P-201A/B), associated piping, and instrumentation. Liquid is transferred from the storage tank to another location (T-301) via the pumps and piping. The diagram labels piping sizes and materials, and instrumentation includes flow transmitters, control valves and indicators.
The document discusses analytical method development for HPLC. It notes that method development requires selecting requirements, instrumentation type, and why. Existing methods may be unreliable, expensive, or time-consuming, necessitating new method development. Key steps in development include defining goals, establishing sample preparation, selecting detector and mode of separation, performing preliminary separations, optimizing conditions, and validating the method. Method development is informed by factors like number of analytes, sample matrix, and analyte properties.
The document discusses various piping codes and standards. It provides an overview of different ASME B31 codes for different types of piping systems used in power generation, processing plants, transportation of liquids and gases, refrigeration, building services, and slurry transportation. It also summarizes some key aspects covered in ASME B31.3 code for process piping such as scope, exclusions, design pressure, temperature, fluid categories, thickness calculations for pipes, bends, flanges, and other components. The document further discusses welding related topics like preheating, heat treatment, and impact testing requirements.
Selection of amine solvents for CO2 capture from natural gas power plant - presentation by Jiafei Zhang in the Natural Gas CCS session at the UKCCSRC Cardiff Biannual Meeting, 10-11 September 2014
A simbologia de instrumentação analógica e digital, compartilhada e integral, distribuída e centralizada se baseia nas seguintes normas americanas (geralmente traduzidas para o português) :
1. ISA S5.1, Instrumentation Symbols and Identification, 1984
2. ISA S5.3, Graphic Symbols for Distributed Control/Shared Display Instrumentation, Logic and Computer Systems, 1983
El documento proporciona información sobre espectroscopia infrarroja (IR) y Raman. Brevemente:
1) La espectroscopia IR observa las vibraciones y deformaciones de los enlaces entre átomos cuando una molécula es irradiada con IR.
2) La espectroscopia Raman, aunque menos intensa que IR, es complementaria y puede observar vibraciones que IR no detecta.
3) Ambas técnicas son útiles para deducir estructuras moleculares.
Heat Exchangers presentation on Types, Classification and governing EquationsHassan ElBanhawi
You can find here all that you need to know about Heat Exchangers. This is an introduction to understand more about their:-
-Types.
-Governing Equations.
-Worked Example.
-Excel Sheets for Calculation.
You can find also more at:
http://hassanelbanhawi.com/staticequipment/heatexchangers/
All the data and the illustrative figures presented here can be found through two reference books:-
ENGINEERING DATA BOOK by Gas Processors Suppliers Association
Process Technology - Equipment and Systems by Charles E. Thomas
Thank you.
ELECTRIC MOTOR (EM) DRIVEN COMPRESSOR IN ASPEN HYSYS DYNAMICSVijay Sarathy
Aspen HYSYS Dynamics provides the option of simulating centrifugal compressors with an Electric Motor (EM). In order to setup the electric motor, the following calculations can be made to arrive at the Electric Motor Input data in Aspen HYSYS Dynamics.
The document discusses tag numbering systems used in oil, gas, and petrochemical plants. It explains that every component and piece of equipment requires a unique identification tag for safety and maintenance purposes. While there is no single standard, companies follow common conventions and best practices. Tag numbers are applied during design and construction, and are used on equipment, drawings, manuals, and computer systems for life. Examples of tag numbering processes and standards are provided.
This document summarizes saponification of ethyl acetate and sodium hydroxide in an isothermal batch reactor. It describes the basic design of a batch reactor where reactants are placed inside and allowed to react over time before removing products. The general mass balance equation and basic design equation for a batch reactor are provided. Kinetic parameters like rate of reaction, concentration, and temperature are also discussed. Procedures for a titration experiment to determine concentration are outlined. Tips are given to ensure accurate measurements in experiments.
The document is an inspection report of an electrical transfer pump. It summarizes:
1) An inspection was conducted of the pump which included document verification, functional testing at low and high pressures, and verification of calibration certificates.
2) The inspection found the pump to be in good working order, but the bourdon pressure gauge serial number was not marked and needed replacing to meet requirements.
