Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
Physiology Retreat 2016 - Blitz- Shayan
1. miR146a is a microRNA
Well known to regulate
Inflammation
Injecting
PCSK9 AAV vector to
mimic
high cholesterol
Where to go:
miR146a and lipids metabolism
Effect on atherosclerosis
PCSK9 gain of function
mutation results in increased
cholesterol by reducing LDL
receptors
TotalCholesterol(mg/dl)
0
50
100
150
200
250
WT
KO
Plasma Cholesterol
PCSK9 mechanism of action on hypercholesterolemia:
possible role of miR146a
Shayan Mohamamdmoradi – Dr. Subramanian Laboratory
Investigating
role of miR146a
*
Baseline Week 4
*P<0.05 WT vs KO
Editor's Notes
PCSK9 is an enzyme that its GOF mutation will result in increased cholesterol. Also, miR146a is a microRNA that seems to play a role in cholesterol efflux.
In this project, we investigated the role of miR146a in PCSK9 induced hypercholesterolemia. Using miR146a WT and KO mice, miR146a KO mice showed a significant reduction of plasma total cholesterol, inducing HDL-C levels irrespective to comparable PCSK9 levels. Our current focus is to understand the mechanism i.e. identifying its targets by which miR146a regulates HDL-C and its effect on atherosclerosis development.
