Report
Share
Download to read offline
Recommended
Lecture 3 Dl.ppt
This document discusses voltage-gated ion channels and the action potential. It describes Hodgkin and Huxley's experiments identifying sodium and potassium currents in the squid giant axon. It contrasts the topology of different voltage-gated channels and discusses how voltage sensitivity is recognized in single-channel recordings. Finally, it explains how sodium and potassium channel activation shape the action potential and discusses channelopathies that can lead to disease.
Quick Coarse-grained kinetic Monte Carlo overview
Overviews the motivation and underworkings of kinetic Monte Carlo, a computer simulation method used to study subjects from biological cell membranes to reactions on platinum surfaces. Then expands kMC to CGMC - a method for speeding up the simulation by averaging out details deemed unimportant to the overall outcome of the simulation.
Monte Carlo Simulations & Membrane Simulation and Dynamics
Monte Carlo simulations and molecular dynamics simulations are common computational methods to study membrane proteins and lipid bilayers. Monte Carlo simulations use random sampling to explore the behavior of complex systems. Molecular dynamics simulations numerically simulate particle motions under internal and external forces based on empirical energy functions. There are different levels of molecular dynamics simulations including atomistic, united atom, and coarse grained simulations, each with varying degrees of atomic detail and accessible timescales. Parameterized force fields are used to model interactions in lipid and protein systems. These computational methods provide insights into membrane and protein dynamics that are difficult to obtain experimentally.
Ionic Equilibria and Membrane Potential
The document discusses ionic equilibria and membrane potential, including the Nernst and Goldman-Hodgkin-Katz equations. It describes voltage-gated sodium and potassium channels, their structure and function, and how they contribute to the generation and repolarization of action potentials. The document also discusses channelopathies like paramyotonia congenita, a sodium channel mutation that causes muscle stiffness and weakness in response to cold temperatures due to impaired channel inactivation.
Ab Initio Protein Structure Prediction
Ab initio protein structure prediction uses computational methods to predict a protein's 3D structure from its amino acid sequence. It relies on conformational searching to generate structure decoys and selecting native-like models. The key factors for success are an accurate energy function, efficient search methods like molecular dynamics or genetic algorithms, and effective selection of models close to the native structure. Model selection approaches include energy evaluations, compatibility scores, clustering of similar decoys, and identifying the lowest energy conformations.
From Atomistic to Coarse Grain Systems - Procedures & Methods
The physical and mathematical basis as well as the historical background of the most popular coarse graining methods (Reverse/Inverse Monte-Carlo, Iterative Boltzmann Inversion and Force Matching method) in the field of fluids and soft matter are presented here. In terms of lengths and time scale, I refer here to the classical coarse grain systems, which are in between the atomistic and mesoscale systems. The focus is on the path to derive the coarse grain force fields from reference data obtained from atomistic simulations.
Ion channels
Ion channels are pore-forming membrane proteins that selectively transport ions across cell membranes. They are classified based on their gating mechanism (voltage-gated or ligand-gated), the type of ion transported, and their localization. Voltage-gated channels open and close in response to changes in membrane potential, while ligand-gated channels open when specific ligands bind. Dysfunctions in ion channels can cause diseases. Ion channels are important drug targets, and several drugs like tetrodotoxin, ziconotide, benzodiazepines, and lidocaine act by modulating specific ion channels.
Action potential (niraj)
The document discusses the generation and propagation of action potentials in neurons. It begins by explaining the resting membrane potential, which arises from ion concentration gradients maintained by the sodium-potassium pump and potassium leakage channels. It then describes how an action potential is triggered when the membrane potential reaches a threshold, causing voltage-gated sodium channels to open and sodium ions to rush in, rapidly depolarizing the membrane. This wave of depolarization then propagates along the neuron as adjacent areas are triggered to reach threshold. The action potential involves sequential phases of depolarization, repolarization, and hyperpolarization.