3) Non-conformances were identified regarding certification and testing of the lifting skid and accessories that support the pump. Corrective actions were recommended to address these issues.
The document discusses reference standards which are substances used to ensure the identity, strength, quality and purity of medicines. Reference standards are obtained from organizations like USP and used to support various measurements in chemical, biological, clinical and physical areas. The document outlines the process of preparation, characterization, storage and utilization of reference standards. It provides guidelines on properties like purity, stability and intended use of reference standards.
A condenser is a heat exchanger that transfers vapors into a liquid state by removing latent heat with a coolant like water. This document provides design calculations for an 8 unit shell and tube condenser with 1030 tubes that uses cold water as the coolant to condense steam at a rate of 8060 kg/hr and 4343 kW of heat duty. Key specifications are provided, like a calculated overall heat transfer coefficient of 1100.97 W/m2C and pressure drops of 0.59 psi for the tube side and 0.109 psi for the shell side. References on condenser design are also listed.
This document discusses different types of capital cost estimates for projects with increasing levels of accuracy:
1. Order of magnitude estimates (25-15% accuracy) use existing plant data for capacity and inflation adjustments.
2. Study estimates (30-20% accuracy) roughly size major equipment.
3. Preliminary design estimates (25-15% accuracy) include major equipment, piping, instrumentation, and electrical costs.
The total capital cost includes direct costs, indirect costs, contingency, fees, and auxiliary facilities. Direct costs cover equipment, materials, labor, freight, and taxes. Indirect costs include construction overhead and engineering expenses.
The document discusses the McCabe-Thiele design method for distillation column design using vapor-liquid equilibrium (VLE) data. It explains that the McCabe-Thiele method uses a graphical approach to determine the theoretical number of stages required for a binary separation based on the VLE plot. Operating lines are drawn on the VLE diagram to define the mass balance relationships between the liquid and vapor phases. The operating line for the rectification section is constructed by drawing a line with slope R/(R+1) from the desired top product composition point, where R is the reflux ratio. The operating line for the stripping section has a slope of Ls/Vs, where Ls and Vs are the liquid and
This document lists 117 technical books related to mechanical engineering topics such as fluid mechanics, thermodynamics, heat transfer, stress analysis, dynamics and vibrations, materials properties, manufacturing processes, CAD/CAM, and instrumentation and controls. The books cover fundamental principles, design applications, case studies, and reference information for mechanical engineers.
110921 commissioning of offshore installationslaithu2908
This document discusses the commissioning process for offshore installations built in yards. It covers the total commissioning activity and defines the key phases of mechanical completion, pre-commissioning and commissioning. Mechanical completion involves verifying construction work is complete according to design. Pre-commissioning verifies functionality and system integration. Commissioning verifies systems are ready for operation. The document provides details on planning, organization and activities for each phase. Estimates suggest 95-105 systems for an FPSO requiring around 135,000-145,000 hours for commissioning, taking around 6 months with a team of 90 people. Addressing issues can help improve estimates over time.
Este documento describe los conceptos básicos de los circuitos eléctricos, incluyendo sus componentes (resistencias, fuentes, nodos), clasificaciones (corriente continua, corriente alterna, serie, paralelo), y leyes fundamentales (leyes de Kirchhoff, ley de Ohm, teoremas de Norton y Thévenin). También explica los métodos para diseñar circuitos usando simulaciones por computadora y que los ingenieros de sistemas se involucran en el diseño del software y lógica para microcontroladores usados en circuit
Actividad paso nº4 tipos de reacciones quimicasGarcia505
Este documento proporciona 10 reacciones químicas y solicita identificar el tipo de reacción (cambio químico) que ocurre en cada una de acuerdo a la clasificación estudiada. Las reacciones incluyen descomposición, combustión, reacción ácido-base y reacción de reemplazo o doble reemplazo.
