Softness tester TP-H10 is adopted with microprocessor controlled technology and liquid crystal display to view and observe test parameters and result values.
Portable Chlorine Meter is small size designed and developed based on colorimetric method. Designed with LED light source and offers 515 nm wavelength of light.
Portable airborne particle counter is a six channel microcomputer controlled unit. It has a provision of simultaneously counting particles in six different size ranges with real time monitoring.
Softness tester TP-H10 is adopted with microprocessor controlled technology and liquid crystal display to view and observe test parameters and result values.
Portable Chlorine Meter is small size designed and developed based on colorimetric method. Designed with LED light source and offers 515 nm wavelength of light.
Portable airborne particle counter is a six channel microcomputer controlled unit. It has a provision of simultaneously counting particles in six different size ranges with real time monitoring.
Platelet Incubator is a continuous side-to-side motion agitation incubator which operates at a temperature range of 4°C to 26°C with one agitation chamber.
Water absorption tester TP-C20 is used to measure the degree of water absorption of a paper & cloth. Designed using ‘Rise in capillary by millimetres' principle, where a specimen is suspended in a vat filled with water.
Lighting Incubator is a 2 side light illuminating incubator runs under microprocessor PID control system with lighting illumination of 0 to 12000 lx. Offers two types of temperature control range: with illumination 10 °C to 50 °C and without illumination 5 °C to 50 °C.
Laser Theodolite with built-in diode, the laser beam is visible up to 200 m away outside in daylight. A clear laser spot is visible up to 100 m through eyepiece.
Manifold Freeze Dryer is a compact table-top unit with 3 kg condenser capacity and condenser temperature of - 50 °C used for drying aqueous specimens.It allows larger glassware like flasks to be dried independent of the shelving units.
Gas Chromatography is a benchtop unit with advanced flow controller (AFC) technology. System has digital control mode and polar capillary columns to separate polar analytes.
Ducted Fume hood is a microprocessor controlled ducted fume hood with built in centrifugal blower which removes toxic gases to the outside of the working environment.
Drying oven LDO-A10 comes with polished stainless steel chamber design. With double layered glass door, large observation window helps in inspection of the sample kept inside oven during process.
Double Beam UV-Vis Spectrophotometer LUS-B10 is a compact, table top double beam designed UV-Vis spectrophotometer comprising Silicon photodiode detector, Tungsten and Deuterium lamp as light source.
Digital Refractometer LDRF-A12 is a benchtop unit used to measure refractive index of transparent or translucent solid, liquid substances and also to measure percent of sugar in solutions.
Digital microscopes LDM-B10 is in demand for the provision of high resolution image on the LCD screen. The zoom objectives of different range offers superior magnification. I
Differential Scanning Calorimeter LDSC-A10 is an analyser which allows the measurement of different characteristic properties of various samples from RT to 800°C.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Platelet Incubator is a continuous side-to-side motion agitation incubator which operates at a temperature range of 4°C to 26°C with one agitation chamber.
Water absorption tester TP-C20 is used to measure the degree of water absorption of a paper & cloth. Designed using ‘Rise in capillary by millimetres' principle, where a specimen is suspended in a vat filled with water.
Lighting Incubator is a 2 side light illuminating incubator runs under microprocessor PID control system with lighting illumination of 0 to 12000 lx. Offers two types of temperature control range: with illumination 10 °C to 50 °C and without illumination 5 °C to 50 °C.
Laser Theodolite with built-in diode, the laser beam is visible up to 200 m away outside in daylight. A clear laser spot is visible up to 100 m through eyepiece.
Manifold Freeze Dryer is a compact table-top unit with 3 kg condenser capacity and condenser temperature of - 50 °C used for drying aqueous specimens.It allows larger glassware like flasks to be dried independent of the shelving units.
Gas Chromatography is a benchtop unit with advanced flow controller (AFC) technology. System has digital control mode and polar capillary columns to separate polar analytes.
Ducted Fume hood is a microprocessor controlled ducted fume hood with built in centrifugal blower which removes toxic gases to the outside of the working environment.
Drying oven LDO-A10 comes with polished stainless steel chamber design. With double layered glass door, large observation window helps in inspection of the sample kept inside oven during process.
Double Beam UV-Vis Spectrophotometer LUS-B10 is a compact, table top double beam designed UV-Vis spectrophotometer comprising Silicon photodiode detector, Tungsten and Deuterium lamp as light source.
Digital Refractometer LDRF-A12 is a benchtop unit used to measure refractive index of transparent or translucent solid, liquid substances and also to measure percent of sugar in solutions.
Digital microscopes LDM-B10 is in demand for the provision of high resolution image on the LCD screen. The zoom objectives of different range offers superior magnification. I
Differential Scanning Calorimeter LDSC-A10 is an analyser which allows the measurement of different characteristic properties of various samples from RT to 800°C.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
2. Overview
Paper and cardboard thickness meter TP-E20 measures thickness of
paper, corrugated papers using contact measurement method. The
Analogue (pointer type) type gauge display is mounted at top with a false
weight so as to develop a uniform, reproducible constant pressure on the
anvil through the foot. It finds applications in paper, printing, and
packaging industry.
Specifications :
Measuring range 0 to 4 mm
Accuracy 0.01 or 0.001 mm
Gauge Analogue gauge display
Contact pressure (to create false
weight)
100 ± 10 kPa
Contact diameter 16.0 ± 0.5 mm
Error of depth parallelism 0.005 mm or 1 %
Indicating Error ± 0.0025 mm or ± 0.5 %
Indication variability ≤ 0.0025 mm or ≤ 0.5 %
Dimension 233×160×120 mm
Weight 5.5 kg
Features :
- Portable, compact design
- Measuring range 0 to 4 mm for normal paper
- Incorporated with contact measurement method
3. - Analogue gauge display
- Manual operations
- Easy to use
Applications :
Thickness tester is used to measure thickness of paper, corrugated
paper, cardboard & other sheets widely used in paper testing, printing,
packaging industry.
Labtron Equipment Ltd.Quatro House,Lyon
Way,Camberley,SurreyGU16 7ER, United Kingdom
Email: |
Phone: +44 2080 043 608
info@labtron.uk Website: www.labtron.uk
