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DIAGNOSIS AND TREATMENT OF
OCULAR POSTERIOR SEGMENT TUMORS
Yo-Chang Chen1, Chi-Ting Horng2 M.D.,
Szu-Yuan Lin3 M.D., Ming-Ling Tsai1, M.D., Ph.D.
Purpose: A literature review of the important ocular choroidal hemangioma associated with Sturge-Weber
posterior segment tumors. syndrome, astrocytic hamartoma associated with tube-
Method: A PubMed search for English-language rous sclerosis, and congenital hypertrophy of the retinal
articles published between 1976 and 2009 was conduc- pigment epithelium (CHRPE) associated with Gardner
ted. Search terms used were "intraocular", "tumors" syndrome. We highlight recent developments in diagno-
ocular tumors- related term, and the generic names of sing and treating each intraocular disease process.
agents commonly used to treat intraocular tumors. Conclusion: Ocular posterior segment tumors are
Results: According to the etiologies, the ocular usually challenging for clinicians and require detailed
posterior segment tumors can be divided into three differential diagnosis between other simulating lesions.
groups. The first group had systemic tumors including Clinicians should be familiar with the management of
choroidal metastatic tumors, lymphoma, and leukemia. ocular posterior segment tumors, as some might be
The second group had primary tumors including mela- lethal and cause blindness. Recent advances in treatment
noma and retinoblastoma. The last group had systemic and diagnosis are helpful for early diagnosis and prompt
disease associated tumors including retinal hemangiob- therapy to improve the prognosis of vision and overall
lastoma associated with von Hippel-Lindau syndrome, life quality.
1
Department of Ophthalmolgy, Tri-Service General Hospital
2
Department of Ophthalmolgy, Kaohsiung Armed Forced General Hospital.
3
Department of Ophthalmology, Cathay General Hospital
Correspondence and reprint requests to: Ming-Ling Tsai Department of Ophthalmology, Tri-service General
Hospital. 325, Sec. 2, Cheng-Kung Rd. Taipei, Taiwan. 114 E-mail: doc30845@yahoo.com.tw
Chan-Han Foundation and Research & Development Fund of Tri-Service General Hospital (TSGH-C97-69;
TSGH-C98-69; TSGH-C97-69)