Episode 55 : Conceptual Process Synthesis-Design
Process Flowsheet Synthesis: Method to determine a process flowsheet that satisfies all product, operational and other requirements
SAJJAD KHUDHUR ABBAS
Ceo , Founder & Head of SHacademy
Chemical Engineering , Al-Muthanna University, Iraq
Oil & Gas Safety and Health Professional – OSHACADEMY
Trainer of Trainers (TOT) - Canadian Center of Human
Development
The document discusses analytical method development for HPLC. It notes that method development requires selecting requirements, instrumentation type, and why. Existing methods may be unreliable, expensive, or time-consuming, necessitating new method development. Key steps in development include defining goals, establishing sample preparation, selecting detector and mode of separation, performing preliminary separations, optimizing conditions, and validating the method. Method development is informed by factors like number of analytes, sample matrix, and analyte properties.
The document discusses various piping codes and standards. It provides an overview of different ASME B31 codes for different types of piping systems used in power generation, processing plants, transportation of liquids and gases, refrigeration, building services, and slurry transportation. It also summarizes some key aspects covered in ASME B31.3 code for process piping such as scope, exclusions, design pressure, temperature, fluid categories, thickness calculations for pipes, bends, flanges, and other components. The document further discusses welding related topics like preheating, heat treatment, and impact testing requirements.
Selection of amine solvents for CO2 capture from natural gas power plant - presentation by Jiafei Zhang in the Natural Gas CCS session at the UKCCSRC Cardiff Biannual Meeting, 10-11 September 2014
A simbologia de instrumentação analógica e digital, compartilhada e integral, distribuída e centralizada se baseia nas seguintes normas americanas (geralmente traduzidas para o português) :
1. ISA S5.1, Instrumentation Symbols and Identification, 1984
2. ISA S5.3, Graphic Symbols for Distributed Control/Shared Display Instrumentation, Logic and Computer Systems, 1983
El documento proporciona información sobre espectroscopia infrarroja (IR) y Raman. Brevemente:
1) La espectroscopia IR observa las vibraciones y deformaciones de los enlaces entre átomos cuando una molécula es irradiada con IR.
2) La espectroscopia Raman, aunque menos intensa que IR, es complementaria y puede observar vibraciones que IR no detecta.
3) Ambas técnicas son útiles para deducir estructuras moleculares.
Heat Exchangers presentation on Types, Classification and governing EquationsHassan ElBanhawi
You can find here all that you need to know about Heat Exchangers. This is an introduction to understand more about their:-
-Types.
-Governing Equations.
-Worked Example.
-Excel Sheets for Calculation.
You can find also more at:
http://hassanelbanhawi.com/staticequipment/heatexchangers/
All the data and the illustrative figures presented here can be found through two reference books:-
ENGINEERING DATA BOOK by Gas Processors Suppliers Association
Process Technology - Equipment and Systems by Charles E. Thomas
Thank you.
ELECTRIC MOTOR (EM) DRIVEN COMPRESSOR IN ASPEN HYSYS DYNAMICSVijay Sarathy
Aspen HYSYS Dynamics provides the option of simulating centrifugal compressors with an Electric Motor (EM). In order to setup the electric motor, the following calculations can be made to arrive at the Electric Motor Input data in Aspen HYSYS Dynamics.
The document discusses tag numbering systems used in oil, gas, and petrochemical plants. It explains that every component and piece of equipment requires a unique identification tag for safety and maintenance purposes. While there is no single standard, companies follow common conventions and best practices. Tag numbers are applied during design and construction, and are used on equipment, drawings, manuals, and computer systems for life. Examples of tag numbering processes and standards are provided.
This document summarizes saponification of ethyl acetate and sodium hydroxide in an isothermal batch reactor. It describes the basic design of a batch reactor where reactants are placed inside and allowed to react over time before removing products. The general mass balance equation and basic design equation for a batch reactor are provided. Kinetic parameters like rate of reaction, concentration, and temperature are also discussed. Procedures for a titration experiment to determine concentration are outlined. Tips are given to ensure accurate measurements in experiments.
The document is an inspection report of an electrical transfer pump. It summarizes:
1) An inspection was conducted of the pump which included document verification, functional testing at low and high pressures, and verification of calibration certificates.
2) The inspection found the pump to be in good working order, but the bourdon pressure gauge serial number was not marked and needed replacing to meet requirements.
3) Non-conformances were identified regarding certification and testing of the lifting skid and accessories that support the pump. Corrective actions were recommended to address these issues.
