The COVID-19 pandemic has significantly impacted the hotel industry. The major hotel chains, while initially facing weaknesses due to their size and crowded spaces, are best positioned to leverage their resources and expertise to establish new health and safety standards through technology solutions. By proactively partnering with startups and innovating quickly, the large chains can become the gold standard for hygiene and establish customer trust in a post-COVID world. Meanwhile, independent hotels, hostels, and alternative accommodations face challenges in implementing new standards with limited resources, but some may find opportunities through agility and adapting to changing customer needs.