Recommended
Lecture 3 Dl.ppt
This document discusses voltage-gated ion channels and the action potential. It describes Hodgkin and Huxley's experiments identifying sodium and potassium currents in the squid giant axon. It contrasts the topology of different voltage-gated channels and discusses how voltage sensitivity is recognized in single-channel recordings. Finally, it explains how sodium and potassium channel activation shape the action potential and discusses channelopathies that can lead to disease.
Quick Coarse-grained kinetic Monte Carlo overview
Overviews the motivation and underworkings of kinetic Monte Carlo, a computer simulation method used to study subjects from biological cell membranes to reactions on platinum surfaces. Then expands kMC to CGMC - a method for speeding up the simulation by averaging out details deemed unimportant to the overall outcome of the simulation.
Monte Carlo Simulations & Membrane Simulation and Dynamics
Monte Carlo simulations and molecular dynamics simulations are common computational methods to study membrane proteins and lipid bilayers. Monte Carlo simulations use random sampling to explore the behavior of complex systems. Molecular dynamics simulations numerically simulate particle motions under internal and external forces based on empirical energy functions. There are different levels of molecular dynamics simulations including atomistic, united atom, and coarse grained simulations, each with varying degrees of atomic detail and accessible timescales. Parameterized force fields are used to model interactions in lipid and protein systems. These computational methods provide insights into membrane and protein dynamics that are difficult to obtain experimentally.
Ionic Equilibria and Membrane Potential
The document discusses ionic equilibria and membrane potential, including the Nernst and Goldman-Hodgkin-Katz equations. It describes voltage-gated sodium and potassium channels, their structure and function, and how they contribute to the generation and repolarization of action potentials. The document also discusses channelopathies like paramyotonia congenita, a sodium channel mutation that causes muscle stiffness and weakness in response to cold temperatures due to impaired channel inactivation.
Ab Initio Protein Structure Prediction
Ab initio protein structure prediction uses computational methods to predict a protein's 3D structure from its amino acid sequence. It relies on conformational searching to generate structure decoys and selecting native-like models. The key factors for success are an accurate energy function, efficient search methods like molecular dynamics or genetic algorithms, and effective selection of models close to the native structure. Model selection approaches include energy evaluations, compatibility scores, clustering of similar decoys, and identifying the lowest energy conformations.
From Atomistic to Coarse Grain Systems - Procedures & Methods
The physical and mathematical basis as well as the historical background of the most popular coarse graining methods (Reverse/Inverse Monte-Carlo, Iterative Boltzmann Inversion and Force Matching method) in the field of fluids and soft matter are presented here. In terms of lengths and time scale, I refer here to the classical coarse grain systems, which are in between the atomistic and mesoscale systems. The focus is on the path to derive the coarse grain force fields from reference data obtained from atomistic simulations.
Ion channels
Ion channels are pore-forming membrane proteins that selectively transport ions across cell membranes. They are classified based on their gating mechanism (voltage-gated or ligand-gated), the type of ion transported, and their localization. Voltage-gated channels open and close in response to changes in membrane potential, while ligand-gated channels open when specific ligands bind. Dysfunctions in ion channels can cause diseases. Ion channels are important drug targets, and several drugs like tetrodotoxin, ziconotide, benzodiazepines, and lidocaine act by modulating specific ion channels.
Action potential (niraj)
The document discusses the generation and propagation of action potentials in neurons. It begins by explaining the resting membrane potential, which arises from ion concentration gradients maintained by the sodium-potassium pump and potassium leakage channels. It then describes how an action potential is triggered when the membrane potential reaches a threshold, causing voltage-gated sodium channels to open and sodium ions to rush in, rapidly depolarizing the membrane. This wave of depolarization then propagates along the neuron as adjacent areas are triggered to reach threshold. The action potential involves sequential phases of depolarization, repolarization, and hyperpolarization.
Long Mac Kinnon05.Dl.pdf
This document discusses the x-ray crystal structure of the mammalian Shaker family potassium ion channel Kv1.2 determined by the authors. Three key conclusions are presented:
1) The voltage sensors that allow the channel to switch between conductive and nonconductive states are independent domains within the membrane.
2) The voltage sensors perform mechanical work on the pore via the S4-S5 linker helices, positioned to constrict or dilate the pore.
