This document advertises a job opening for a Pre-Clinical Development Scientist position at a drug discovery and development company located in the UK home counties. The company is focused on developing two clinical-stage programs targeting neuromuscular disease and infectious disease. The Pre-Clinical Development Scientist will be responsible for delivering the pre-clinical development strategy, planning and executing pharmacological, toxicology, DMPK and ADME studies for the neuromuscular program. This is a permanent position offering autonomy, independence, and a leadership role within an innovative company committed to developing novel drug candidates.

1. Should you be interested in the above position and wish to apply, please send your application with your CV,
quoting the above reference number, to our recruitment team at recruitment@ctcon.ch
CTC Resourcing Solutions, 117 Waterloo Road, SE1 8UL, London, UK
Tel.: +44 207 193 9972 www.ctcresourcing.com info@ctcon.ch
Providing Flexible Resourcing Solutions
CTC Resourcing Solutions, founded 1997, is a pan-European specialist staffing organisation with
offices in London, Basel and Munich, providing flexible resourcing solutions to the pharmaceutical
industry across Europe, with contract and permanent placements in clinical development, data
management, statistics, regulatory affairs and medical marketing
For a key client, we are currently looking for a:
Pre-Clinical Development Scientist
Reference Number: 893175-W
Type of placement: Permanent
Location: Home counties, UK
Our client is a drug discovery and development company focused on the development of two
innovative high-value clinical-stage programmes that target diseases of significant unmet medical
needs specifically neuromuscular disease and infectious disease.
With the objective of developing best-in-class drugs, activities are continuing in parallel with the
advancement of the company’s lead compound which is expected to enter clinical trials in patients
during Q4 2013. In order to ensure achieve this, our client now requires a Pre-clinical development
Scientist who will plan and direct pre-clinical programmes with the objective of identifying viable
candidates for further development.
The Pre-clinical Development Scientist will be responsible for delivering the pre-clinical development
strategy including the planning and execution of pharmacological, toxicology, DMPK and ADME
studies for the neuromuscular programme. You will enjoy a high level of autonomy and independence
working closely with the leadership team to guide and shape the pre-clinical development strategy. As
well as providing direction to CROs and other vendors you will be hands-on in all aspects of pre-
clinical research, expediting next generation molecules from lead optimization to preclinical drug
development and Phase 1 healthy volunteer trials.
In summary, this is an outstanding and unique opportunity for an experienced pre-clinical development
professional with a range of skills and expertise in pharmacology, ADME and DMPK to take a leading
role within an innovative and exciting drug development company. You will have a high profile role
within the organisation and will work in partnership with the executive leadership of an organisation
that is highly committed to the development of novel DMD drug candidates.
Key Responsibilities:
 Provide leadership and direct the development of in vivo data packages to advance next
generation molecules to Investigational New Drug Application (IND)
 Oversee the conduct of in vivo studies in support of the neuromuscular programme
 Design and conduct DMPK, ADME and Toxicology studies to be performed externally
 Establish collaborations with outside academic and industry experts
 Manage outside projects with CROs
 Accountability for project success and results delivery
Person Specification:
 PhD with 5+ years industry in conducting in vivo pharmacology, ADME, DMPK and toxicology
required
 Experience of delivering a small molecule candidate to pre-clinical and clinical development
 Extensive experience running external in vivo platform, DMPK, and Toxicology studies
 Direct recent experience of in vivo data analysis – application of computational models