Non tubercular mycobacteria progress report at a site

1. Prevalence, risk factors, laboratory diagnosis and treatment of non-
tuberculous mycobacterial (NTM) disease: a multicentre study
Progress Report
(October 2023)

2. Patients Pulmonary Extrapulmonary Total
TB suspects 2530 504 3034
NTM suspects 28 3 31
Confirmed NTM 08 1 9
Treatment initiated 07 1 8
Follow-up 5 1 6
Died 2 0 2
NTM study results (Period= January 2021 to
October 2023)
Total confirmed NTM Cases at JNMC Wardha Till date - 9

3. Characteristics mean (±SD)
Age (yrs) 54.4
BMI (kg/m2)
Gender
Male /Female 6/3
*Systemic symptoms
Fever
Night sweats
Loss of appetite
Significant weight loss
Other symptoms
 General weakness
 Headache
57%
42%
71%
42%
100%
*Pulmonary symptoms
Cough
Shortness of breath
Chest pain
Haemoptysis
57 %
42%
28%
14%
Clinical characteristics of NTM-PD patients
NTM-PD=pulmonary NTM disease; BMI=body mass index
Significant weight loss: >10% of body weight loss over 6 months or >5% of body weight loss over 3 months

4. Pulmonary risk factors No. of patients
Past history of Tuberculosis
Bronchiectasis
COPD
Cystic fibrosis
Oesophageal disorder (specify)
Any other risk factor (specify)
07
01
00
00
00
00
Other risk factors
Smoking history (pack-year)
Chronic alcohol intake
Type 2 diabetes mellitus
Obesity
Use of corticosteroids/ other immunosuppressive drugs
(provide names in footnotes)
HIV/AIDS
Others (specify)
01
02
01
00
00
00
00
COPD=chronic obstructive pulmonary disease; Obesity= BMI>28kg/m2
Some patients may have more that one risk factors
Risk factors for pulmonary NTM disease (n=)

5. Radiological features No. of patients (%)
Type of disease
Cavitary/fibro-cavitary
Nodular bronchiectasis
Mixed
57%
15%
28%
Lungs involved
Unilateral disease
Bilateral disease
12.5%
87.5%
Extent of disease
Limited
Extensive
00%
100%
NTM-PD=pulmonary NTM disease
Radiological features of NTM-PD patients (n=)

6. Characteristics Mean (±SD)
Age (yrs) 52yr
BMI (kg/m2) 26.04
Gender
Male
Female
M
Clinical specimen
Lymph node biopsy
Cerebrospinal fluid
Skin lesion biopsy
Peritoneal dialysis fluid
Ileocecal biopsy
Urine
Others (Specify)
Skin
Clinical features of extrapulmonary NTM patients (n=)
Extrapulmonary risk factors No. of patients
Use of tap water to wash wounds 01
Use of unautoclaved surgical instruments 00
Surgical implants (specify) 00
Prosthetic heart valve replacements 00
Any type of laparotomy 00
Caesarean section 00
If any other invasive procedure or trauma, specify 00

7. Follow-up details
Characteristics Numbers
On treatment 06
Drug regimen(s) E, R, AZITHROMYCIN
Died 02
Lost to follow up 01
AEs & SAEs
• Gastrointestinal disturbances
• Hepato toxicity
• Visual impairment
• Renal impairment
• Cardiac esp. QTc prolongation
• Ototoxicity
• Vitamin deficiencies
• Cytopenia
• Neurological specify
1
0
0
0
0
0
0
0

8. 49 year old male with a past history of pulmonary
tuberculosis presented with complaints of cough with
expectoration, hemoptysis, fever with chills,
breathlessness MMRC grade I-II
Sputum AFB negative
Trunaat negative
BAL AFB negative
Sputum NTM culture positive

9. 45 year old male with a past history of pulmonary
tuberculosis presented with complaints of
breathlessness MMRC GRADE II-III , cough with
expectoration , high grade fever with chills for the
past 2 days.
Sputum AFB positive 2+
Trunaat negative
Sputum NTM culture positive