3) In the open conformation, two of the four conserved arginine residues on S4 are on a lipid-facing surface while two are buried within the voltage sensor.
Lecture 2 Dl.ppt
The document discusses membrane structure and ligand-gated ion channels. It covers topics like lipid structure and properties, membrane structure and fluidity, membrane proteins and their interactions with lipids, and different classes of ligand-gated ion channels including ATP-sensitive potassium channels, G protein-gated potassium channels, cyclic nucleotide-gated channels involved in phototransduction, nicotinic acetylcholine receptors, and glutamate receptors. Experimental techniques like fluorescence recovery after photobleaching are also mentioned for studying membrane component diffusion.
Lecture 3 Dl.doc
1) The document discusses voltage-gated ion channels and how they generate action potentials. It provides historical context from Hodgkin and Huxley's experiments identifying sodium and potassium currents.
2) Single channel recordings show channels fluctuating between open and closed states, with open probability increasing with depolarization.
3) Voltage-gated sodium and potassium channels underlie the upstroke and repolarization of action potentials, respectively, through their changing open probabilities with membrane potential.
Lecture 1 Dl.doc
This document outlines the goals and objectives of a lecture on ion transport through membrane transport proteins. Specifically, it will discuss:
1. The three main classes of membrane transport proteins - transporters, ion channels, and ATP-powered pumps - and how they differ in transport rates and energy utilization.
2. Uniporter-catalyzed transport through GLUT1 glucose transporters as a representative example, including the Michaelis-Menten kinetics of transport and the current model of GLUT1's transport mechanism.
3. How ion movement through ion channels serves electrical signaling roles by changing membrane potential and intracellular ion concentrations, allowing rapid cell-environment communication.
Lecture 2 Dl.doc
This document provides an overview of a lecture on membrane structure and ligand-gated ion channels. The first part of the lecture will discuss the lipid composition and forces that contribute to the stability of the lipid bilayer membrane environment that ion channels reside in. The second part will present ion channels that are gated by intracellular molecules like ATP and G proteins, as well as those gated by extracellular molecules like acetylcholine and glutamate. Learning objectives cover topics like lipid structure, membrane dynamics, protein-membrane interactions, and specific ion channel activation mechanisms.
Lecture 1 Dl.ppt
This document provides an overview of ion channels and membrane transport proteins. It lists 14 learning objectives related to understanding ion transport mechanisms, membrane potentials, the Nernst equation, Ohm's law, different types of ion channels, and patch clamp techniques. Key concepts covered include the distribution of ions inside and outside cells, equilibrium potentials, selectivity and permeation of potassium channels, and the role of PIP2 in channel gating.
Ps1.Dl.doc
This document contains 4 practice problems about membrane potentials and ion concentrations:
1. It asks the reader to calculate equilibrium potentials for Na+, K+, and Ca2+ ions in a muscle cell based on given concentrations, and asks which ion the membrane is most permeable to at the peak of an action potential.
2. It asks the reader to calculate the membrane potential across mitochondria given concentrations of a lipid-soluble ion on both sides of the membrane.
3. It asks whether a neurotransmitter that opens proton channels would be excitatory or inhibitory given internal and external pH levels and the resting potential.
4. It asks about the Nernst equilibrium potential for Cl- in skeletal muscle
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Simplify your search for a reliable Python development partner! This list presents the top 10 trusted US providers offering comprehensive Python development services, ensuring your project's success from conception to completion.
Taking AI to the Next Level in Manufacturing.pdf
Read Taking AI to the Next Level in Manufacturing to gain insights on AI adoption in the manufacturing industry, such as:
1. How quickly AI is being implemented in manufacturing.
2. Which barriers stand in the way of AI adoption.
3. How data quality and governance form the backbone of AI.
4. Organizational processes and structures that may inhibit effective AI adoption.
6. Ideas and approaches to help build your organization's AI strategy.
The Microsoft 365 Migration Tutorial For Beginner.pptx
This presentation will help you understand the power of Microsoft 365. However, we have mentioned every productivity app included in Office 365. Additionally, we have suggested the migration situation related to Office 365 and how we can help you.
