This document discusses using patient delivered partner therapy (PDPT) to manage sexual partners of patients diagnosed with chlamydia or gonorrhea. PDPT involves providing patients antibiotics or prescriptions to give to partners who may not seek treatment. The document outlines California laws allowing PDPT for chlamydia and gonorrhea, recommended antibiotics, guidelines for using PDPT, educating partners, and resources for implementation.
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Using PDPT for Partner Management
1. Using Patient Delivered Partner
Therapy (PDPT) for Partner
Management
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2. CFHC’s PDPT Trainings
• This is Part 2 of a 3-part series on PDPT
– Part 1: Background information about PDPT
– Part 2: Using PDPT for Partner Management
– Part 3: PDPT Law in California and
CFHC PDPT Guidelines
• For more information on PDPT:
http://
www.cdph.ca.gov/pubsforms/Guidelines/Documents/CA-STD-PDPT-Guidelines-1-
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3. What is PDPT?
Patient delivered partner therapy (PDPT) is one
form of EPT.
PDPT involves providing the index client with the
appropriate medication, information and
educational materials for sexual partners
exposed to the index client’s STI(s).
PDPT is an alternative to traditional partner
notification methods for testing and treatment of
STIs.
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4. PDPT and California Law
Chlamydia trachomatis (since 2001)
Neisseria gonorrhoeae (since 2007)
Because optimal treatment of syphilis
requires an injection, PDPT is not
recommended for syphilis.
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5. Antibiotics for PDPT
Chlamydia:
Azithromycin 1 gram
orally once
Gonorrhea:
Cefixime 400mg orally once
+
Azithromycin 1 gram
orally once
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6. Gonorrhea Treatment:
Dual Therapy Approach
Ceftriaxone 250 mg Azithromycin 1 gm orally in a single dose
PLUS OR
IM in a single dose
Doxycyline 100 mg orally twice daily for 7 days
OR
If ceftriaxone is not an option,
Cefixime 400 mg Azithromycin 1 gm orally in a single dose
PLUS OR
orally in a single dose Doxycyline 100 mg orally twice daily for 7 days
CDC 2010 STD Treatment Guidelines:
www.cdc.gov/std/treatment
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7. Neisseria gonorrhoeae Isolates with CDC "Alert" Values or
Decreased Susceptibility to Cephalosporins in Five
California STD Clinics, 1987-2011
*
*
* Cefixime was dropped from testing panel in 2007 and reinstated in
2009;
Cefpodoxime was added to testing panel in 2009
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8. PDPT for Gonorrhea
Not first line of partner management for
GC.
Other aspects of PDPT dispensing and
counseling remain the same.
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9. When Should PDPT Be Used?
Only use PDPT if partner(s) are unable to or
are unlikely to seek care.
PDPT should not be a substitute for clients
returning with their partners for treatment.
Every attempt should be made to bring
partners in for clinical evaluation and
treatment.
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10. Which Partners Can Get PDPT?
All sex partners within previous 2 months
of client’s symptoms or diagnosis.
If client had no sex partners within last 60
days, then most recent sex partner(s).
PDPT is appropriate for both male and
female partners.
There is no limit to # doses that can be
distributed for sex partners.
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11. Educational Materials with PDPT
Written informational materials directed to
the partner should ALWAYS accompany
PDPT medication.
Materials should discuss:
Medication instructions
Warnings and referrals
Concern about pelvic inflammatory disease
(PID) in female partners.
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12. Risks of PDPT
As with any treatment, there is always a
risk of adverse reactions to medications.
Minimal risks associated with single dose
azithromycin, and cefixime.
PDPT may compromise the quality of care
for partners, especially if the partner is co-
infected with another STI or has
undiagnosed HIV infection.
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13. When Should PDPT NOT Be
Used?
Do not use PDPT with clients co-infected with
STDs that are not treatable by PDPT
medications.
Do not use PDPT in cases of suspected child
abuse, sexual assault, or cases where the
client’s safety is in question.
Do not use PDPT when it is known that
partners have severe allergies to antibiotics.
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15. Key PDPT Counseling Messages
1. Partners should seek a complete STD
evaluation as soon as possible, regardless
of whether they take the medication.
2. Partners should read the informational
material very carefully before taking the
medication.
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16. Key PDPT Counseling Messages
3. Partners who have allergies to antibiotics
or who have serious health problems
should not take the medications and
should see a healthcare provider.
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17. Key PDPT Counseling Messages
4. Partners who have symptoms of a more
serious infection (e.g., pelvic pain in
women, testicular pain in men, fever in
women or men) should not take the PDPT
medications and should seek care as soon
as possible.
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18. Key PDPT Counseling Messages
5. Partners who are or could be pregnant
should seek care as soon as possible.
6. Clients and partners should abstain from
sex for at least seven days after treatment
and until seven days after all partners have
been treated, in order to decrease the risk
of re-infection.
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20. IPP Guidance & Toolkit
CARDEA Region IX Guidance and Toolkit for
the Use of Expedited Partner Therapy and
Retesting at Three Months To Prevent and
Detect Chlamydia and Gonorrhea
Reinfections
http://www.cardeaservices.org/projects/documents/R9_
EPT_Retesting_Nov08.pdf
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21. CFHC Patient Education Materials
Samples of the chlamydia PDPT patient education
handouts in English, Spanish, Chinese, and
Vietnamese are available for free on the CFHC
website, as well as gonorrhea PDPT patient
education handouts in English and Spanish.
http://www.cfhc.org/Resources/SamplesFile/sexually
-transmitted-disease.html
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22. Questions?
