Cancer is one of the most serve disease and is no pure cure but only preventable at some level of this Oral Squamous cell carcinoma.

1. ORAL SQUAMOUS CELL CARCINOMA
By
Sejal Mahajan
Government Dental College & Hospital

2. What is Oral Squamous Cell Carcinoma (OSCC)?
Oral Squamous Cell Carcinoma (OSCC) is the most common neoplasm of oral cavity.
OSCC is Also known as Epidermal Carcinoma
OSCC is defined as that malignant Epithelial neoplasm which exhibit squamous differentiation
characterised by formation of keratin and/or presence of intercellular bridges (seen as desmosomes
or tight junctions)
Intercellular bridges And
Keratinization

3. Oral Squamous cell carcinoma normal vs tumor
Immunohistochemical analysis of normal and tumor
oral samples from patients
Weak staining of N-myristoyltransferase was
observed in the normal adjacent oral tissues as
compared to the intense staining in the oral
squamous cell carcinoma samples at different
magnifications.
Normal Tumor

4. ETIOLOGY:
Etiology is unknown, but no. of etiological factor have been implicated.
Strong Association :
● Tobacco smoking And chewing. (Tobacco smoking is major cause of oral cancer)
● Chronic alcoholic consumption.
● Human PapillomaVirus infection.

5. Weak Association:
● Chronic irritation from ill fitting denture.
● Submucosal fibrosis.
● Nutritional deficiency (esp. Vit. A keeps epithelium Healthy).
● Poor dental hygiene.
● Exposure to sunlight (lip cancer).
● Plummer Vinson Syndrome(disorder marked by anaemia caused by fe deficiency web lik
growth membrane in throat that makes swallowing difficult).

6. Epidemiology:
● M:F ratio is 2:1 ( except for carcinoma of vermillion border
of lower lip).
● Found after 4 th decade. (>40yr)
Clinical Features:
● Lip or mouth sores that don’t heal.
● A loose tooth.
● Early carcinoma shows white lesion, red lesion or both as
exophytic mass.
● Painful swallowing.
● Erosion or Ulcer is most Common clinical presentation.
● Ulcer has irregular papillary Surface elevated borders,
indurated margins
hard base on palpitations.

7. INCIDENCE:
● Lateral border of tongue and ventral surface of tongue most commonly affected sites.
● Lips.
● Soft Palate.
● floor of mouth.
● Gingival ridge.
● Buccal Mucosa.

8. INCIDENCE:
● Lateral border of tongue and ventral surface of tongue most commonly affected sites.
● Lips.
● Soft Palate.
● floor of mouth.
● Gingival ridge.
● Buccal Mucosa.

9. HISTOLOGICAL FEATURES:
● Increased mytotic activity.
● Most of the lesions are well differentiated.
● Keratin Pearls (abnormal keratinization).
● Hyperchromatic nuclei.
● Pluromorphism.
● Connective tissue stroma with chronic inflammation
Hyperchromatic Nuclei and pleuromorphism

10. Histological subtype Of OSCC

11. Well differentiated,
Non metastasizing
ocal recurrences may
progress to SCC
Other varients of OSCC
Papillary SCC
Verrucos SCC Spindle Cell
SCC
Keratinizing and
non-Keratinizing
types better
prognosis then
conventional
SCC
Worse prognosis
then
conventional
SCC set maybe
radiation-
induced
Carcinoma
Cuniculatum
Well-differentiated
locally destructive
with the burrowing
pattern metastasis
rare

12. Basaloid SSC Acantholytic SCC
Well differentiated
Non metastasizing
Local recurrences
May progress to
SCC
More aggressive
than conventional
SCCPropensity for
recurrenceLocal and
distant metastasis
Adenosquamous
SCC
Lymphoepithelil
Carcinoma
Rear in oral cavity
present at high
stage~70% lymph node
metastasisSome cases
are Epstein Barr virus
High grade
carcinoma frequent
metastasis prognosis
similar to
conventional SCC

13. Metastasis:
Interaural carcinoma of different sites involves chiefly
submaxillary and superficial and deep cervical lymph
node.
Treatment:
● Surgical excision
● Radiotherapy
● Chemotherapy
Prognosis:
Depends on tumor stage and histopathological pattern

14. THANKYOU