You can also read: https://www.systoolsgroup.com/updates/office-365-tenant-to-tenant-migration-step-by-step-complete-guide/
How to Interpret Trends in the Kalyan Rajdhani Mix Chart.pdf
A Mix Chart displays historical data of numbers in a graphical or tabular form. The Kalyan Rajdhani Mix Chart specifically shows the results of a sequence of numbers over different periods.
Digital Banking in the Cloud: How Citizens Bank Unlocked Their Mainframe
Inconsistent user experience and siloed data, high costs, and changing customer expectations – Citizens Bank was experiencing these challenges while it was attempting to deliver a superior digital banking experience for its clients. Its core banking applications run on the mainframe and Citizens was using legacy utilities to get the critical mainframe data to feed customer-facing channels, like call centers, web, and mobile. Ultimately, this led to higher operating costs (MIPS), delayed response times, and longer time to market.
Ever-changing customer expectations demand more modern digital experiences, and the bank needed to find a solution that could provide real-time data to its customer channels with low latency and operating costs. Join this session to learn how Citizens is leveraging Precisely to replicate mainframe data to its customer channels and deliver on their “modern digital bank” experiences.
Choosing The Best AWS Service For Your Website + API.pptx
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
Programming Foundation Models with DSPy - Meetup Slides
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Tomaz Bratanic
Graph ML and GenAI Expert - Neo4j
TrustArc Webinar - 2024 Global Privacy Survey
How does your privacy program stack up against your peers? What challenges are privacy teams tackling and prioritizing in 2024?
In the fifth annual Global Privacy Benchmarks Survey, we asked over 1,800 global privacy professionals and business executives to share their perspectives on the current state of privacy inside and outside of their organizations. This year’s report focused on emerging areas of importance for privacy and compliance professionals, including considerations and implications of Artificial Intelligence (AI) technologies, building brand trust, and different approaches for achieving higher privacy competence scores.
See how organizational priorities and strategic approaches to data security and privacy are evolving around the globe.
This webinar will review:
- The top 10 privacy insights from the fifth annual Global Privacy Benchmarks Survey
- The top challenges for privacy leaders, practitioners, and organizations in 2024
- Key themes to consider in developing and maintaining your privacy program
Generating privacy-protected synthetic data using Secludy and Milvus
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Skybuffer SAM4U tool for SAP license adoption
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
Leveraging the Graph for Clinical Trials and Standards
Katja Glaß
OpenStudyBuilder Community Manager - Katja Glaß Consulting
Marius Conjeaud
Principal Consultant - Neo4j
Fueling AI with Great Data with Airbyte Webinar
This talk will focus on how to collect data from a variety of sources, leveraging this data for RAG and other GenAI use cases, and finally charting your course to productionalization.
More Related Content
More from guestbd13f18
Long Mac Kinnon05.Dl.pdf
This document discusses the x-ray crystal structure of the mammalian Shaker family potassium ion channel Kv1.2 determined by the authors. Three key conclusions are presented:
1) The voltage sensors that allow the channel to switch between conductive and nonconductive states are independent domains within the membrane.
2) The voltage sensors perform mechanical work on the pore via the S4-S5 linker helices, positioned to constrict or dilate the pore.
3) In the open conformation, two of the four conserved arginine residues on S4 are on a lipid-facing surface while two are buried within the voltage sensor.
Lecture 2 Dl.ppt
The document discusses membrane structure and ligand-gated ion channels. It covers topics like lipid structure and properties, membrane structure and fluidity, membrane proteins and their interactions with lipids, and different classes of ligand-gated ion channels including ATP-sensitive potassium channels, G protein-gated potassium channels, cyclic nucleotide-gated channels involved in phototransduction, nicotinic acetylcholine receptors, and glutamate receptors. Experimental techniques like fluorescence recovery after photobleaching are also mentioned for studying membrane component diffusion.
Lecture 3 Dl.doc
1) The document discusses voltage-gated ion channels and how they generate action potentials. It provides historical context from Hodgkin and Huxley's experiments identifying sodium and potassium currents.