The document discusses reference standards which are substances used to ensure the identity, strength, quality and purity of medicines. Reference standards are obtained from organizations like USP and used to support various measurements in chemical, biological, clinical and physical areas. The document outlines the process of preparation, characterization, storage and utilization of reference standards. It provides guidelines on properties like purity, stability and intended use of reference standards.
A condenser is a heat exchanger that transfers vapors into a liquid state by removing latent heat with a coolant like water. This document provides design calculations for an 8 unit shell and tube condenser with 1030 tubes that uses cold water as the coolant to condense steam at a rate of 8060 kg/hr and 4343 kW of heat duty. Key specifications are provided, like a calculated overall heat transfer coefficient of 1100.97 W/m2C and pressure drops of 0.59 psi for the tube side and 0.109 psi for the shell side. References on condenser design are also listed.
This document discusses different types of capital cost estimates for projects with increasing levels of accuracy:
1. Order of magnitude estimates (25-15% accuracy) use existing plant data for capacity and inflation adjustments.
2. Study estimates (30-20% accuracy) roughly size major equipment.
3. Preliminary design estimates (25-15% accuracy) include major equipment, piping, instrumentation, and electrical costs.
The total capital cost includes direct costs, indirect costs, contingency, fees, and auxiliary facilities. Direct costs cover equipment, materials, labor, freight, and taxes. Indirect costs include construction overhead and engineering expenses.
The document discusses the McCabe-Thiele design method for distillation column design using vapor-liquid equilibrium (VLE) data. It explains that the McCabe-Thiele method uses a graphical approach to determine the theoretical number of stages required for a binary separation based on the VLE plot. Operating lines are drawn on the VLE diagram to define the mass balance relationships between the liquid and vapor phases. The operating line for the rectification section is constructed by drawing a line with slope R/(R+1) from the desired top product composition point, where R is the reflux ratio. The operating line for the stripping section has a slope of Ls/Vs, where Ls and Vs are the liquid and
This document lists 117 technical books related to mechanical engineering topics such as fluid mechanics, thermodynamics, heat transfer, stress analysis, dynamics and vibrations, materials properties, manufacturing processes, CAD/CAM, and instrumentation and controls. The books cover fundamental principles, design applications, case studies, and reference information for mechanical engineers.
110921 commissioning of offshore installationslaithu2908
This document discusses the commissioning process for offshore installations built in yards. It covers the total commissioning activity and defines the key phases of mechanical completion, pre-commissioning and commissioning. Mechanical completion involves verifying construction work is complete according to design. Pre-commissioning verifies functionality and system integration. Commissioning verifies systems are ready for operation. The document provides details on planning, organization and activities for each phase. Estimates suggest 95-105 systems for an FPSO requiring around 135,000-145,000 hours for commissioning, taking around 6 months with a team of 90 people. Addressing issues can help improve estimates over time.
Este documento describe los conceptos básicos de los circuitos eléctricos, incluyendo sus componentes (resistencias, fuentes, nodos), clasificaciones (corriente continua, corriente alterna, serie, paralelo), y leyes fundamentales (leyes de Kirchhoff, ley de Ohm, teoremas de Norton y Thévenin). También explica los métodos para diseñar circuitos usando simulaciones por computadora y que los ingenieros de sistemas se involucran en el diseño del software y lógica para microcontroladores usados en circuit
Actividad paso nº4 tipos de reacciones quimicasGarcia505
Este documento proporciona 10 reacciones químicas y solicita identificar el tipo de reacción (cambio químico) que ocurre en cada una de acuerdo a la clasificación estudiada. Las reacciones incluyen descomposición, combustión, reacción ácido-base y reacción de reemplazo o doble reemplazo.
Episode 55 : Conceptual Process Synthesis-Design
Process Flowsheet Synthesis: Method to determine a process flowsheet that satisfies all product, operational and other requirements
SAJJAD KHUDHUR ABBAS
Ceo , Founder & Head of SHacademy
Chemical Engineering , Al-Muthanna University, Iraq
Oil & Gas Safety and Health Professional – OSHACADEMY
Trainer of Trainers (TOT) - Canadian Center of Human
Development