For CFHC PDPT Program information, please
contact:
Aileen Barandas MSN, NP
STD Programs Director
barandasa@cfhc.org
510.486.0412 ext 2334
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23. Medical and scientific consultation for this
webcast was provided by the California
Department of Public Health, STD Control
Branch
For more information, please visit
www.std.ca.gov
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Editor's Notes
Hello, and welcome to the California Family Health Council’s webcasts about Patient Delivered Partner Therapy, or PDPT. I’m Linda Creegan, family nurse practitioner with the California STD/HIV Prevention Training Center.
This webcast is Part 1 of a 3-part series. In this segment, I’ll be discussing the specifics of using PDPT in your clinic settings. Please listen to Parts 2 and 3 for some background information about PDPT for chlamydia and gonorrhea infections, and about California law as it relates to PDPT, and the California Family Health Council’s Azithromycin distribution program for PDPT.
PDPT is a type of expedited partner therapy, and essentially means that the provider gives medication or a prescription to the patient to take to her partner. Think of PDPT as a harm-reduction option for partner management, instead of as the first choice. This method is most feasible and effective in cases where the patient has contact with her partners, but doesn’t believe they will be willing or able to access care in a timely fashion.
In 2001, a law was passed in California that expressly permits medical providers, including physicians, nurse practitioners and physician assistants, to use PDPT for their patients with chlamydia. In 2007, the law was extended to cover PDPT for gonorrhea as well. PDPT is not feasible for the treatment of partners of persons diagnosed with syphilis, however, because treatment for syphilis requires an injection.
Here are the medication regimens currently recommended for PDPT: For chlamydia, azithromycin in and 1 gran single oral dose, And for gonorrhea, cefixime 400 mg in a single oral dose, together with azithromycin 1 gram, also in a single oral dose.
Let’s take a little detour for just a moment now to talk about some special concerns regarding PDPT for gonorrhea infections. You are no doubt aware that the treatment of gonorrhea is a special challenge, because of developing antibiotic resistance. The CDC currently recommended a dual therapy approach, that is, using 2 antibiotics for the treatment of all cases of gonorrhea, even when the chlamydia test is negative. Here you see those regimens given: the preferred combination is ceftriaxone 250 mg IM with azithromycin 1 gram.
Recently, increasing numbers of gonorrhea Isolates have shown decreased susceptibility to various antibiotics, including the cephalosoprins. In this graph, you see at the bottom of the columns towards the right in dark and lighter red, that the percentage of isolates showing some resistance to this class of antibiotics has increased markedly in the past few years. So with 2 antibiotics used together as dual therapy, we hope to delay the spread of these resistant strains.
So for gonorrhea in particular, PDPT should not be considered the first choice, but as a harm-reduction approach in cases where patients are quite sure that partners will not seek treatment in person.
This slide reiterates some important points: Regarding both chlamydia and gonorrhea infections, PDTD is used for partners who are unable or unlikely to seek care, rather than as a first line recommendation, or as a substitute for working to see that partners find a source of care for an in-person evaluation.
PDPT can be used for any partner from within the prior 2 months, or for the most recent partner if the patient hasn’t had sex with anyone in the last 2 months. PDPT can be used for both male and female partners, and the number of doses given will be determined by the # of partners the patient feels he or she needs to use this option for.
It’s very important to package written materials about the infection, about the medication, and about where to go for medical care with every dose of PDPT. Patient may not themselves be aware of limitations to use of PDPT that their partners have. For female partners, this information should include information regarding signs and symptoms of PID, so that women know to seek care immediately if they are experiencing these , because the PDPT regimen is not adequate for treatment of PID.
PDPT is not completely without risks, but in fact no treatment ever is. The risks associated with the medications themselves are minimal. It is true that PDPT might compromise the quality of care that a partner receives. When patients come to be evaluated b/o an exposure to an STD, they would be tested for other STDs; of course this is not happening for partners who take PDPT. So again, PDPT should be reserved for use in those cases where patients suspect that if they don’t take the medication to the partner, the partner will not receive treatment at all.
At times a client is co-infected with more than one STD – gonorrhea and syphilis, for instance. In these cases, PDPT should not be used. Nor should PDPT be used in cases of child sexual abuse, sexual assault or if the patient feels it may be unsafe for her to discuss the treatment with her partner. And of course if the partner is known to be allergic to one of the PDPT medication, they should not take it. Information about allergies should always be included in the information that is given with the medication.
So to summarize, here are the key counseling points about PDPT for our patients with chlamydia or gonorrhea.
For the best and most complete care, partners should find a source for medical evaluation. They can do this even after they have taken PDPT, to be tested for other infections. Information about the infection and the medication accompany the PDPT dose, and should be read carefully by the partner.
Partners with allergies or any kind of health condition that affects their ability to take medication should not use PDPT, but should see a health care provider instead.
Partners who have symptoms, like abdominal pain in women or testicular pain in men, should not take PDPT.
Partners who are pregnant can use PDPT, but should be strongly encouraged to seek care because of the contact. And even with the single dose treatment, patients and their partners should abstain from sex for seven days after taking the medication, to prevent reinfection.
The last few slides point you towards some resources, for more information about PDPT and to help your clinic to implement this option of partner treatment.
The Infertility Prevention Project here in Region IX has a great document devoted to issues of PDPT and retesting. You’ll find that posted at this website.
The California Family Health Council has examples of information factsheets in several languages, which you can use with PDPT. Here’s that web address…..
And finally, you can contact Aileen Barandas with CFHC directly with any questions you may have; here is her email address and phone number. We’ve covered the important guidelines for using PDPT with you patients. Be sure to listen to the other 2 short webcasts, about the background reasons for PDPT, and about the California Family Health Council’s PDPT Distribution program, whereby your Title X clinic can receive azithromycin, free of charge, specifically to use for PDPT. Thanks for listening, and thanks for the work you do.