2) Single channel recordings show channels fluctuating between open and closed states, with open probability increasing with depolarization.
3) Voltage-gated sodium and potassium channels underlie the upstroke and repolarization of action potentials, respectively, through their changing open probabilities with membrane potential.
Lecture 1 Dl.doc
This document outlines the goals and objectives of a lecture on ion transport through membrane transport proteins. Specifically, it will discuss:
1. The three main classes of membrane transport proteins - transporters, ion channels, and ATP-powered pumps - and how they differ in transport rates and energy utilization.
2. Uniporter-catalyzed transport through GLUT1 glucose transporters as a representative example, including the Michaelis-Menten kinetics of transport and the current model of GLUT1's transport mechanism.
3. How ion movement through ion channels serves electrical signaling roles by changing membrane potential and intracellular ion concentrations, allowing rapid cell-environment communication.
Lecture 2 Dl.doc
This document provides an overview of a lecture on membrane structure and ligand-gated ion channels. The first part of the lecture will discuss the lipid composition and forces that contribute to the stability of the lipid bilayer membrane environment that ion channels reside in. The second part will present ion channels that are gated by intracellular molecules like ATP and G proteins, as well as those gated by extracellular molecules like acetylcholine and glutamate. Learning objectives cover topics like lipid structure, membrane dynamics, protein-membrane interactions, and specific ion channel activation mechanisms.
Lecture 1 Dl.ppt
This document provides an overview of ion channels and membrane transport proteins. It lists 14 learning objectives related to understanding ion transport mechanisms, membrane potentials, the Nernst equation, Ohm's law, different types of ion channels, and patch clamp techniques. Key concepts covered include the distribution of ions inside and outside cells, equilibrium potentials, selectivity and permeation of potassium channels, and the role of PIP2 in channel gating.
Ps1.Dl.doc
This document contains 4 practice problems about membrane potentials and ion concentrations:
1. It asks the reader to calculate equilibrium potentials for Na+, K+, and Ca2+ ions in a muscle cell based on given concentrations, and asks which ion the membrane is most permeable to at the peak of an action potential.
2. It asks the reader to calculate the membrane potential across mitochondria given concentrations of a lipid-soluble ion on both sides of the membrane.
3. It asks whether a neurotransmitter that opens proton channels would be excitatory or inhibitory given internal and external pH levels and the resting potential.
4. It asks about the Nernst equilibrium potential for Cl- in skeletal muscle
More from guestbd13f18 (7)
Recently uploaded
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Simplify your search for a reliable Python development partner! This list presents the top 10 trusted US providers offering comprehensive Python development services, ensuring your project's success from conception to completion.
Taking AI to the Next Level in Manufacturing.pdf
Read Taking AI to the Next Level in Manufacturing to gain insights on AI adoption in the manufacturing industry, such as:
1. How quickly AI is being implemented in manufacturing.
2. Which barriers stand in the way of AI adoption.
3. How data quality and governance form the backbone of AI.
4. Organizational processes and structures that may inhibit effective AI adoption.
6. Ideas and approaches to help build your organization's AI strategy.
The Microsoft 365 Migration Tutorial For Beginner.pptx
This presentation will help you understand the power of Microsoft 365. However, we have mentioned every productivity app included in Office 365. Additionally, we have suggested the migration situation related to Office 365 and how we can help you.
You can also read: https://www.systoolsgroup.com/updates/office-365-tenant-to-tenant-migration-step-by-step-complete-guide/
How to Interpret Trends in the Kalyan Rajdhani Mix Chart.pdf
A Mix Chart displays historical data of numbers in a graphical or tabular form. The Kalyan Rajdhani Mix Chart specifically shows the results of a sequence of numbers over different periods.
Digital Banking in the Cloud: How Citizens Bank Unlocked Their Mainframe
Inconsistent user experience and siloed data, high costs, and changing customer expectations – Citizens Bank was experiencing these challenges while it was attempting to deliver a superior digital banking experience for its clients. Its core banking applications run on the mainframe and Citizens was using legacy utilities to get the critical mainframe data to feed customer-facing channels, like call centers, web, and mobile. Ultimately, this led to higher operating costs (MIPS), delayed response times, and longer time to market.
Ever-changing customer expectations demand more modern digital experiences, and the bank needed to find a solution that could provide real-time data to its customer channels with low latency and operating costs. Join this session to learn how Citizens is leveraging Precisely to replicate mainframe data to its customer channels and deliver on their “modern digital bank” experiences.
Choosing The Best AWS Service For Your Website + API.pptx
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
Programming Foundation Models with DSPy - Meetup Slides
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Tomaz Bratanic
Graph ML and GenAI Expert - Neo4j
TrustArc Webinar - 2024 Global Privacy Survey
How does your privacy program stack up against your peers? What challenges are privacy teams tackling and prioritizing in 2024?
In the fifth annual Global Privacy Benchmarks Survey, we asked over 1,800 global privacy professionals and business executives to share their perspectives on the current state of privacy inside and outside of their organizations. This year’s report focused on emerging areas of importance for privacy and compliance professionals, including considerations and implications of Artificial Intelligence (AI) technologies, building brand trust, and different approaches for achieving higher privacy competence scores.
See how organizational priorities and strategic approaches to data security and privacy are evolving around the globe.
This webinar will review:
- The top 10 privacy insights from the fifth annual Global Privacy Benchmarks Survey
- The top challenges for privacy leaders, practitioners, and organizations in 2024
- Key themes to consider in developing and maintaining your privacy program
Generating privacy-protected synthetic data using Secludy and Milvus
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Skybuffer SAM4U tool for SAP license adoption
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
Leveraging the Graph for Clinical Trials and Standards
Katja Glaß
OpenStudyBuilder Community Manager - Katja Glaß Consulting
Marius Conjeaud
Principal Consultant - Neo4j
Fueling AI with Great Data with Airbyte Webinar
This talk will focus on how to collect data from a variety of sources, leveraging this data for RAG and other GenAI use cases, and finally charting your course to productionalization.
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-und-domino-lizenzkostenreduzierung-in-der-welt-von-dlau/
DLAU und die Lizenzen nach dem CCB- und CCX-Modell sind für viele in der HCL-Community seit letztem Jahr ein heißes Thema. Als Notes- oder Domino-Kunde haben Sie vielleicht mit unerwartet hohen Benutzerzahlen und Lizenzgebühren zu kämpfen. Sie fragen sich vielleicht, wie diese neue Art der Lizenzierung funktioniert und welchen Nutzen sie Ihnen bringt. Vor allem wollen Sie sicherlich Ihr Budget einhalten und Kosten sparen, wo immer möglich. Das verstehen wir und wir möchten Ihnen dabei helfen!
Wir erklären Ihnen, wie Sie häufige Konfigurationsprobleme lösen können, die dazu führen können, dass mehr Benutzer gezählt werden als nötig, und wie Sie überflüssige oder ungenutzte Konten identifizieren und entfernen können, um Geld zu sparen. Es gibt auch einige Ansätze, die zu unnötigen Ausgaben führen können, z. B. wenn ein Personendokument anstelle eines Mail-Ins für geteilte Mailboxen verwendet wird. Wir zeigen Ihnen solche Fälle und deren Lösungen. Und natürlich erklären wir Ihnen das neue Lizenzmodell.
Nehmen Sie an diesem Webinar teil, bei dem HCL-Ambassador Marc Thomas und Gastredner Franz Walder Ihnen diese neue Welt näherbringen. Es vermittelt Ihnen die Tools und das Know-how, um den Überblick zu bewahren. Sie werden in der Lage sein, Ihre Kosten durch eine optimierte Domino-Konfiguration zu reduzieren und auch in Zukunft gering zu halten.
Diese Themen werden behandelt
- Reduzierung der Lizenzkosten durch Auffinden und Beheben von Fehlkonfigurationen und überflüssigen Konten
- Wie funktionieren CCB- und CCX-Lizenzen wirklich?
- Verstehen des DLAU-Tools und wie man es am besten nutzt
- Tipps für häufige Problembereiche, wie z. B. Team-Postfächer, Funktions-/Testbenutzer usw.
- Praxisbeispiele und Best Practices zum sofortigen Umsetzen
GNSS spoofing via SDR (Criptored Talks 2024)
In the realm of cybersecurity, offensive security practices act as a critical shield. By simulating real-world attacks in a controlled environment, these techniques expose vulnerabilities before malicious actors can exploit them. This proactive approach allows manufacturers to identify and fix weaknesses, significantly enhancing system security.
This presentation delves into the development of a system designed to mimic Galileo's Open Service signal using software-defined radio (SDR) technology. We'll begin with a foundational overview of both Global Navigation Satellite Systems (GNSS) and the intricacies of digital signal processing.
The presentation culminates in a live demonstration. We'll showcase the manipulation of Galileo's Open Service pilot signal, simulating an attack on various software and hardware systems. This practical demonstration serves to highlight the potential consequences of unaddressed vulnerabilities, emphasizing the importance of offensive security practices in safeguarding critical infrastructure.
Dandelion Hashtable: beyond billion requests per second on a commodity server
This slide deck presents DLHT, a concurrent in-memory hashtable. Despite efforts to optimize hashtables, that go as far as sacrificing core functionality, state-of-the-art designs still incur multiple memory accesses per request and block request processing in three cases. First, most hashtables block while waiting for data to be retrieved from memory. Second, open-addressing designs, which represent the current state-of-the-art, either cannot free index slots on deletes or must block all requests to do so. Third, index resizes block every request until all objects are copied to the new index. Defying folklore wisdom, DLHT forgoes open-addressing and adopts a fully-featured and memory-aware closed-addressing design based on bounded cache-line-chaining. This design offers lock-free index operations and deletes that free slots instantly, (2) completes most requests with a single memory access, (3) utilizes software prefetching to hide memory latencies, and (4) employs a novel non-blocking and parallel resizing. In a commodity server and a memory-resident workload, DLHT surpasses 1.6B requests per second and provides 3.5x (12x) the throughput of the state-of-the-art closed-addressing (open-addressing) resizable hashtable on Gets (Deletes).
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Join us to learn how UiPath Apps can directly and easily interact with prebuilt connectors via Integration Service--including Salesforce, ServiceNow, Open GenAI, and more.
The best part is you can achieve this without building a custom workflow! Say goodbye to the hassle of using separate automations to call APIs. By seamlessly integrating within App Studio, you can now easily streamline your workflow, while gaining direct access to our Connector Catalog of popular applications.
We’ll discuss and demo the benefits of UiPath Apps and connectors including:
Creating a compelling user experience for any software, without the limitations of APIs.
Accelerating the app creation process, saving time and effort
Enjoying high-performance CRUD (create, read, update, delete) operations, for
seamless data management.
Speakers:
Russell Alfeche, Technology Leader, RPA at qBotic and UiPath MVP
Charlie Greenberg, host
Recently uploaded (20)
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Deep Dive: AI-Powered Marketing to Get More Leads and Customers with HyperGro...
Deep Dive: AI-Powered Marketing to Get More Leads and Customers with HyperGro...
The Microsoft 365 Migration Tutorial For Beginner.pptx
The Microsoft 365 Migration Tutorial For Beginner.pptx
How to Interpret Trends in the Kalyan Rajdhani Mix Chart.pdf
How to Interpret Trends in the Kalyan Rajdhani Mix Chart.pdf
Digital Banking in the Cloud: How Citizens Bank Unlocked Their Mainframe
Digital Banking in the Cloud: How Citizens Bank Unlocked Their Mainframe
Choosing The Best AWS Service For Your Website + API.pptx
Choosing The Best AWS Service For Your Website + API.pptx
Programming Foundation Models with DSPy - Meetup Slides
Programming Foundation Models with DSPy - Meetup Slides
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Generating privacy-protected synthetic data using Secludy and Milvus
Generating privacy-protected synthetic data using Secludy and Milvus
Leveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and Standards
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
Nordic Marketo Engage User Group_June 13_ 2024.pptx
Nordic Marketo Engage User Group_June 13_ 2024.pptx
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors